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1. 发明授权

US07973016B2 Methods of treating, reducing, or preventing autoimmune conditions 失效
标题翻译：治疗，减少或预防自身免疫病症的方法
公开(公告)号：US07973016B2
公开(公告)日：2011-07-05
申请号：US10586401
申请日：2005-01-24
申请人： Diane Mathis , Christophe O. Benoist , Hsin-Jung Wu
发明人： Diane Mathis , Christophe O. Benoist , Hsin-Jung Wu
IPC分类号： C12N15/11 , C07H21/02 , C07H21/04
CPC分类号： C12N15/117 , C12N2310/17 , C12N2310/313 , C12N2310/315 , C12N2320/31
摘要： The present invention relates to methods and kits for treating, reducing, or preventing autoimmune conditions such as rheumatoid arthritis by administering to a mammal in need thereof an agent that modulates the expression level or biological activity of Toll-like receptor-9 (TLR-9). Also disclosed are screening methods that make use of TLR-9 for the identification of novel therapeutics for autoimmune conditions.
摘要翻译：本发明涉及通过向有需要的哺乳动物施用调节Toll样受体-9（TLR-9）的表达水平或生物学活性的试剂来治疗，减少或预防自身免疫性疾病如类风湿性关节炎的方法和试剂盒）。还公开了利用TLR-9鉴定自身免疫病症的新疗法的筛选方法。

2. 发明申请

US20080020991A1 Methods of Treating, Reducing, or Preventing Autoimmune Conditions 失效
标题翻译：治疗，减少或预防自身免疫病症的方法
公开(公告)号：US20080020991A1
公开(公告)日：2008-01-24
申请号：US10586401
申请日：2005-01-24
申请人： Diane Mathis , Christophe O. Benoist , Hsin-Jung Wu
发明人： Diane Mathis , Christophe O. Benoist , Hsin-Jung Wu
IPC分类号： A61K31/7088 , A61P37/00 , C12Q1/68 , G01N33/53
CPC分类号： C12N15/117 , C12N2310/17 , C12N2310/313 , C12N2310/315 , C12N2320/31
摘要： The present invention relates to methods and kits for treating, reducing, or preventing autoimmune conditions such as rheumatoid arthritis by administering to a mammal in need thereof an agent that modulates the expression level or biological activity of Toll-like receptor-9 (TLR-9). Also disclosed are screening methods that make use of TLR-9 for the identification of novel therapeutics for autoimmune conditions.
摘要翻译：本发明涉及通过向有需要的哺乳动物施用调节Toll样受体-9（TLR-9）的表达水平或生物学活性的试剂来治疗，减少或预防自身免疫性疾病如类风湿性关节炎的方法和试剂盒）。还公开了利用TLR-9鉴定自身免疫病症的新疗法的筛选方法。

3. 发明申请

US20080103824A1 MEDICATION DOSE CALCULATOR AND ASSOCIATED METHODS 审中-公开
标题翻译：药物剂量计算器及相关方法
公开(公告)号：US20080103824A1
公开(公告)日：2008-05-01
申请号：US11928573
申请日：2007-10-30
申请人： Katharine Francis , Diane Mathis , Gary Conkright
发明人： Katharine Francis , Diane Mathis , Gary Conkright
IPC分类号： G06Q50/00
CPC分类号： G06F19/3456 , G06F19/326 , G06Q50/22
摘要： A medication dose calculator and method for comparing an inputted, ordered medication dosage with a known medication dosage range in a database including an input device for inputting a desired drug name, indicating whether the drug is for a child or an adult, an amount of the drugs that are ordered, the body weight or body surface of the patient, and a computing mechanism for determining the dose of the drug to be delivered. The medication dose calculator provides warnings when the inputted amount of drug exceeds the dosage range limits or is incorrect. The medication dose calculator converts an inputted drug unit of measure into a desired unit of measure. In addition, various methods for receiving, recording, storing, transmitting, transferring, and editing information along with various processes utilizing the medication dose calculator are disclosed.
摘要翻译：一种药物剂量计算器和方法，用于将输入的有序药物剂量与数据库中的已知药物剂量范围进行比较，所述数据库包括用于输入所需药物名称的输入装置，指示药物是针对儿童还是成人，订购的药物，患者的体重或身体表面，以及用于确定待递送药物的剂量的计算机构。当输入的药物量超过剂量范围限制或不正确时，药物剂量计算器提供警告。药物剂量计算器将输入的药物测量单位转换成期望的测量单位。此外，公开了用于接收，记录，存储，传输，转移和编辑信息以及利用药物剂量计算器的各种过程的各种方法。

4. 发明申请

US20140112898A1 UNIQUE POPULATION OF REGULATORY T CELLS THAT REGULATE TISSUE REGENERATION AND WOUND HEALING 审中-公开
标题翻译：监管组织再生和治愈的监管细胞的独特人群
公开(公告)号：US20140112898A1
公开(公告)日：2014-04-24
申请号：US14008955
申请日：2012-04-02
申请人： Diane Mathis , Christophe Benoist , Dalia Burzyn , Amy Wagers
发明人： Diane Mathis , Christophe Benoist , Dalia Burzyn , Amy Wagers
IPC分类号： A61K35/14 , A61K45/06
CPC分类号： A61K35/17 , A61K45/06 , A61K2039/505 , C07K16/2866 , C12N5/0637
摘要： A unique type of regulatory T cell has been identified in muscle. These tissue-regenerative Treg cells play a role in regulating wound healing. These cells, as well as agents that control their differentiation and/or activity and agents produced by the cells, can be used to modulate wound healing and the differentiation of muscle cells.
摘要翻译：已经在肌肉中鉴定出独特类型的调节性T细胞。这些组织再生的Treg细胞在调节伤口愈合中发挥作用。这些细胞以及控制其分化和/或活性的细胞和由细胞产生的药剂可用于调节伤口愈合和肌肉细胞的分化。

5. 发明申请

US20060129357A1 Medication dose calculator 审中-公开
标题翻译：药物剂量计算器
公开(公告)号：US20060129357A1
公开(公告)日：2006-06-15
申请号：US11273698
申请日：2005-11-14
申请人： Katharine Francis , Diane Mathis , Gary Conkright
发明人： Katharine Francis , Diane Mathis , Gary Conkright
IPC分类号： G06F11/00
CPC分类号： G06F19/3456 , G06F19/326 , G06Q50/22
摘要： A medication dose calculator and method for comparing an inputted, ordered medication dosage with a known medication dosage range in a database including an input device for inputting a desired drug name, indicating whether the drug is for a child or an adult, an amount of the drugs that are ordered, the body weight or body surface of the patient, and a computing mechanism for determining the dose of the drug to be delivered. The medication dose calculator provides warnings when the inputted amount of drug exceeds the dosage range limits or is incorrect. The medication dose calculator converts an inputted drug unit of measure into a desired unit of measure. In addition, various methods for receiving, recording, storing, transmitting, transferring, and editing information along with various processes utilizing the medication dose calculator are disclosed.
摘要翻译：一种药物剂量计算器和方法，用于将输入的有序药物剂量与数据库中的已知药物剂量范围进行比较，所述数据库包括用于输入所需药物名称的输入装置，指示药物是针对儿童还是成人，订购的药物，患者的体重或身体表面，以及用于确定待递送药物的剂量的计算机构。当输入的药物量超过剂量范围限制或不正确时，药物剂量计算器提供警告。药物剂量计算器将输入的药物测量单位转换成期望的测量单位。此外，公开了用于接收，记录，存储，传输，转移和编辑信息以及利用药物剂量计算器的各种过程的各种方法。

6. 发明授权

US07662375B2 Use of glucose-6-phosphate isomerase and antibodies thereto for the diagnosis and therapy of arthritis, and test of anti-arthritic compounds 有权
标题翻译：使用葡萄糖-6-磷酸异构酶及其抗体进行关节炎的诊断和治疗，并测定抗关节炎化合物
公开(公告)号：US07662375B2
公开(公告)日：2010-02-16
申请号：US11360515
申请日：2006-02-24
申请人： Christophe Benoist , Isao Matsumoto , Anne-Sophie Korganow , Diane Mathis , Mariana Maccioni , Hong Ji
发明人： Christophe Benoist , Isao Matsumoto , Anne-Sophie Korganow , Diane Mathis , Mariana Maccioni , Hong Ji
IPC分类号： A61K39/395 , A61K39/00 , G01N33/00 , C12P21/00
CPC分类号： G01N33/564 , G01N2333/992 , G01N2800/102
摘要： The present invention relates to the use of antibodies against glucose-6-phosphate isomerase (GPI) and like protein for diagnosis of arthritis and the use of said protein for treatment of arthritis. It is also aimed at a process for isolating monoclonal antibodies capable of transferring arthritis and antibodies thereof, as well as a method for determining the anti-arthritis potential of a composition.
摘要翻译：本发明涉及抗葡萄糖-6-磷酸异构酶（GPI）等抗体的抗体用于诊断关节炎和使用所述蛋白质治疗关节炎的用途。还涉及一种分离能够转移关节炎及其抗体的单克隆抗体的方法，以及用于测定组合物的抗关节炎潜力的方法。

7. 发明申请

US20080052317A1 MEDICATION DOSE CALCULATOR AND ASSOCIATED METHODS 审中-公开
公开(公告)号：US20080052317A1
公开(公告)日：2008-02-28
申请号：US11928636
申请日：2007-10-30
申请人： Katharine Francis , Diane Mathis , Gary Conkright
发明人： Katharine Francis , Diane Mathis , Gary Conkright
IPC分类号： G06F7/00
CPC分类号： G06F19/3456 , G06F19/326
摘要： A medication dose calculator and method for comparing an inputted, ordered medication dosage with a known medication dosage range in a database including an input device for inputting a desired drug name, indicating whether the drug is for a child or an adult, an amount of the drugs that are ordered, the body weight or body surface of the patient, and a computing mechanism for determining the dose of the drug to be delivered. The medication dose calculator provides warnings when the inputted amount of drug exceeds the dosage range limits or is incorrect. The medication dose calculator converts an inputted drug unit of measure into a desired unit of measure. In addition, various methods for receiving, recording, storing, transmitting, transferring, and editing information along with various processes utilizing the medication dose calculator are disclosed.

8. 发明申请

US20060143723A1 Use of glucose-6-phosphate isomerase and antibodies thereto for the diagnosis and therapy of arthritis, and test of anti-arthritic compounds 有权
标题翻译：使用葡萄糖-6-磷酸异构酶及其抗体进行关节炎的诊断和治疗，并测定抗关节炎化合物
公开(公告)号：US20060143723A1
公开(公告)日：2006-06-29
申请号：US11360515
申请日：2006-02-24
申请人： Christophe Benoist , Isao Matsumoto , Anne-Sophie Korganow , Diane Mathis , Mariana Maccioni , Hong Ji
发明人： Christophe Benoist , Isao Matsumoto , Anne-Sophie Korganow , Diane Mathis , Mariana Maccioni , Hong Ji
IPC分类号： A01K67/027 , A61K39/395
CPC分类号： G01N33/564 , G01N2333/992 , G01N2800/102
摘要： The present invention relates to the use of antibodies against glucose-6-phosphate isomerase (GPI) and like protein for diagnosis of arthritis and the use of said protein for treatment of arthritis. It is also aimed at a process for isolating monoclonal antibodies capable of transferring arthritis and antibodies thereof, as well as a method for determining the anti-arthritis potential of a composition.
摘要翻译：本发明涉及抗葡萄糖-6-磷酸异构酶（GPI）等抗体的抗体用于诊断关节炎和使用所述蛋白质治疗关节炎的用途。还涉及一种分离能够转移关节炎及其抗体的单克隆抗体的方法，以及用于测定组合物的抗关节炎潜力的方法。

9. 发明授权

US07033745B1 Use of gluclose-6-phosphate isomerase and antibodies thereto for the diagnosis and therapy of arthritis, and test of anti-arthritic compounds 有权
标题翻译：使用葡萄糖-6-磷酸异构酶及其抗体进行关节炎的诊断和治疗，并测定抗关节炎化合物
公开(公告)号：US07033745B1
公开(公告)日：2006-04-25
申请号：US09959230
申请日：2000-04-21
申请人： Christophe Benoist , Isao Matsumoto , Anne-Sophie Korganow , Diane Mathis , Mariana Maccioni , Hong Ji
发明人： Christophe Benoist , Isao Matsumoto , Anne-Sophie Korganow , Diane Mathis , Mariana Maccioni , Hong Ji
IPC分类号： C12Q1/00
CPC分类号： G01N33/564 , G01N2333/992 , G01N2800/102
摘要： The present invention relates to the use of antibodies against glucose-6-phosphate isomerase and like protein for diagnosis of arthritis and the use of said protein for treatment of arthritis. It is also aimed at a process for isolating monoclonal antibodies capable of transferring arthritis and antibodies thereof, as well as a method for determining the anti-arthritic potential of a composition.
摘要翻译：本发明涉及抗葡萄糖-6-磷酸异构酶等蛋白质的抗体用于诊断关节炎以及所述蛋白质用于治疗关节炎的用途。还涉及一种分离能够转移关节炎及其抗体的单克隆抗体的方法，以及用于测定组合物的抗关节炎潜力的方法。

10. 发明授权

US5644065A Genetically engineered mice containing alterations in the MHC class II genes 失效
标题翻译：含有MHC II类基因改变的遗传工程小鼠
公开(公告)号：US5644065A
公开(公告)日：1997-07-01
申请号：US312984
申请日：1994-10-03
申请人： Christophe Benoist , Diane Mathis , Dominic Cosgrove
发明人： Christophe Benoist , Diane Mathis , Dominic Cosgrove
IPC分类号： A01K67/027 , C07K14/74 , C12N15/85 , G01N33/50 , G01N33/531 , C12N15/00
CPC分类号： C12N15/8509 , A01K67/0275 , A01K67/0276 , C07K14/70539 , C12N15/85 , G01N33/5005 , A01K2217/05 , A01K2217/075 , A01K2227/105 , A01K2267/03 , A01K2267/0312 , A01K2267/0381 , C12N2517/02
摘要： The present invention provides mice which are deficient in the normal expression of one or more MHC class II genes, to mice heterozygous for such deficiency, and to cell lines, preferably pluripotent or totipotent cell lines, which are heterozygous, homozygous or chimeric for such deficiency, as well as to the use of any of the above, especially in situations where the absence of at least one MHC gene, or the normal expression thereof, is desirable.
摘要翻译：本发明提供了一种或多种MHC II类基因的正常表达缺陷，对于这种缺陷是杂合的小鼠的小鼠，以及对于这种缺陷是杂合，纯合或嵌合的细胞系，优选多能或全能细胞系的小鼠，以及上述任何一种的使用，特别是在不需要至少一种MHC基因或其正常表达的情况下。

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