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1. 发明授权

US08460699B2 Clay-based hemostatic agents and devices for the delivery thereof 有权
公开(公告)号：US08460699B2
公开(公告)日：2013-06-11
申请号：US13593310
申请日：2012-08-23
申请人： Raymond J. Huey , Denny Lo , Daniel J. Burns , Giacomo Basadonna , Francis X. Hursey
发明人： Raymond J. Huey , Denny Lo , Daniel J. Burns , Giacomo Basadonna , Francis X. Hursey
IPC分类号： A61L15/14 , A61L15/16 , A61L15/18 , A61K9/14 , A61F13/00
CPC分类号： A61F13/534 , A61L15/18 , A61L15/44 , A61L2300/102 , A61L2300/402 , A61L2300/404 , A61L2300/41 , A61L2300/418 , A61L2400/04
摘要： A device for promoting the clotting of blood comprises a clay material in particle form and a receptacle for containing the clay material. At least a portion of the receptacle is defined by a mesh. Another device comprises a gauze substrate and a clay material disposed on the gauze substrate. Another device is a bandage comprising a substrate, a mesh mounted on the substrate, and particles of a clay material retained in the mesh. A hemostatic sponge comprises a substrate, a hemostatic material disposed on a first surface of the substrate, and a release agent disposed on a second surface of the substrate. The release agent is disposed on the wound-contacting surface of the substrate. When treating a bleeding wound, application of the hemostatic sponge causes at least a portion of the hemostatic material to come into contact with blood through the release agent and through the substrate.

2. 发明申请

US20120070470A1 HEMOSTATIC COMPOSITIONS, DEVICES, AND METHODS 有权
标题翻译： HEMOSTATIC COMPOSITIONS，DEVICES，AND METHODS
公开(公告)号：US20120070470A1
公开(公告)日：2012-03-22
申请号：US13240795
申请日：2011-09-22
申请人： Mohan Prasad Pahari , Giacomo Basadonna , Denny Lo
发明人： Mohan Prasad Pahari , Giacomo Basadonna , Denny Lo
IPC分类号： A61K9/14 , A61M5/00 , A61M37/00 , A61K33/06 , A61P7/04 , B82Y5/00
CPC分类号： A61K33/06 , A61F13/00034 , A61F13/00063 , A61F13/36 , A61F2013/00472 , A61K8/0208 , A61K9/14 , A61L15/28 , A61L15/44 , A61L15/60 , A61L26/0004 , A61L26/0066 , A61L26/0076 , A61L2300/404 , A61L2400/04 , A61M11/007 , A61M35/003 , A61M2202/064
摘要： Compositions that include a clay such as kaolin dispersed in a liquid such as water may be useful for promoting the clotting of blood. The compositions may be in a liquid, gel, paste, foam, or another form. Uses may include treating a traumatic injury such as in injury caused by a bullet, an explosive, a blade etc., or an injury caused during a medical procedure such as surgery.
摘要翻译：包括分散在诸如水的液体中的粘土如高岭土的组合物可用于促进血液凝固。组合物可以是液体，凝胶，糊剂，泡沫或其它形式。用途可以包括治疗创伤性损伤，例如由子弹，爆炸物，刀片等引起的损伤，或在诸如手术的医疗过程中引起的损伤。

3. 发明申请

US20090162406A1 WOUND HEALING WITH ZEOLITE-BASED HEMOSTATIC DEVICES 审中-公开
标题翻译：用基于沸石的HEMOSTATIC装置进行伤口愈合
公开(公告)号：US20090162406A1
公开(公告)日：2009-06-25
申请号：US12204129
申请日：2008-09-04
申请人： Giacomo Basadonna , Raymond J. Huey , Denny Lo
发明人： Giacomo Basadonna , Raymond J. Huey , Denny Lo
IPC分类号： A61K9/00 , A61K33/06 , A61K33/00 , A61P17/02
CPC分类号： A61K33/06 , A61L15/18 , A61L26/0004 , A61L2400/04
摘要： A method for decreasing the time it takes for a wound to heal includes applying hemostatic agent to the wound, inflaming tissue surrounding the wound to facilitate the deposition of fibroblast, thereby accelerating the subsequent contraction of the wound and the onset of the proliferative healing stage, and causing the re-epithelization of the tissue at a faster rate than if no hemostatic agent was applied. A method for promoting the healing of a bleeding wound includes coating a hemostatic agent onto a substrate, applying the substrate to the bleeding wound so that an effective amount of the hemostatic agent is applied to the wound, inflaming the tissue, and causing the re-epithelization of the tissue at a faster rate than if no hemostatic agent was applied. In at least some methods, a clotting cascade and platelet aggregation within the bleeding wound is accelerated, and blood loss from the wound is decreased.
摘要翻译：减少伤口愈合所需的时间的方法包括将伤口上的止血剂施加到伤口周围，使周围的组织发炎，促进成纤维细胞的沉积，从而加速伤口随后的收缩和增殖愈合阶段的开始，并且以比没有使用止血剂更快的速率引起组织的再上皮化。用于促进出血性伤口愈合的方法包括将止血剂涂覆在基底上，将基底施加到出血伤口，使得有效量的止血剂施加到伤口上，使组织发炎，组织的上皮化速度比没有使用止血剂的速率更快。在至少一些方法中，加速了出血性伤口内的凝血级联和血小板聚集，并且伤口的失血减少。

4. 发明授权

US08383148B2 Clay-based hemostatic agents and devices for the delivery thereof 有权
标题翻译：基于粘土的止血剂和用于输送的装置
公开(公告)号：US08383148B2
公开(公告)日：2013-02-26
申请号：US13526431
申请日：2012-06-18
申请人： Raymond J. Huey , Denny Lo , Daniel J. Burns , Giacomo Basadonna , Francis X. Hursey
发明人： Raymond J. Huey , Denny Lo , Daniel J. Burns , Giacomo Basadonna , Francis X. Hursey
IPC分类号： A61L15/14 , A61L15/16 , A61K9/14 , A61F13/00
CPC分类号： A61L15/18 , A61F13/00063 , A61F2013/00472 , A61F2013/00548 , A61F2013/00744 , A61L15/44 , A61L2300/418 , A61L2300/802 , A61L2400/04
摘要： A device for promoting the clotting of blood comprises a clay material in particle form and a receptacle for containing the clay material. At least a portion of the receptacle is defined by a mesh. Another device comprises a gauze substrate and a clay material disposed on the gauze substrate. Another device is a bandage comprising a substrate, a mesh mounted on the substrate, and particles of a clay material retained in the mesh. A hemostatic sponge comprises a substrate, a hemostatic material disposed on a first surface of the substrate, and a release agent disposed on a second surface of the substrate. The release agent is disposed on the wound-contacting surface of the substrate. When treating a bleeding wound, application of the hemostatic sponge causes at least a portion of the hemostatic material to come into contact with blood through the release agent and through the substrate.
摘要翻译：用于促进血液凝结的装置包括颗粒形式的粘土材料和用于容纳粘土材料的容器。容器的至少一部分由网格限定。另一种装置包括纱布基底和布置在纱布基底上的粘土材料。另一种装置是包括基底，安装在基底上的网和保留在网中的粘土材料颗粒的绷带。止血海绵包括基材，设置在基材的第一表面上的止血材料和设置在基材的第二表面上的脱模剂。脱模剂设置在基材的卷绕接触表面上。当治疗出血的伤口时，止血海绵的施用使至少一部分止血材料通过脱模剂和通过基底与血液接触。

5. 发明授权

US08257732B2 Clay-based hemostatic agents and devices for the delivery thereof 有权
标题翻译：基于粘土的止血剂和用于输送的装置
公开(公告)号：US08257732B2
公开(公告)日：2012-09-04
申请号：US13115699
申请日：2011-05-25
申请人： Raymond J. Huey , Denny Lo , Daniel J. Burns , Giacomo Basadonna , Francis X. Hursey
发明人： Raymond J. Huey , Denny Lo , Daniel J. Burns , Giacomo Basadonna , Francis X. Hursey
IPC分类号： A61L15/14 , A61K9/14 , A61F13/00 , A61F13/37 , A61L15/16 , A61L15/18
CPC分类号： A61F13/534 , A61L15/18 , A61L15/44 , A61L2300/102 , A61L2300/402 , A61L2300/404 , A61L2300/41 , A61L2300/418 , A61L2400/04
摘要： A device for promoting the clotting of blood comprises a clay material in particle form and a receptacle for containing the clay material. At least a portion of the receptacle is defined by a mesh. Another device comprises a gauze substrate and a clay material disposed on the gauze substrate. Another device is a bandage comprising a substrate, a mesh mounted on the substrate, and particles of a clay material retained in the mesh. A hemostatic sponge comprises a substrate, a hemostatic material disposed on a first surface of the substrate, and a release agent disposed on a second surface of the substrate. The release agent is disposed on the wound-contacting surface of the substrate. When treating a bleeding wound, application of the hemostatic sponge causes at least a portion of the hemostatic material to come into contact with blood through the release agent and through the substrate.
摘要翻译：用于促进血液凝结的装置包括颗粒形式的粘土材料和用于容纳粘土材料的容器。容器的至少一部分由网格限定。另一种装置包括纱布基底和布置在纱布基底上的粘土材料。另一种装置是包括基底，安装在基底上的网和保留在网中的粘土材料颗粒的绷带。止血海绵包括基材，设置在基材的第一表面上的止血材料和设置在基材的第二表面上的脱模剂。脱模剂设置在基材的卷绕接触表面上。当治疗出血的伤口时，止血海绵的施用使至少一部分止血材料通过脱模剂和通过基底与血液接触。

6. 发明授权

US08343537B2 Clay-based hemostatic agents and devices for the delivery thereof 有权
标题翻译：基于粘土的止血剂和用于输送的装置
公开(公告)号：US08343537B2
公开(公告)日：2013-01-01
申请号：US13363270
申请日：2012-01-31
申请人： Raymond J. Huey , Denny Lo , Daniel J. Burns , Giacomo Basadonna , Francis X. Hursey
发明人： Raymond J. Huey , Denny Lo , Daniel J. Burns , Giacomo Basadonna , Francis X. Hursey
IPC分类号： A61L15/14 , A61L15/16 , A61L15/18 , A61K9/14 , A61F13/00
CPC分类号： A61L15/44 , A61F13/00012 , A61F13/00063 , A61L15/18 , A61L15/28 , A61L15/425 , A61L2300/404 , A61L2300/406 , A61L2400/04 , A61L2400/16
摘要： A hemostatic device for promoting the dotting of blood includes a gauze substrate, a clay material disposed on the gauze substrate, and also a polyol such as glycerol or the like disposed on the gauze substrate to bind the clay material. When the device is used to treat a bleeding wound, at least a portion of the clay material comes into contact with blood emanating from the wound to cause the clotting. A bandage that can be applied to a bleeding wound to promote the clotting of blood includes a flexible substrate and a gauze substrate mounted thereon. The gauze substrate includes a clay material and a polyol. A hemostatic sponge also includes a gauze substrate and a dispersion of hemostatic material and a polyol on a first surface of the substrate.
摘要翻译：用于促进血液点滴的止血装置包括纱布基材，布置在纱布基材上的粘土材料，以及布置在纱布基材上以粘合粘土材料的多元醇如甘油等。当该装置用于治疗流血的伤口时，至少一部分粘土材料与从伤口发出的血液接触以引起凝血。可以应用于流血伤口以促进血液凝结的绷带包括安装在其上的柔性基底和纱布基底。纱布基材包括粘土材料和多元醇。止血海绵还包括纱布基底和止血材料和多元醇在基底的第一表面上的分散体。

7. 发明申请

US20110268784A1 CLAY-BASED HEMOSTATIC AGENTS AND DEVICES FOR THE DELIVERY THEREOF 有权
标题翻译：基于粘土的催化剂及其输送装置
公开(公告)号：US20110268784A1
公开(公告)日：2011-11-03
申请号：US13115699
申请日：2011-05-25
申请人： Raymond J. Huey , Denny Lo , Daniel J. Burns , Giacomo Basadonna , Francis X. Hursey
发明人： Raymond J. Huey , Denny Lo , Daniel J. Burns , Giacomo Basadonna , Francis X. Hursey
IPC分类号： A61K9/70 , A61K33/38 , A61P31/10 , A61P7/04 , A61P29/00 , A61P31/00 , A61K33/06 , A61K33/34
CPC分类号： A61F13/534 , A61L15/18 , A61L15/44 , A61L2300/102 , A61L2300/402 , A61L2300/404 , A61L2300/41 , A61L2300/418 , A61L2400/04
摘要： A device for promoting the clotting of blood comprises a clay material in particle form and a receptacle for containing the clay material. At least a portion of the receptacle is defined by a mesh. Another device comprises a gauze substrate and a clay material disposed on the gauze substrate. Another device is a bandage comprising a substrate, a mesh mounted on the substrate, and particles of a clay material retained in the mesh. A hemostatic sponge comprises a substrate, a hemostatic material disposed on a first surface of the substrate, and a release agent disposed on a second surface of the substrate. The release agent is disposed on the wound-contacting surface of the substrate. When treating a bleeding wound, application of the hemostatic sponge causes at least a portion of the hemostatic material to come into contact with blood through the release agent and through the substrate.
摘要翻译：用于促进血液凝结的装置包括颗粒形式的粘土材料和用于容纳粘土材料的容器。容器的至少一部分由网格限定。另一种装置包括纱布基底和布置在纱布基底上的粘土材料。另一种装置是包括基底，安装在基底上的网和保留在网中的粘土材料颗粒的绷带。止血海绵包括基材，设置在基材的第一表面上的止血材料和设置在基材的第二表面上的脱模剂。脱模剂设置在基材的卷绕接触表面上。当治疗出血的伤口时，止血海绵的施用使至少一部分止血材料通过脱模剂和通过基底与血液接触。

8. 发明授权

US07968114B2 Clay-based hemostatic agents and devices for the delivery thereof 有权
标题翻译：基于粘土的止血剂和用于输送的装置
公开(公告)号：US07968114B2
公开(公告)日：2011-06-28
申请号：US11590427
申请日：2006-10-30
申请人： Raymond J. Huey , Denny Lo , Daniel J. Burns , Giacomo Basadonna , Francis X. Hursey
发明人： Raymond J. Huey , Denny Lo , Daniel J. Burns , Giacomo Basadonna , Francis X. Hursey
IPC分类号： A61L15/14 , A61L15/16 , A61L15/18 , A61K9/14 , A61F13/00 , A61F13/37
CPC分类号： A61F13/534 , A61L15/18 , A61L15/44 , A61L2300/102 , A61L2300/402 , A61L2300/404 , A61L2300/41 , A61L2300/418 , A61L2400/04
摘要： A device for promoting the clotting of blood comprises a clay material in particle form and a receptacle for containing the clay material. At least a portion of the receptacle is defined by a mesh. Another device comprises a gauze substrate and a clay material disposed on the gauze substrate. Another device is a bandage comprising a substrate, a mesh mounted on the substrate, and particles of a clay material retained in the mesh. A hemostatic sponge comprises a substrate, a hemostatic material disposed on a first surface of the substrate, and a release agent disposed on a second surface of the substrate. The release agent is disposed on the wound-contacting surface of the substrate. When treating a bleeding wound, application of the hemostatic sponge causes at least a portion of the hemostatic material to come into contact with blood through the release agent and through the substrate.
摘要翻译：用于促进血液凝结的装置包括颗粒形式的粘土材料和用于容纳粘土材料的容器。容器的至少一部分由网格限定。另一种装置包括纱布基底和布置在纱布基底上的粘土材料。另一种装置是包括基底，安装在基底上的网和保留在网中的粘土材料颗粒的绷带。止血海绵包括基材，设置在基材的第一表面上的止血材料和设置在基材的第二表面上的脱模剂。脱模剂设置在基材的卷绕接触表面上。当治疗出血的伤口时，止血海绵的施用使至少一部分止血材料通过脱模剂和通过基底与血液接触。

9. 发明授权

US08858969B2 Hemostatic compositions, devices, and methods 有权
标题翻译：止血组合物，装置和方法
公开(公告)号：US08858969B2
公开(公告)日：2014-10-14
申请号：US13240795
申请日：2011-09-22
申请人： Mohan Prasad Pahari , Giacomo Basadonna , Denny Lo
发明人： Mohan Prasad Pahari , Giacomo Basadonna , Denny Lo
IPC分类号： A61K8/02 , A61K9/14 , A61F13/00 , A61K33/06 , A61L26/00 , A61F13/36
CPC分类号： A61K33/06 , A61F13/00034 , A61F13/00063 , A61F13/36 , A61F2013/00472 , A61K8/0208 , A61K9/14 , A61L15/28 , A61L15/44 , A61L15/60 , A61L26/0004 , A61L26/0066 , A61L26/0076 , A61L2300/404 , A61L2400/04 , A61M11/007 , A61M35/003 , A61M2202/064
摘要： Compositions that include a clay such as kaolin dispersed in a liquid such as water may be useful for promoting the clotting of blood. The compositions may be in a liquid, gel, paste, foam, or another form. Uses may include treating a traumatic injury such as in injury caused by a bullet, an explosive, a blade etc., or an injury caused during a medical procedure such as surgery.
摘要翻译：包括分散在诸如水的液体中的粘土如高岭土的组合物可用于促进血液凝固。组合物可以是液体，凝胶，糊剂，泡沫或其它形式。用途可以包括治疗创伤性损伤，例如由子弹，爆炸物，刀片等引起的损伤，或在诸如手术的医疗过程中引起的损伤。

10. 发明申请

US20120321691A1 CLAY-BASED HEMOSTATIC AGENTS AND DEVICES FOR THE DELIVERY THEREOF 有权
标题翻译：基于粘土的催化剂及其输送装置
公开(公告)号：US20120321691A1
公开(公告)日：2012-12-20
申请号：US13593310
申请日：2012-08-23
申请人： Raymond J. Huey , Denny Lo , Daniel J. Burns , Giacomo Basadonna , Francis X. Hursey
发明人： Raymond J. Huey , Denny Lo , Daniel J. Burns , Giacomo Basadonna , Francis X. Hursey
IPC分类号： A61K33/06 , A61P7/04 , A61P29/00 , A61K33/34 , A61P31/10 , A61P31/00 , A61K33/38 , A61L15/18 , A61P31/04
CPC分类号： A61F13/534 , A61L15/18 , A61L15/44 , A61L2300/102 , A61L2300/402 , A61L2300/404 , A61L2300/41 , A61L2300/418 , A61L2400/04
摘要： A device for promoting the clotting of blood comprises a clay material in particle form and a receptacle for containing the clay material. At least a portion of the receptacle is defined by a mesh. Another device comprises a gauze substrate and a clay material disposed on the gauze substrate. Another device is a bandage comprising a substrate, a mesh mounted on the substrate, and particles of a clay material retained in the mesh. A hemostatic sponge comprises a substrate, a hemostatic material disposed on a first surface of the substrate, and a release agent disposed on a second surface of the substrate. The release agent is disposed on the wound-contacting surface of the substrate. When treating a bleeding wound, application of the hemostatic sponge causes at least a portion of the hemostatic material to come into contact with blood through the release agent and through the substrate.
摘要翻译：用于促进血液凝结的装置包括颗粒形式的粘土材料和用于容纳粘土材料的容器。容器的至少一部分由网格限定。另一种装置包括纱布基底和布置在纱布基底上的粘土材料。另一种装置是包括基底，安装在基底上的网和保留在网中的粘土材料颗粒的绷带。止血海绵包括基材，设置在基材的第一表面上的止血材料和设置在基材的第二表面上的脱模剂。脱模剂设置在基材的卷绕接触表面上。当治疗出血的伤口时，止血海绵的施用使至少一部分止血材料通过脱模剂和通过基底与血液接触。

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