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1. 发明授权

US06309635B1 Seeding parenchymal cells into compression resistant porous scaffold after vascularizing in vivo 失效
标题翻译：在体内血管化后将实质细胞接种到抗压多孔支架中
公开(公告)号：US06309635B1
公开(公告)日：2001-10-30
申请号：US08345217
申请日：1994-11-28
申请人： Donald E. Ingber , Robert S. Langer , Joseph P. Vacanti
发明人： Donald E. Ingber , Robert S. Langer , Joseph P. Vacanti
IPC分类号： A01N6300
CPC分类号： A61L27/3804 , A61F2/022 , A61F2/062 , A61L27/3839 , A61L2430/06 , C12N5/0068 , C12N5/0671 , C12N2501/18 , C12N2533/30 , C12N2533/40
摘要： A method is provided whereby cells having a desired function are seeded on and into biocompatible, biodegradable or non-degradable porous polymer scaffolding matrix, previously implanted in a patient and infiltrated with blood vessels and connective tissue, to produce a functional organ equivalent. The resulting organoid is a chimera formed of parenchymal elements of the donated tissue and vascular and matrix elements of the host. The matrix should be compression resistant and a non-toxic, porous template for vascular ingrowth. The pore size, usually between approximately 100 and 300 microns, should allow vascular and connective tissue ingrowth throughout approximately 10 to 90% of the matrix, and the injection of cells such as hepatocytes without damage to the cells or patient. The introduced cells attach to the connective tissue and are fed by the blood vessels. Immediately prior to matrix implantation portacaval shunts can be created to provide trophic stimulatory factors to the implanted matrix to enhance replication and function.
摘要翻译：提供了一种方法，其中具有期望功能的细胞接种在生物相容性，可生物降解或不可降解的多孔聚合物支架基质上，先前植入患者并渗入血管和结缔组织，以产生功能性器官当量。所得的有机体是由捐赠的组织的实质元素和宿主的血管和基质元素形成的嵌合体。基质应具有抗压缩性和无毒，多孔的模板用于血管向内生长。通常在约100和300微米之间的孔径应允许血管和结缔组织在基质的约10至90％内向内生长，并且注射细胞如肝细胞而不损伤细胞或患者。引入的细胞附着于结缔组织并由血管进食。在矩阵植入之前，可以产生口腔分流，以向植入的基质提供营养刺激因子以增强复制和功能。

2. 发明授权

US07914579B2 Tissue engineered tendons and ligaments 失效
标题翻译：组织工程肌腱和韧带
公开(公告)号：US07914579B2
公开(公告)日：2011-03-29
申请号：US11351127
申请日：2006-02-09
申请人： Charles A. Vacanti , Yi Lin Cao , Robert S. Langer , Joseph P. Vacanti , Keith Paige , Joseph Upton
发明人： Charles A. Vacanti , Yi Lin Cao , Robert S. Langer , Joseph P. Vacanti , Keith Paige , Joseph Upton
IPC分类号： A61F2/08 , A61F2/42
CPC分类号： A61L27/3804 , A61F2/08 , A61L27/18 , A61L27/3604 , A61L27/3662 , A61L27/3817 , A61L27/3843 , A61L27/386 , A61L27/58 , A61L2430/10 , C08L67/04
摘要： Connective tissue, including neo-tendons and ligaments, has been constructed using biodegradable synthetic scaffolds seeded with tenocytes. The scaffolds are preferably formed from biodegradable fibers formed of a polymer such as polyglycolic acid-polylactic acid copolymers, and seeded with cells isolated from autologous tendon or ligament by means of enzymatic digestion or direct seeding into tissue culture dishes from explants. The cell polymer constructs are then surgically transplanted to replace missing segments of functioning tendon or ligament.
摘要翻译：结缔组织，包括新肌腱和韧带，已经使用可生物降解的合成支架构建，种子与细胞接种。支架优选由聚合物如聚乙醇酸 - 聚乳酸共聚物形成的可生物降解的纤维形成，并通过酶切消化或直接接种到外植体的组织培养皿中，从自体肌腱或韧带分离的细胞接种。然后手术移植细胞聚合物构建体以代替功能性肌腱或韧带的缺失部分。

3. 发明申请

US20090060969A1 Porous biodegradable polymeric materials for cell transplantation 失效
标题翻译：用于细胞移植的多孔可生物降解聚合物材料
公开(公告)号：US20090060969A1
公开(公告)日：2009-03-05
申请号：US12218448
申请日：2008-07-15
申请人： Antonios G. Mikos , Robert S. Langer , Joseph P. Vacanti , Linda G. Griffith , Georgios Sarakinos
发明人： Antonios G. Mikos , Robert S. Langer , Joseph P. Vacanti , Linda G. Griffith , Georgios Sarakinos
IPC分类号： A61K9/00 , A61K35/12 , A61P17/02
CPC分类号： C08J9/28 , A61F2/0077 , A61F2/18 , A61F2/186 , A61F2/28 , A61F2/30756 , A61F2/3094 , A61F2/30942 , A61F2/4241 , A61F2002/30011 , A61F2002/30062 , A61F2002/30156 , A61F2002/30299 , A61F2002/30304 , A61F2002/30929 , A61F2002/30971 , A61F2002/4251 , A61F2210/0004 , A61F2230/0023 , A61F2230/0063 , A61F2230/0093 , A61F2240/001 , A61F2240/002 , A61F2250/0023 , A61L27/18 , A61L27/38 , B01D67/003 , B01D2325/02 , C08J9/26 , C08L67/04
摘要： Polymeric materials are used to make a pliable, non-toxic, injectable porous template for vascular ingrowth. The pore size, usually between approximately 100 and 300 microns, allows vascular and connective tissue ingrowth throughout approximately 10 to 90% of the matrix following implantation, and the injection of cells uniformly throughout the implanted matrix without damage to the cells or patient. The introduced cells attach to the connective tissue within the matrix and are fed by the blood vessels. The preferred material for forming the matrix or support structure is a biocompatible synthetic polymer which degrades in a controlled manner by hydrolysis into harmless metabolites, for example, polyglycolic acid, polylactic acid, polyorthoester, polyanhydride, or copolymers thereof. The rate of tissue ingrowth increases as the porosity and/or the pore size of the implanted devices increases. The time required for the tissue to fill the device depends on the polymer crystallinity and is less for amorphous polymers versus semicrystalline polymers. The vascularity of the advancing tissue is consistent with time and independent of the biomaterial composition and morphology.
摘要翻译：聚合材料用于制造一种柔韧，无毒，可注射的多孔模板，用于血管向内生长。通常在约100和300微米之间的孔径允许血管和结缔组织在植入后约10至90％的基质向内生长，并且在整个植入的基质中均匀注射细胞而不损伤细胞或患者。引入的细胞附着到基质内的结缔组织，并由血管进食。用于形成基质或支撑结构的优选材料是生物相容的合成聚合物，其通过水解以受控的方式降解成无害的代谢物，例如聚乙醇酸，聚乳酸，聚原酸酯，聚酐或其共聚物。随着植入装置的孔隙率和/或孔径增加，组织向内生长的速率增加。组织填充装置所需的时间取决于聚合物的结晶度，对于无定形聚合物与半结晶聚合物相比较少。前进组织的血管分布与时间一致，与生物材料组成和形态无关。

4. 发明授权

US06689608B1 Porous biodegradable polymeric materials for cell transplantation 失效
标题翻译：用于细胞移植的多孔可生物降解聚合物材料
公开(公告)号：US06689608B1
公开(公告)日：2004-02-10
申请号：US09669760
申请日：2000-09-26
申请人： Antonios G. Mikos , Robert S. Langer , Joseph P. Vacanti , Linda G. Griffith , Georgios Sarakinos
发明人： Antonios G. Mikos , Robert S. Langer , Joseph P. Vacanti , Linda G. Griffith , Georgios Sarakinos
IPC分类号： C12N506
CPC分类号： C08J9/28 , A61F2/0077 , A61F2/18 , A61F2/186 , A61F2/28 , A61F2/30756 , A61F2/3094 , A61F2/30942 , A61F2/4241 , A61F2002/30011 , A61F2002/30062 , A61F2002/30156 , A61F2002/30299 , A61F2002/30304 , A61F2002/30929 , A61F2002/30971 , A61F2002/4251 , A61F2210/0004 , A61F2230/0023 , A61F2230/0063 , A61F2230/0093 , A61F2240/001 , A61F2240/002 , A61F2250/0023 , A61L27/18 , A61L27/38 , B01D67/003 , B01D2325/02 , C08J9/26 , C08L67/04
摘要： Polymeric materials are used,to make a pliable, non-toxic, injectable porous template for vascular ingrowth. The pore size, usually between approximately 100 and 300 microns, allows vascular and connective tissue ingrowth throughout approximately 10 to 90% of the matrix following implantation, and the injection of cells uniformly throughout the implanted matrix without damage to the cells or patient. The introduced cells attach to the connective tissue within the matrix and are fed by the blood vessels. The preferred material for forming the matrix or support structure is a biocompatible synthetic polymer which degrades in a controlled manner by hydrolysis into harmless metabolites, for example, polyglycolic acid, polylactic acid, polyorthoester, polyanhydride, or copolymers thereof. The rate of tissue ingrowth increases as the porosity and/or the pore size of the implanted devices increases. The time required for the tissue to fill the device depends on the polymer crystallinity and is less for amorphous polymers versus semicrystalline polymers. The vascularity of the advancing tissue is consistent with time and independent of the biomaterial composition and morphology.
摘要翻译：使用聚合材料制成柔韧，无毒，可注射的多孔模板用于血管向内生长。通常在约100和300微米之间的孔径允许血管和结缔组织在植入后约10至90％的基质向内生长，并且在整个植入的基质中均匀注射细胞而不损伤细胞或患者。引入的细胞附着到基质内的结缔组织，并由血管进食。用于形成基质或支撑结构的优选材料是生物相容的合成聚合物，其通过水解以受控的方式降解成无害的代谢物，例如聚乙醇酸，聚乳酸，聚原酸酯，聚酐或其共聚物。随着植入装置的孔隙率和/或孔径增加，组织向内生长的速率增加。组织填充装置所需的时间取决于聚合物的结晶度，对于无定形聚合物与半结晶聚合物相比较少。前进组织的血管分布与时间一致，与生物材料组成和形态无关。

5. 发明授权

US5804178A Implantation of cell-matrix structure adjacent mesentery, omentum or peritoneum tissue 失效
标题翻译：植入细胞基质结构邻近肠系膜，网膜或腹膜组织
公开(公告)号：US5804178A
公开(公告)日：1998-09-08
申请号：US203509
申请日：1994-02-28
申请人： Joseph P. Vacanti , Robert S. Langer , Lynt Johnson
发明人： Joseph P. Vacanti , Robert S. Langer , Lynt Johnson
IPC分类号： A61L27/36 , A61L27/38 , C12N5/00 , C12N11/08 , A61F2/18 , A61F2/28
CPC分类号： A61L27/3839 , A61L27/3843 , A61L27/3869 , C12N5/0068 , A61L2430/06 , C12N2501/18 , C12N2533/30 , C12N2533/40
摘要： A matrix structure containing attached cells such as endocrine cells, fibroblasts, endothelial cells or genitourinary cells is implanted in a patient adjacent tissue having a high surface area and vasculature such as mesentery, omentum or peritoneum tissue. Large volumes of cells can be attached to the matrix and the matrix implanted with minimum trauma and blood loss into a patient to produce a functional organ equivalent. Multiple matrix structures containing cells can be implanted to functionally resemble naturally occurring organs. Implanting multiple matrices between folds of the mesentery is particularly well suited for growth of endocrine structures, including liver, pancreas, and adrenal gland. The matrix structure is preferably formed from a biodegradable artificial polymer. Collagen and non-biodegradable materials can also be used, and the matrix structure can be overlaid with a material that enhances cell attachment. Materials such as angiogenesis factors can be incorporated into a matrix and implanted prior to implanting the matrix containing cells or the materials can be incorporated into the matrix containing cells. Cells attached to the matrix may be cultured in vitro prior to implanting. Matrix structures containing different types of cells can be implanted juxtapositioned with each other.
摘要翻译：将包含附着细胞如内分泌细胞，成纤维细胞，内皮细胞或泌尿生殖细胞的基质结构植入具有高表面积和脉管系统如肠系膜，网膜或腹膜组织的邻近组织中。大量的细胞可以连接到基质上，并且基质以最小的创伤和失血植入患者体内以产生功能性器官当量。可以将包含细胞的多个基质结构植入功能上类似天然存在的器官。在肠系膜的折叠之间植入多个基质特别适用于内分泌结构的生长，包括肝，胰腺和肾上腺。基质结构优选由生物可降解的人造聚合物形成。还可以使用胶原蛋白和不可生物降解的材料，并且可以用增强细胞附着的材料覆盖基质结构。诸如血管生成因子的材料可以掺入基质中并在植入包含细胞的基质之前植入，或者该材料可以并入含有基质的细胞中。附着于基质的细胞可以在植入前在体外培养。含有不同类型细胞的基质结构可以彼此并置。

6. 发明授权

US5514378A Biocompatible polymer membranes and methods of preparation of three dimensional membrane structures 失效
标题翻译：生物相容性聚合物膜和制备三维膜结构的方法
公开(公告)号：US5514378A
公开(公告)日：1996-05-07
申请号：US012270
申请日：1993-02-01
申请人： Antonios G. Mikos , Georgios Sarakinos , Joseph P. Vacanti , Robert S. Langer , Linda G. Cima
发明人： Antonios G. Mikos , Georgios Sarakinos , Joseph P. Vacanti , Robert S. Langer , Linda G. Cima
IPC分类号： A61F2/00 , A61F2/02 , A61F2/18 , A61F2/28 , A61F2/30 , A61F2/42 , A61L27/18 , B01D67/00 , C08J9/26 , C08J9/28 , C08J5/20
CPC分类号： C08J9/28 , A61F2/4241 , A61L27/18 , B01D67/003 , C08J9/26 , A61F2/0077 , A61F2/28 , A61F2/30756 , A61F2/3094 , A61F2/30942 , A61F2002/30011 , A61F2002/30062 , A61F2002/30156 , A61F2002/30299 , A61F2002/30304 , A61F2002/30929 , A61F2002/30971 , A61F2002/4251 , A61F2210/0004 , A61F2230/0023 , A61F2230/0063 , A61F2230/0093 , A61F2240/001 , A61F2240/002 , A61F2250/0023 , B01D2323/12 , B01D67/0083 , B01D71/40 , B01D71/48
摘要： Biocompatible porous polymer membranes are prepared by dispersing salt particles in a biocompatible polymer solution. The solvent in which the polymer is dissolved is evaporated to produce a polymer/salt composite membrane. The polymer can then be heated and cooled at a predetermined constant rate to provide the desired amount of crystallinity. Salt particles are leached out of the membrane by immersing the membrane in water or another solvent for the salt but not the polymer. The membrane is dried, resulting in a porous, biocompatible membrane to which dissociated cells can attach and proliferate. A three-dimensional structure can be manufactured using the polymer membranes by preparing a contour drawing of the shape of the structure, determining the dimensions of thin cross-sectional layers of the shape, forming porous polymer membranes corresponding to the dimensions of the layers, and laminating the membranes together to form a three-dimensional matrix having the desired shape.
摘要翻译：通过将盐颗粒分散在生物相容的聚合物溶液中来制备生物相容的多孔聚合物膜。溶解聚合物的溶剂被蒸发以产生聚合物/盐复合膜。然后可以以预定的恒定速率加热和冷却聚合物，以提供所需量的结晶度。通过将膜浸入水或其它溶剂中而不是聚合物将盐颗粒浸出膜外。将膜干燥，得到多孔的，生物相容的膜，离解的细胞可附着和增殖。可以通过制备结构形状的轮廓图，确定形状的薄截面层的尺寸，形成对应于层的尺寸的多孔聚合物膜，可以使用聚合物膜制造三维结构，以及将膜层压在一起以形成具有所需形状的三维矩阵。

7. 发明授权

US08110213B2 Method of forming a tissue structure by introducing cells into an implanted matrix 失效
标题翻译：通过将细胞引入到植入的基质中形成组织结构的方法
公开(公告)号：US08110213B2
公开(公告)日：2012-02-07
申请号：US12218448
申请日：2008-07-15
申请人： Antonios G. Mikos , Robert S. Langer , Joseph P. Vacanti , Linda G. Griffith , Georgios Sarakinos
发明人： Antonios G. Mikos , Robert S. Langer , Joseph P. Vacanti , Linda G. Griffith , Georgios Sarakinos
IPC分类号： A61F2/00 , C12N11/08 , C12N11/04 , C12N5/07
CPC分类号： C08J9/28 , A61F2/0077 , A61F2/18 , A61F2/186 , A61F2/28 , A61F2/30756 , A61F2/3094 , A61F2/30942 , A61F2/4241 , A61F2002/30011 , A61F2002/30062 , A61F2002/30156 , A61F2002/30299 , A61F2002/30304 , A61F2002/30929 , A61F2002/30971 , A61F2002/4251 , A61F2210/0004 , A61F2230/0023 , A61F2230/0063 , A61F2230/0093 , A61F2240/001 , A61F2240/002 , A61F2250/0023 , A61L27/18 , A61L27/38 , B01D67/003 , B01D2325/02 , C08J9/26 , C08L67/04
摘要： Polymeric materials are used to make a pliable, non-toxic, injectable porous template for vascular ingrowth. The pore size, usually between approximately 100 and 300 microns, allows vascular and connective tissue ingrowth throughout approximately 10 to 90% of the matrix following implantation, and the injection of cells uniformly throughout the implanted matrix without damage to the cells or patient. The introduced cells attach to the connective tissue within the matrix and are fed by the blood vessels. The preferred material for forming the matrix or support structure is a biocompatible synthetic polymer which degrades in a controlled manner by hydrolysis into harmless metabolites, for example, polyglycolic acid, polylactic acid, polyorthoester, polyanhydride, or copolymers thereof. The rate of tissue ingrowth increases as the porosity and/or the pore size of the implanted devices increases. The time required for the tissue to fill the device depends on the polymer crystallinity and is less for amorphous polymers versus semicrystalline polymers. The vascularity of the advancing tissue is consistent with time and independent of the biomaterial composition and morphology.
摘要翻译：聚合材料用于制造一种柔韧，无毒，可注射的多孔模板，用于血管向内生长。通常在约100和300微米之间的孔径允许血管和结缔组织在植入后约10至90％的基质向内生长，并且在整个植入的基质中均匀注射细胞而不损伤细胞或患者。引入的细胞附着到基质内的结缔组织，并由血管进食。用于形成基质或支撑结构的优选材料是生物相容的合成聚合物，其通过水解以受控的方式降解成无害的代谢物，例如聚乙醇酸，聚乳酸，聚原酸酯，聚酐或其共聚物。随着植入装置的孔隙率和/或孔径增加，组织向内生长的速率增加。组织填充装置所需的时间取决于聚合物的结晶度，对于无定形聚合物与半结晶聚合物相比较少。前进组织的血管分布与时间一致，与生物材料组成和形态无关。

8. 发明授权

US6123727A Tissue engineered tendons and ligaments 失效
标题翻译：组织工程肌腱和韧带
公开(公告)号：US6123727A
公开(公告)日：2000-09-26
申请号：US905491
申请日：1997-08-04
申请人： Charles A. Vacanti , Yi Lin Cao , Robert S. Langer , Joseph P. Vacanti , Keith Paige , Joseph Upton
发明人： Charles A. Vacanti , Yi Lin Cao , Robert S. Langer , Joseph P. Vacanti , Keith Paige , Joseph Upton
IPC分类号： A61F2/08 , A61L27/18 , A61L27/38 , A61L27/58
CPC分类号： A61L27/3804 , A61L27/18 , A61L27/3604 , A61L27/3662 , A61L27/3817 , A61L27/3843 , A61L27/386 , A61L27/58 , A61F2/08 , A61L2430/10
摘要： Connective tissue, including neo-tendons and ligaments, has been constructed using biodegradable synthetic scaffolds seeded with tenocytes. The scaffolds are preferably formed from biodegradable fibers formed of a polymer such as polyglycolic acid-polylactic acid copolymers, and seeded with cells isolated from autologous tendon or ligament by means of enzymatic digestion or direct seeding into tissue culture dishes from explants. The cell polymer constructs are then surgically transplanted to replace missing segments of functioning tendon or ligament.
摘要翻译：结缔组织，包括新肌腱和韧带，已经使用可生物降解的合成支架构建，种子与细胞接种。支架优选由聚合物如聚乙醇酸 - 聚乳酸共聚物形成的可生物降解的纤维形成，并通过酶切消化或直接接种到外植体的组织培养皿中，从自体肌腱或韧带分离的细胞接种。然后手术移植细胞聚合物构建体以代替功能性肌腱或韧带的缺失部分。

9. 发明授权

US5716404A Breast tissue engineering 失效
标题翻译：乳腺组织工程
公开(公告)号：US5716404A
公开(公告)日：1998-02-10
申请号：US358189
申请日：1994-12-16
申请人： Joseph P. Vacanti , Anthony Atala , David J. Mooney , Robert S. Langer
发明人： Joseph P. Vacanti , Anthony Atala , David J. Mooney , Robert S. Langer
IPC分类号： C12N5/06 , A61L27/00 , A61L27/38 , C12N5/08 , A61F2/12
CPC分类号： A61L27/3804 , A61F2/12 , A61L27/3839 , A61F2002/0086 , A61F2250/0003 , A61L2430/04
摘要： Methods and compositions are described herein for reconstruction or augmentation of breast tissue. Dissociated cells, preferably muscle cells, are implanted in combination with a suitable biodegradable, polymeric matrix to form new tissue. There are two forms of matrices which can be used: a polymeric hydrogel formed of a material such as alginate having cells suspended therein, and a fibrous matrix having an interstitial spacing between about 100 and 300 microns. Preferred polymeric materials are those degrading over about one to two months, such as polylactic acid-glycolic acid copolymers. The matrices can be seeded prior to implantation or implanted, allowed to vascularize, then seeded with cells. In a preferred embodiment, the cell-matrix structures are implanted in combination with tissue expander devices. As cell-matrix is implanted, or cells proliferate and form new tissue, the expander size is decreased, until it can be removed and the desired reconstruction or augmentation is obtained. The preferred cell types are muscle cells, although other types of mesenchymal cells, fibroblasts, chondrocytes, and adipocytes can be used. Cells obtained from tissue such as the labia can be used for specialized applications such as formation of a nipple type tissue. Other materials, such as bioactive molecules that enhance vascularization of the implanted tissue and/or which inhibit ingrowth of fibrotic tissue, can be implanted with the matrix to enhance development of more normal tissue.
摘要翻译：本文描述了用于重建或增加乳腺组织的方法和组合物。离解的细胞，优选肌肉细胞，与合适的可生物降解的聚合物基质组合植入以形成新的组织。可以使用两种形式的基质：由具有悬浮于其中的细胞的诸如藻酸盐的材料形成的聚合物水凝胶和具有约100至300微米间隙的纤维基质。优选的聚合物材料是在约一至两个月内降解的物质，例如聚乳酸 - 乙醇酸共聚物。可以在植入或植入之前将基质接种，允许血管化，然后用细胞接种。在优选实施例中，细胞 - 基质结构与组织扩张器装置组合植入。随着细胞基质被植入，或细胞增殖并形成新的组织，扩张器尺寸减小，直到其被去除并且获得所需的重建或增加。优选的细胞类型是肌肉细胞，尽管可以使用其他类型的间充质细胞，成纤维细胞，软骨细胞和脂肪细胞。从组织如阴唇获得的细胞可用于特殊应用，例如形成乳头型组织。其他材料，例如增强植入组织的血管形成和/或抑制纤维化组织向内生长的生物活性分子可以用基质植入以增强更正常组织的发育。

10. 发明授权

US5399665A Biodegradable polymers for cell transplantation 失效
标题翻译：用于细胞移植的可生物降解聚合物
公开(公告)号：US5399665A
公开(公告)日：1995-03-21
申请号：US972156
申请日：1992-11-05
申请人： Denise Barrera , Robert S. Langer , Peter T. Lansbury, Jr. , Joseph P. Vacanti
发明人： Denise Barrera , Robert S. Langer , Peter T. Lansbury, Jr. , Joseph P. Vacanti
IPC分类号： A61K35/12 , A61K47/48 , A61L27/18 , A61L27/38 , A61L27/54 , C07K14/00 , C08G63/06 , C08G63/685 , C08G69/10 , C08G69/44 , C12N5/00 , C08G63/08 , C08G69/00 , C08G69/12
CPC分类号： A61L27/54 , A61K47/482 , A61K47/48315 , A61L27/18 , A61L27/38 , C07K14/001 , C08G63/6852 , C12N5/0068 , A61L2300/25 , A61L2300/604 , A61L2300/64 , C12N2533/40 , Y10S530/815
摘要： Polymers more suitable for use in organ transplantation are formed by coupling biologically active moieties to the free amino groups of polymers formed by incorporation of .alpha. amino acids into polymers formed of alpha hydroxy acids such as lactic acids. In the preferred embodiment, the peptides are coupled to the free amino groups.
摘要翻译：更适合用于器官移植的聚合物通过将生物活性部分与通过将α-氨基酸掺入由α-羟基酸如乳酸形成的聚合物形成的聚合物的游离氨基上而形成。在优选的实施方案中，肽与游离氨基偶联。

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