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1. 发明授权

US5496301A Fluid sampling device for closed collection systems 失效
标题翻译：用于封闭收集系统的流体取样装置
公开(公告)号：US5496301A
公开(公告)日：1996-03-05
申请号：US104343
申请日：1993-08-09
申请人： Dennis J. Hlavinka , Robert L. White , Todd C. Green
发明人： Dennis J. Hlavinka , Robert L. White , Todd C. Green
IPC分类号： A61M5/14 , B29C57/10 , B29C65/00 , B29C65/04 , B29C65/74 , B29L23/00 , B65B51/10 , A61B19/00
CPC分类号： B29C65/04 , B29C65/743 , B29C66/1122 , B29C66/4312 , B29C66/73921 , B29C66/8122 , B29C66/81263 , B29C66/81422 , B29C66/8187 , B29C66/8322 , B29C66/857 , B29C66/8614 , B29C57/10 , B29C66/71 , B29C66/81871 , B29L2023/007 , B29L2031/753 , Y10S128/24 , Y10S604/905
摘要： A method and device for sampling biological fluids during collection without opening the functionally closed collection system, thereby compromising the sterility of the collected fluid. A sample bag connected to a fluid line or collection reservoir is filled coincident with fluid collection, then hermetically sealed and physically separated from the collection system using a radio frequency tubing sealer. A vacuum tube collection device is attached to the sample bag to minimize exposure to the fluid during sample handling and processing.
摘要翻译：一种用于在收集期间对生物流体进行采样的方法和装置，而不打开功能密闭的收集系统，从而损害所收集的流体的无菌性。连接到流体管线或收集容器的样品袋与流体收集一致地填充，然后使用射频管封口机与收集系统气密密封并物理分离。真空管收集装置连接到样品袋，以在样品处理和处理期间最小化对流体的暴露。

2. 发明授权

US5345070A Radio frequency tubing sealer 失效
标题翻译：射频管封口机
公开(公告)号：US5345070A
公开(公告)日：1994-09-06
申请号：US21507
申请日：1993-02-23
申请人： Dennis J. Hlavinka , Frank Corbin, III , Robert L. White
发明人： Dennis J. Hlavinka , Frank Corbin, III , Robert L. White
IPC分类号： A61M5/14 , B29C57/10 , B29C65/00 , B29C65/04 , B29C65/74 , B29L23/00 , B65B51/10 , H05B6/62
CPC分类号： B29C65/04 , B29C65/743 , B29C66/1122 , B29C66/4312 , B29C66/73921 , B29C66/8122 , B29C66/81263 , B29C66/81422 , B29C66/8187 , B29C66/8322 , B29C66/857 , B29C66/8614 , B29C57/10 , B29C66/71 , B29C66/81871 , B29L2023/007 , B29L2031/753 , Y10S128/24 , Y10S604/905
摘要： An insulating sleeve retains heat in the plastic of a flexible plastic medical tube when the plastic of the medical tube is dielectrically heated by a radio frequency tubing sealer. The heat retained by the insulating sleeve permits additional melting of the plastic of the medical tube after a seal has been formed. The additional melting results in forming an easily tearable web between the segments of the medical tube in the same operation as the sealing operation. The medical tube is selectively sealed without forming the easily tearable web by using the radio frequency tubing sealer without the insulating sleeve.
摘要翻译：当医疗管的塑料被射频管密封器介电加热时，绝缘套管在柔性塑料医疗管的塑料中保持热量。在形成密封件之后，由绝缘套管保留的热量允许医用管的塑料的额外熔化。在与密封操作相同的操作中，额外的熔化导致在医疗管的段之间形成容易撕裂的网。通过使用没有绝缘套筒的射频管封口机，医疗管被选择性地密封，而不形成易撕层。

3. 发明授权

US5520218A Medical tubing set for the use with an improved radio frequency tubing sealer 失效
标题翻译：医疗油管套装用于改进的射频管封口机
公开(公告)号：US5520218A
公开(公告)日：1996-05-28
申请号：US257653
申请日：1994-06-09
申请人： Dennis J. Hlavinka , Frank Corbin, III , Robert L. White
发明人： Dennis J. Hlavinka , Frank Corbin, III , Robert L. White
IPC分类号： A61M5/14 , B29C57/10 , B29C65/00 , B29C65/04 , B29C65/74 , B29L23/00 , B65B51/10 , F16L55/10
CPC分类号： B29C65/04 , B29C65/743 , B29C66/1122 , B29C66/4312 , B29C66/73921 , B29C66/8122 , B29C66/81263 , B29C66/81422 , B29C66/8187 , B29C66/8322 , B29C66/857 , B29C66/8614 , B29C57/10 , B29C66/71 , B29C66/81871 , B29L2023/007 , B29L2031/753 , Y10S128/24 , Y10S604/905
摘要： A tubing set includes at least one fluid conveying tube. The fluid conveying tube has a predetermined outside diameter, and is formed of a material adapted to be dielectrically heated at a sealing location. The insulating sleeve has an inside dimension at least as large as the outside diameter of the fluid conveying tube. The tubular insulating sleeve is positioned in a substantially coaxial relationship with the fluid conveying tube at the sealing location, and has a wall with thickness which insulates the fluid conveying tube to permit sealing the fluid conveying tube, and forming a thin, easily tearable web, by the application of the radio frequency dielectric heating.
摘要翻译：管组包括至少一个流体输送管。流体输送管具有预定的外径，并且由适于在密封位置进行介电加热的材料形成。绝缘套筒具有至少与流体输送管的外径一样大的内部尺寸。管状绝缘套管在密封位置处与流体输送管基本上同轴的关系定位，并且具有厚度的壁，该壁具有使流体输送管绝缘以允许密封流体输送管，并且形成薄的易撕层的腹板，通过应用射频电介质加热。

4. 发明授权

US09044523B2 Reduction of contaminants in blood and blood products using photosensitizers and peak wavelengths of light 有权
标题翻译：使用光敏剂和光的峰值波长减少血液和血液制品中的污染物
公开(公告)号：US09044523B2
公开(公告)日：2015-06-02
申请号：US11840759
申请日：2007-08-17
申请人： Dennis J. Hlavinka , Raymond P. Goodrich , Heather Reddy
发明人： Dennis J. Hlavinka , Raymond P. Goodrich , Heather Reddy
IPC分类号： A01N1/02 , A61L2/24 , A61K41/00 , A61L2/00 , A61L2/08 , A61L2/10 , C07F11/00 , C07F13/00 , C07F15/02 , C07F17/00
CPC分类号： A61L2/24 , A61K41/0019 , A61L2/0011 , A61L2/0088 , A61L2/08 , A61L2/10 , C07F11/005 , C07F13/005 , C07F15/02 , C07F17/00
摘要： Methods and apparatuses are provided for reduction of pathogens in fluids containing blood products. Preferred methods include the steps of adding an effective, non-toxic amount of a photosensitizer such as riboflavin to the blood product and exposing the fluid to light having a peak wavelength.
摘要翻译：提供了用于减少含有血液制品的流体中的病原体的方法和装置。优选的方法包括将有效的无毒量的光敏剂如核黄素添加到血液制品中并将流体暴露于具有峰值波长的光的步骤。

5. 发明申请

US20110220290A1 Heat Weld Tubing Connectors 审中-公开
标题翻译：热焊管连接器
公开(公告)号：US20110220290A1
公开(公告)日：2011-09-15
申请号：US13114170
申请日：2011-05-24
申请人： Dennis J. Hlavinka , Keith Manica , Frank Corbin, III , Terrence M. Cussen
发明人： Dennis J. Hlavinka , Keith Manica , Frank Corbin, III , Terrence M. Cussen
IPC分类号： B29C65/02
CPC分类号： F16L47/02 , A61M39/143 , A61M39/146 , A61M39/18 , B29C65/2046 , B29C65/2076 , B29C66/0042 , B29C66/00441 , B29C66/1122 , B29C66/1142 , B29C66/5221 , B29C66/71 , B29C66/712 , B29C66/73116 , B29C66/73921 , B29C66/80 , B29C66/8122 , B29C66/81821 , B29C66/8432 , B29C66/857 , B29K2021/003 , B29K2023/00 , B29K2027/06 , B29K2101/12 , B29K2827/18 , B29C65/00 , B29K2909/02 , B29K2867/00 , B29K2905/02 , B29K2905/10
摘要： The present invention provides thermoplastic tubes, thermoplastic melting plates, thermoplastic tube connecting apparatus, and methods for using the same.
摘要翻译：本发明提供热塑性管，热塑性熔融板，热塑性管连接装置及其使用方法。

6. 发明授权

US07582049B2 Fluid separation devices, systems and/or methods using a centrifuge and roller pump 失效
标题翻译：流体分离装置，使用离心机和滚子泵的系统和/或方法
公开(公告)号：US07582049B2
公开(公告)日：2009-09-01
申请号：US11307451
申请日：2006-02-08
申请人： Dennis J. Hlavinka , William G Palsulich , Thomas J. Felt , Frank Corbin, III
发明人： Dennis J. Hlavinka , William G Palsulich , Thomas J. Felt , Frank Corbin, III
IPC分类号： B04B5/02
CPC分类号： A61M1/0209 , A61M1/3693 , B04B5/0428
摘要： A centrifugal fluid separation system is disclosed for centrifugally separating a composite fluid into components thereof. This centrifugal separation system includes at least a centrifugal rotor which has a composite fluid containment area, a fluid flow channel/tubing and at least one separated component collection area defined therein. A composite fluid to be separated is delivered to the fluid containment area where under centrifugal forces the composite fluid is separated into components and then from which a component travels through an outlet channel to a respective separated component fluids flowing therethrough. A centrally disposed pump is also provided to move the separated component(s) to the collection area(s). Optical sensing of the interface of the separated fluid components may be used with a clamp to stop flow. A disposable bag and tubing system is also disclosed for use with reusable rotor devices.
摘要翻译：公开了用于将复合流体离心分离成其组分的离心流体分离系统。该离心分离系统至少包括离心转子，其具有复合流体容纳区域，流体流动通道/管道和限定在其中的至少一个分离的部件收集区域。要分离的复合流体被输送到流体容纳区域，在离心力作用下，复合流体被分离成组分，然后组分通过出口通道行进到流过其中的各自分离的组分流体。还提供了一个集中设置的泵以将分离的部件移动到收集区域。分离的流体组分的界面的光学感测可以与夹具一起使用以阻止流动。还公开了一次性袋和管道系统，用于可重复使用的转子装置。

7. 发明授权

US06736768B2 Fluid separation devices, systems and/or methods using a fluid pressure driven and/or balanced approach 有权
标题翻译：使用流体压力驱动和/或平衡方法的流体分离装置，系统和/或方法
公开(公告)号：US06736768B2
公开(公告)日：2004-05-18
申请号：US10008989
申请日：2001-11-02
申请人： Thomas J. Felt , Dennis J. Hlavinka
发明人： Thomas J. Felt , Dennis J. Hlavinka
IPC分类号： B04B100
CPC分类号： B04B5/0442 , A61M1/0231 , A61M1/3693 , A61M1/3696 , A61M1/38 , B04B5/0428 , B04B7/08 , B04B9/08 , B04B2005/045 , B04B2005/0464 , B04B2009/143
摘要： A centrifugal separation device separates a composite fluid, such as blood, into the components thereof. The fluid is delivered to a fluid receiving area in a rotor from which area the fluid travels through a radial inlet channel having an inlet channel height to a proximal end of a circumferential fluid separation channel. Near a distal end of the separation channel, fluid components travel into distinct first and second outlet channels. The height of the first channel is greater than the height of the more distal second channel. The inlet channel height is greater than the height of the first channel. The rotor may be balanced by axially symmetrical sets of inlet channels, separation channels and outlet channels or by a balance channel connected to the separation channel but displaced from the outlet channels.
摘要翻译：离心分离装置将诸如血液的复合流体分离成其组分。流体被输送到转子中的流体接收区域，流体从该区域流过具有到周向流体分离通道的近端的入口通道高度的径向入口通道。在分离通道的远端附近，流体组分行进到不同的第一和第二出口通道。第一通道的高度大于较远端第二通道的高度。入口通道高度大于第一通道的高度。转子可以通过轴向对称的入口通道，分离通道和出口通道组合或通过连接到分离通道但从出口通道移位的平衡通道来平衡。

8. 发明申请

US20080009833A1 Heat Weld Tubing Connectors 有权
标题翻译：热焊管连接器
公开(公告)号：US20080009833A1
公开(公告)日：2008-01-10
申请号：US11772337
申请日：2007-07-02
申请人： Frank Corbin , Terrence M. Cussen , Dennis J. Hlavinka , Keith Manica
发明人： Frank Corbin , Terrence M. Cussen , Dennis J. Hlavinka , Keith Manica
IPC分类号： A61M39/10
CPC分类号： F16L47/02 , A61M39/143 , A61M39/146 , A61M39/18 , B29C65/2046 , B29C65/2076 , B29C66/0042 , B29C66/00441 , B29C66/1122 , B29C66/1142 , B29C66/5221 , B29C66/71 , B29C66/712 , B29C66/73116 , B29C66/73921 , B29C66/80 , B29C66/8122 , B29C66/81821 , B29C66/8432 , B29C66/857 , B29K2021/003 , B29K2023/00 , B29K2027/06 , B29K2101/12 , B29K2827/18 , B29C65/00 , B29K2909/02 , B29K2867/00 , B29K2905/02 , B29K2905/10
摘要： The present invention provides thermoplastic tubes, thermoplastic melting plates, thermoplastic tube connecting apparatus, and methods for using the same.
摘要翻译：本发明提供热塑性管，热塑性熔融板，热塑性管连接装置及其使用方法。

9. 发明授权

US07077559B2 Container or bag mixing apparatuses and/or methods 有权
公开(公告)号：US07077559B2
公开(公告)日：2006-07-18
申请号：US10425281
申请日：2003-04-28
申请人： Dennis J. Hlavinka , Michael A. Martinez
发明人： Dennis J. Hlavinka , Michael A. Martinez
IPC分类号： B01F11/00
CPC分类号： B01F5/0682 , A61L2/0011 , A61L2/0088 , A61L2/08 , A61L2/084 , A61L2/10 , A61L2202/22 , A61M1/025 , A61M1/0277 , A61M1/3683 , B01F5/0683 , B01F5/0688 , B01F9/0014 , B01F11/0065 , B01F13/0001 , B01F13/001
摘要： A mixing system, apparatus and/or method. Pathogen reduction of and/or mixing storage solutions into blood or blood components are useful purposes for these. Squeezing or clapping devices may be used to activate the mixing process, as may rotational devices or laterally movable, rotational and/or orbital devices. Constriction elements may also be used to create useful vortex mixing actions. Photoradiation may be provided while the components continue to be mixed together for pathogen reduction of blood or blood components.

10. 发明授权

US4246121A Fluid flow transfer device with formed-in-place manifold gasket and method of making same 失效
标题翻译：具有形成在位的歧管垫片的流体流动传送装置及其制造方法
公开(公告)号：US4246121A
公开(公告)日：1981-01-20
申请号：US961618
申请日：1978-11-17
申请人： Frank Corbin, III , Dennis J. Hlavinka
发明人： Frank Corbin, III , Dennis J. Hlavinka
IPC分类号： B01D31/00
CPC分类号： B01D63/14 , B01D2313/04
摘要： A fluid flow transfer device having a pleated membrane bonded at its tips to the interior of a housing and a method of making the same wherein a fluid manifold is provided by forming a channel portion in the housing interior, applying a gasket material around the channel portion, and placing the membrane tips against the adhesive to provide a formed-in-place gasket prior to potting of the membrane tips to the housing interior with a potting material.
摘要翻译：一种流体流动传递装置，具有在其顶端处连接到壳体内部的褶皱膜及其制造方法，其中通过在壳体内部形成通道部分来提供流体歧管，在通道部分周围施加垫圈材料，并且将膜尖端抵靠粘合剂，以在用封装材料将膜尖端灌封到壳体内部之前提供形成就位的垫圈。

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