专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20100311659A1 Novel VIII Factors for the Treatment of Type A Hemophilia 有权
标题翻译： A型血友病治疗的新型VIII因素
公开(公告)号：US20100311659A1
公开(公告)日：2010-12-09
申请号：US12528379
申请日：2008-02-22
申请人： Didier Saboulard , Jean-Luc Plantier , Marc Delcourt , Claude Negrier , Thierry Menguy , Stephane Blesa , Sylvie Marin
发明人： Didier Saboulard , Jean-Luc Plantier , Marc Delcourt , Claude Negrier , Thierry Menguy , Stephane Blesa , Sylvie Marin
IPC分类号： A61K38/37 , C07K14/755 , C07H21/04 , C12N15/63 , G01N33/53 , A61P7/04
CPC分类号： C07K14/755 , A61K38/00
摘要： The present invention relates to improved human FVIII variants having at least one substitution in the A2 and/or C2 domain. The present invention also relates to their uses in the treatment of hemophilia A, particularly in patients with inhibitors.
摘要翻译：本发明涉及在A2和/或C2结构域中具有至少一个取代的改进的人FVIII变体。本发明还涉及其在治疗血友病A中的用途，特别是在抑制剂患者中。

2. 发明授权

US08623824B2 VIII factors for the treatment of type A hemophilia 有权
标题翻译： Ⅷ因素治疗A型血友病
公开(公告)号：US08623824B2
公开(公告)日：2014-01-07
申请号：US12528379
申请日：2008-02-22
申请人： Didier Saboulard , Jean-Luc Plantier , Marc Delcourt , Claude Negrier , Thierry Menguy , Stephane Blesa , Sylvie Marin
发明人： Didier Saboulard , Jean-Luc Plantier , Marc Delcourt , Claude Negrier , Thierry Menguy , Stephane Blesa , Sylvie Marin
IPC分类号： A61K38/37 , C12Q1/56
CPC分类号： C07K14/755 , A61K38/00
摘要： The present invention relates to improved human FVIII variants having at least one substitution in the A2 and/or C2 domain. The present invention also relates to their uses in the treatment of hemophilia A, particularly in patients with inhibitors.
摘要翻译：本发明涉及在A2和/或C2结构域中具有至少一个取代的改进的人FVIII变体。本发明还涉及其在治疗血友病A中的用途，特别是在抑制剂患者中。

3. 发明申请

US20130122567A1 ENHANCED PHYTASE VARIANTS 有权
标题翻译：增强植物变种
公开(公告)号：US20130122567A1
公开(公告)日：2013-05-16
申请号：US13380694
申请日：2010-07-01
申请人： Stephane Blesa , Helene Chautard , Marc Delcourt , Laurent Mesta , Bruno Winter
发明人： Stephane Blesa , Helene Chautard , Marc Delcourt , Laurent Mesta , Bruno Winter
IPC分类号： C12N9/16
CPC分类号： C12N9/16 , C12Y301/03008 , C12Y301/03026
摘要： The present invention provides the field of enhancing proteins and in particular to that of proteins enhanced by molecular change. It provides a variant of a phytase that is termed enhanced in that is has better thermostability and/or activity than the original phytase. The invention also provides a nucleic acid coding for said variant, a cassette or an expression vector containing said variant, a host cell expressing said variant, a composition comprising said variant and uses thereof, principally in the preparation of food additives and animal feed.
摘要翻译：本发明提供增强蛋白质的领域，特别是通过分子变化增强蛋白质的领域。它提供了一种植酸酶的变体，其被称为增强的，其具有比原始植酸酶更好的热稳定性和/或活性。本发明还提供编码所述变体的核酸，含有所述变体的盒或表达载体，表达所述变体的宿主细胞，包含所述变体的组合物及其用途，主要用于制备食品添加剂和动物饲料。

4. 发明授权

US09109210B2 Enhanced phytase variants 有权
标题翻译：增强的植酸酶变体
公开(公告)号：US09109210B2
公开(公告)日：2015-08-18
申请号：US13380694
申请日：2010-07-01
申请人： Stephane Blesa , Helene Chautard , Marc Delcourt , Laurent Mesta , Bruno Winter
发明人： Stephane Blesa , Helene Chautard , Marc Delcourt , Laurent Mesta , Bruno Winter
IPC分类号： C12N9/16
CPC分类号： C12N9/16 , C12Y301/03008 , C12Y301/03026
摘要： The present invention provides the field of enhancing proteins and in particular to that of proteins enhanced by molecular change. It provides a variant of a phytase that is termed enhanced in that is has better thermostability and/or activity than the original phytase. The invention also provides a nucleic acid coding for said variant, a cassette or an expression vector containing said variant, a host cell expressing said variant, a composition comprising said variant and uses thereof, principally in the preparation of food additives and animal feed.
摘要翻译：本发明提供增强蛋白质的领域，特别是通过分子变化增强蛋白质的领域。它提供了一种植酸酶的变体，其被称为增强的，其具有比原始植酸酶更好的热稳定性和/或活性。本发明还提供编码所述变体的核酸，含有所述变体的盒或表达载体，表达所述变体的宿主细胞，包含所述变体的组合物及其用途，主要用于制备食品添加剂和动物饲料。

5. 发明授权

US07202086B2 Method for massive directed mutagenesis 有权
标题翻译：大规模定向诱变方法
公开(公告)号：US07202086B2
公开(公告)日：2007-04-10
申请号：US10362576
申请日：2001-08-24
申请人： Marc Delcourt , Stephane Blesa
发明人： Marc Delcourt , Stephane Blesa
IPC分类号： C12N1/15 , C12Q1/68 , C07H21/02 , C07H21/04
CPC分类号： C12N15/1031 , C12N15/102 , C12N15/1058
摘要： The invention concerns the field of molecular biology and more particularly that of mutagenesis. It concerns a method of high-rate directed mutagenesis, that is the formation of numerous directed mutants in reduced time and with reduced number of steps. Said method is therefore referred to as massive mutagenesis.
摘要翻译：本发明涉及分子生物学领域，更具体地涉及诱变领域。它涉及高速定向诱变的方法，即在减少的时间和减少的步骤数目中形成许多定向突变体。因此所述方法被称为大量诱变。

6. 发明申请

US20100260704A1 HUMAN INTERFERON-GAMMA (INFGAMMA) VARIANTS 审中-公开
标题翻译：人间干扰（INFGAMMA）变种
公开(公告)号：US20100260704A1
公开(公告)日：2010-10-14
申请号：US12281192
申请日：2007-03-08
申请人： Jose Berenguer , Marc Delcourt , Héléne Chautard , Thierry Menguy
发明人： Jose Berenguer , Marc Delcourt , Héléne Chautard , Thierry Menguy
IPC分类号： A61K38/20 , A61K38/21 , C12P21/06 , C12N5/10 , C12N15/63 , C07K14/57 , C07H21/04 , A61P37/00 , A61P11/06 , A61P11/00 , A61P31/04 , A61P35/04 , A61P19/10 , A61P19/02
CPC分类号： C07K14/57 , A61K38/00
摘要： The present invention relates to human interferon gamma variants with improved thermostability, to a nucleic acid encoding said variants, to a pharmaceutical composition containing them, and to their use for the treatment of a viral infection and of cancer.
摘要翻译：本发明涉及具有改进的热稳定性的人干扰素γ变体，编码所述变体的核酸，含有它们的药物组合物，以及它们用于治疗病毒感染和癌症的用途。

7. 发明申请

US20130052706A1 PROCESS FOR THE PRODUCTION OF ISOPRENOL FROM MEVALONATE EMPLOYING A DIPHOSPHO-MEVOLONATE DECARBOXYLASE 有权
标题翻译：从使用二磷酸甲酯脱羧酶的甲酸盐生产异丙苯酚的方法
公开(公告)号：US20130052706A1
公开(公告)日：2013-02-28
申请号：US13518146
申请日：2009-12-22
申请人： Philippe Marliere , Maria Anissimova , Romain Chayot , Marc Delcourt
发明人： Philippe Marliere , Maria Anissimova , Romain Chayot , Marc Delcourt
IPC分类号： C12P7/04 , C12P5/02
CPC分类号： C12P7/04 , C12N9/88 , C12P5/007 , C12Y401/01033
摘要： Described is a method for the enzymatic production of isoprenol using mevalonate as a substrate and enzymatically converting it by a decarboxylation step into isoprenol as well as the use of an enzyme which is capable of catalyzing the decarboxylation of mevalonate for the production of isoprenol from mevalonate. Furthermore described is the use of mevalonate as a starting material for the production of isoprenol in an enzymatically catalysed reaction. Also disclosed is a method for the production of isoprene comprising the method for the production of isoprenol using mevalonate as a substrate and enzymatically converting it by a decarboxylation step into isoprenol and further comprising the step of converting the produced isoprenol into isoprene as well as a method for the production of isoamyl alcohol comprising the method for the production of isoprenol using mevalonate as a substrate and enzymatically converting it by a decarboxylation step into isoprenol and further comprising the step of converting the produced isoprenol into isoamyl alcohol.
摘要翻译：描述了使用甲羟戊酸作为底物酶促生产异戊二烯的方法，并通过脱羧步骤将其酶促转化成异戊二烯，以及使用能够催化甲羟戊酸脱羧从甲羟戊酸生产异戊二烯的酶。此外还描述了在酶催化反应中使用甲羟戊酸作为产生异戊二烯醇的起始原料。还公开了一种生产异戊二烯的方法，其包括使用甲羟甲酸盐作为底物生产异戊二烯的方法，并通过脱羧步骤将其酶促转化为异戊二烯醇，并且还包括将所产生的异戊二烯转化为异戊二烯的步骤以及方法用于生产异戊醇，其包括使用甲羟甲酸盐作为底物生产异戊二烯的方法，并通过脱羧步骤将其酶转化成异戊二烯，并且还包括将所生产的异戊烯醇转化为异戊醇的步骤。

8. 发明申请

US20050153343A1 Method of massive directed mutagenesis 审中-公开
标题翻译：大规模定向诱变方法
公开(公告)号：US20050153343A1
公开(公告)日：2005-07-14
申请号：US11012068
申请日：2004-12-15
申请人： Julien Sylvestre , Marc Delcourt
发明人： Julien Sylvestre , Marc Delcourt
IPC分类号： C12N15/10 , C12Q1/68 , C12N15/85
CPC分类号： C12N15/102
摘要： The invention relates to the field of molecular biology and more particularly that of mutagenesis. The invention has as its object a method of high throughput directed mutagenesis, that is to say, constitution of a large number of directed mutants at a reduced cost, time and number of steps. The invention also relates to the double stranded polynucleotides so obtained and the peptides, polypeptides, or proteins so obtained having one or more improved properties, and the uses of said method.
摘要翻译：本发明涉及分子生物学领域，更具体地涉及诱变领域。本发明的目的是提供高通量定向诱变的方法，也就是说，以降低的成本，时间和步骤数量构成大量定向突变体。本发明还涉及如此获得的双链多核苷酸和如此获得的具有一种或多种改善的性质的肽，多肽或蛋白质，以及所述方法的用途。

9. 发明授权

US09102952B2 Process for the production of isoprenol from mevalonate employing a diphospho-mevolonate decarboxylase 有权
标题翻译：使用二磷酸 - 螺旋体脱羧酶从甲羟戊酸生产异戊二烯的方法
公开(公告)号：US09102952B2
公开(公告)日：2015-08-11
申请号：US13518146
申请日：2009-12-22
申请人： Philippe Marliere , Maria Anissimova , Romain Chayot , Marc Delcourt
发明人： Philippe Marliere , Maria Anissimova , Romain Chayot , Marc Delcourt
IPC分类号： C12P5/02 , C12P7/04 , C12Q1/00 , C12N9/00 , C07H21/04 , C12P5/00
CPC分类号： C12P7/04 , C12N9/88 , C12P5/007 , C12Y401/01033
摘要： Described is a method for the enzymatic production of isoprenol using mevalonate as a substrate and enzymatically converting it by a decarboxylation step into isoprenol as well as the use of an enzyme which is capable of catalyzing the decarboxylation of mevalonate for the production of isoprenol from mevalonate. Furthermore described is the use of mevalonate as a starting material for the production of isoprenol in an enzymatically catalyzed reaction. Also disclosed is a method for the production of isoprene comprising the method for the production of isoprenol using mevalonate as a substrate and enzymatically converting it by a decarboxylation step into isoprenol and further comprising the step of converting the produced isoprenol into isoprene as well as a method for the production of isoamyl alcohol comprising the method for the production of isoprenol using mevalonate as a substrate and enzymatically converting it by a decarboxylation step into isoprenol and further comprising the step of converting the produced isoprenol into isoamyl alcohol.
摘要翻译：描述了使用甲羟戊酸作为底物酶促生产异戊二烯的方法，并通过脱羧步骤将其酶促转化成异戊二烯，以及使用能够催化甲羟戊酸脱羧从甲羟戊酸生产异戊二烯的酶。此外还描述了在酶催化反应中使用甲羟戊酸作为起始材料来生产异戊二烯醇。还公开了一种生产异戊二烯的方法，其包括使用甲羟甲酸盐作为底物生产异戊二烯的方法，并通过脱羧步骤将其酶促转化为异戊二烯醇，并且还包括将所产生的异戊二烯转化为异戊二烯的步骤以及方法用于生产异戊醇，其包括使用甲羟甲酸盐作为底物生产异戊二烯的方法，并通过脱羧步骤将其酶转化成异戊二烯，并且还包括将所生产的异戊烯醇转化为异戊醇的步骤。

10. 发明授权

US09903873B2 Method for selecting stable proteins in non-standard physicochemical conditions 有权
公开(公告)号：US09903873B2
公开(公告)日：2018-02-27
申请号：US11916112
申请日：2006-04-04
申请人： Marc Delcourt
发明人： Marc Delcourt
IPC分类号： C40B30/00 , C40B30/06 , C12N15/62 , C12N15/63 , G01N33/68 , C12N15/52
CPC分类号： G01N33/6842 , C07K2319/00 , C12N15/52 , C12N15/62 , C12N15/63 , C40B30/00 , C40B30/06 , G01N33/68
摘要： The invention relates to a method for selecting proteins stable in non-standard physicochemical conditions (temperature, pressure, pH, osmolarity, salinity, solvent, etc.) comprising the expression, in an extremophilic microorganism, of variants of the protein of interest in the form of a fusion protein with a reporter protein which is stable in extreme conditions and acts as a selection marker.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式