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1. 发明授权

US07795301B2 Dimeric compounds and their use as anti-viral agents 有权
标题翻译：二聚体化合物及其作为抗病毒剂的用途
公开(公告)号：US07795301B2
公开(公告)日：2010-09-14
申请号：US11751269
申请日：2007-05-21
申请人： Derek A. Demaine , Graham G. A. Inglis , Simon J. F. MacDonald , Stephen E. Shanahan , Simon P. Tucker , Keith G. Watson , Wen-Yang Wu
发明人： Derek A. Demaine , Graham G. A. Inglis , Simon J. F. MacDonald , Stephen E. Shanahan , Simon P. Tucker , Keith G. Watson , Wen-Yang Wu
IPC分类号： A61K31/35
CPC分类号： A61K31/7056 , A61K31/13 , A61K31/351 , A61K45/06 , A61K47/54 , A61K47/55 , C07D309/28 , A61K2300/00
摘要： The invention relates to compounds of general formula (I); in which R is an amino or guanidino group; R2 is acetyl or trifluoroacetyl; and n is an integer from 10 to 18 or a pharmaceutically acceptable derivative thereof, methods for their preparation, pharmaceutical formulations containing them or their use in the prevention or treatment of a viral infection.
摘要翻译：本发明涉及通式（I）的化合物; 其中R是氨基或胍基; R2是乙酰基或三氟乙酰基; 并且n为10至18的整数或其药学上可接受的衍生物，其制备方法，含有它们的药物制剂或其在预防或治疗病毒感染中的用途。

2. 发明授权

US07230028B2 Dimeric compounds and their use as anti-viral agents 失效
标题翻译：二聚体化合物及其作为抗病毒剂的用途
公开(公告)号：US07230028B2
公开(公告)日：2007-06-12
申请号：US10494241
申请日：2002-11-08
申请人： Derek A. Demaine , Graham G. A. Inglis , Simon J. F. MacDonald , Stephen E. Shanahan , Simon P. Tucker , Keith G. Watson , Wen-Yang Wu
发明人： Derek A. Demaine , Graham G. A. Inglis , Simon J. F. MacDonald , Stephen E. Shanahan , Simon P. Tucker , Keith G. Watson , Wen-Yang Wu
IPC分类号： A61K31/35
CPC分类号： A61K31/7056 , A61K31/13 , A61K31/351 , A61K45/06 , A61K47/54 , A61K47/55 , C07D309/28 , A61K2300/00
摘要： The invention relates to compounds of general formula (I); in which R is an amino or guanidino group; R2 is acetyl or trifluoroacetyl; and n is an integer from 10 to 18 or a pharmaceutically acceptable derivative thereof, methods for their preparation, pharmaceutical formulations containing them or their use in the prevention or treatment of a viral infection
摘要翻译：本发明涉及通式（I）的化合物; 其中R是氨基或胍基; R 2是乙酰基或三氟乙酰基; 且n为10至18的整数或其药学上可接受的衍生物，其制备方法，含有它们的药物制剂或其在预防或治疗病毒感染中的用途

3. 发明授权

US07371755B1 Antiviral agents 失效
标题翻译：抗病毒剂
公开(公告)号：US07371755B1
公开(公告)日：2008-05-13
申请号：US10088282
申请日：2000-09-15
申请人： Guy Krippner , Phillip A. Reece , Keith G. Watson , Wen-Yang Wu , Betty Jin , Simon P. Tucker
发明人： Guy Krippner , Phillip A. Reece , Keith G. Watson , Wen-Yang Wu , Betty Jin , Simon P. Tucker
IPC分类号： C07D413/12 , C07D413/14 , C07D403/12 , C07D409/12 , A61K31/42 , A61K31/496 , A61K31/501 , A61K31/787 , A61P31/16
CPC分类号： C07D401/14 , A61K31/4245 , C07D237/22 , C07D261/08 , C07D413/14 , C07D495/04 , G01N33/56983 , G01N2333/095 , Y02A50/463 , Y02A50/54
摘要： This invention relates to a compound capable of binding to a picornavirus capsid comprising two or more capsid binding moieties.
摘要翻译：本发明涉及能够结合包含两个或多个衣壳结合部分的微小RNA病毒衣壳的化合物。

4. 发明授权

US4806141A Herbicidal compounds and compositions 失效
标题翻译：除草剂及组合物
公开(公告)号：US4806141A
公开(公告)日：1989-02-21
申请号：US937467
申请日：1986-12-02
申请人： Keith G. Watson , Lynette A. Garson , Graham J. Bird , Graeme J. Farquharson
发明人： Keith G. Watson , Lynette A. Garson , Graham J. Bird , Graeme J. Farquharson
IPC分类号： A01N47/04 , A01N33/24 , A01N35/06 , A01N35/10 , A01N37/00 , A01N37/02 , A01N37/10 , A01N37/22 , A01N37/34 , A01N37/48 , A01N41/04 , A01N41/06 , A01N41/10 , C07C45/00 , C07C45/45 , C07C45/51 , C07C45/67 , C07C45/71 , C07C45/74 , C07C47/542 , C07C47/55 , C07C47/565 , C07C47/575 , C07C49/255 , C07C49/657 , C07C49/697 , C07C49/747 , C07C49/753 , C07C49/86 , C07C67/00 , C07C239/00 , C07C251/42 , C07C251/44 , C07C251/50 , C07C301/00 , C07C303/28 , C07C309/63 , C07C309/73 , C07C313/00 , C07C323/21 , A01N33/00
CPC分类号： C07C255/00 , A01N35/10 , A01N37/00 , A01N37/02 , A01N37/10 , A01N37/22 , A01N37/48 , A01N41/04 , A01N41/06 , A01N41/10 , C07C323/00 , C07C45/455 , C07C45/513 , C07C45/673 , C07C45/71 , C07C45/74 , C07C47/542 , C07C47/55 , C07C47/565 , C07C47/575 , C07C49/255 , C07C49/657 , C07C49/697 , C07C49/747 , C07C49/753 , C07C49/86
摘要： The invention concerns novel compounds of the formula I ##STR1## wherein Z is selected from hydrogen, halogen, C.sub.1 to C.sub.6 alkyl, and C.sub.1 to C.sub.6 alkoxy;Y is selected from halogen, C.sub.1 to C.sub.6 alkyl and C.sub.1 to C.sub.6 alkoxy;X is selected from halogen, C.sub.1 to C.sub.6 alkyl and C.sub.1 to C.sub.6 alkoxy and if Y is methyl and Z is hydrogen or methyl then at least one of X is not methyl;R.sup.1 is selected from hydrogen, alkyl, alkenyl, alkynyl, substituted alkyl, alkylsulfonyl, arylsulfonyl, acyl and an inorganic or organic cation;R.sup.2 is selected from alkyl, substituted alkyl, alkenyl, haloalkenyl, alkynyl and haloalkynyl;R.sup.3 is selected from alkyl, fluoroalkyl, alkenyl, alkynyl and phenyl; andm is an integer chosen from 1 to 3.The compounds are cereal selective herbicides and in further embodiments the invention provides processes for the preparation of compounds of formula I, intermediates useful in the preparation of compounds of formula I, herbicidal compositions containing as active ingredient a compound of formula I, and processes for severely damaging or killing unwanted plants by applying to the plants or to the growth medium of the plants an effective amount of a compound of formula I.
摘要翻译：本发明涉及式I的新型化合物其中Z选自氢，卤素，C 1至C 6烷基和C 1至C 6烷氧基; Y选自卤素，C 1至C 6烷基和C 1至C 6烷氧基; X选自卤素，C 1至C 6烷基和C 1至C 6烷氧基，如果Y是甲基，Z是氢或甲基，那么X中的至少一个不是甲基; R 1选自氢，烷基，烯基，炔基，取代的烷基，烷基磺酰基，芳基磺酰基，酰基和无机或有机阳离子; R2选自烷基，取代的烷基，烯基，卤代烯基，炔基和卤代炔基; R3选自烷基，氟烷基，烯基，炔基和苯基; 并且m是选自1至3的整数。化合物是谷物选择性除草剂，并且在进一步的实施方案中，本发明提供了制备式I化合物的方法，可用于制备式I化合物的中间体，含有活性的除草组合物成分为式I化合物，以及通过向植物或植物的生长培养基施用有效量的式I化合物来严重损害或杀死有害植物的方法。

5. 发明授权

US4704157A Herbicidal 5-(3-substituted-isoxazoyl or isothiazoyl)-cyclohexane-1,3-dione derivatives 失效
标题翻译：除草剂5-（3-取代 - 异恶唑基或异硫脲基） - 环己烷-1,3-二酮衍生物
公开(公告)号：US4704157A
公开(公告)日：1987-11-03
申请号：US860796
申请日：1986-05-08
申请人： Richard J. Conway , Keith G. Watson , Graeme J. Farquharson
发明人： Richard J. Conway , Keith G. Watson , Graeme J. Farquharson
IPC分类号： A01N43/72 , A01N43/74 , A01N43/76 , A01N43/78 , A01N43/80 , A01N43/82 , A01N43/824 , A01N43/828 , A01N43/836 , C07D261/08 , C07D261/10 , C07D261/12 , C07D261/14 , C07D261/18 , C07D263/32 , C07D263/34 , C07D263/36 , C07D263/46 , C07D263/48 , C07D271/02 , C07D271/04 , C07D271/06 , C07D271/10 , C07D273/00 , C07D275/02 , C07D277/20 , C07D277/22 , C07D277/24 , C07D277/28 , C07D277/30 , C07D277/32 , C07D277/34 , C07D277/36 , C07D277/42 , C07D285/04 , C07D285/06 , C07D285/08 , C07D285/12
CPC分类号： C07D275/02 , A01N43/74 , A01N43/80 , A01N43/82 , C07D261/08 , C07D277/24 , C07D277/28 , C07D277/32 , C07D277/34 , C07D277/36 , C07D277/42 , C07D285/12
摘要： The invention concerns novel compounds of the formula I ##STR1## wherein: A, B and D are selected from CH and N;E is selected from oxygen and sulfur;X are selected from halogen, nitro, cyano, alkyl, substituted alkyl, hydroxy, alkoxy, substituted alkoxy, alkenyl, alkenyloxy, alkynyl, alkynyloxy, acyloxy, alkoxycarbonyl, alkylthio, alkylsulfinyl, alkylsulfonyl, sulfamoyl, substituted sulfamoyl, alkanoyloxy, benzyloxy, substituted benzyloxy, phenyl, substituted phenyl, amino, substituted amino, and the groups formyl and alkanoyl and the oxime, imine and Schiff base derivatives thereof;R.sup.1 is selected from hydrogen, alkyl, alkenyl, alkynyl, substituted alkyl, alkylsulfonyl, arylsulfonyl, acyl and an inorglanic or organic cation;R.sup.2 is selected from alkyl substituted alkyl, alkenyl, haloalkenyl, alkynyl and haloalkynyl;R.sup.3 is selected from alkyl, fluoroalkyl, alkenyl, alkynyl, and phenyl;R.sup.4 is selected from hydrogen, halogen, alkyl, cyano and alkoxycarbonyl; andn is 0 or an integer chosen from 1 and 2.The compounds of the invention show herbicidal properties and plant growth regulating properties and in further embodiments the invention provides processes for the preparation of compounds of formula I, intermediates useful in the preparation of the compounds of formula I, compositions containing as active ingredient a compound of formula I, and herbicidal and plant growth regulating processes utilizing compounds of formula I.

6. 发明授权

US4460588A 5-Substituted pyrimidine derivatives active against internal animal parasites 失效
标题翻译： 5-取代的针对内部动物寄生虫的嘧啶衍生物
公开(公告)号：US4460588A
公开(公告)日：1984-07-17
申请号：US119006
申请日：1980-02-05
申请人： Alexander Serban , Keith G. Watson , Colin Wilshire , Bruce A. Forsyth
发明人： Alexander Serban , Keith G. Watson , Colin Wilshire , Bruce A. Forsyth
IPC分类号： A01N43/54 , C07D239/34 , C07D239/38 , C07D239/46 , C07D239/52 , A61K31/505
CPC分类号： C07D239/52 , A01N43/54 , C07D239/34 , C07D239/38 , C07D239/47
摘要： The invention concerns a process for killing internal parasites, especially trematodes or nematodes, affecting warm blooded animals such as cattle, sheep and goats by administering an effective amount of a composition containing as active ingredient a compound of the formula ##STR1## Certain of the compounds of formula I are novel and in further embodiments the invention provides novel compounds and compositions for use in the process of the invention. The process of the invention is especially applicable to the tretment of warm blooded animals infected with the trematodes Fasciola hepatica (liver fluke).
摘要翻译：本发明涉及通过施用有效量的含有作为活性成分的化合物的组合物来杀死影响温血动物如牛，绵羊和山羊的内部寄生虫，特别是吸虫或线虫的方法。式I化合物是新的，并且在进一步的实施方案中，本发明提供用于本发明方法的新化合物和组合物。本发明的方法特别适用于感染肝炎肝炎（肝吸虫）的温血动物。

7. 发明授权

US4444584A Ethyl 2[4-(7-chloroquinolin-3-yloxy)phenoxy]propionate, the N-oxide, and herbicidal compositions and methods employing them 失效
标题翻译：乙基2 [4-（7-氯喹啉-3-基氧基）苯氧基]丙酸酯，N-氧化物和除草组合物和使用它们的方法
公开(公告)号：US4444584A
公开(公告)日：1984-04-24
申请号：US201979
申请日：1980-10-29
申请人： Alexander Serban , Keith G. Watson
发明人： Alexander Serban , Keith G. Watson
IPC分类号： C07D215/22 , A01N43/42 , C07D215/20 , C07D215/227 , C07D215/233 , C07D215/38 , C07D215/60
CPC分类号： C07D215/227 , A01N43/42 , C07D215/20 , C07D215/233 , C07D215/38 , C07D215/60
摘要： The invention concerns novel compounds of the formula I ##STR1## The compounds are herbicides and in further embodiments the invention provides herbicidal compositions containing as active ingredient a compound of formula I and a process for severely damaging or killing unwanted plants by applying to the plants or to the growth medium of the plants an effective amount of a compound of formula I.
摘要翻译：本发明涉及式I的新化合物。该化合物是除草剂，并且在进一步的实施方案中，本发明提供含有作为活性成分的式I化合物的除草组合物，以及通过施用于植物而严重破坏或杀死不想要的植物的方法或植物的生长培养基中有效量的式I化合物。

8. 发明授权

US4938793A Compounds and compositions 失效
标题翻译：化合物和组合物
公开(公告)号：US4938793A
公开(公告)日：1990-07-03
申请号：US210174
申请日：1988-06-20
申请人： Keith G. Watson , Graeme J. Farquharson
发明人： Keith G. Watson , Graeme J. Farquharson
IPC分类号： A01N43/54 , C07D239/24 , C07D239/26 , C07D239/34 , C07D239/38 , C07D239/42 , C07D239/52 , C07D239/60
CPC分类号： C07D239/26 , A01N43/54 , C07D239/24 , C07D239/34 , C07D239/38 , C07D239/42 , C07D239/52 , C07D239/60
摘要： The invention concerns novel compounds of the formula I ##STR1## wherein: X are selected from halogen, nitro, cyano, alkyl, substituted alkyl, hydroxy, alkoxy, substituted alkoxy, alkenyl, alkenyloxy, alkynyl, alkynyloxy, acyloxy, alkoxycarbonyl, alkylthio, alkylsulfinyl, alkylsulfonyl, sulfamoyl, substituted sulfamoyl, alkanoyloxy, benzyloxy, substituted benzyloxy, amino, substituted amino, and the groups formyl and alkanoyl and the oxime, imine and Schiff base derivatives thereof;R.sup.1 is selected from hydrogen, alkyl, alkenyl, alkynyl, substituted alkyl, alkylsulfonyl, arylsulfonyl, acyl and an inorganic or organic cation;R.sup.2 is selected from alkyl, substituted alkyl, alkenyl, haloalkenyl, alkynyl and haloalkynyl;R.sup.3 is selected from alkyl, fluoroalkyl, alkenyl, alkynyl, and phenyl;R.sup.4 is selected from hydrogen, halogen, alkyl, cyano and alkoxycarbonyl; andn is selected from the integers 1 and 2.The compounds of the invention show herbicidal properties and plant growth regulating properties and in further embodiments the invention provides processes for the preparation of compounds of formula I, intermediates useful in the preparation of the compounds of formula I, compositions containing as active ingredient a compound of formula I, and herbicidal and plant growth regulating processes utilizing compounds of formula I.
摘要翻译：本发明涉及式I的新型化合物其中：X选自卤素，硝基，氰基，烷基，取代的烷基，羟基，烷氧基，取代的烷氧基，烯基，烯氧基，炔基，炔氧基，酰氧基，烷氧基羰基，烷基亚磺酰基，烷基磺酰基，氨磺酰基，取代氨磺酰基，烷酰氧基，苄氧基，取代的苄氧基，氨基，取代的氨基，以及甲酰基和烷酰基及其肟，亚胺和席夫碱衍生物; R 1选自氢，烷基，烯基，炔基，取代的烷基，烷基磺酰基，芳基磺酰基，酰基和无机或有机阳离子; R2选自烷基，取代的烷基，烯基，卤代烯基，炔基和卤代炔基; R3选自烷基，氟烷基，烯基，炔基和苯基; R4选自氢，卤素，烷基，氰基和烷氧基羰基; 本发明的化合物显示除草性质和植物生长调节性质，并且在进一步的实施方案中，本发明提供制备式I化合物的方法，可用于制备式I化合物的中间体式I，含有式I化合物作为活性成分的组合物，以及利用式I化合物的除草和植物生长调节方法。

9. 发明授权

US4767879A Compounds and compositions 失效
标题翻译：化合物和组合物
公开(公告)号：US4767879A
公开(公告)日：1988-08-30
申请号：US942827
申请日：1986-12-17
申请人： Keith G. Watson , Lynette A. Garson , Graham J. Bird , Lindsay E. Cross , Graeme J. Farquharson
发明人： Keith G. Watson , Lynette A. Garson , Graham J. Bird , Lindsay E. Cross , Graeme J. Farquharson
IPC分类号： C07C69/013 , A01N31/08 , A01N33/08 , A01N35/10 , A01N37/00 , A01N37/02 , A01N37/10 , A01N37/22 , A01N37/34 , A01N37/48 , A01N41/02 , A01N41/04 , A01N41/06 , A01N41/10 , A01N41/12 , C07C45/00 , C07C45/45 , C07C45/51 , C07C45/67 , C07C45/71 , C07C45/74 , C07C47/542 , C07C47/575 , C07C49/255 , C07C49/747 , C07C49/753 , C07C49/83 , C07C49/86 , C07C59/90 , C07C65/40 , C07C67/00 , C07C69/017 , C07C69/63 , C07C69/94 , C07C205/45 , C07C225/22 , C07C233/33 , C07C233/43 , C07C239/00 , C07C241/00 , C07C251/18 , C07C251/42 , C07C251/44 , C07C251/46 , C07C251/48 , C07C251/50 , C07C253/00 , C07C255/56 , C07C255/62 , C07C301/00 , C07C303/28 , C07C303/40 , C07C309/63 , C07C309/73 , C07C311/00 , C07C311/29 , C07C311/37 , C07C313/00 , C07C315/04 , C07C317/24 , C07C317/32 , C07C317/36 , C07C317/46 , C07C319/20 , C07C323/22 , C07C323/47 , C07C121/34
CPC分类号： C07C205/45 , A01N35/10 , A01N37/00 , A01N37/02 , A01N37/10 , A01N37/22 , A01N37/48 , A01N41/04 , A01N41/06 , A01N41/10 , C07C255/00 , C07C323/00 , C07C45/455 , C07C45/513 , C07C45/673 , C07C45/71 , C07C45/74 , C07C47/542 , C07C47/575 , C07C49/255 , C07C49/747 , C07C49/753 , C07C49/86
摘要： The invention concerns novel compounds of the formula I ##STR1## wherein: X is selected from halogen, nitro, cyano, alkyl, substituted alkyl, hydroxy, alkoxy, substituted alkoxy, alkenyl, alkynyl, alkenyloxy, alkynyloxy, acyloxy, alkoxycarbonyl, alkylthio, alkylsulfinyl, alkylsulfonyl, sulfamoyl, substituted sulfamoyl, amino, substituted amino, and the groups formyl and alkanoyl and the oxime, imine and Schiff base derivatives thereof;R.sup.1 is selected from hydrogen, alkyl, alkenyl, alkynyl, substituted alkyl, alkylsulfonyl, arylsulfonyl, acyl and an inorganic or organic cation;R.sup.2 is selected from alkyl, substituted alkyl, alkenyl, haloalkenyl, alkynyl and haloalkynyl;R.sup.3 is selected from alkyl, fluoroalkyl, alkenyl, alkynyl, and phenyl;m is an integer chosen from 3 to 5.The compounds of the invention show herbicidal properties and plant growth regulating properties and in further embodiments the invention provides processes for the preparation of compounds of formula I, intermediates useful in the preparation of the compounds of formula I, compositions containing as active ingredient a compound of formula I, and herbicidal and plant growth regulating processes utilizing compounds of formula I.

10. 发明授权

US4760192A Herbicidal cyclohexane-1,3-dione derivatives 失效
标题翻译：除草环己烷-1,3-二酮衍生物
公开(公告)号：US4760192A
公开(公告)日：1988-07-26
申请号：US947366
申请日：1986-12-29
申请人： Richard B. Warner , Alexander Serban , Keith G. Watson , Graham J. Bird , Lindsay E. Cross , Graeme Farquharson
发明人： Richard B. Warner , Alexander Serban , Keith G. Watson , Graham J. Bird , Lindsay E. Cross , Graeme Farquharson
IPC分类号： A01N35/10 , A01N37/02 , A01N37/10 , C07C45/00 , C07C45/45 , C07C45/64 , C07C45/67 , C07C49/217 , C07C49/657 , C07C49/747 , C07C49/835 , C07C67/00 , C07C239/00 , C07C249/08 , C07C251/42 , C07C251/44 , C07C251/48 , C07C251/50 , C07C251/52 , C07C261/02 , C07C309/73 , C07C313/00 , C07C323/12 , C07C323/19 , C07C323/20 , C07C323/66 , C07C49/543
CPC分类号： C07C49/835 , A01N35/10 , A01N37/02 , A01N37/10 , C07C45/455 , C07C45/64 , C07C45/673 , C07C49/217 , C07C49/657 , C07C49/747
摘要： The invention concerns novel compounds of the formula I ##STR1## wherein R.sup.1 is selected from hydrogen, alkyl, alkenyl, alkynyl, substituted alkyl, acyl, alkylsulfonyl, benzenesulfonyl, substituted benzenesulfonyl, and an inorganic or organic cation;R.sup.2 is selected from alkyl, alkenyl, alkynyl, substituted alkyl, haloalkenyl and haloalkynyl;R.sup.3 is selected from alkyl, fluoroalkyl, alkenyl, alkynyl and phenyl; andn is an integer chosen from 2 to 5.The compounds are cereal selective herbicides and in further embodiments the invention provides processes for the preparation of compounds of formula I, intermediates useful in the preparation of compounds of formula I, herbicidal compositions containing as active ingredient a compound of formula I, and processes for severely damaging or killing unwanted plants by applying to the plants or to the growth medium of the plants an effective amount of a compound of formula I.

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