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1. 发明授权

US06107036A Heterocyclic dioxethane substrates, process for their preparation and their use 失效
标题翻译：杂环二恶烷基质，其制备方法及其用途
公开(公告)号：US06107036A
公开(公告)日：2000-08-22
申请号：US051487
申请日：1998-04-20
申请人： Dieter Heindl , Hans-Peter Josel , Herbert Von Der Eltz , Rupert Herrmann , Hans-Joachim Holtke , Rainer Beckert , Dieter Weiss , Waldemar Adam
发明人： Dieter Heindl , Hans-Peter Josel , Herbert Von Der Eltz , Rupert Herrmann , Hans-Joachim Holtke , Rainer Beckert , Dieter Weiss , Waldemar Adam
IPC分类号： C07D321/00 , C07D491/113 , C07D493/10 , C07F7/18 , C07F9/38 , C07F9/6561 , C07J1/00 , C07J17/00 , C07J21/00 , C07J51/00 , G01N33/533 , G01N33/58 , C12Q1/68 , C12Q1/44 , C07D263/52 , C07D305/00
CPC分类号： C07D493/10 , C07D321/00 , C07F7/1856 , C07F9/6561 , C07J17/00 , C07J21/00 , C07J51/00 , G01N33/582
摘要： Compounds of the general formula Ia and Ib are described ##STR1## in which R.sup.1 and R.sup.2 are the same or different and represent hydrogen, straight-chain or branched C.sub.1 to C.sub.6 lower alkyl or an aryl group optionally substituted by electron-withdrawing groups, R.sup.3 denotes a cleavable group, W is hydrogen, halogen or a pseudohalogen and at least one of the groups R.sup.4 or R.sup.5 is a group stabilizing the dioxetane structure and at most one of the groups R.sup.4 or R.sup.5 represents hydrogen and X or Y represents oxygen, N-R or C(R).sub.2 in which R has the meanings stated for R.sup.1 and R.sup.2 or represents a mesomeric double bond or a carbonyl group and n denotes the number 0 or 1 and m denotes the number 1 or 2, as well as a process for their production. These compounds are new and can be used as substrates in immunological assays and in DNA diagnostics using activating agents for colour formation.
摘要翻译： PCT No.PCT / EP96 / 04506 Sec。 371日期：1998年4月20日 102（e）1998年4月20日PCT PCT 1996年10月17日PCT公布。公开号WO97 / 14696 日本1997年4月24日描述了通式Ia和Ib的化合物，其中R 1和R 2相同或不同，表示氢，直链或支链C 1至C 6低级烷基或任选被吸电子基团取代的芳基，R3表示可裂解基团，W表示氢，卤素或假卤素，R 4或R 5中的至少一个是稳定二氧杂环丁烷结构的基团，R4或R5中至少一个表示氢，X或Y表示氧，NR或C（R）2，其中R具有R 1和R 2所述的含义或表示中间双键或羰基，n表示数字0或1，m表示数字1或2，以及a 他们的生产过程。这些化合物是新的，可用作免疫学测定中的底物和使用活化剂进行染色形成的DNA诊断。

2. 发明申请

US20110092689A1 FLUORESCENCE QUENCHER MOLECULES 有权
标题翻译：荧光猝灭分子
公开(公告)号：US20110092689A1
公开(公告)日：2011-04-21
申请号：US12898107
申请日：2010-10-05
申请人： Rainer Beckert , Frank Bergmann , Dieter Heindl , Rupert Herrmann , Hans-Peter Josel , Thomas Welzel
发明人： Rainer Beckert , Frank Bergmann , Dieter Heindl , Rupert Herrmann , Hans-Peter Josel , Thomas Welzel
IPC分类号： C07H21/04 , C07D401/04
CPC分类号： C07D401/04
摘要： Disclosed are pyridinyl-isoquinoline-dione derivatives, methods of producing these derivatives, conjugates comprising the pyridinyl-isoquinoline dione derivatives and (i) a solid support, or (ii) a biomolecule, methods of producing these conjugates as well as the use of these conjugates as quenchers in fluorescence resonance energy transfer (FRET).
摘要翻译：公开了吡啶基 - 异喹啉二酮衍生物，制备这些衍生物的方法，包含吡啶基 - 异喹啉二酮衍生物的共轭物和（i）固体支持物，或（ii）生物分子，制备这些缀合物的方法以及这些共轭物作为荧光共振能量转移（FRET）中的猝灭剂。

3. 发明授权

US08350038B2 Fluorescence quencher molecules 有权
标题翻译：荧光猝灭剂分子
公开(公告)号：US08350038B2
公开(公告)日：2013-01-08
申请号：US12898107
申请日：2010-10-05
申请人： Rainer Beckert , Frank Bergmann , Dieter Heindl , Rupert Herrmann , Hans-Peter Josel , Thomas Welzel
发明人： Rainer Beckert , Frank Bergmann , Dieter Heindl , Rupert Herrmann , Hans-Peter Josel , Thomas Welzel
IPC分类号： C07D217/22 , C07D217/00
CPC分类号： C07D401/04
摘要： Disclosed are pyridinyl-isoquinoline-dione derivatives, methods of producing these derivatives, conjugates comprising the pyridinyl-isoquinoline dione derivatives and (i) a solid support, or (ii) a biomolecule, methods of producing these conjugates as well as the use of these conjugates as quenchers in fluorescence resonance energy transfer (FRET).
摘要翻译：公开了吡啶基 - 异喹啉二酮衍生物，制备这些衍生物的方法，包含吡啶基 - 异喹啉二酮衍生物的共轭物和（i）固体支持物，或（ii）生物分子，制备这些缀合物的方法以及这些共轭物作为荧光共振能量转移（FRET）中的猝灭剂。

4. 发明申请

US20090264618A1 Compounds With a Branched Linker 审中-公开
标题翻译：具有分支链接器的化合物
公开(公告)号：US20090264618A1
公开(公告)日：2009-10-22
申请号：US12370886
申请日：2009-02-13
申请人： Herbert Andres , Hans-Peter Josel , Eva Hoess , Rupert Herrmann , Herbert Von Der Eltz
发明人： Herbert Andres , Hans-Peter Josel , Eva Hoess , Rupert Herrmann , Herbert Von Der Eltz
IPC分类号： C07K14/00 , C07K16/00
CPC分类号： G01N33/6845 , C07K1/1075 , C07K1/1077 , C07K14/001 , G01N33/5306 , G01N33/531 , G01N33/532 , G01N33/533 , G01N33/68
摘要： Disclosed herein are branched linkers of the formula: Zn-Y-Xm Wherein X, Y, Z, m, and n are as defined herein. The branched linkers are useful for producing conjugates that are used in diagnostic or therapeutic methods. Methods of producing the branched linkers are also described.
摘要翻译：本文公开了下式的支链接头：Zn-Y-Xm，其中X，Y，Z，m和n如本文所定义。支链接头可用于制备用于诊断或治疗方法的缀合物。还描述了生产支化接头的方法。

5. 发明授权

US07378255B2 Fluorimetric determination of analytes by an intramolecular quencher-fluorophore conjugate 有权
标题翻译：通过分子内猝灭剂 - 荧光团缀合物进行荧光测定分析物
公开(公告)号：US07378255B2
公开(公告)日：2008-05-27
申请号：US10766457
申请日：2004-01-28
申请人： Carina Horn , Hans-Peter Josel , Jürgen Spinke , Rupert Herrmann , Dieter Heindl
发明人： Carina Horn , Hans-Peter Josel , Jürgen Spinke , Rupert Herrmann , Dieter Heindl
IPC分类号： C12Q1/26
CPC分类号： G01N21/6428 , G01N2021/6432 , Y10S436/80 , Y10S436/904
摘要： A method and reagent for detecting an analyte by a redox reaction and a fluorimetric determination, is disclosed. The method comprises contacting a sample containing the analyte with a detection reagent which contains a compound of the general formula Q-F as a fluorimetric redox indicator, wherein Q is a quencher group and F is a fluorophore group.
摘要翻译：公开了一种用于通过氧化还原反应和荧光测定来检测分析物的方法和试剂。该方法包括将含有分析物的样品与含有通式Q-F化合物的检测试剂接触，作为荧光氧化还原指示剂，其中Q为猝灭剂基团，F为荧光团。

6. 发明申请

US20060199223A1 Chemiluminescent compounds and their use 失效
公开(公告)号：US20060199223A1
公开(公告)日：2006-09-07
申请号：US11326852
申请日：2006-01-06
申请人： Wolfgang Jenni , Dieter Heindl , Rupert Herrmann , Hans-Peter Josel , Gunter Lampert
发明人： Wolfgang Jenni , Dieter Heindl , Rupert Herrmann , Hans-Peter Josel , Gunter Lampert
IPC分类号： G01N33/53 , C12Q1/66 , C07D277/84 , C07D263/60 , C07K16/46
CPC分类号： C07D209/60 , G01N33/533
摘要： The present invention relates to novel chemiluminescent compounds, to a method for synthesizing these compounds, to derivatives and conjugates comprising these compounds, to the use of these compounds or conjugates thereof in chemiluminescence based assays, especially in immunoassays.

7. 发明授权

US07332354B2 Compounds for chemiluminescense procedures 失效
标题翻译：化学发光法的化合物
公开(公告)号：US07332354B2
公开(公告)日：2008-02-19
申请号：US10479320
申请日：2002-05-28
申请人： Dieter Heindl , Rupert Herrmann , Hans-Peter Josel , Erasmus Huber , Ursula Klause
发明人： Dieter Heindl , Rupert Herrmann , Hans-Peter Josel , Erasmus Huber , Ursula Klause
IPC分类号： G01N33/532 , G01N33/533 , C12P7/40 , C07D219/00 , C07D277/62
CPC分类号： C07D401/12 , C07D219/06 , C07D417/04 , C07D417/14 , C12Q1/28 , G01N33/533 , G01N33/582 , Y10S435/968 , Y10S436/80 , Y10S436/904
摘要： The present invention relates to a chemical compound comprising a light emitting moiety precursor and a precursor of a leaving group, bound to each other by an amide or by an ester bond and characterized in that the leaving group precursor upon oxidation is converted into the leaving group. The invention also relates to compounds additionally comprising a coupling group to the use of such compounds for labeling of biomolecules and more generally to the use of such compounds in chemiluminescence detection procedures.
摘要翻译：本发明涉及包含发光部分前体和离去基团的前体的化合物，其通过酰胺或酯键彼此结合，并且其特征在于，离去基团前体在氧化时转化为离去基团。本发明还涉及另外包含使用这种化合物的偶联基团用于标记生物分子的化合物，更一般地，在化学发光检测程序中使用这些化合物。

8. 发明授权

US06184379B2 Rhodamine derivatives and the use thereof 有权
标题翻译：罗丹明衍生物及其用途
公开(公告)号：US06184379B2
公开(公告)日：2001-02-06
申请号：US09324265
申请日：1999-06-02
申请人： Hans-Peter Josel , Rupert Herrmann , Dieter Heindl , Klaus Muhlegger , Gregor Sagner , Karl Heinz Drexhage , Jorg Frantzeskos , Jutta Arden-Jacob
发明人： Hans-Peter Josel , Rupert Herrmann , Dieter Heindl , Klaus Muhlegger , Gregor Sagner , Karl Heinz Drexhage , Jorg Frantzeskos , Jutta Arden-Jacob
IPC分类号： C07D49147
CPC分类号： C09B11/24 , Y10S436/80
摘要： The invention concerns rhodamine derivatives of the general formulae in which Ca-Cd each denote a C atom, and Ca and Cb as well as Cc and Cd are either linked together by a single bond or by a double bond; X1 to X16 denote independently of one another halogen, sulfonic acid, hydrogen or an alkyl residue with 1-20 C atoms in which the alkyl residue can be substituted with one or several halogen or sulfonic acid residues; R1 and R2 are either identical or different and denote either hydrogen, alkyl with 1-20 C atoms, polyoxyhydrocarbyl units, phenyl or phenylalkyl with 1-3 carbon atoms in the alkyl chain in which the alkyl and/or phenyl residues can be substituted by one or several hydroxy, halogen, sulfonic acid, amino, carboxy or alkoxycarbonyl groups where alkoxy can have 1-4 carbon atoms, R1 contains at least one activatable group, R2 and X4 can be optionally linked together via a bridge composed of 0-2 C atoms. In contrast to the prior art, these compounds are characterized in that A1, A2 and A3 can independently of one another denote hydrogen, cyano, halogen and sulfonic acid; B1 denotes either halogen, cyano or hydrogen; B2 denotes hydrogen, amide, halogen and an alkyl residue with 1-20 C atoms. In addition the invention concerns activated rhodamine derivatives, correspondingly conjugated biomolecules and their use in diagnostic systems.
摘要翻译：本发明涉及一般式的罗丹明衍生物，其中Ca-Cd各自表示C原子，Ca和Cb以及C c和Cd通过单键或双键连接在一起; X1至X16彼此独立地表示卤素，磺酸，氢或具有1-20个C原子的烷基残基，其中烷基残基可被一个或几个卤素或磺酸残基取代; R 1和R 2可以相同或不同，表示氢，具有1-20个C原子的烷基，聚氧烃基单元，烷基链中具有1-3个碳原子的苯基或苯基烷基，其中烷基和/或苯基残基可被一个或几个羟基，卤素，磺酸，氨基，羧基或烷氧基羰基，其中烷氧基可以具有1-4个碳原子，R 1包含至少一个可活化基团，R 2和X 4可以任选地通过由0-2 C原子。与现有技术相反，这些化合物的特征在于，A1，A2和A3可以彼此独立地表示氢，氰基，卤素和磺酸; B1表示卤素，氰基或氢; B2表示氢，酰胺，卤素和具有1-20个C原子的烷基。此外，本发明涉及活化的罗丹明衍生物，相应的共轭生物分子及其在诊断系统中的用途。

9. 发明授权

US5712106A Process for the production of substituted thiazolin-dioxetan substrates and use thereof 失效
标题翻译：制备取代噻唑啉 - 二氧杂靛蓝基质的方法及其用途
公开(公告)号：US5712106A
公开(公告)日：1998-01-27
申请号：US450211
申请日：1995-05-25
申请人： Rupert Herrmann , Hans-Peter Josel , Christian Klein , Dieter Heindl
发明人： Rupert Herrmann , Hans-Peter Josel , Christian Klein , Dieter Heindl
IPC分类号： C07D513/10 , C07F9/6561 , C09K11/07 , C12Q1/34 , G01N33/535 , G01N33/58 , C12Q1/66
CPC分类号： C07D513/10 , C07F9/6561 , C09K11/07 , C12Q1/34 , G01N33/582
摘要： Compounds of the general formula III, ##STR1## in which R represents ##STR2## and in which R.sub.1 and R.sub.2 are the same or different and represent hydrogen or straight-chained or branched lower alkyl C.sub.1 -C.sub.6, and X represents a cleavable group, at least one of the groups R.sub.4 or R.sub.5 represents a group that stabilizes the dioxetan structure and at most one of the groups R.sub.4 or R.sub.5 represents hydrogen. These compounds can be used as substrates in immunological assays and in DNA diagnostics using activating agents for the formation of colour.
摘要翻译：通式III的化合物，其中R表示或，其中R1和R2相同或不同，表示氢或直链或支链的低级烷基C1-C6，X表示可切割基团，R4或R5中的至少一个表示稳定二氧杂环丁烷结构的基团，并且基团R4或R5中的至少一个表示氢。这些化合物可用作免疫学测定中的底物，以及使用活化剂形成颜色的DNA诊断。

10. 发明授权

US07807402B2 Reagent for fluorimetric determination of analytes 有权
标题翻译：用于荧光测定分析物的试剂
公开(公告)号：US07807402B2
公开(公告)日：2010-10-05
申请号：US12107116
申请日：2008-04-22
申请人： Carina Horn , Hans-Peter Josel , Juergen Spinke , Rupert Herrmann , Dieter Heindl
发明人： Carina Horn , Hans-Peter Josel , Juergen Spinke , Rupert Herrmann , Dieter Heindl
IPC分类号： C12Q1/26
CPC分类号： G01N21/6428 , G01N2021/6432 , Y10S436/80 , Y10S436/904
摘要： A method and reagent for detecting the presence or amount of an analyte by a redox reaction and a fluorimetric determination, is disclosed. The reagent comprises a compound of the general formula Q-F as a redox indicator, wherein Q is a quencher group and F is a fluorophore group. The quencher group Q or/and the fluorophore group F can be reduced or oxidized, and the fluorescence can change depending on the reduction or oxidation.
摘要翻译：公开了一种用于通过氧化还原反应和荧光测定来检测分析物的存在或量的方法和试剂。试剂包含通式Q-F的化合物作为氧化还原指示剂，其中Q为猝灭剂基团，F为荧光团。淬灭基团Q或/和荧光团F可以被还原或氧化，并且荧光可以根据还原或氧化而改变。

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