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1. 发明申请

US20100196926A1 Combined Method And Kit For The Sequential Measurement of (1) The Enzymatically Active Fraction And (2) The Total Amount Of An Enzyme 审中-公开
标题翻译：（1）酶活性分数的顺序测定的组合方法和试剂盒（2）酶的总量
公开(公告)号：US20100196926A1
公开(公告)日：2010-08-05
申请号：US12669781
申请日：2008-06-02
申请人： Didier Serteyn , Ginette Dupont , Thierry Franck , Stephane Kohnen
发明人： Didier Serteyn , Ginette Dupont , Thierry Franck , Stephane Kohnen
IPC分类号： G01N33/573 , G01N33/53
CPC分类号： C12Q1/28 , C12Q1/00 , G01N33/543 , G01N33/573
摘要： The present invention is related to a combined method and kit (or device) for the sequential measurement of the enzymatically active fraction and the total amount of an enzyme [(such as myeloperoxidase (MPO)] in a sample, and that find improved applications in veterinary and human health fields.
摘要翻译：本发明涉及用于连续测量样品中酶活性级分和酶总量（如髓过氧化物酶（MPO））的组合方法和试剂盒（或装置），并且可以在兽医和人类健康领域。

2. 发明申请

US20080233600A1 Method and Kit for the Measurement of Neutrophil Cell Activation 失效
标题翻译：用于测量中性粒细胞活化的方法和试剂盒
公开(公告)号：US20080233600A1
公开(公告)日：2008-09-25
申请号：US10597636
申请日：2005-02-07
申请人： Didier Serteyn , Ginette DuPont , Thierry Franck , Stephane Kohnen
发明人： Didier Serteyn , Ginette DuPont , Thierry Franck , Stephane Kohnen
IPC分类号： G01N33/50 , G01N33/573
CPC分类号： G01N33/5091 , C12Q1/28 , G01N33/56972 , G01N33/573 , G01N2500/04 , Y10T436/25125
摘要： The present invention is related to accurate detection methods for the measurement only of myelopexidase (MPO) levels or neutrophils, preferably equine neutrophils, in complex biological samples. The present invention is further related to ELISA and SIEFED assays for such detection. SIEFED detection sensitivity of active peroxidase activity was found to be enhanced by the addition of nitrite. Such MPO measurement finds its use in many applications such as the prediction, diagnosis and/or monitoring of pathologies correlated with neutrophil activation and/or destruction; the evaluation of drugs and/or immunomodulators; the assessment of immune responses, either natural and/or after treatment with immunomodulators and/or drugs; and the study of cells and their ability to fight microorganisms and/or to destroy them.
摘要翻译：本发明涉及在复杂生物样品中仅测量骨髓过氧化物酶（MPO）水平或嗜中性粒细胞，优选马中性粒细胞的精确检测方法。本发明还涉及用于这种检测的ELISA和SIEFED测定。发现活性过氧化物酶活性的SIEFED检测灵敏度通过加入亚硝酸盐而增强。这样的MPO测量可以在诸如预测，诊断和/或监测与嗜中性粒细胞活化和/或破坏相关的病理学的许多应用中得到应用。药物和/或免疫调节剂的评估; 用免疫调节剂和/或药物进行天然和/或治疗后免疫应答的评估; 细胞的研究及其对抗微生物和/或破坏细胞的能力。

3. 发明授权

US08399208B2 Method and kit for the measurement of neutrophil cell activation 失效
标题翻译：用于测量嗜中性粒细胞活化的方法和试剂盒
公开(公告)号：US08399208B2
公开(公告)日：2013-03-19
申请号：US10597636
申请日：2005-02-07
申请人： Didier Serteyn , Ginette Dupont , Thierry Franck , Stéphane Kohnen
发明人： Didier Serteyn , Ginette Dupont , Thierry Franck , Stéphane Kohnen
IPC分类号： G01N33/00 , G01N33/53
CPC分类号： G01N33/5091 , C12Q1/28 , G01N33/56972 , G01N33/573 , G01N2500/04 , Y10T436/25125
摘要： The present invention is related to accurate detection methods for the measurement only of myeloperoxidase (MPO) levels or neutrophils, preferably equine neutrophils, in complex biological samples. The present invention is further related to ELISA and SIEFED assays for such detection. SIEFED detection sensitivity of active peroxidase activity was found to be enhanced by the addition of nitrite. Such MPO measurement finds its use in many applications such as the prediction, diagnosis and/or monitoring of pathologies correlated with neutrophil activation and/or destruction; the evaluation of drugs and/or immunomodulators; the assessment of immune responses, either natural and/or after treatment with immunomodulators and/or drugs; and the study of cells and their ability to fight microorganisms and/or to destroy them.
摘要翻译：本发明涉及在复杂生物样品中仅测量髓过氧化物酶（MPO）水平或嗜中性粒细胞，优选马中性粒细胞的精确检测方法。本发明还涉及用于这种检测的ELISA和SIEFED测定。发现活性过氧化物酶活性的SIEFED检测灵敏度通过加入亚硝酸盐而增强。这样的MPO测量可以在诸如预测，诊断和/或监测与嗜中性粒细胞活化和/或破坏相关的病理学的许多应用中得到应用。药物和/或免疫调节剂的评估; 用免疫调节剂和/或药物进行天然和/或治疗后免疫应答的评估; 细胞的研究及其对抗微生物和/或破坏细胞的能力。

4. 发明申请

US20060252707A1 Pharmaceutical composition for the treatment and/or the prevention of atherosclerosis from infectious origin 审中-公开
标题翻译：用于治疗和/或预防感染性动脉粥样硬化的药物组合物
公开(公告)号：US20060252707A1
公开(公告)日：2006-11-09
申请号：US10558503
申请日：2004-05-28
申请人： Carol Deby , Ginette Dupont , Didier Serteyn
发明人： Carol Deby , Ginette Dupont , Didier Serteyn
IPC分类号： A61K31/7048 , A61K31/573 , A61K31/353 , A01N31/08
CPC分类号： A61K31/05 , A61K31/352 , A61K31/573 , A61K2300/00
摘要： The present invention is related to a pharmaceutical composition suitable for the treatment and/or the prevention of atherosclerosis from infectious origin, which comprises an adequate pharmaceutical carrier, a corticosteroid and a stilbene-type alexin, preferably further comprising a flavonoid to regenerate the stilbene and/or to increase the effect of the latter. The latter compositions are highly suitable for long-term therapies like the treatment of atherosclerosis from infectious origin.
摘要翻译：本发明涉及一种适用于治疗和/或预防感染性动物的动脉粥样硬化的药物组合物，其包含足够的药物载体，皮质类固醇和二苯乙烯型亚历山大，优选还包含类黄酮以再生1,2-二苯乙烯， /或增加后者的效果。后一种组合物非常适合于长期疗法，如治疗来自传染源的动脉粥样硬化。

5. 发明申请

US20110257126A1 WATER SOLUBLE CURCUMIN COMPOSITIONS FOR USE IN ANTI-CANCER AND ANTI-INFLAMMATORY THERAPY 有权
标题翻译：用于抗癌和抗炎治疗的水溶性曲霉素组合物
公开(公告)号：US20110257126A1
公开(公告)日：2011-10-20
申请号：US12995126
申请日：2009-05-26
申请人： Philippe Neven , Didier Serteyn , Jacques Delarge , Eva Scheer , Robert Kiss , Veronique Mathieu , Didier Cataldo , Natacha Rocks
发明人： Philippe Neven , Didier Serteyn , Jacques Delarge , Eva Scheer , Robert Kiss , Veronique Mathieu , Didier Cataldo , Natacha Rocks
IPC分类号： A61K31/724 , A61P35/00 , A61P29/00 , A61P35/02 , A61P17/06 , A61P25/00 , A61P1/00 , A61P25/28 , A61P25/16 , A61P9/10 , A61P3/10 , A61P19/02 , A61P37/06 , A61P37/08 , C08B37/16
CPC分类号： B82Y5/00 , A61K31/724 , A61K45/06 , A61K47/6951 , A61K2300/00
摘要： The present invention relates to the medical field. In a first aspect the present invention relates to novel water soluble cyclodextrin-curcumin complexes having a pharmacological activity, in particular an anti-tumour and/or anti-inflammatory activity, and improved physico-chemical properties. In a second aspect, the present invention relates to a method for preparation of said water soluble curcumin derivatives. The invention further relates in a third aspect to a pharmaceutical composition comprising an effective amount of said water soluble curcumin derivatives. In a fourth aspect, the present invention concerns the use of said water soluble cucumin derivatives as a medicament and the use of said water soluble curcumin derivatives for the preparation of a medicament for the treatment of cancer and inflammatory diseases. In a fifth aspect, the present invention relates to the use of a pharmaceutical composition comprising said water soluble curcumin derivatives in the treatment of cancer and inflammatory diseases and to a new pharmaceutical composition comprising said water soluble curcumin derivatives.
摘要翻译：本发明涉及医疗领域。在第一方面，本发明涉及具有药理活性，特别是抗肿瘤和/或抗炎活性以及改善的物理化学性质的新的水溶性环糊精 - 姜黄素复合物。在第二方面，本发明涉及一种制备所述水溶性姜黄素衍生物的方法。本发明在第三方面进一步涉及包含有效量的所述水溶性姜黄素衍生物的药物组合物。在第四方面，本发明涉及所述水溶性姜黄素衍生物作为药物的用途，以及所述水溶性姜黄素衍生物在制备用于治疗癌症和炎性疾病的药物中的用途。在第五方面，本发明涉及包含所述水溶性姜黄素衍生物的药物组合物在治疗癌症和炎性疾病中的用途以及包含所述水溶性姜黄素衍生物的新药物组合物的用途。

6. 发明授权

US08772265B2 Water soluble curcumin compositions for use in anti-cancer and anti-inflammatory therapy 有权
标题翻译：用于抗癌和抗炎治疗的水溶性姜黄素组合物
公开(公告)号：US08772265B2
公开(公告)日：2014-07-08
申请号：US12995126
申请日：2009-05-26
申请人： Philippe Neven , Didier Serteyn , Robert Kiss , Veronique Mathieu , Didier Cataldo , Natacha Rocks , Eva Scheer
发明人： Philippe Neven , Didier Serteyn , Jacques Delarge , Robert Kiss , Veronique Mathieu , Didier Cataldo , Natacha Rocks
IPC分类号： A01N43/04 , A61K31/715
CPC分类号： B82Y5/00 , A61K31/724 , A61K45/06 , A61K47/6951 , A61K2300/00
摘要： The present invention relates to the medical field. In a first aspect the present invention relates to novel water soluble cyclodextrin-curcumin complexes having a pharmacological activity, in particular an anti-tumor and/or anti-inflammatory activity, and improved physico-chemical properties. In a second aspect, the present invention relates to a method for preparation of said water soluble curcumin derivatives. The invention further relates in a third aspect to a pharmaceutical composition comprising an effective amount of said water soluble curcumin derivatives. In a fourth aspect, the present invention concerns the use of said water soluble cucumin derivatives as a medicament and the use of said water soluble curcumin derivatives for the preparation of a medicament for the treatment of cancer and inflammatory diseases. In a fifth aspect, the present invention relates to the use of a pharmaceutical composition comprising said water soluble curcumin derivatives in the treatment of cancer and inflammatory diseases and to a new pharmaceutical composition comprising said water soluble curcumin derivatives.
摘要翻译：本发明涉及医疗领域。在第一方面，本发明涉及具有药理活性，特别是抗肿瘤和/或抗炎活性以及改善的物理化学性质的新的水溶性环糊精 - 姜黄素复合物。在第二方面，本发明涉及一种制备所述水溶性姜黄素衍生物的方法。本发明在第三方面进一步涉及包含有效量的所述水溶性姜黄素衍生物的药物组合物。在第四方面，本发明涉及所述水溶性姜黄素衍生物作为药物的用途，以及所述水溶性姜黄素衍生物在制备用于治疗癌症和炎性疾病的药物中的用途。在第五方面，本发明涉及包含所述水溶性姜黄素衍生物的药物组合物在治疗癌症和炎性疾病中的用途以及包含所述水溶性姜黄素衍生物的新药物组合物的用途。

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