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1. 发明申请

US20080140061A1 Method And Device For Combined Treatment 审中-公开
标题翻译：联合治疗方法与装置
公开(公告)号：US20080140061A1
公开(公告)日：2008-06-12
申请号：US11851055
申请日：2007-09-06
申请人： Didier TOUBIA , Alexander LEVIN , Miron KAGANOVICH , Liliach Eyal-Waldman
发明人： Didier TOUBIA , Alexander LEVIN , Miron KAGANOVICH , Liliach Eyal-Waldman
IPC分类号： A61B18/18
CPC分类号： A61B18/02 , A61B2018/0262 , A61M5/3287 , A61M2005/341
摘要： A cryoprobe supports administration of an active agent to a location of cryogenic treatment. The cryoprobe may optionally be combined with a syringe to form a cryoprobe system; alternatively and optionally, the syringe may be external to the cryoprobe.
摘要翻译：冷冻探针支持将活性剂施用于低温处理的位置。冷冻探针可以可选地与注射器组合以形成冷冻探针系统; 替代地和任选地，注射器可以在冷冻探针的外部。

2. 发明申请

US20090082761A1 CRYOSURGICAL INSTRUMENT WITH EMBEDDED SEPARATING UNIT 审中-公开
标题翻译：具有嵌入式分离单元的晶状体仪器
公开(公告)号：US20090082761A1
公开(公告)日：2009-03-26
申请号：US12237805
申请日：2008-09-25
申请人： Alexander LEVIN , Didier TOUBIA , Miron KAGANOVICH
发明人： Alexander LEVIN , Didier TOUBIA , Miron KAGANOVICH
IPC分类号： A61B18/02
CPC分类号： A61B18/02 , A61B2018/0262
摘要： A cryosurgical instrument, in which a separator is installed in a central feeding lumen and/or in a cryotip to separate gaseous and liquid components of a cryogen.
摘要翻译：一种冷冻手术器械，其中分离器安装在中央给药腔和/或冷冻液中以分离冷冻剂的气体和液体组分。

3. 发明申请

US20080307800A1 Siphon for Delivery of Liquid Cryogen from Dewar Flask 审中-公开
标题翻译：虹吸用于从杜瓦瓶中输送液体冷冻剂
公开(公告)号：US20080307800A1
公开(公告)日：2008-12-18
申请号：US11763093
申请日：2007-06-14
申请人： Alexander LEVIN , Didier TOUBIA , Miron KAGANOVICH
发明人： Alexander LEVIN , Didier TOUBIA , Miron KAGANOVICH
IPC分类号： F17C6/00
CPC分类号： F17C9/00 , F17C2205/0358 , F17C2221/01 , F17C2223/0161 , F17C2223/033 , F17C2223/047 , F17C2225/0161 , F17C2250/032 , F17C2250/0408 , F17C2250/043 , F17C2260/044 , F17C2265/012 , F17C2270/05
摘要： The invention involves a siphon for delivery of a liquid cryogen from a container such as a Dewar flask. The siphon ensures delivery of a liquid cryogen with a lower proportion of the gaseous fraction. The siphon comprises a central feeding conduit, which is largely contained within the Dewar flask. There is an auxiliary conduit surrounding the central feeding conduit; the outer upper section of this auxiliary conduit is provided with an adjustable valve intended to release a gaseous fraction of the cryogen contained in the annular gap between the auxiliary and central feeding conduits. The upper section of the central feeding conduit is provided with an external layer of a porous capillary coating or with a wick; this ensures that the upper section of the central feeding conduit is continuously wetted with the liquid cryogen. This porous capillary coating prevents gasification of the liquid cryogen in the central feeding conduit. Alternatively, the problem of liquid cryogen gasification may be solved through thermal insulation of the central feeding conduit.
摘要翻译：本发明涉及用于从诸如杜瓦瓶的容器输送液体冷冻剂的虹吸管。虹吸管确保用较低比例的气体馏分输送液体冷冻剂。虹吸管包括一个主要包含在杜瓦瓶内的中央供料管道。有一个围绕中央给料管道的辅助管道; 该辅助导管的外部上部设置有可调节的阀，其用于释放包含在辅助和中央供给导管之间的环形间隙中的致冷剂的气态部分。中央给料导管的上部设置有多孔毛细管涂层或芯的外层; 这确保了中央供给导管的上部部分被液体冷冻剂连续地润湿。这种多孔毛细管涂层防止液体冷冻剂在中央进料管道中的气化。或者，液体冷冻剂气化的问题可以通过中央供给管道的绝热来解决。

4. 发明申请

US20080033416A1 Cryogenic Probe for Treating Enlarged Volume of Tissue 有权
标题翻译：用于治疗组织扩大体积的低温探针
公开(公告)号：US20080033416A1
公开(公告)日：2008-02-07
申请号：US11832778
申请日：2007-08-02
申请人： Didier TOUBIA , Alexander LEVIN , Miron KAGANOVICH
发明人： Didier TOUBIA , Alexander LEVIN , Miron KAGANOVICH
IPC分类号： A61B18/02
CPC分类号： A61B18/02 , A61B2018/0268
摘要： A cryoprobe for surgical and other treatments. The cryoprobe comprises an expandable section that performs displacement of a distal cryotip forwards when there is elevation of the operation pressure in the interior of the cryoprobe. Needle-wise metal elements are installed on the external side of the cryotip. These needle-wise elements are deflecting outwards by a deflecting member fastened on the distal edge of an external shaft of the cryoprobe. This allows a significant enlargement of the frozen volume of the treated tissue with the same operation temperature and the outer diameter of the cryoprobe. In another embodiment, the needle elements are formed in a displaceable metal sheath and a distal section of a cryotip and/or special protrusions on this distal section act as the deflecting member.
摘要翻译：用于手术和其他治疗的冷冻探针。冷冻探针包括可膨胀部分，当在冷冻探针的内部存在操作压力升高时，该扩张部分向远侧冷冻滚筒向前移动。针状金属元件安装在冷冻液的外侧。这些针状元件由固定在冷冻探针的外部轴的远端上的偏转构件向外偏转。这允许以相同的操作温度和冷冻探针的外径显着地扩大处理过的组织的冷冻体积。在另一个实施例中，针元件形成在可移动的金属护套中，并且该远端部分上的冷冻滚筒和/或特殊突起的远端部分用作偏转构件。

5. 发明申请

US20080033414A1 Cryogenic Probe for Treating Enlarged Volume of Tissue 有权
标题翻译：用于治疗组织扩大体积的低温探针
公开(公告)号：US20080033414A1
公开(公告)日：2008-02-07
申请号：US11462244
申请日：2006-08-03
申请人： Alexander LEVIN , Didier TOUBIA
发明人： Alexander LEVIN , Didier TOUBIA
IPC分类号： A61B18/02
CPC分类号： A61B18/02 , A61B2018/0262 , A61B2018/0275
摘要： The invention proposes a cryoprobe for surgical and other treatments. The cryoprobe comprises a bellow-wise section that performs displacement of a distal cryotip forwards with elevation of operation pressure in the interior of the cryoprobe. Needle-wise metal elements are installed on the external side of the cryotip. These needle-wise elements are deflecting outwards by a deflecting member fastened on the distal edge of an external shaft of the cryoprobe. This allows to enlarge significantly a frozen volume of the treated tissue for same operation temperature and the outer diameter of the cryoprobe.
摘要翻译：本发明提出了一种用于手术和其他治疗的冷冻探针。冷冻探针包括一个波纹管部分，其在冷冻探针内部执行远程冷冻液向前的移动，并具有操作压力的升高。针状金属元件安装在冷冻液的外侧。这些针状元件由固定在冷冻探针的外部轴的远端上的偏转构件向外偏转。这允许相同的操作温度和冷冻探针的外径显着地增加处理过的组织的冷冻体积。

6. 发明申请

US20080114346A1 Cryosurgical Instrument 审中-公开
标题翻译：冷冻手术器械
公开(公告)号：US20080114346A1
公开(公告)日：2008-05-15
申请号：US11857085
申请日：2007-09-18
申请人： Alexander LEVIN , Didier TOUBIA
发明人： Alexander LEVIN , Didier TOUBIA
IPC分类号： A61B18/02
CPC分类号： A61B18/02 , A61B18/0218 , A61B2018/00577 , A61B2018/0212 , A61B2018/0231 , A61B2018/0262 , A61B2018/0293
摘要： A cryosurgical probe (cryoprobe) for ablation of a superficial tissue. The cryoprobe operation is preferably based on combination of two freezing effects: a) heat transfer from a liquid, gaseous or aerosolized cryogen, which is delivered from openings in the cryoprobe tip immediately on the surface of the treated tissue, and b) heat transfer from needle(s) installed on the outer surface of the cryotip. This needle (or needles) is constructed from material with high thermal conductivity. In addition, the outer surface of the cryotip may be provided with spacers, which limit the depth of penetration of the needle(s) into the tissue.
摘要翻译：用于消融浅表组织的冷冻手术探针（cryoprobe）。冷冻探针操作优选地基于两种冷冻效果的组合：a）来自液体，气态或雾化的冷冻剂的热传递，其直接从处理过的组织的表面上从冷冻探针尖端的开口输送，以及b）从针头安装在冷冻液的外表面上。该针（或针）由具有高导热性的材料构成。此外，冷冻液的外表面可以设置有间隔件，其限制针穿入组织的深度。

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