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    • 5. 发明授权
    • 1H-pyrido[2,3-b][1,5]benzodiazipine vasopressin agonists
    • 1H-吡啶并[2,3-b] [1,5]苯并二氮嗪加压素激动剂
    • US06268360B1
    • 2001-07-31
    • US09698725
    • 2000-10-27
    • Amedeo A. FailliDavid K. WilliamsThomas J. CaggianoJay S. ShumskyMark A. Ashwell
    • Amedeo A. FailliDavid K. WilliamsThomas J. CaggianoJay S. ShumskyMark A. Ashwell
    • C07D40910
    • C07D471/04C07D487/04
    • The present invention provides compounds of the general formula: wherein Y is a moiety selected independently, from NH or —(CH2)n— wherein n is 1; m is an integer from 1 to 2; and the moiety represents: (1) a 5-membered aromatic (unsaturated) heterocyclic ring having one nitrogen (wherein A is nitrogen, and B and C are CH), (2) a 6-membered aromatic (unsaturated) heterocyclic ring having one nitrogen (wherein A is carbon, B is nitrogen, and C is —CH—CH—), (3) a 6-membered aromatic (unsaturated) ring (wherein A is carbon, B is CH, and C is —CH—CH—); as well as methods and pharmaceutical compositions utilizing these compounds for the treatment of disorder which may be remedied or alleviated by vasopressin agonist activity, including diabetes insipidus, nocturnal enuresis, nocturia, urinary incontinence, bleeding and coagulation disorders, or temporary delay of urination.
    • 本发明提供以下通式的化合物:其中Y是独立地选自NH或 - (CH 2)n - 其中n为1的部分; m为1〜2的整数; 并且该部分表示:(1)具有一个氮的5元芳族(不饱和的)杂环(其中A是氮,B和C是CH),(2)具有一个氮的6元芳族(不饱和的)杂环 (其中A为碳,B为氮,C为-CH-CH-),(3)6元芳族(不饱和的)环(其中A为碳,B为CH,C为-CH-CH- ); 以及利用这些化合物治疗可通过加压素激动剂活性(包括尿崩症,夜尿,夜尿,尿失禁,出血和凝血障碍)或临时排尿延迟而补救或缓解的病症的方法和药物组合物。
    • 7. 发明授权
    • System and method for planning or monitoring system transformations
    • 用于规划或监测系统转换的系统和方法
    • US08027956B1
    • 2011-09-27
    • US11929157
    • 2007-10-30
    • James E. Van RiperClint MillerDavid K. Williams
    • James E. Van RiperClint MillerDavid K. Williams
    • G06F7/00G06F17/30G06F17/00
    • G06Q10/00
    • Embodiments provide systems and methods for planning or monitoring system transformations. One embodiment of a method for planning or monitoring the transformation of a system includes developing one or more states, each state representing a system and associated with data structures representing entities comprising the system, wherein the states are ordered in a succession of states to form a scenario modeling the transformation of the system. States can be populated by reflecting one or more data structures or properties of data structures across one or more states. The method can further include collecting data associated with the system at intervals and reflecting the collected data across states. Data structures may be contained in a repository and collected data may be used to update the repository and data structures contained in the repository. A modeling tool may be utilized to display data structures in the repository according to different representations.
    • 实施例提供了用于规划或监视系统变换的系统和方法。 用于规划或监视系统的变换的方法的一个实施例包括开发一个或多个状态,每个状态表示系统并与表示包括该系统的实体的数据结构相关联,其中状态在一系列状态中排序以形成 场景建模系统的转型。 可以通过反映跨越一个或多个状态的数据结构的一个或多个数据结构或属性来填充状态。 该方法还可以包括以间隔收集与系统相关联的数据,并反映所收集的数据跨越状态。 数据结构可以包含在存储库中,并且收集的数据可以用于更新存储库中包含的存储库和数据结构。 可以使用建模工具来根据不同的表示在仓库中显示数据结构。