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1. 发明申请

US20050171117A1 Preparation of pharmaceutical salts 失效
标题翻译：药用盐的制备
公开(公告)号：US20050171117A1
公开(公告)日：2005-08-04
申请号：US11093560
申请日：2005-03-30
申请人： Dinesh Gala , Andrew Goodman , Gary Lee , Hongbiao Liao , Martin Schwartz , Suhan Tang , David Tsai , Wenxue Wu
发明人： Dinesh Gala , Andrew Goodman , Gary Lee , Hongbiao Liao , Martin Schwartz , Suhan Tang , David Tsai , Wenxue Wu
IPC分类号： C07D401/14 , A61K31/095 , A61K31/19 , A61K31/194 , A61K31/506 , A61P1/04 , A61P11/06 , A61P17/00 , A61P17/06 , A61P19/02 , A61P25/00 , A61P29/00 , A61P37/06 , A61P37/08 , A61P43/00 , C07D401/06 , C07D43/14
CPC分类号： C07D401/06
摘要： In one embodiment, the present invention discloses a process to directly prepare an unequal ratio of rotamers of an acid salt from a basic compound, by creative choice of a solvent medium. The process is particularly useful in preparing specific rotamers of pharmaceutically useful salts in desired preponderance.
摘要翻译：在一个实施方案中，本发明公开了通过创造性地选择溶剂介质来直接制备酸性盐与碱性化合物的不等比例的旋转异构体的方法。该方法特别可用于制备具有期望优势的药学上有用的盐的特定旋转异构体。

2. 发明申请

US20050171120A1 Stereoselective alkylation of chiral 2-methyl-4-protected piperazines 失效
公开(公告)号：US20050171120A1
公开(公告)日：2005-08-04
申请号：US11089858
申请日：2005-03-25
申请人： Wenxue Wu , Hongbiao Liao , David Tsai , David Andrews , Dinesh Gala , Gary Lee , Martin Schwartz , Timothy McAllister , Xiaoyong Fu , Donal Maloney , Tiruvettipuram Thiruvengadam , Chou-Hang Tann
发明人： Wenxue Wu , Hongbiao Liao , David Tsai , David Andrews , Dinesh Gala , Gary Lee , Martin Schwartz , Timothy McAllister , Xiaoyong Fu , Donal Maloney , Tiruvettipuram Thiruvengadam , Chou-Hang Tann
IPC分类号： C07D241/04 , C07B53/00 , C07B61/00 , C07C45/51 , C07C303/28 , C07C309/73 , C07D295/084 , C07D295/088 , C07D295/185 , C07D295/192 , C07D295/205 , A61K31/495 , A61K31/496
CPC分类号： C07D295/185 , C07B2200/07 , C07C45/512 , C07C67/343 , C07C309/73 , C07D295/088 , C07D295/092 , C07D295/192 , C07D295/205 , C07C49/255 , C07C69/734 , C07C49/84
摘要： In an illustrative embodiment, the present invention describes the synthesis of the following compound and similar compounds, in high stereochemical purity by a novel stereoselective alkylation process:

3. 发明申请

US20060247437A1 Preparation of ketone amides 失效
标题翻译：酮酰胺的制备
公开(公告)号：US20060247437A1
公开(公告)日：2006-11-02
申请号：US11326156
申请日：2006-01-05
申请人： Shen-Chun Kuo , David Tsai , Hongbiao Liao
发明人： Shen-Chun Kuo , David Tsai , Hongbiao Liao
IPC分类号： A61K31/506 , C07D403/02 , C07D401/02 , C07D211/22
CPC分类号： C07D211/74 , C07D401/06 , C07D401/14
摘要： The present invention discloses a novel process to prepare ketone amides, which are useful intermediates for the preparation of antagonists of CCR5 receptor and therefore useful for the treatment of HIV virus infected mammals. It specifically discloses a novel process to synthesize 1-(2,4-dimethylpyrimidine-5-carbonyl)-4-piperidone, 1-[(2,4-dimethyl-3-pyridinyl)carbonyl]-4-piperidone and related compounds. A salient feature of the invention is the use of a three-phase reaction medium with an organic phase and a buffer salt slurry.
摘要翻译：本发明公开了一种制备酮酰胺的新方法，它们是制备CCR5受体拮抗剂的有用中间体，因此可用于治疗HIV感染的哺乳动物。具体公开了合成1-（2,4-二甲基嘧啶-5-羰基）-4-哌啶酮，1 - [（2,4-二甲基-3-吡啶基）羰基] -4-哌啶酮和相关化合物的新方法。本发明的一个显着特征是使用具有有机相和缓冲盐浆料的三相反应介质。

4. 发明申请

US20060173189A1 Synthesis of himbacine analogs 有权
公开(公告)号：US20060173189A1
公开(公告)日：2006-08-03
申请号：US11330935
申请日：2006-01-12
申请人： Tiruvettipuram Thiruvengadam , Tao Wang , Jing Liao , John Chiu , David Tsai , Hong-Chang Lee , Wenxue Wu , Xiaoyong Fu
发明人： Tiruvettipuram Thiruvengadam , Tao Wang , Jing Liao , John Chiu , David Tsai , Hong-Chang Lee , Wenxue Wu , Xiaoyong Fu
IPC分类号： C07D405/02
CPC分类号： C07D405/06
摘要： The present invention relates to an improved process for preparing himbacine analogs. The compounds are useful as thrombin receptor antagonists. The improved process may allow for at least one of easier purification by crystallization, easier scalability, and improved process yield on the desired enantiomer. An example of a step in the synthesis of such a himbacine analog is as follows:

5. 发明授权

US08403310B2 Apparatus for holding a flat object 失效
标题翻译：用于保持平面物体的装置
公开(公告)号：US08403310B2
公开(公告)日：2013-03-26
申请号：US12769842
申请日：2010-04-29
申请人： Kun-Jie Wang , Rong-Jin Liang , David Tsai
发明人： Kun-Jie Wang , Rong-Jin Liang , David Tsai
IPC分类号： B23Q3/00 , B23Q1/25 , B25B1/00 , B25B1/22
CPC分类号： B25B11/00 , A63C17/0006 , A63C17/01 , A63C2203/44 , B25B5/14
摘要： An apparatus is disclosed for holding a flat object. The apparatus includes a post, a supporting mechanism movably connected to the post, a clamping mechanism pivotally connected to the post, and a linking element for linking the supporting mechanism and the clamping mechanism together. Thus, the flat object is clamped by the clamping mechanism clamps when the flat object is supported on the supporting mechanism.
摘要翻译：公开了一种用于保持平坦物体的装置。该装置包括柱，可移动地连接到柱的支撑机构，可枢转地连接到柱的夹紧机构和用于将支撑机构和夹紧机构连接在一起的连接元件。因此，当平坦物体被支撑在支撑机构上时，扁平物体被夹紧机构夹具夹紧。

6. 发明申请

US20120034023A1 Telescopic Apparatus 审中-公开
标题翻译：伸缩装置
公开(公告)号：US20120034023A1
公开(公告)日：2012-02-09
申请号：US12853286
申请日：2010-08-09
申请人： Kun-Jie WANG , Rong-Jin Liang , David Tsai
发明人： Kun-Jie WANG , Rong-Jin Liang , David Tsai
IPC分类号： F16B7/10
CPC分类号： B60P7/15 , F16B7/105 , Y10T403/32483
摘要： A telescopic apparatus includes an internal tube telescopically inserted in an external tube. The internal tube includes depressions defined therein. A frame is secured to the external tube. A lever is pivotally connected to the frame. The lever includes a space transversely defined therein, a groove in communication with and in parallel to the space, and a pawl for insertion in a selected one of the depressions for locking the internal tube relative to the external tube. A spring is substantially located in the space. The spring includes a hook for hooking the frame and a bent section located in the groove. A short tube is located in the space and against the spring. A screw is inserted through the frame, the spring and the short tube. A security unit is movably connected to the frame between a locking position against the lever to avoid pivoting of the lever and a releasing position away from the lever to allow pivoting of the lever.
摘要翻译：伸缩式装置包括可伸缩地插入外管的内管。内管包括限定在其中的凹陷。框架固定在外管上。杠杆枢转地连接到框架。杠杆包括横向地限定在其中的空间，与空间连通并平行的凹槽，以及用于插入到所选凹陷中的用于相对于外管锁定内管的棘爪。弹簧基本位于该空间中。弹簧包括用于钩住框架的钩和位于凹槽中的弯曲部分。短管位于空间和弹簧之间。螺钉插入框架，弹簧和短管中。安全单元可在与杠杆之间的锁定位置之间可移动地连接到框架，以避免杠杆的枢转以及远离杠杆的释放位置以允许杠杆的枢转。

7. 发明申请

US20110071724A1 SYSTEM AND METHOD FOR DATA COLLECTION AND MESSAGING 有权
标题翻译：用于数据收集和消息传递的系统和方法
公开(公告)号：US20110071724A1
公开(公告)日：2011-03-24
申请号：US12562859
申请日：2009-09-18
申请人： Gary Herbert HEINE , David Tsai , Bruce Andrew Mutter , Thomas Fallow Trisdale
发明人： Gary Herbert HEINE , David Tsai , Bruce Andrew Mutter , Thomas Fallow Trisdale
IPC分类号： G06F7/00
CPC分类号： G07C5/0808 , G07C5/008 , G07C2205/02
摘要： A system for diagnosing vehicle problems that may include a client device and central device. The client device may include a connector to connect to a vehicle and a vehicle interface to send and receive information from the vehicle. The client may also include an input/output system, a processor, and a communication system to communicate with the central device. The client device may capture a vehicle identification number (VIN) and may transmit the captured VIN along with geographic information to the central device. In response to received instructions from the central device, the client device may passively capture diagnostic information from the vehicle and transmit the diagnostic information to the central device. In response to the diagnostic information, the central device may transmit further instructions to the client device.
摘要翻译：用于诊断可能包括客户端设备和中央设备的车辆问题的系统。客户端设备可以包括连接到车辆的连接器和用于从车辆发送和接收信息的车辆接口。客户端还可以包括输入/输出系统，处理器和与中央设备通信的通信系统。客户端设备可以捕获车辆识别号码（VIN），并且可以将捕获的VIN与地理信息一起发送到中央设备。响应于来自中央设备的接收到的指令，客户端设备可以被动地捕获来自车辆的诊断信息并将诊断信息发送到中央设备。响应于诊断信息，中央设备可以向客户端设备传送进一步的指令。

8. 发明申请

US20070093737A1 Water flush type massaging device 审中-公开
标题翻译：水冲式按摩器
公开(公告)号：US20070093737A1
公开(公告)日：2007-04-26
申请号：US11258513
申请日：2005-10-25
申请人： Wen-Ching Lee , David Tsai
发明人： Wen-Ching Lee , David Tsai
IPC分类号： A61H9/00
CPC分类号： A61H23/04 , A61H2205/12
摘要： A massaging device includes a main body, a massaging member, a rotation member, a retaining ring, a protective hood, a motor, and a cover. Thus, the massaging device provides a soft massaging effect in a water flush manner without applying an excessive force on a user, thereby efficiently producing a comfortable sensation to the user. In addition, the massaging device can function as an individual massager and can also be mounted on other massager to provide a massaging effect, thereby enhancing the versatility of the massaging device.
摘要翻译：按摩装置包括主体，按摩构件，旋转构件，保持环，保护罩，马达和盖。因此，按摩设备以水冲洗方式提供柔软的按摩效果，而不会对用户施加过大的力，从而有效地为用户产生舒适的感觉。此外，按摩装置可以用作单独的按摩器，并且还可以安装在其他按摩器上以提供按摩效果，从而增强按摩装置的通用性。

9. 发明授权

US07193040B2 Polypeptide for the treatment of cancer and a method for preparation thereof 失效
标题翻译：用于治疗癌症的多肽及其制备方法
公开(公告)号：US07193040B2
公开(公告)日：2007-03-20
申请号：US10772537
申请日：2004-02-05
申请人： David Tsai
发明人： David Tsai
IPC分类号： A61K38/04 , C07K7/06
CPC分类号： C07K14/4747 , A61K33/30 , A61K38/1741 , C07K14/71
摘要： This invention characterizes the specific peptide fragment derived from specially prepared zinc charged fetuin and a method of preparation thereof, wherein the fragment was found to contain an apoptosis-inducing activity. Specifically, the amino acid sequence of this peptide is His Thr Phe Ser Gly Val Ala Ser Val Glu and correlates to amino acid no. 300-309 of fetuin, referred to herein as Fetuin Peptide Fragment (FPF 300-09). FPF 300-09 strongly induced apoptosis in LNCaP (prostate cancer) and HT-29 (colon cancer) cells without affecting CCD 18 Co (normal colon) cells. The in vitro tissue culture study demonstrated that the FPF 300-09 is more potent than the parent molecule (full-length zinc charged fetuin) in inducing apoptosis. FPF 300-09 has a LD50 of 0.3–0.4 μM while the LD50 for zinc-charged fetuin is 3–10 μM.
摘要翻译：本发明的特征在于特别制备的加入锌的胎球蛋白的特异性肽片段及其制备方法，其中发现该片段含有凋亡诱导活性。具体地说，该肽的氨基酸序列是His Thr Phe Ser Gly Val Ala Ser Val Glu，并与氨基酸编号相关。 300-309的胎球蛋白，在本文中称为胎儿蛋白肽片段（FPF 300-09）。 FPF 300-09强烈诱导LNCaP（前列腺癌）和HT-29（结肠癌）细胞凋亡，而不影响CCD 18 Co（正常结肠）细胞。体外组织培养研究表明，FPF 300-09在诱导细胞凋亡中比母体分子（全长锌带电球蛋白）更有效。 FPF 300-09具有0.3-0.4μm的LD 50，而对于带锌的胎球蛋白的LD <50>为3-10μm。

10. 发明申请

US20060258595A1 Polypeptide for the treatment of cancer and a method for preparation thereof 失效
标题翻译：用于治疗癌症的多肽及其制备方法
公开(公告)号：US20060258595A1
公开(公告)日：2006-11-16
申请号：US11409780
申请日：2006-04-24
申请人： David Tsai
发明人： David Tsai
IPC分类号： C07K7/08 , A61K38/10
CPC分类号： C07K14/4747 , A61K33/30 , A61K38/1741 , C07K14/71
摘要： This invention characterizes the specific peptide fragment derived from specially prepared zinc charged fetuin and a method of preparation thereof, wherein the fragment was found to contain an apoptosis-inducing activity. Specifically, the amino acid sequence of this peptide is His Ala Phe Ser Pro Val Ala Ser Val Glu. The peptide induced apoptosis in LNCaP (prostate cancer) and HT-29 (colon cancer) cells without affecting CCD 18 Co (normal colon) cells. The in vitro tissue culture study demonstrated that the peptide is more potent than the parent molecule (full-length zinc charged fetuin) in inducing apoptosis. The peptide has a LD50 of 0.3-0.4 μM, while the LD50 for zinc-charged fetuin is 3-10 μM.
摘要翻译：本发明的特征在于特别制备的加入锌的胎球蛋白的特异性肽片段及其制备方法，其中发现该片段含有凋亡诱导活性。具体地，该肽的氨基酸序列是His Ala Phe Ser Pro Val Ala Ser Val Glu。该肽诱导LNCaP（前列腺癌）和HT-29（结肠癌）细胞凋亡，而不影响CCD 18 Co（正常结肠）细胞。体外组织培养研究表明，该肽比诱导凋亡的母体分子（全长锌带电球蛋白）更有效。该肽具有0.3-0.4μm的LD 50，而对于含锌载体的胎球蛋白的LD 50为3-10μm。

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