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1. 发明授权

US08394415B2 Modified release analgesic suspensions 有权
标题翻译：改性释放止痛剂悬浮液
公开(公告)号：US08394415B2
公开(公告)日：2013-03-12
申请号：US11942826
申请日：2007-11-20
申请人： Der-Yang Lee , Jen-Chi Chen , Vincent Chen , Robert Shen
发明人： Der-Yang Lee , Jen-Chi Chen , Vincent Chen , Robert Shen
IPC分类号： A61K31/10 , A61K9/14 , A61P11/02 , A61P25/04
CPC分类号： A61K9/5084 , A61K9/0095 , A61K9/5026 , A61K9/5047 , A61K9/5073 , A61K31/137 , A61K31/192 , A61K45/06 , A61K47/585 , A61K2300/00
摘要： A pharmaceutical dosage form comprising non-steroidal-anti-inflammatory drugs, in particular propionic acid derivatives such as ibuprofen, along with a second active ingredient having a shorter therapeutically effective plasma concentration duration, such as phenylephrine, and methods of administering the same are provided. This method provides improved therapeutic effect, in particular pain relief along with decongestant relief, over extended time periods.
摘要翻译：提供包含非甾体抗炎药物，特别是丙酸衍生物如布洛芬的药物剂型，以及具有较短治疗有效血浆浓度持续时间的第二活性成分，例如去氧肾上腺素及其施用方法。该方法在延长的时间段内提供改善的治疗效果，特别是与减充血剂缓解一起的疼痛缓解。

2. 发明授权

US09833510B2 Modified release solid or semi-solid dosage forms 有权
公开(公告)号：US09833510B2
公开(公告)日：2017-12-05
申请号：US11761698
申请日：2007-06-12
申请人： Der-Yang Lee , Robert Shen , Jen-Chi Chen , Vincent Chen
发明人： Der-Yang Lee , Robert Shen , Jen-Chi Chen , Vincent Chen
IPC分类号： A61K9/24 , A61K45/06 , A61K9/20 , A61K9/48 , A61K31/137 , A61K31/192 , A61K9/50
CPC分类号： A61K45/06 , A61K9/2081 , A61K9/4808 , A61K9/5073 , A61K9/5084 , A61K31/137 , A61K31/192 , A61K2300/00
摘要： A solid or semi-solid pharmaceutical dosage form comprising non-steroidal-anti-inflammatory drugs, in particular propionic acid derivatives such as ibuprofen, along with a second active ingredient having a shorter therapeutically effective plasma concentration duration, such as phenylephrine, and methods of administering the same are provided. This method provides improved therapeutic effect, in particular pain relief along with decongestant relief, over extended time periods.

3. 发明申请

US20080118571A1 MODIFIED RELEASE ANALGESIC SUSPENSIONS 有权
标题翻译：改良释放止血药
公开(公告)号：US20080118571A1
公开(公告)日：2008-05-22
申请号：US11942826
申请日：2007-11-20
申请人： Der-Yang Lee , Jen-Chi Chen , Vincent Chen , Robert Shen
发明人： Der-Yang Lee , Jen-Chi Chen , Vincent Chen , Robert Shen
IPC分类号： A61K31/19 , A61K9/14 , A61P11/02 , A61P25/04
CPC分类号： A61K9/5084 , A61K9/0095 , A61K9/5026 , A61K9/5047 , A61K9/5073 , A61K31/137 , A61K31/192 , A61K45/06 , A61K47/585 , A61K2300/00
摘要： A pharmaceutical dosage form comprising non-steroidal-anti-inflammatory drugs, in particular propionic acid derivatives such as ibuprofen, along with a second active ingredient having a shorter therapeutically effective plasma concentration duration, such as phenylephrine, and methods of administering the same are provided. This method provides improved therapeutic effect, in particular pain relief along with decongestant relief, over extended time periods.
摘要翻译：提供包含非甾体抗炎药物，特别是丙酸衍生物如布洛芬的药物剂型，以及具有较短治疗有效血浆浓度持续时间的第二活性成分，例如去氧肾上腺素及其施用方法。该方法在延长的时间段内提供改善的治疗效果，特别是与减充血剂缓解一起的疼痛缓解。

4. 发明申请

US20100112052A1 OSMOTIC TABLET WITH A COMPRESSED OUTER COATING 审中-公开
标题翻译：具有压缩外涂层的OSMOTIC板
公开(公告)号：US20100112052A1
公开(公告)日：2010-05-06
申请号：US12607248
申请日：2009-10-28
申请人： Vincent Chen , Shun-Por Li , Robert Shen , Der-Yang Lee
发明人： Vincent Chen , Shun-Por Li , Robert Shen , Der-Yang Lee
IPC分类号： A61K9/22 , A61K31/135 , A61K31/495
CPC分类号： A61K9/209 , A61K9/0004
摘要： The present invention features a method of manufacturing an osmotic tablet including the steps of (i) compressing a tablet core including a first pharmaceutically active agent and a hydrophilic polymer; (ii) applying an osmotic coating to the outer surface of the tablet core to form a coated tablet, wherein the osmotic coating includes at least one opening exposing the tablet core; and (iii) compressing an immediate release coating onto the surface of the coated tablet, wherein the release coating includes a second pharmaceutically active agent.
摘要翻译：本发明的特征在于一种制造渗透性片剂的方法，包括以下步骤：（i）压缩包含第一药物活性剂和亲水性聚合物的片芯; （ii）将渗透涂层施加到片芯的外表面以形成包衣片，其中所述渗透涂层包括暴露片芯的至少一个开口; 和（iii）将即时释放涂层压缩到所述包衣片剂的表面上，其中所述剥离包衣包含第二药物活性剂。

5. 发明授权

US08282957B2 Coated particles containing pharmaceutically active agents 有权
标题翻译：含有药物活性剂的包衣颗粒
公开(公告)号：US08282957B2
公开(公告)日：2012-10-09
申请号：US12490465
申请日：2009-06-24
申请人： Robert Shen , Vincent Chen , Der-Yang Lee
发明人： Robert Shen , Vincent Chen , Der-Yang Lee
IPC分类号： A61K9/26
CPC分类号： A61K9/2081 , A61K9/5078
摘要： The present invention features a tablet including particles containing a pharmaceutically active agent, wherein the particles are coated with (a) a first film layer containing a modified release polymer; and (b) a second film layer containing (i) a first polymer, wherein the first polymer is a polymer of ethyl acrylate and methyl methacrylate and (ii) a second polymer, wherein the second polymer is a polymer of methyl acrylate, methyl methacrylate and methacrylic acid.
摘要翻译：本发明的特征在于包含含有药物活性剂的颗粒的片剂，其中所述颗粒涂覆有（a）含有改性释放聚合物的第一膜层; 和（b）含有（i）第一聚合物的第二膜层，其中第一聚合物是丙烯酸乙酯和甲基丙烯酸甲酯的聚合物和（ii）第二聚合物，其中第二聚合物是丙烯酸甲酯，甲基丙烯酸甲酯和甲基丙烯酸。

6. 发明申请

US20090324716A1 Coated Particles Containing Pharmaceutically Active Agents 有权
标题翻译：包含药物活性剂的包衣颗粒
公开(公告)号：US20090324716A1
公开(公告)日：2009-12-31
申请号：US12490465
申请日：2009-06-24
申请人： Robert Shen , Vincent Chen , Del-Yang Lee
发明人： Robert Shen , Vincent Chen , Del-Yang Lee
IPC分类号： A61K9/26 , A61K9/16 , A61K47/32
CPC分类号： A61K9/2081 , A61K9/5078
摘要： The present invention features a tablet including particles containing a pharmaceutically active agent, wherein the particles are coated with (a) a first film layer containing a modified release polymer; and (b) a second film layer containing (i) a first polymer, wherein the first polymer is a polymer of ethyl acrylate and methyl methacrylate and (ii) a second polymer, wherein the second polymer is a polymer of methyl acrylate, methyl methacrylate and methacrylic acid.
摘要翻译：本发明的特征在于包含含有药物活性剂的颗粒的片剂，其中所述颗粒涂覆有（a）含有改性释放聚合物的第一膜层; 和（b）含有（i）第一聚合物的第二膜层，其中第一聚合物是丙烯酸乙酯和甲基丙烯酸甲酯的聚合物和（ii）第二聚合物，其中第二聚合物是丙烯酸甲酯，甲基丙烯酸甲酯和甲基丙烯酸。

7. 发明申请

US20060078611A1 Enteric coated aspirin granules comingled with binder 有权
标题翻译：肠粘膜阿司匹林颗粒与粘合剂混合
公开(公告)号：US20060078611A1
公开(公告)日：2006-04-13
申请号：US10961562
申请日：2004-10-08
申请人： Manoj Shah , James Beahm , Robert Shen
发明人： Manoj Shah , James Beahm , Robert Shen
IPC分类号： A61K9/20
CPC分类号： A61K9/5031 , A61K9/0056 , A61K9/2081
摘要： The invention relates to a tablet capable of being chewed or disintegrated in the oral cavity, which comprises an enteric coated granule comprising an intimate mixture of an aspirin active ingredient and at least one binder capable of preferentially absorbing ambient moisture.
摘要翻译：本发明涉及能够在口腔中咀嚼或分解的片剂，其包含肠溶包衣颗粒，其包含阿斯匹林活性成分和至少一种能够优先吸收环境水分的粘合剂的紧密混合物。

8. 发明申请

US20060078612A1 Chewable enteric coated aspirin tablets 有权
公开(公告)号：US20060078612A1
公开(公告)日：2006-04-13
申请号：US10961563
申请日：2004-10-08
申请人： Manoj Shah , James Beahm , Robert Shen
发明人： Manoj Shah , James Beahm , Robert Shen
IPC分类号： A61K9/20
CPC分类号： A61K9/2027 , A61K9/0056 , A61K31/616
摘要： The invention relates to a tablet capable of being chewed or disintegrated in the oral cavity, which comprises an enteric coated aspirin active ingredient, and preferably a lightly compressed matrix comprising directly compressible carbohydrate(s) and at least one sweetener.

9. 发明授权

US5841724A Voltage source and memory-voltage switch in a memory chip 失效
标题翻译：存储器芯片中的电压源和存储器 - 电压开关
公开(公告)号：US5841724A
公开(公告)日：1998-11-24
申请号：US873445
申请日：1997-06-12
申请人： Mark S. Ebel , Robert Shen
发明人： Mark S. Ebel , Robert Shen
IPC分类号： G11C5/14 , G11C7/00
CPC分类号： G11C5/143
摘要： A circuit for connecting a memory cell matrix to voltage sources includes a voltage sensor responsive to the voltage levels of a first voltage source and of a second voltage source by producing a sense signal, and a voltage source coupler connected between the memory cell matrix and the voltage sensor. When the first voltage source voltage level is greater than a predetermined threshold voltage level, the sense signal causes the voltage source coupler to drive the first voltage source voltage level into the memory cell matrix. When the first voltage source voltage level falls to the threshold voltage level, the sense signal also causes the voltage source coupler to drive the second voltage source voltage level into the memory cell matrix to sustain memory cell data.
摘要翻译：用于将存储单元矩阵连接到电压源的电路包括响应于第一电压源的电压电平和通过产生感测信号的第二电压源的电压电平的电压传感器，以及连接在存储单元矩阵和电压传感器当第一电压源电压电平大于预定阈值电压电平时，感测信号使电压源耦合器将第一电压源电压电平驱动到存储单元矩阵中。当第一电压源电压电平下降到阈值电压电平时，感测信号也使电压源耦合器将第二电压源电压电平驱动到存储单元矩阵中以维持存储单元数据。

10. 发明授权

US08758814B2 Chewable enteric coated aspirin tablets 有权
标题翻译：咀嚼肠溶包衣阿司匹林片
公开(公告)号：US08758814B2
公开(公告)日：2014-06-24
申请号：US10961563
申请日：2004-10-08
申请人： Manoj N. Shah , James S. Beahm , Robert Shen
发明人： Manoj N. Shah , James S. Beahm , Robert Shen
IPC分类号： A61K9/20
CPC分类号： A61K9/2027 , A61K9/0056 , A61K31/616
摘要： The invention relates to a tablet capable of being chewed or disintegrated in the oral cavity, which comprises an enteric coated aspirin active ingredient, and preferably a lightly compressed matrix comprising directly compressible carbohydrate(s) and at least one sweetener.
摘要翻译：本发明涉及能够在口腔中咀嚼或分解的片剂，其包含肠溶衣阿司匹林活性成分，优选轻度压缩的基质，其包含直接可压缩的碳水化合物和至少一种甜味剂。

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