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1. 发明授权

US09115133B2 Substituted fused tricyclic compounds, compositions and medicinal applications thereof 有权
标题翻译：取代的稠合三环化合物，组合物及其药用应用
公开(公告)号：US09115133B2
公开(公告)日：2015-08-25
申请号：US14006630
申请日：2012-03-21
申请人： Dinesh Barawkar , Tanushree Bende , Robert Zahler , Anish Bandyopadhyay , Robindro Singh Sarangthem , Jignesh Doshi , Yogesh Waman , Rushikesh Jadhav , Umesh Prasad Singh
发明人： Dinesh Barawkar , Tanushree Bende , Robert Zahler , Anish Bandyopadhyay , Robindro Singh Sarangthem , Jignesh Doshi , Yogesh Waman , Rushikesh Jadhav , Umesh Prasad Singh
IPC分类号： C07D471/14 , A61K31/4375 , A61K31/5025 , A61K31/5377 , A61K31/519 , A61K45/06 , A61K31/496
CPC分类号： C07D471/14 , A61K31/4375 , A61K31/496 , A61K31/5025 , A61K31/519 , A61K31/5377 , A61K45/06 , Y02A50/475 , A61K2300/00
摘要： The present invention relates to substituted fused tricyclic compounds of formula (I) or (Ia), their tautomers, polymorphs, stereoisomers, prodrugs, solvates, co-crystals, pharmaceutically acceptable salts, pharmaceutical compositions containing them and methods of treating conditions and diseases that are mediated by JAK activity. The compounds of the present invention are useful in the treatment, prevention or suppression of diseases and disorders mediated by JAK activity. Such conditions include, but not limited to, arthritis, Alzheimer's disease, autoimmune thyroid disorders, cancer, diabetes, leukemia, T-cell prolymphocytic leukemia, lymphoma, myleoproliferation disorders, lupus, multiple myeloma, multiple sclerosis, osteoarthritis, sepsis, psoriatic arthritis, prostate cancer, T-cell autoimmune disease, inflammatory diseases, chronic and acute allograft transplant rejection, bone marrow transplant, stroke, asthma, chronic obstructive pulmonary disease, allergy, bronchitis, viral diseases, or Type I diabetes, complications from diabetes, rheumatoid arthritis, asthma, Crohn's disease, dry eye, uveitis, inflammatory bowel disease, organ transplant rejection, psoriasis and ulcerative colitis. The present disclosure also relates to process for the preparation of such compounds, and to pharmaceutical compositions containing them.
摘要翻译：本发明涉及式（I）或（Ia）的取代的稠合三环化合物，其互变异构体，多晶型物，立体异构体，前药，溶剂合物，共晶体，药学上可接受的盐，含有它们的药物组合物和治疗病症和疾病的方法由JAK活动介导。本发明的化合物可用于治疗，预防或抑制由JAK活性介导的疾病和病症。这些病症包括但不限于关节炎，阿尔茨海默氏病，自身免疫性甲状腺疾病，癌症，糖尿病，白血病，T细胞淋巴细胞性白血病，淋巴瘤，组织增生障碍，狼疮，多发性骨髓瘤，多发性硬化，骨关节炎，败血症，牛皮癣关节炎，前列腺癌，T细胞自身免疫疾病，炎性疾病，慢性和急性同种异体移植排斥反应，骨髓移植，中风，哮喘，慢性阻塞性肺病，过敏，支气管炎，病毒性疾病或I型糖尿病，糖尿病并发症，类风湿关节炎，哮喘，克罗恩病，干眼症，葡萄膜炎，炎性肠病，器官移植排斥反应，牛皮癣和溃疡性结肠炎。本公开还涉及制备这些化合物的方法以及含有它们的药物组合物。

2. 发明申请

US20140023614A1 SUBSTITUTED FUSED TRICYCLIC COMPOUNDS, COMPOSITIONS AND MEDICINAL APPLICATIONS THEREOF 有权
标题翻译：取代的熔融三氯化合物，其组合物和药物应用
公开(公告)号：US20140023614A1
公开(公告)日：2014-01-23
申请号：US14006630
申请日：2012-03-21
申请人： Dinesh Barawkar , Tanushree Bende , Robert Zahler , Anish Bandyopadhyay , Robindro Singh Sarangthem , Jignesh Doshi , Yogesh Waman , Rushikesh Jadhav , Umesh Prasad Singh
发明人： Dinesh Barawkar , Tanushree Bende , Robert Zahler , Anish Bandyopadhyay , Robindro Singh Sarangthem , Jignesh Doshi , Yogesh Waman , Rushikesh Jadhav , Umesh Prasad Singh
IPC分类号： C07D471/14 , A61K31/5025 , A61K45/06 , A61K31/519 , A61K31/4375 , A61K31/5377 , A61K31/496
CPC分类号： C07D471/14 , A61K31/4375 , A61K31/496 , A61K31/5025 , A61K31/519 , A61K31/5377 , A61K45/06 , Y02A50/475 , A61K2300/00
摘要： The present invention relates to substituted fused tricyclic compounds of formula (I) or (Ia), their tautomers, polymorphs, stereoisomers, prodrugs, solvates, co-crystals, pharmaceutically acceptable salts, pharmaceutical compositions containing them and methods of treating conditions and diseases that are mediated by JAK activity. The compounds of the present invention are useful in the treatment, prevention or suppression of diseases and disorders mediated by JAK activity. Such conditions include, but not limited to, arthritis, Alzheimer's disease, autoimmune thyroid disorders, cancer, diabetes, leukemia, T-cell prolymphocytic leukemia, lymphoma, myleoproliferation disorders, lupus, multiple myeloma, multiple sclerosis, osteoarthritis, sepsis, psoriatic arthritis, prostate cancer, T-cell autoimmune disease, inflammatory diseases, chronic and acute allograft transplant rejection, bone marrow transplant, stroke, asthma, chronic obstructive pulmonary disease, allergy, bronchitis, viral diseases, or Type I diabetes, complications from diabetes, rheumatoid arthritis, asthma, Crohn's disease, dry eye, uveitis, inflammatory bowel disease, organ transplant rejection, psoriasis and ulcerative colitis. The present disclosure also relates to process for the preparation of such compounds, and to pharmaceutical compositions containing them.
摘要翻译：本发明涉及式（I）或（Ia）的取代的稠合三环化合物，其互变异构体，多晶型物，立体异构体，前药，溶剂合物，共晶体，药学上可接受的盐，含有它们的药物组合物和治疗病症和疾病的方法由JAK活动介导。本发明的化合物可用于治疗，预防或抑制由JAK活性介导的疾病和病症。这些病症包括但不限于关节炎，阿尔茨海默氏病，自身免疫性甲状腺疾病，癌症，糖尿病，白血病，T细胞淋巴细胞性白血病，淋巴瘤，组织增生障碍，狼疮，多发性骨髓瘤，多发性硬化，骨关节炎，败血症，牛皮癣关节炎，前列腺癌，T细胞自身免疫疾病，炎性疾病，慢性和急性同种异体移植排斥反应，骨髓移植，中风，哮喘，慢性阻塞性肺病，过敏，支气管炎，病毒性疾病或I型糖尿病，糖尿病并发症，类风湿关节炎，哮喘，克罗恩病，干眼症，葡萄膜炎，炎性肠病，器官移植排斥反应，牛皮癣和溃疡性结肠炎。本公开还涉及制备这些化合物的方法以及含有它们的药物组合物。

3. 发明授权

US09176788B2 Method and system for real time detection of resource requirement and automatic adjustments 有权
标题翻译：用于实时检测资源需求和自动调整的方法和系统
公开(公告)号：US09176788B2
公开(公告)日：2015-11-03
申请号：US13495906
申请日：2012-06-13
申请人： Rushikesh Jadhav , Piyush Somani
发明人： Rushikesh Jadhav , Piyush Somani
IPC分类号： G06F9/455 , G06F9/50
CPC分类号： G06F9/5077 , G06F2209/5022 , G06F2209/508 , Y02D10/22 , Y02D10/36
摘要： A method and system for detecting, in real time, resource requirements of a system in virtual environment and automatic scaling of resource parameters to compensate resource requirement in a system. The Virtual machine controller constantly measures resource utilization in the servers and virtual machines associated with it. If a resource requirement is detected with any virtual machine, the automatic resource scaling system detects the type of resource to be scaled and scales the selected resource. Further, the resource may be scaled up or scaled down, based on the requirements. Further, the scaled resource may be CPU, RAM, disk or any such resource. The proposed system helps to save space and power without compromising security, performance and accessibility.
摘要翻译：一种用于实时检测虚拟环境中的系统的资源需求的方法和系统，并且自动缩放资源参数以补偿系统中的资源需求。虚拟机控制器不断测量与其相关联的服务器和虚拟机中的资源利用率。如果使用任何虚拟机检测到资源需求，则自动资源缩放系统检测要缩放的资源类型并缩放所选资源。此外，可以基于需求来扩大或缩小资源。此外，缩放的资源可以是CPU，RAM，磁盘或任何这样的资源。所提出的系统有助于节省空间和功率，而不会影响安全性，性能和可访问性。

4. 发明申请

US20130047158A1 Method and System for Real Time Detection of Resource Requirement and Automatic Adjustments 有权
标题翻译：实时检测资源需求和自动调整方法与系统
公开(公告)号：US20130047158A1
公开(公告)日：2013-02-21
申请号：US13495906
申请日：2012-06-13
申请人： Rushikesh Jadhav , Piyush Somani
发明人： Rushikesh Jadhav , Piyush Somani
IPC分类号： G06F9/455
CPC分类号： G06F9/5077 , G06F2209/5022 , G06F2209/508 , Y02D10/22 , Y02D10/36
摘要： A method and system for detecting, in real time, resource requirements of a system in virtual environment and automatic scaling of resource parameters to compensate resource requirement in a system. The Virtual machine controller constantly measures resource utilization in the servers and virtual machines associated with it. If a resource requirement is detected with any virtual machine, the automatic resource scaling system detects the type of resource to be scaled and scales the selected resource. Further, the resource may be scaled up or scaled down, based on the requirements. Further, the scaled resource may be CPU, RAM, disk or any such resource. The proposed system helps to save space and power without compromising security, performance and accessibility.
摘要翻译：一种用于实时检测虚拟环境中的系统的资源需求的方法和系统，并且自动缩放资源参数以补偿系统中的资源需求。虚拟机控制器不断测量与其相关联的服务器和虚拟机中的资源利用率。如果使用任何虚拟机检测到资源需求，则自动资源缩放系统检测要缩放的资源类型并缩放所选资源。此外，可以基于需求来扩大或缩小资源。此外，缩放的资源可以是CPU，RAM，磁盘或任何这样的资源。所提出的系统有助于节省空间和功率，而不会影响安全性，性能和可访问性。

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