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1. 发明授权

US5095027A Method for treating reperfusion injury employing L-2-oxothiazolidine-4-carboxylic acid 失效
标题翻译：用L-2-氧代噻唑烷-4-羧酸治疗再灌注损伤的方法
公开(公告)号：US5095027A
公开(公告)日：1992-03-10
申请号：US662557
申请日：1991-02-28
申请人： Dennis I. Goldberg , David C. Madsen , W. Bruce Rowe
发明人： Dennis I. Goldberg , David C. Madsen , W. Bruce Rowe
IPC分类号： A61K31/095 , A61K31/22 , A61K31/425 , A61K38/00 , A61K45/00 , A61P9/00 , A61P9/10
CPC分类号： A61K31/425
摘要： The present invention provides a method for treating and/or reducing ischemic reperfusion injury. To this end, in embodiment, a method for treating and/or reducing reperfusion injury is provided comprising the step of administering to a patient in danger of reperfusion injury a therapeutically effective amount of L-2-oxothiazolidine-4-carboxylic acid. In an embodiment, a method is provided for limiting an expected ischemic reperfusion injury comprising the step of administering prior to an expected ischemic event a therapeutically effective amount of L-2-oxothiazolidine-4-carboxylic acid. In a further embodiment of the present invention, a method is provided for limiting ischemic reperfusion injury comprising the step of administering to a patient after the onset of an ischemic event a therapeutically effective amount of L-2-oxothiazolidine-4-carboxylic acid.

2. 发明授权

US5189016A Nutrient compositions containing peptides and method for administering the same 失效
标题翻译：含有肽的营养组合物及其施用方法
公开(公告)号：US5189016A
公开(公告)日：1993-02-23
申请号：US525861
申请日：1990-05-18
申请人： David C. Madsen , W. Bruce Rowe
发明人： David C. Madsen , W. Bruce Rowe
IPC分类号： A23L1/305 , C07K5/065 , C07K5/072
CPC分类号： C07K5/06104 , A23L33/18 , C07K5/06078
摘要： The present invention relates to nutrient compositions containing dipeptides and methods for administering the same. In particular, according to the present invention, a nutrient composition comprising an aqueous solution having at least one dipeptide with an N-terminal amino acid selected from the class consisting of glutamine, asparagine, tyrosine, tryptophan, and aspargine is provided. Glutamine (4.8 grams/100 ml at 30.degree. C.), asparagine (3.5 grams/100 mL at 28.degree. C.), tyrosine (0.45 grams/100 mL at 25.degree. C.) and tryptophan (11.4 grams/100 mL at 25.degree. C.) and arginine (15.0 grams/100 mL at 21.degree. C.) are all less soluble in water than glycine (25 grams/100 mL at 25.degree. C.). The C-terminal amino acid is selected from the group consisting of alanine, glycine, tryptophan, arginine, proline and serine. The nutritional solutions contain from about 0.1 to 25.0 percent by weight of oligopeptides, preferably about 0.5 to 5.0 percent by weight.

3. 发明授权

US5747459A Method for insuring adequate intracellular glutathione in tissue 失效
标题翻译：确保组织中足够的细胞内谷胱甘肽的方法
公开(公告)号：US5747459A
公开(公告)日：1998-05-05
申请号：US795150
申请日：1997-02-07
申请人： W. Bruce Rowe , David A. Mark , David C. Madsen
发明人： W. Bruce Rowe , David A. Mark , David C. Madsen
IPC分类号： A61K38/01 , A23J1/20 , A23C23/00 , A23C35/00
CPC分类号： A61K38/018
摘要： A method is provided for increasing and/or maintaining the level of intracellular glutathione. Pursuant to the invention, compositions including denatured and at least partially hydrolyzed proteins are administered to a patient in an amount sufficient to increase glutathione levels in the patient.
摘要翻译：提供了增加和/或维持细胞内谷胱甘肽水平的方法。根据本发明，包含变性和至少部分水解的蛋白质的组合物以足以增加患者中谷胱甘肽水平的量施用于患者。

4. 发明授权

US4920098A Nutritional support or therapy for individuals at risk or under treatment for atherosclerotic vascular, cardiovascular, and/or thrombotic diseases 失效
标题翻译：危险或正在治疗动脉粥样硬化血管，心血管和/或血栓性疾病的个体的营养支持或治疗
公开(公告)号：US4920098A
公开(公告)日：1990-04-24
申请号：US403849
申请日：1989-08-28
申请人： Richard Cotter , Robert C. Johnson , Michael Ward , David C. Madsen , Anthony J. Valicenti , Michael P. Menard , Hugh N. Tucker
发明人： Richard Cotter , Robert C. Johnson , Michael Ward , David C. Madsen , Anthony J. Valicenti , Michael P. Menard , Hugh N. Tucker
IPC分类号： A23L1/30 , A23L1/305 , A61K9/00
CPC分类号： A61K9/0029 , A23L33/12 , A23L33/18 , Y10S514/824 , Y10S514/943
摘要： A method is provided for individuals under treatment for or at risk of atherosclerotic, vascular, cardiovascular, and/or thrombotic disease by administering a composition which comprises a protein source; a carbohydrate source; and at least one lipid selected from the group consisting of: gamma-linolenic acid; eicosapentaenoic acid; docosahexaenoic acid; sterodonic acid; and linolenic acid. Both an enteral and parenteral composition are provided.
摘要翻译：通过施用包含蛋白质来源的组合物，为治疗或处于动脉粥样硬化，血管，心血管和/或血栓形成疾病风险的个体提供了一种方法; 碳水化合物来源; 和至少一种选自以下的脂质：γ-亚麻酸; 二十碳五烯酸二十二碳六烯酸甾体酸和亚麻酸。提供肠内和肠胃外组合物。

5. 发明授权

US4791570A Guide wire communication system and method 失效
标题翻译：导线通讯系统及方法
公开(公告)号：US4791570A
公开(公告)日：1988-12-13
申请号：US873032
申请日：1986-06-11
申请人： Leigh E. Sherman , Gary L. Whatcott , Richard M. Dicks , David C. Madsen
发明人： Leigh E. Sherman , Gary L. Whatcott , Richard M. Dicks , David C. Madsen
IPC分类号： G05D1/02 , G06F15/48
CPC分类号： G05D1/0297 , G05D1/0265
摘要： A guidance system for guiding a plurality of unmanned vehicles along guide wires. A plurality of data communication circuits are provided which form an extensive network. A traffic control computer composes a coded vehicle instruction for assigning tasks and allocates resources to said unmanned vehicles. The traffic control computer polls the status of each vehicle at varying time intervals and receives a response from said vehicle. The network connecting the computer and the communication circuits prevents reception of data transmissions from more than one vehicle at a time. Other messages are temporarily, stored. Data transmitters generate low frequency, low power signals which have a high data transmission rate. Digital data is converted at the transmitters into cosine waveforms of selected frequencies. The cosine waveforms are transposed into sine waveforms at receivers. Low impedance or high impedance characteristics are imposed upon the guide wires. A low frequency, high gain transmit antenna for each vehicle is prorated.
摘要翻译：一种用于沿导丝引导多个无人驾驶车辆的引导系统。提供形成广泛网络的多个数据通信电路。交通控制计算机构成用于分配任务的编码车辆指令，并向所述无人车辆分配资源。交通控制计算机以变化的时间间隔轮询每个车辆的状态并接收来自所述车辆的响应。连接计算机和通信电路的网络阻止一次从多于一个车辆接收数据传输。暂时存储其他消息。数据发射机产生具有高数据传输速率的低频，低功率信号。发射机将数字数据转换成所选频率的余弦波形。余弦波形在接收器处转换成正弦波形。引导线上施加低阻抗或高阻抗特性。每个车辆的低频，高增益发射天线是按比例分配的。

6. 发明授权

US5853377A System and method for monitoring and analyzing dynamic nutritional status in patients with chronic disease 失效
标题翻译：用于监测和分析慢性病患者动态营养状况的系统和方法
公开(公告)号：US5853377A
公开(公告)日：1998-12-29
申请号：US843986
申请日：1997-04-17
申请人： David C. Madsen , Chris Kruzel , Susan Trimbo , Theresa Voss , Kathryn Hennessy , Carol Siegel , Hugh N. Tucker
发明人： David C. Madsen , Chris Kruzel , Susan Trimbo , Theresa Voss , Kathryn Hennessy , Carol Siegel , Hugh N. Tucker
IPC分类号： G06F19/00 , A61B5/103
CPC分类号： G06F19/3418 , G06F19/3406
摘要： A system and a method are provided for monitoring a patient. The system receives information relating to weight and/or LBM of a patient as well as other clinical and medical variable may be input relating to the patient. Warning levels or alert levels are input to the system such that a patient or clinician is immediately notified upon the patient reaching such levels. The system provides local transmission to a patient or remote transmission to, for example, a clinician of the patient or the like. The system and method are particularly useful for patients with chronic disease such that the dynamic nutritional status may be closely monitored and analyzed and ultimately addressed when significant changes occur.
摘要翻译：提供了一种用于监测患者的系统和方法。系统接收与患者的体重和/或LBM有关的信息，以及可以输入与患者相关的其它临床和医学变量。将警告级别或警报级别输入到系统，使得患者或临床医生在患者达到这样的水平时立即被通知。该系统向患者提供本地传输或者向例如患者的临床医生等的远程传输。该系统和方法对于患有慢性疾病的患者特别有用，使得动态营养状态可以被密切监测和分析，并且在发生重大变化时最终被解决。

7. 发明授权

US5378722A Nutritional compositions for management of nitrogen metabolism 失效
标题翻译：用于管理氮代谢的营养组合物
公开(公告)号：US5378722A
公开(公告)日：1995-01-03
申请号：US161917
申请日：1993-12-03
申请人： David C. Madsen , David Mark
发明人： David C. Madsen , David Mark
IPC分类号： A23L1/305 , A61K31/415 , A01N43/38
CPC分类号： A61K31/415 , A23L33/175
摘要： A nutritional composition is provided that is low ammoniagenic, scavenges ammonia well, and yet does not contribute to excess nitric oxide production. The nutritional composition includes an amino acid profile having less than 20 percent of the total amino acids as ammoniagenic amino acids. The nutritional composition also includes less than 0.2 percent of the total amino acids as arginine and at least 0.2 percent of the total amino acids as ornithine and/citrulline.
摘要翻译：提供了一种营养组合物，其具有低的产氨性，能够很好地清除氨，并且不会导致过量的一氧化氮产生。营养组合物包含具有少于总氨基酸的20％作为产氨性氨基酸的氨基酸分布。营养组合物还包括作为精氨酸的总氨基酸的0.2％以下，作为鸟氨酸和/瓜氨酸的总氨基酸的至少0.2％。

8. 发明授权

US4357343A Nutritional composition for management of renal failure 失效
标题翻译：肾衰竭的营养组合物
公开(公告)号：US4357343A
公开(公告)日：1982-11-02
申请号：US277526
申请日：1981-06-26
申请人： David C. Madsen , Hugh N. Tucker
发明人： David C. Madsen , Hugh N. Tucker
IPC分类号： A61K38/01
CPC分类号： A61K38/01
摘要： A novel amino acid composition is provided for the nutritional maintenance of renal failure patients.
摘要翻译：提供了一种新的氨基酸组成，用于肾衰竭患者的营养维持。

9. 发明授权

US5389657A Method for treating infertility 失效
标题翻译：治疗不孕症的方法
公开(公告)号：US5389657A
公开(公告)日：1995-02-14
申请号：US12006
申请日：1993-02-01
申请人： David C. Madsen
发明人： David C. Madsen
IPC分类号： A61K31/00 , A61K31/195 , A61K31/425 , A61K38/06 , A61K38/17 , A61K38/38
CPC分类号： A61K31/00 , A61K31/195 , A61K31/425 , A61K38/063 , A61K38/1709 , A61K38/38
摘要： The present invention provides a method of treating infertility comprising administering to a female mammal having fertility problems a therapeutically effective amount of the glutathione stimulator L-2-oxothiazolidine-4-carboxylate or esters thereof.
摘要翻译：本发明提供了治疗不育症的方法，包括对具有生育能力问题的雌性哺乳动物施用治疗有效量的谷胱甘肽激动剂L-2-氧代噻唑烷-4-羧酸酯或其酯。

10. 发明授权

US4902948A Guide wire communication system and method 失效
标题翻译：导线通讯系统及方法
公开(公告)号：US4902948A
公开(公告)日：1990-02-20
申请号：US214242
申请日：1988-07-01
申请人： Leigh E. Sherman , Gary L. Whatcott , Richard M. Dicks , David C. Madsen
发明人： Leigh E. Sherman , Gary L. Whatcott , Richard M. Dicks , David C. Madsen
IPC分类号： G05D1/02
CPC分类号： G05D1/0297 , G05D1/0265
摘要： A guidance system for guiding a plurality of unmanned vehicles along guide wires. A plurality of data communication circuits are provided which form an extensive network. A traffic control computer composes a coded vehicle instruction for assigning tasks and allocates resources to said unmanned vehicles. The traffic control computer polls the status of each vehicle at varying time intervals and receives a response from said vehicle.The network connecting the computer and the communication circuits prevents reception of data transmissions from more than one vehicle at a time. Other messages are temporarily stored.Data transmitters generate low frequency, low power signals which have a high data transmission rate.Digital data is converted at the transmitters into cosine waveforms of selected frequencies. The cosine waveforms are transposed into sine waveforms at receivers. Low impedance or high impedance characteristics are imposed upon the guide wires.A low frequency, high gain transmit antenna for each vehicle is prorated.
摘要翻译：一种用于沿导丝引导多个无人驾驶车辆的引导系统。提供形成广泛网络的多个数据通信电路。交通控制计算机构成用于分配任务的编码车辆指令，并向所述无人车辆分配资源。交通控制计算机以变化的时间间隔轮询每个车辆的状态并接收来自所述车辆的响应。连接计算机和通信电路的网络阻止一次从多于一个车辆接收数据传输。暂时存储其他消息。数据发射机产生具有高数据传输速率的低频，低功率信号。发射机将数字数据转换成所选频率的余弦波形。余弦波形在接收器处转换成正弦波形。引导线上施加低阻抗或高阻抗特性。每个车辆的低频，高增益发射天线是按比例分配的。

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