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1. 发明申请

US20080176208A1 Reduction of Contaminants in Blood and Blood Products Using Photosensitizers and Peak Wavelengths of Light 有权
标题翻译：使用光敏剂减少血液和血液中的污染物和光的峰值波长
公开(公告)号：US20080176208A1
公开(公告)日：2008-07-24
申请号：US11840759
申请日：2007-08-17
申请人： Dennis J. HLAVINKA , Raymond P. GOODRICH , Heather REDDY
发明人： Dennis J. HLAVINKA , Raymond P. GOODRICH , Heather REDDY
IPC分类号： A01N1/02 , C12M1/00
CPC分类号： A61L2/24 , A61K41/0019 , A61L2/0011 , A61L2/0088 , A61L2/08 , A61L2/10 , C07F11/005 , C07F13/005 , C07F15/02 , C07F17/00
摘要： Methods and apparatuses are provided for reduction of pathogens in fluids containing blood products. Preferred methods include the steps of adding an effective, non-toxic amount of a photosensitizer such as riboflavin to the blood product and exposing the fluid to light having a peak wavelength.
摘要翻译：提供了用于减少含有血液制品的流体中的病原体的方法和装置。优选的方法包括将有效的无毒量的光敏剂如核黄素添加到血液制品中并将流体暴露于具有峰值波长的光的步骤。

2. 发明申请

US20080096750A1 Methods for Washing a Red Blood Cell Component and for Removing Prions Therefrom 有权
标题翻译：洗涤红细胞成分和去除朊病毒的方法
公开(公告)号：US20080096750A1
公开(公告)日：2008-04-24
申请号：US11875334
申请日：2007-10-19
申请人： Dennis J. HLAVINKA , Raymond P. GOODRICH , Eric T. HANSEN
发明人： Dennis J. HLAVINKA , Raymond P. GOODRICH , Eric T. HANSEN
IPC分类号： B01D43/00 , B04B5/02
CPC分类号： A61M1/3693 , A61M1/0209 , A61M1/0218 , A61M1/3692 , A61M1/3696 , A61M1/3698 , B04B5/0428 , B04B9/14 , B04B2009/143
摘要： A method for washing multiple units of blood product including providing a centrifuge having a wash cell for each unit of blood product, balancing the centrifuge to accommodate for differences in the wash cells, and transferring supernatant including any wash solution from each unit of blood product on the centrifuge.
摘要翻译：一种用于洗涤多个血液制品单元的方法，包括提供具有用于每个血液制品单位的洗涤池的离心机，平衡离心机以适应洗涤细胞的差异，以及将来自每一单位血液制品的任何洗涤溶液的上清液离心机

3. 发明申请

US20080299538A1 Pathogen Inactivation of Whole Blood 审中-公开
标题翻译：病原体灭活全血
公开(公告)号：US20080299538A1
公开(公告)日：2008-12-04
申请号：US12182280
申请日：2008-07-30
申请人： Raymond P. GOODRICH , Dennis J. HLAVINKA , Heather L. REDDY
发明人： Raymond P. GOODRICH , Dennis J. HLAVINKA , Heather L. REDDY
IPC分类号： A01N1/02 , A61J1/10
CPC分类号： A61M1/3693 , A61K41/0019 , A61L2/0011 , A61L2/0082 , A61L2/0088 , A61M1/0213 , A61M1/029 , A61M1/3681 , A61M1/3683 , A61M1/3696 , A61M1/3698 , A61M2205/123
摘要： This invention is directed toward a method of pathogen inactivating whole blood. The steps include collecting whole blood from a donor into a bag; illuminating the whole blood with light at a sufficient energy so that an alloxazine photosensitizer present in the whole blood may be photolyzed to inactivate any pathogens which may be present in the whole blood; and storing the pathogen inactivated whole blood. The invention also includes a method of separating the pathogen inactivated whole blood into components.
摘要翻译：本发明涉及一种灭活全血的病原体的方法。这些步骤包括将供体中的全血收集到袋子中; 以足够的能量照亮整个血液，使得存在于全血中的全氟嗪光敏剂可以被光解以灭活全血中可能存在的任何病原体; 并存储病原体灭活的全血。本发明还包括将病原体灭活的全血分离成组分的方法。

4. 发明申请

US20100282980A1 Stable Calibration Means for Apparatus for Photo Reduction of Contaminants in Blood 审中-公开
标题翻译：用于血液中污染物减少照片的装置的稳定校正装置
公开(公告)号：US20100282980A1
公开(公告)日：2010-11-11
申请号：US12760627
申请日：2010-04-15
申请人： Abraham BELKIND , Daniel Thomas MCGINNIS , Dennis J. HLAVINKA , Terrence M. CUSSEN
发明人： Abraham BELKIND , Daniel Thomas MCGINNIS , Dennis J. HLAVINKA , Terrence M. CUSSEN
IPC分类号： A61L2/08 , H01L31/0232 , G02B5/10 , C23C16/513
CPC分类号： G01J1/429 , A61K41/0019 , A61L2/0047 , A61L2/0052 , A61L2202/14 , A61L2202/22 , G01J1/04 , G01J2001/0481 , G01N21/4785 , G02B5/0808
摘要： An apparatus for irradiating blood or blood products, preferably with ultra violet or visible light, to reduce contaminants in the blood or blood products. A removable radiometer having light integrating chambers detects the light intensity, allowing the radiation characteristics of the apparatus to be calibrated. The light chambers have an aluminum reflecting surface prepared by machining, grit blasting, polishing and plasma treatment including plasma cleaning and oxidation.
摘要翻译：用于照射血液或血液制品的装置，优选用紫外或可见光照射，以减少血液或血液制品中的污染物。具有光积分室的可移动辐射计检测光强度，允许校准装置的辐射特性。光室具有通过机械加工，喷砂，抛光和等离子体处理（包括等离子体清洁和氧化）制备的铝反射表面。

5. 发明申请

US20090317296A1 Clamp Assembly for Displacing Fluid from Portions of Fluid Containers 有权
标题翻译：用于从流体容器的部分排出流体的夹紧组件
公开(公告)号：US20090317296A1
公开(公告)日：2009-12-24
申请号：US12548656
申请日：2009-08-27
申请人： Dennis J. HLAVINKA , Terrence M. CUSSEN
发明人： Dennis J. HLAVINKA , Terrence M. CUSSEN
IPC分类号： A61M1/02 , B01L11/00
CPC分类号： A61L2/0011 , A61M1/0277 , A61M1/3683
摘要： Clamps and methods are disclosed for clamping portions of fluid containers and displacing fluid from portions of fluid containers. In one embodiment, a clamp has a first jaw having a photopermeable main body portion and a second jaw. The first and second jaws are operatively associated so that at least one jaw, or both jaws, may be moved between clamped and released positions. The clamp is sized to receive a portion of a fluid container and displace fluid in the fluid container from a clamped region of the fluid container when the first and/or second jaw(s) are in the clamped position. The photopermeable main body portion(s) of the first and/or second jaw(s) allow some light to reach the clamped region of the fluid container during photoradiation to inactivate pathogens in the fluid. Various clamp embodiments and assemblies having lock members and interlocks are also disclosed herein.
摘要翻译：公开了用于夹紧流体容器的部分并且从流体容器的部分移出流体的夹具和方法。在一个实施例中，夹具具有具有光透过主体部分和第二钳口的第一钳口。第一和第二钳口可操作地相关联，使得至少一个钳口或两个钳口可在夹紧位置和释放位置之间移动。当第一和/或第二钳口处于夹紧位置时，夹具的尺寸设定成接收流体容器的一部分并且从流体容器的夹紧区域移动流体容器中的流体。第一和/或第二钳口的光透过主体部分允许一些光在光辐射期间到达流体容器的夹紧区域以灭活流体中的病原体。本文还公开了具有锁定构件和互锁的各种夹具实施例和组件。

6. 发明申请

US20100189597A1 Methods and Systems for Preparing Blood Products 审中-公开
标题翻译：血液制品制备方法与系统
公开(公告)号：US20100189597A1
公开(公告)日：2010-07-29
申请号：US12753933
申请日：2010-04-05
申请人： Dennis J. HLAVINKA
发明人： Dennis J. HLAVINKA
IPC分类号： A61L2/08
CPC分类号： A61M1/0209 , A61M1/0231 , A61M1/0236 , A61M1/3681 , A61M1/3683 , A61M1/3686 , A61M1/3693 , A61M1/38
摘要： The present invention is related to pre-connected disposable sets including a pre-connected bag containing a photosensitizer for use in a blood separation and pathogen inactivation procedure.
摘要翻译：本发明涉及预先连接的一次性组合物，其包括含有用于血液分离和病原体灭活过程的光敏剂的预连接袋。

7. 发明申请

US20120015795A1 CENTRIFUGE FOR PROCESSING BLOOD AND BLOOD COMPONENTS 有权
标题翻译：用于加工血液和血液成分的离心机
公开(公告)号：US20120015795A1
公开(公告)日：2012-01-19
申请号：US13185256
申请日：2011-07-18
申请人： Dennis J. HLAVINKA , John R. MERKLING
发明人： Dennis J. HLAVINKA , John R. MERKLING
IPC分类号： B04B5/04 , B01D21/26 , B04B7/12
CPC分类号： B04B5/0428 , A61M1/0209 , A61M1/3693 , A61M2202/0427 , B04B7/12
摘要： The present invention relates generally to the field of extracorporeal blood processing methods and apparatus which are particularly useful in blood component collection, and more specifically, the present invention relates to methods and apparatus for centrifugally separating buffy coat that reduce the surface available for separated buffy coat components to sediment on by varying the radius of the product collection bag.
摘要翻译：本发明一般涉及在血液成分收集中特别有用的体外血液加工方法和装置的领域，更具体地说，本发明涉及用于离心分离血沉棕黄层的方法和装置，其减少可用于分离的血沉棕黄层的表面通过改变产品收集袋的半径来沉淀的成分。

8. 发明申请

US20110019182A1 Apparatus for Photo Reduction of Contaminants in Blood and Blood Products with Calibration Means 有权
标题翻译：血液和血液制品中用污染物照相还原仪器
公开(公告)号：US20110019182A1
公开(公告)日：2011-01-27
申请号：US12893887
申请日：2010-09-29
申请人： Dennis J. HLAVINKA , Terrence M. CUSSEN , Daniel T. MCGINNIS
发明人： Dennis J. HLAVINKA , Terrence M. CUSSEN , Daniel T. MCGINNIS
IPC分类号： G01J1/42
CPC分类号： A61L2/0011 , A61M1/0272 , A61M1/3683
摘要： An apparatus for irradiating blood or blood products, preferably with ultra violet or visible light, to reduce contaminants in the blood or blood products. A removable radiometer having light integrating chambers detects the light intensity, allowing the radiation characteristics of the apparatus to be calibrated. A control circuit uses the measurements to control the delivery of an effective dose of illumination to blood or blood products in a bag or container. One or more light integrating optical chambers in the radiometer allow a single light sensor to sense light across an entire field. Thermistors in the irradiating apparatus or the radiometer or both sense the temperature of photo sensors. The control circuit compensates for temperature-dependant variations in the output of the photo sensors.
摘要翻译：用于照射血液或血液制品的装置，优选用紫外或可见光照射，以减少血液或血液制品中的污染物。具有光积分室的可移动辐射计检测光强度，允许校准装置的辐射特性。控制电路使用测量来控制有效剂量的照射到袋子或容器中的血液或血液制品的传送。辐射计中的一个或多个光积分光学室允许单个光传感器在整个场上感测光。照射装置或辐射计中的热敏电阻或两者都感测光传感器的温度。控制电路补偿光传感器输出中的温度变化。

9. 发明申请

US20090010806A1 Apparatus for Photo Reduction of Contaminants in Blood and Blood Products with Calibration Means 有权
标题翻译：血液和血液制品中用污染物照相还原仪器
公开(公告)号：US20090010806A1
公开(公告)日：2009-01-08
申请号：US12032963
申请日：2008-02-18
申请人： Dennis J. HLAVINKA , Terrence M. CUSSEN , Daniel T. MCGINNIS
发明人： Dennis J. HLAVINKA , Terrence M. CUSSEN , Daniel T. MCGINNIS
IPC分类号： A61L2/28
CPC分类号： A61L2/0011 , A61M1/0272 , A61M1/3683
摘要： An apparatus for irradiating blood or blood products, preferably with ultra violet or visible light, to reduce contaminants in the blood or blood products. A removable radiometer having light integrating chambers detects the light intensity, allowing the radiation characteristics of the apparatus to be calibrated. A control circuit uses the measurements to control the delivery of an effective dose of illumination to blood or blood products in a bag or container. One or more light integrating optical chambers in the radiometer allow a single light sensor to sense light across an entire field. Thermistors in the irradiating apparatus or the radiometer or both sense the temperature of photo sensors. The control circuit compensates for temperature-dependant variations in the output of the photo sensors.
摘要翻译：用于照射血液或血液制品的装置，优选用紫外或可见光照射，以减少血液或血液制品中的污染物。具有光积分室的可移动辐射计检测光强度，允许校准装置的辐射特性。控制电路使用测量来控制有效剂量的照射到袋子或容器中的血液或血液制品的传送。辐射计中的一个或多个光积分光学室允许单个光传感器在整个场上感测光。照射装置或辐射计中的热敏电阻或两者都感测光传感器的温度。控制电路补偿光传感器输出中的温度变化。

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