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1. 发明申请

US20050196686A1 Method for compensation of the shortening of line ends during the formation of lines on a wafer 审中-公开
标题翻译：在晶圆上形成线时补偿线末端缩短的方法
公开(公告)号：US20050196686A1
公开(公告)日：2005-09-08
申请号：US11066734
申请日：2005-02-25
申请人： Dirk Meyer , Thomas Henkel , Jorg Thiele , Martin Keck
发明人： Dirk Meyer , Thomas Henkel , Jorg Thiele , Martin Keck
IPC分类号： G03F7/20 , G03F9/00
CPC分类号： G03F1/36
摘要： In order to compensate for the shortening of line ends (30) in a circuit design of an integrated circuit, in a first step, hammerheads or serifs (50) are attached to the line ends (30) by means of rule-based OPC corrections. The line ends modified in this way are revised further by downstream application of a simulation-based OPC correction before mask or direct wafer writer data are calculated. As a result of the formation of the pattern revised by the simulation-based correction on the wafer, there actually arises in an approximate manner owing to the proximity effects the layout created by the rule-based correction with the supplemented line ends (30) on the wafer.
摘要翻译：为了补偿集成电路的电路设计中的线端（30）的缩短，在第一步骤中，通过基于规则的OPC校正将锤头或衬线（50）附接到线端（30）。通过在掩模或直接晶片写入器数据计算之前，通过下游应用基于模拟的OPC校正来进一步修改以这种方式修改的线端。由于通过在晶片上的基于模拟的校正而修改的图案的形成，实际上由于邻近效应而产生的邻近效应由基于规则的校正创建的布局与补充的行末端（30）在晶圆。

2. 发明授权

US09274175B2 Method and apparatus for testing a device-under-test 有权
标题翻译：用于测试被测设备的方法和装置
公开(公告)号：US09274175B2
公开(公告)日：2016-03-01
申请号：US13574573
申请日：2010-01-20
申请人： Gil Golov , Thomas Henkel , Ronald Larson , Ulrich Knoch
发明人： Gil Golov , Thomas Henkel , Ronald Larson , Ulrich Knoch
IPC分类号： G01R31/319
CPC分类号： G01R31/319 , G01R31/31907
摘要： A method for testing a device-under-test includes receiving, from at least one test channel circuit dedicated to communicate with an input/output pin of the device-under-test by means of at least one hardware resource, at least one logical control command describing a desired operation of the at least one hardware resource, and converting, by means of a resource controller, the at least one logical control command into at least one dedicated control command for the at least one hardware resource, wherein the at least one dedicated control command is adapted to be received by a physical implementation of the at least one hardware resource.
摘要翻译：一种用于测试被测器件的方法包括：从至少一个测试通道电路接收至少一个逻辑控制器，所述至少一个测试通道电路专用于通过至少一个硬件资源与待测器件的输入/输出引脚通信; 描述所述至少一个硬件资源的期望操作，以及通过资源控制器将所述至少一个逻辑控制命令转换成所述至少一个硬件资源的至少一个专用控制命令，其中所述至少一个专用控制命令适于由所述至少一个硬件资源的物理实现来接收。

3. 发明申请

US20050084923A1 Methods for cultivating and analyzing microbial individual cell cultures 审中-公开
标题翻译：培养和分析微生物个体细胞培养物的方法
公开(公告)号：US20050084923A1
公开(公告)日：2005-04-21
申请号：US10489141
申请日：2002-09-13
申请人： Peter-Juergen Mueller , Martin Roth , Monika Hilliger , Stephan Hilliger , Ingrid Groth , Christel Kummer , Karin Martin , Volker Schoeckh , Jose Metze , Michael Kohler , Thomas Henkel , Gunter Gastrock , Karen Lemke
发明人： Peter-Juergen Mueller , Martin Roth , Monika Hilliger , Stephan Hilliger , Ingrid Groth , Christel Kummer , Karin Martin , Volker Schoeckh , Jose Metze , Michael Kohler , Thomas Henkel , Gunter Gastrock , Karen Lemke
IPC分类号： C12N1/00 , C12M1/00 , C12N1/02 , C12Q1/04 , C12N1/20
CPC分类号： C12M21/16 , C12M41/36
摘要： The invention relates to methods for individually separating microorganisms from a suspension or culture, parallel cultivation of individual cells and analyzing the metabolic performances thereof. The invention enables basic microbial operations such as media optimization, screening according to images of novel natural substances and special metabolic performances, qualitative and quantitative detection of the effects of nutrient substrates, effectors and active substances including the media optimization and selection of microorganism clones with specific properties from large populations according to mutagenesis, transformation, transfection and genetic processing in addition to the detection of microbial contaminations to be carried out. One advantage of the invention is that it can be applied when microorganisms having outstanding properties can be respectively obtained as individual cells or individual organisms from a large population and can be characterized as pure cultures or when the effect of influencing variables can be examined in many fully comparable cultures.
摘要翻译：本发明涉及用于从悬浮液或培养物中单独分离微生物的方法，并行培养单个细胞并分析其代谢性能。本发明能够进行基础微生物操作，例如介质优化，根据新型天然物质的图像筛选和特殊代谢性能，定性和定量检测营养底物，作用剂和活性物质的影响，包括介质优化和选择具有特异性的微生物克隆除了检测要进行的微生物污染外，还要根据诱变，转化，转染和遗传处理从大量种群中获得性状。本发明的一个优点是可以应用于具有突出性质的微生物作为来自大量群体的单个细胞或个体生物体，并且可以被表征为纯培养物，或者当影响变量的影响可以在许多完全可比文化。

4. 发明授权

US5679525A Epstein-barr virus transcription factor binding assay 失效
标题翻译：爱泼斯坦 - 巴尔病毒转录因子结合测定
公开(公告)号：US5679525A
公开(公告)日：1997-10-21
申请号：US704398
申请日：1996-07-17
申请人： Michael Gregory Peterson , Thomas Henkel
发明人： Michael Gregory Peterson , Thomas Henkel
IPC分类号： C07K14/05 , C07K14/47 , C12N15/12 , C12Q1/68 , G01N33/50
CPC分类号： G01N33/5091 , C07K14/005 , C07K14/4705 , C12Q1/6897 , G01N33/5008 , G01N33/5011 , G01N33/5023 , C12N2710/16222
摘要： The invention provides methods and compositions for identifying pharmacological agents useful in the diagnosis or treatment of disease associated with the expression of a gene modulated by a transcription complex containing at least CBF1 and a transcription factor. The methods involve combining CBF1, the Epstein-Barr virus transcription factor EBNA2 or cellular homolog thereof, and a candidate pharmacological agent. This mixture is incubated under conditions whereby, but for the presence of the candidate pharmacological agent, CBF1 binds EBNA2. The absence of selective binding indicates that the candidate pharmacological agent is capable of selectively modulating the expression of a gene dependent on CBF1-transcription factor binding. The mixture may further comprise a CBF1 binding element including the nucleotide sequence: C-G-T-G-G-G-A-A. This mixture is incubated under conditions whereby, but for the presence of the candidate pharmacological agent, a transcription complex comprising both polypeptides bound, directly or indirectly to the nucleic acid is formed. The methods are particularly suited to high-throughput screening where one or more steps are performed by a computer controlled electromechanical robot comprising an axial rotatable arm and said solid substrate is a portion of a well of a microtiter plate.
摘要翻译：本发明提供用于鉴定可用于诊断或治疗由至少含有CBF1和转录因子的转录复合物调节的基因的表达相关疾病的药理学试剂的方法和组合物。所述方法包括将CBF1，爱泼斯坦 - 巴尔病毒转录因子EBNA2或其细胞同源物和候选药理学试剂结合。该混合物在条件下孵育，但是对于候选药理学试剂的存在，CBF1结合EBNA2。不存在选择性结合表明候选药理学试剂能够选择性调节依赖于CBF1转录因子结合的基因的表达。该混合物可以进一步包含包含核苷酸序列：C-G-T-G-G-G-A-A的CBF1结合元件。该混合物在条件下孵育，但是对于候选药理学试剂的存在，形成包含与核酸直接或间接结合的两个多肽的转录复合体。该方法特别适用于高通量筛选，其中一个或多个步骤由包括轴向可旋转臂的计算机控制的机电机器人执行，所述固体基质是微量滴定板的孔的一部分。

5. 发明申请

US20130193993A1 METHOD AND APPARATUS FOR TESTING A DEVICE-UNDER-TEST 有权
标题翻译：用于测试设备下测试的方法和装置
公开(公告)号：US20130193993A1
公开(公告)日：2013-08-01
申请号：US13574573
申请日：2010-01-20
申请人： Gil Golov , Thomas Henkel , Ronald Larson , Ulrich Knoch
发明人： Gil Golov , Thomas Henkel , Ronald Larson , Ulrich Knoch
IPC分类号： G01R31/319
CPC分类号： G01R31/319 , G01R31/31907
摘要： A method for testing a device-under-test includes receiving, from at least one test channel circuit dedicated to communicate with an input/output pin of the device-under-test by means of at least one hardware resource, at least one logical control command describing a desired operation of the at least one hardware resource, and converting, by means of a resource controller, the at least one logical control command into at least one dedicated control command for the at least one hardware resource, wherein the at least one dedicated control command is adapted to be received by a physical implementation of the at least one hardware resource.
摘要翻译：一种用于测试被测器件的方法包括：从至少一个测试通道电路接收至少一个逻辑控制器，所述至少一个测试通道电路专用于通过至少一个硬件资源与待测器件的输入/输出引脚通信; 描述所述至少一个硬件资源的期望操作，以及通过资源控制器将所述至少一个逻辑控制命令转换成所述至少一个硬件资源的至少一个专用控制命令，其中所述至少一个专用控制命令适于由所述至少一个硬件资源的物理实现来接收。

6. 发明申请

US20110212072A1 Inhibitors of Fatty Acid Oxidation for Prophylaxis and Treatment of Diseases Related to Mitochondrial Dysfunction 审中-公开
标题翻译：脂肪酸氧化抑制剂用于预防和治疗与线粒体功能障碍有关的疾病
公开(公告)号：US20110212072A1
公开(公告)日：2011-09-01
申请号：US13089979
申请日：2011-04-19
申请人： Thomas Henkel , Christoph Rehfuess
发明人： Thomas Henkel , Christoph Rehfuess
IPC分类号： A61K38/44 , A61K31/7088 , A61K38/46 , A61K38/51 , A61K38/43 , A61P25/28 , A61P25/16 , A61P29/00 , A61P9/10 , A61P25/18 , A61P25/08 , A61P25/06 , A61P5/18 , C12Q1/02 , C12Q1/37 , G01N33/53 , A61K31/4458 , C07D303/40 , A61K31/336 , C12Q1/68 , C07D211/12 , C07D295/096 , A61K31/495 , C07C229/34 , A61K31/198 , C07C57/03 , A61K31/202 , C07C309/47 , A61K31/185
CPC分类号： A61K31/336 , A61K31/4025 , A61K31/435 , A61K31/443 , A61K31/495
摘要： Described are a method and a composition for preventing and/or treating a disease related to mitochondrial dysfunction by inhibiting the fatty acid oxidation of one or more cells of an organism. Particularly, the fatty acid oxidation is inhibited by inhibiting the expression and/or activity of the enzyme Camitin-Palmitoyl-Transferase-1 (CPT-1) by means of an arylalkyl- or arlyoxyalkyl-substitued oxirane carboxylic acid or pharmaceutically acceptable salts and derivatives of the arylalkyl-substituted oxirane carboxylic acid.
摘要翻译：描述了通过抑制生物体的一个或多个细胞的脂肪酸氧化来预防和/或治疗与线粒体功能障碍有关的疾病的方法和组合物。特别地，通过芳基烷基 - 或芳氧基烷基取代的环氧乙烷羧酸或其药学上可接受的盐和衍生物抑制羧甲基 - 棕榈酰转移酶-1（CPT-1）的表达和/或活性来抑制脂肪酸氧化的芳基烷基取代的环氧乙烷羧酸。

7. 发明申请

US20050069030A1 Channel with domain crossing 有权
标题翻译：频道与域交叉
公开(公告)号：US20050069030A1
公开(公告)日：2005-03-31
申请号：US10917966
申请日：2004-08-13
申请人： Thomas Henkel
发明人： Thomas Henkel
IPC分类号： G01R31/28 , G01R31/317 , H04B3/46
CPC分类号： G01R31/31727
摘要： A channel adapted for at least one of providing and receiving signals includes a channel clock domain, whereby said channel clock domain is under clock control of a channel clock. The channel clock domain includes at least one of: a drive path adapted for providing signals and a receive path adapted for receiving signals. The channel also includes a service clock domain adapted for at least one of providing data to and receiving data from said channel clock domain, whereby said service clock domain is under clock control of a service clock.
摘要翻译：适于提供和接收信号中的至少一个信道的信道包括信道时钟域，由此所述信道时钟域在信道时钟的时钟控制之下。信道时钟域包括以下中的至少一个：适于提供信号的驱动路径和适于接收信号的接收路径。信道还包括业务时钟域，适用于向所述信道时钟域提供数据和从所述信道时钟域接收数据中的至少一个，由此所述业务时钟域在服务时钟的时钟控制之下。

8. 发明申请

US20050004173A1 Inhibitors of fatty acid oxidation for prophylaxis and treatment of diseases related to mitochondrial dysfunction 审中-公开
标题翻译：抑制脂肪酸氧化预防和治疗与线粒体功能障碍有关的疾病
公开(公告)号：US20050004173A1
公开(公告)日：2005-01-06
申请号：US10832801
申请日：2004-04-26
申请人： Thomas Henkel , Christoph Rehfuess
发明人： Thomas Henkel , Christoph Rehfuess
IPC分类号： A61K31/336 , A61K31/4025 , A61K31/435 , A61K31/443 , A61K31/495
CPC分类号： A61K31/336 , A61K31/4025 , A61K31/435 , A61K31/443 , A61K31/495
摘要： Described are a method and a composition for preventing and/or treating a disease related to mitochondrial dysfunction by inhibiting the fatty acid oxidation of one or more cells of an organism. Particularly, the fatty acid oxidation is inhibited by inhibiting the expression and/or activity of the enzyme Carnitin-Palmitoyl-Transferase-1 (CPT-1) by means of an arylalkyl- or arlyoxyalkyl-substitued oxirane carboxylic acid or pharmaceutically acceptable salts and derivatives of the arylalkyl-substituted oxirane carboxylic acid.
摘要翻译：描述了通过抑制生物体的一个或多个细胞的脂肪酸氧化来预防和/或治疗与线粒体功能障碍有关的疾病的方法和组合物。特别地，通过芳基烷基 - 或芳氧基烷基取代的环氧乙烷羧酸或其药学上可接受的盐和衍生物抑制肉碱 - 棕榈酰转移酶-1（CPT-1）的表达和/或活性来抑制脂肪酸氧化的芳基烷基取代的环氧乙烷羧酸。

9. 发明授权

US6055644A Multi-channel architecture with channel independent clock signals 失效
标题翻译：具有通道独立时钟信号的多通道架构
公开(公告)号：US6055644A
公开(公告)日：2000-04-25
申请号：US50289
申请日：1998-03-30
申请人： Thomas Henkel
发明人： Thomas Henkel
IPC分类号： G01R31/3183 , G01R31/319 , G06F1/06 , G06F1/04
CPC分类号： G06F1/06 , G01R31/31922
摘要： Described is a multi-channel architecture comprising a central master clock generator for generating a central master clock signal and a plurality of channels connectable with inputs or outputs of a device. The multi-channel architecture further includes a channel master clock gate assigned to a respective channel of the plurality of channels, for receiving the central master clock signal and for generating a channel clock signal from the central master clock signal. The multi-channel architecture can be used in a tester arrangement, and preferably in an IC tester. The described multi-channel architecture allows clock signals to be provided for each one of the channels independent of other channels, e.g. to apply a continuous clock signal in one channel while the clock signal in other channels might be changed, e.g. in order to receive new timing edges as references for testing a DUT.
摘要翻译：描述了一种多通道架构，其包括用于产生中央主时钟信号的中央主时钟发生器和可与设备的输入或输出连接的多个通道。多通道架构还包括分配给多个通道中的相应通道的通道主时钟门，用于接收中央主时钟信号并用于从中央主时钟信号产生通道时钟信号。多通道架构可以用于测试器布置，并且优选地在IC测试器中使用。所描述的多通道架构允许为独立于其他通道的每个通道提供时钟信号，例如。以在一个通道中施加连续的时钟信号，而其它通道中的时钟信号可能被改变，例如，以便接收新的时序边缘作为测试DUT的参考。

10. 发明申请

US20100034796A1 Inhibitors of fatty acid oxidation for prophylaxis and treatment of diseases related to mitochondrial dysfunction 审中-公开
标题翻译：抑制脂肪酸氧化预防和治疗与线粒体功能障碍有关的疾病
公开(公告)号：US20100034796A1
公开(公告)日：2010-02-11
申请号：US12459227
申请日：2009-06-29
申请人： Thomas Henkel , Christoph Rehfuess
发明人： Thomas Henkel , Christoph Rehfuess
IPC分类号： A61K38/43 , C12Q1/02 , A61K48/00 , A61K31/4965 , A61K31/4458 , A61K31/336 , A61K31/202 , A61K31/20 , A61P25/28 , A61P25/16 , A61P19/00 , A61P25/00
CPC分类号： A61K31/336 , A61K31/4025 , A61K31/435 , A61K31/443 , A61K31/495
摘要： Described are a method and a composition for preventing and/or treating a disease related to mitochondrial dysfunction by inhibiting the fatty acid oxidation of one or more cells of an organism. Particularly, the fatty acid oxidation is inhibited by inhibiting the expression and/or activity of the enzyme Carnitin-Palmitoyl-Transferase-1 (CPT-1) by means of an arylalkyl- or arlyoxyalkyl-substitued oxirane carboxylic acid or pharmaceutically acceptable salts and derivatives of the arylalkyl-substituted oxirane carboxylic acid.
摘要翻译：描述了通过抑制生物体的一个或多个细胞的脂肪酸氧化来预防和/或治疗与线粒体功能障碍有关的疾病的方法和组合物。特别地，通过芳基烷基 - 或芳氧基烷基取代的环氧乙烷羧酸或其药学上可接受的盐和衍生物抑制肉碱 - 棕榈酰转移酶-1（CPT-1）的表达和/或活性来抑制脂肪酸氧化的芳基烷基取代的环氧乙烷羧酸。

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