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1. 发明授权

US08168212B2 Topical compositions comprising non-proteogenic amino acids and methods of treating skin 有权
标题翻译：包含非蛋白质氨基酸的局部组合物和治疗皮肤的方法
公开(公告)号：US08168212B2
公开(公告)日：2012-05-01
申请号：US12747272
申请日：2008-11-14
申请人： Dmitri S. Ptchelintsev , Laurence Dryer , Xiaochun Luo
发明人： Dmitri S. Ptchelintsev , Laurence Dryer , Xiaochun Luo
IPC分类号： A61K8/02 , A61K31/385 , A01N43/26
CPC分类号： A61K8/042 , A61K8/25 , A61K8/26 , A61K8/447 , A61K8/49 , A61K8/4913 , A61K8/492 , A61K8/4926 , A61K8/494 , A61K8/4946 , A61K8/4953 , A61K8/4973 , A61K8/4986 , A61K8/891 , A61K31/325 , A61K2800/262 , A61K2800/412 , A61K2800/413 , A61Q19/08
摘要： Cosmetic compositions comprising non-natural, non-proteogenic amino acids and methods of using such compositions to impart antiaging benefits to the skin are disclosed.The non-natural, non-proteogenic amino acids are believed to have modulatory activity against one or more biochemical pathways implicated in skin aging, and in particular, are enhancers of LOXL-1.
摘要翻译：公开了包含非天然的，非蛋白质的氨基酸的化妆品组合物和使用这些组合物赋予皮肤抗衰老益处的方法。认为非天然的，非蛋白质的氨基酸具有针对涉及皮肤老化的一种或多种生物化学途径的调节活性，特别是LOXL-1的增强子。

2. 发明授权

US07592024B1 Topical compositions containing melicope hayselii and a method of treating skin 失效
标题翻译：含有melicope hayselii的局部组合物和治疗皮肤的方法
公开(公告)号：US07592024B1
公开(公告)日：2009-09-22
申请号：US12344787
申请日：2008-12-29
申请人： Dmitri S. Ptchelintsev , Laurence Dryer
发明人： Dmitri S. Ptchelintsev , Laurence Dryer
IPC分类号： A61K36/00
CPC分类号： A61K36/75 , A61K8/97 , A61Q19/08 , A61K2300/00
摘要： Cosmetic compositions comprising an extract of Melicope hayesii and methods of using such compositions to impart anti-aging benefits to the skin are disclosed. These compositions are believed to have modulatory activity against at least one biochemical pathway implicated in skin aging.
摘要翻译：公开了包含Melicope hayesii的提取物的化妆品组合物和使用这些组合物赋予皮肤抗老化效果的方法。据信这些组合物具有针对涉及皮肤老化的至少一种生物化学途径的调节活性。

3. 发明申请

US20100062086A1 Compositions and Methods of Their Use for Improving the Condition and Appearance of Skin 审中-公开
标题翻译：它们用于改善皮肤状况和外观的组合物和方法
公开(公告)号：US20100062086A1
公开(公告)日：2010-03-11
申请号：US12621027
申请日：2009-11-18
申请人： Laurence Dryer , Sherrie R. Tafuri , Dmitri S. Ptchelintsev
发明人： Laurence Dryer , Sherrie R. Tafuri , Dmitri S. Ptchelintsev
IPC分类号： A61K36/00
CPC分类号： G01N33/6893 , A61K9/0014 , A61K36/185 , G01N2333/4737 , G01N2500/04 , G01N2800/20
摘要： The present invention relates to compositions and methods for treating, preventing and improving the condition and aesthetic appearance of skin, particularly, treating, preventing, ameliorating, reducing and/or eliminating fine lines and/or wrinkles of skin, where the compositions include natural plant constituents, or synthetic equivalents thereof, which inhibit or decrease expression of C-reactive protein expression, production or secretion, thereby reducing, inhibiting, or ameliorating dermatological signs of aging. The compositions of the invention may be topically applied to the skin, or are delivered by directed means to a site in need thereof, in an amount effective in improving the condition and aesthetic appearance of skin.
摘要翻译：本发明涉及用于治疗，预防和改善皮肤的状况和美学外观的组合物和方法，特别是治疗，预防，改善，减少和/或消除皮肤细纹和/或皱纹，其中组合物包括天然植物成分或其合成等价物，其抑制或降低C-反应蛋白表达，产生或分泌的表达，从而减少，抑制或改善皮肤病老化迹象。本发明的组合物可以以有效改善皮肤状况和美观外观的量局部施用于皮肤，或通过定向方式递送至有需要的部位。

4. 发明申请

US20100261769A1 Topical Compositions Comprising Non-Proteogenic Amino Acids and Methods of Treating Skin 有权
标题翻译：包含非蛋白质氨基酸的局部组合物和治疗皮肤的方法
公开(公告)号：US20100261769A1
公开(公告)日：2010-10-14
申请号：US12747272
申请日：2008-11-14
申请人： Dmitri S. Ptchelintsev , Laurence Dryer , Xiaochun Luo
发明人： Dmitri S. Ptchelintsev , Laurence Dryer , Xiaochun Luo
IPC分类号： A61K8/49 , A61K31/426 , A61Q19/00 , A61P17/00 , A61Q19/08
CPC分类号： A61K8/042 , A61K8/25 , A61K8/26 , A61K8/447 , A61K8/49 , A61K8/4913 , A61K8/492 , A61K8/4926 , A61K8/494 , A61K8/4946 , A61K8/4953 , A61K8/4973 , A61K8/4986 , A61K8/891 , A61K31/325 , A61K2800/262 , A61K2800/412 , A61K2800/413 , A61Q19/08
摘要： Cosmetic compositions comprising non-natural, non-proteogenic amino acids and methods of using such compositions to impart antiaging benefits to the skin are disclosed. The non-natural, non-proteogenic amino acids are believed to have modulatory activity against one or more biochemical pathways implicated in skin aging, and in particular, are enhancers of LOXL-1.
摘要翻译：公开了包含非天然的，非蛋白质的氨基酸的化妆品组合物和使用这些组合物赋予皮肤抗衰老益处的方法。认为非天然的，非蛋白质的氨基酸具有针对涉及皮肤老化的一种或多种生物化学途径的调节活性，特别是LOXL-1的增强子。

5. 发明授权

US08207171B2 Cosmetic use of 1-Aroyl-N-(2-oxo-3-piperidinyl)-2-piperazine carboxamides and related compounds 有权
标题翻译： 1-芳酰基-N-（2-氧代-3-哌啶基）-2-哌嗪甲酰胺及其相关化合物的化妆品用途
公开(公告)号：US08207171B2
公开(公告)日：2012-06-26
申请号：US13164873
申请日：2011-06-21
申请人： Dmitri S. Ptchelintsev , Hong Hu , Gopinathan K. Menon , Kristine Schmalenberg , John W. Lyga
发明人： Dmitri S. Ptchelintsev , Hong Hu , Gopinathan K. Menon , Kristine Schmalenberg , John W. Lyga
IPC分类号： A61K31/497 , A61K8/02 , C07D401/00
CPC分类号： A61Q19/06 , A61K8/494 , A61Q19/08
摘要： Cosmetic compositions comprising 1-aroyl-N-(2-oxo-3-piperidinyl)-2-piperazine carboxamides and methods of using such compositions to impart anti-aging benefits to the skin are disclosed. The 1-aroyl-N-(2-oxo-3-piperidinyl)-2-piperazine carboxamides are believed to have modulatory activity against one or more biochemical pathways implicated in skin aging.
摘要翻译：公开了包含1-芳酰基-N-（2-氧代-3-哌啶基）-2-哌嗪甲酰胺的化妆品组合物和使用这些组合物给皮肤赋予抗衰老益处的方法。据信1-芳酰基-N-（2-氧代-3-哌啶基）-2-哌嗪甲酰胺具有针对涉及皮肤老化的一种或多种生物化学途径的调节活性。

6. 发明申请

US20120004302A1 Cosmetic Use of N-Substituted Sulfonyloxybenzylamines and Related Compounds 有权
标题翻译： N-取代的磺酰氧基苄胺和相关化合物的化妆品用途
公开(公告)号：US20120004302A1
公开(公告)日：2012-01-05
申请号：US12826864
申请日：2010-06-30
申请人： Dmitri S. Ptchelintsev , John W. Lyga , Russell Wyborski , Qian Zheng , Cheng S. Hwang
发明人： Dmitri S. Ptchelintsev , John W. Lyga , Russell Wyborski , Qian Zheng , Cheng S. Hwang
IPC分类号： A61K8/42 , A61Q19/08
CPC分类号： C07C309/66 , A61K8/466 , A61K8/4973 , A61Q19/00 , A61Q19/08 , C07D307/52 , Y10S514/827 , Y10S514/828 , Y10S514/848
摘要： Cosmetic compositions comprising N-substituted sulfonyloxybenzylamines and methods of using such compositions to impart anti-aging benefits to the skin are disclosed. The N-substituted sulfonyloxybenzylamines are believed to have modulatory activity against one or more biochemical pathways implicated in skin aging.
摘要翻译：公开了包含N-取代的磺酰氧基苄基胺的化妆品组合物和使用这些组合物给皮肤赋予抗老化效果的方法。认为N-取代的磺酰氧基苄胺具有针对涉及皮肤老化的一种或多种生物化学途径的调节活性。

7. 发明授权

US07993663B2 Cosmetic use of 1-aroyl-N-(2-oxo-3-piperidinyl)-2-piperazine carboxamides and related compounds 有权
标题翻译： 1-芳酰基-N-（2-氧代-3-哌啶基）-2-哌嗪甲酰胺及其相关化合物的化妆品用途
公开(公告)号：US07993663B2
公开(公告)日：2011-08-09
申请号：US12645622
申请日：2009-12-23
申请人： Dmitri S. Ptchelintsev , Hong Hu , Gopinathan K. Menon , Kristine Schmalenberg , John W. Lyga
发明人： Dmitri S. Ptchelintsev , Hong Hu , Gopinathan K. Menon , Kristine Schmalenberg , John W. Lyga
IPC分类号： A61K8/02 , A61K31/497 , C07D401/00
CPC分类号： A61Q19/06 , A61K8/494 , A61Q19/08
摘要： Cosmetic compositions comprising 1-aroyl-N-(2-oxo-3-piperidinyl)-2-piperazine carboxamides and methods of using such compositions to impart anti-aging benefits to the skin are disclosed. The 1-aroyl-N-(2-oxo-3-piperidinyl)-2-piperazine carboxamides are believed to have modulatory activity against one or more biochemical pathways implicated in skin aging.
摘要翻译：公开了包含1-芳酰基-N-（2-氧代-3-哌啶基）-2-哌嗪甲酰胺的化妆品组合物和使用这些组合物给皮肤赋予抗衰老益处的方法。据信1-芳酰基-N-（2-氧代-3-哌啶基）-2-哌嗪甲酰胺具有针对涉及皮肤老化的一种或多种生物化学途径的调节活性。

8. 发明申请

US20100168127A1 Cosmetic Use of 1-Aroyl-N-(2-oxo-3-piperidinyl)-2-piperazine Carbomamides and Related Compounds 有权
公开(公告)号：US20100168127A1
公开(公告)日：2010-07-01
申请号：US12645622
申请日：2009-12-23
申请人： Dmitri S. Ptchelintsev , Hong Hu , Gopinathan K. Menon , Kristine Schmalenberg , John W. Lyga
发明人： Dmitri S. Ptchelintsev , Hong Hu , Gopinathan K. Menon , Kristine Schmalenberg , John W. Lyga
IPC分类号： A61K8/49 , A61Q19/06 , A61Q19/08
CPC分类号： A61Q19/06 , A61K8/494 , A61Q19/08
摘要： Cosmetic compositions comprising 1-aroyl-N-(2-oxo-3-piperidinyl)-2-piperazine carboxamides and methods of using such compositions to impart anti-aging benefits to the skin are disclosed. The 1-aroyl-N-(2-oxo-3-piperidinyl)-2-piperazine carboxamides are believed to have modulatory activity against one or more biochemical pathways implicated in skin aging.

9. 发明授权

US08771758B2 Use of Tiliacora triandra in cosmetics and compositions thereof 有权
标题翻译：在化妆品及其组合物中使用三叶草
公开(公告)号：US08771758B2
公开(公告)日：2014-07-08
申请号：US12827001
申请日：2010-06-30
申请人： Dmitri S. Ptchelintsev
发明人： Dmitri S. Ptchelintsev
IPC分类号： A61K36/00 , A61K8/00 , A61K9/00 , A61Q19/08 , A61K8/97
CPC分类号： A61K8/97 , A61Q19/08
摘要： The present disclosure relates to compositions and methods for treating, preventing and improving the condition and aesthetic appearance of skin, particularly, treating, preventing, ameliorating, reducing and/or eliminating fine lines and/or wrinkles of skin, where the compositions include natural plant constituents which increase expression levels genes, collagen replacement and retention, and cell proliferation of epidermis and dermis associated with the dermatological signs of aging. The compositions of the invention are topically applied to the skin, or are delivered by directed means to a site in need thereof, once daily in an amount effective in improving the condition and aesthetic appearance of skin.
摘要翻译：本公开内容涉及用于治疗，预防和改善皮肤的状况和美学外观的组合物和方法，特别是治疗，预防，改善，减少和/或消除皮肤细纹和/或皱纹，其中组合物包括天然植物增加表达水平基因，胶原置换和保留的成分，以及与皮肤老化迹象相关的表皮和真皮的细胞增殖。将本发明的组合物局部施用于皮肤，或通过定向方式递送至有需要的部位，每天一次，其量有效改善皮肤的状况和美观外观。

10. 发明申请

US20120237623A1 Topical Compositions Containing Derris Scandens Benth and a Method of Treating Skin 审中-公开
标题翻译：含有Derris Scandens Benth和治疗皮肤的方法的专题组成
公开(公告)号：US20120237623A1
公开(公告)日：2012-09-20
申请号：US13395682
申请日：2010-10-14
申请人： Dmitri S. Ptchelintsev , Xiaochun Luo
发明人： Dmitri S. Ptchelintsev , Xiaochun Luo
IPC分类号： A61K8/97 , A61Q19/08
CPC分类号： A61Q19/08 , A61K8/97
摘要： Topical compositions and methods of use to treat symptoms of reduced skin elasticity are provided comprising extracts of a. Derris scandens Benth. plant. These compositions are effective in stimulating LOXL-1, activity, inhibiting calcineurin activity, and stimulating glycosaminoglycan synthesis in skin cells and can thus reduce age-related skin damage and improve appearance of fine lines, wrinkles, skin sagging and other symptoms of skin aging and/or skin damage.
摘要翻译：提供用于治疗皮肤弹性降低症状的局部组合物和方法，其包括a。 Derris scandens Benth。厂。这些组合物在刺激LOXL-1，活性，抑制钙调神经磷酸酶活性和刺激皮肤细胞中的糖胺聚糖合成方面是有效的，因此可以减少年龄相关的皮肤损伤，改善细纹，皱纹，皮肤下垂等皮肤老化症状的出现， /或皮肤损伤。

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