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1. 发明授权

US08859011B2 Calcium compositions 有权
标题翻译：钙组成
公开(公告)号：US08859011B2
公开(公告)日：2014-10-14
申请号：US11746832
申请日：2007-05-10
申请人： Denis Stotler , Steven R. Freebersyser , R. Saul Levinson
发明人： Denis Stotler , Steven R. Freebersyser , R. Saul Levinson
IPC分类号： A61K9/20 , A61K33/10 , A61K31/593 , A61K9/16 , A23L1/304 , A23L1/03 , A23L1/00
CPC分类号： A61K9/2059 , A23L29/015 , A23L33/16 , A23P10/25 , A23V2002/00 , A61K9/16 , A61K9/2027 , A61K33/10 , Y10S514/96 , A23V2250/1578 , A23V2250/7106
摘要： Compositions comprising calcium carbonate and processes for making such compositions are provided. The invention provides a granulation comprising about 95% to about 99% by weight calcium carbonate, about 0.5% to about 5% by weight of a binder and about 0.03% to about 3% by weight of a porosity increasing agent. A pharmaceutical or nutritional composition prepared from such a granulation comprises about 90% to about 99% by weight calcium carbonate, about 0.03% to about 3% by weight of a porosity increasing agent, and about 1% to about 10% by weight of other excipients. The composition provides a smaller tablet than conventional calcium carbonate compositions, for improved ease of swallowing.
摘要翻译：提供了包含碳酸钙的组合物及其制备方法。本发明提供了一种颗粒，其包含约95重量％至约99重量％的碳酸钙，约0.5重量％至约5重量％的粘合剂和约0.03重量％至约3重量％的孔隙率增加剂。由这种造粒剂制备的药物或营养组合物包含约90％至约99％重量的碳酸钙，约0.03％至约3％重量的孔隙率增加剂和约1％至约10％重量的其它赋形剂。组合物提供比常规碳酸钙组合物更小的片剂，以改善容易吞咽。

2. 发明申请

US20070264329A1 CALCIUM COMPOSITIONS 有权
标题翻译：钙组合物
公开(公告)号：US20070264329A1
公开(公告)日：2007-11-15
申请号：US11746832
申请日：2007-05-10
申请人： Denis Stotler , Steven R. Freebersyser , R. Saul Levinson
发明人： Denis Stotler , Steven R. Freebersyser , R. Saul Levinson
IPC分类号： A61K31/59 , A61K33/10 , A61K9/20 , B27N3/00
CPC分类号： A61K9/2059 , A23L29/015 , A23L33/16 , A23P10/25 , A23V2002/00 , A61K9/16 , A61K9/2027 , A61K33/10 , Y10S514/96 , A23V2250/1578 , A23V2250/7106
摘要： Compositions comprising calcium carbonate and processes for making such compositions are provided. The invention provides a granulation comprising about 95% to about 99% by weight calcium carbonate, about 0.5% to about 5% by weight of a binder and about 0.03% to about 3% by weight of a porosity increasing agent. A pharmaceutical or nutritional composition prepared from such a granulation comprises about 90% to about 99% by weight calcium carbonate, about 0.03% to about 3% by weight of a porosity increasing agent, and about 1% to about 10% by weight of other excipients. The composition provides a smaller tablet than conventional calcium carbonate compositions, for improved ease of swallowing.
摘要翻译：提供了包含碳酸钙的组合物及其制备方法。本发明提供了一种颗粒，其包含约95重量％至约99重量％的碳酸钙，约0.5重量％至约5重量％的粘合剂和约0.03重量％至约3重量％的孔隙率增加剂。由这种造粒制备的药物或营养组合物包含约90％至约99％重量的碳酸钙，约0.03％至约3％重量的孔隙率增加剂和约1％至约10％重量的其它赋形剂。组合物提供比常规碳酸钙组合物更小的片剂，以改善容易吞咽。

3. 发明授权

US4600579A N-acetyl-p-aminophenol compositions containing partially gelatinized starch and method for preparing same 失效
标题翻译：含有部分糊化淀粉的N-乙酰基对氨基苯酚组合物及其制备方法
公开(公告)号：US4600579A
公开(公告)日：1986-07-15
申请号：US502067
申请日：1983-06-07
申请人： Anil M. Salpekar , Steven R. Freebersyser , Douglas A. Robinson
发明人： Anil M. Salpekar , Steven R. Freebersyser , Douglas A. Robinson
IPC分类号： A61K9/20 , A61K31/165 , A61K47/38 , A61P25/04 , A61K31/16 , A61K31/70
CPC分类号： A61K9/2059 , A61K31/165 , A61K9/2095
摘要： An N-acetyl-p-aminophenol composition capable of being directly formed into a tablet having high hardness, short disintegration time and short dissolution time is disclosed. The composition includes N-acetyl-p-aminophenol, a pharmaceutically acceptable partially gelatinized starch, a pharmaceutically acceptable lubricant, water and optionally an auxiliary binder, an auxiliary disintegrant or both of these optional components. Also disclosed is a method for preparing the essential components (and optional components if desired) and spray drying the slurry.
摘要翻译：公开了能够直接形成具有高硬度，短崩解时间和短溶解时间的片剂的N-乙酰基对氨基苯酚组合物。组合物包括N-乙酰基对氨基苯酚，药学上可接受的部分糊化淀粉，药学上可接受的润滑剂，水和任选的辅助粘合剂，辅助崩解剂或这两种可选组分。还公开了制备基本组分（如果需要）和喷雾干燥浆料的方法。

4. 发明授权

US5306507A Process and composition containing pamabrom and pyrilamine maleate 失效
标题翻译：含有马来酸丙胺和吡拉明的方法和组合物
公开(公告)号：US5306507A
公开(公告)日：1994-04-26
申请号：US857822
申请日：1992-03-26
申请人： Steven R. Freebersyser
发明人： Steven R. Freebersyser
IPC分类号： A61K9/50 , A61K31/52 , A61K9/16
CPC分类号： A61K9/5073 , A61K31/52
摘要： A product and process for preparing a pharmaceutical composition for forming tablets, the composition containing pamabrom and pyrilamine maleate. In preferred embodiments, the composition also contains acetaminophen. A fluid bed granulator is charged with a first material containing pamabrom or pyrilamine maleate, and a first liquid containing pregelatinized starch is sprayed onto the first material so as to form a barrier coat. The barrier coated material is dried and then further coated with a second liquid containing only one of pamabrom and pyrilamine maleate, whichever was not present in the first material charged to the fluid bed granulator. The further coated material is then dried to a moisture content of from about 0.5% to less than about 2% by weight, so as to form particles in which the pamabrom and pyrilamine maleate are separated by the pregelatinized starch barrier.
摘要翻译：用于制备用于形成片剂的药物组合物的产品和方法，所述组合物含有马来酸马来酸马来酸和马来酸。在优选的实施方案中，组合物还含有对乙酰氨基酚。向流化床制粒机中装入含有马来酸马来酸或马来酸吡喃胺的第一种材料，并将含有预胶化淀粉的第一液体喷雾到第一种材料上以形成阻隔涂层。将阻隔涂层材料干燥，然后进一步用仅含有马来酸马来酸和马来酸吡哆醛之一的第二液体涂覆，以第一种材料中不存在的物质加入到流化床制粒机中。然后将另外的涂层材料干燥至约0.5重量％至小于约2重量％的水分含量，以便形成其中马来酸马来酸马来酸和吡喃胺类被预胶化淀粉屏障分离的颗粒。

5. 发明授权

US4496576A Compositions of p-hydroxybenzoic acid esters and methods of preparation and use 失效
标题翻译：对羟基苯甲酸酯的组成及其制备和使用方法
公开(公告)号：US4496576A
公开(公告)日：1985-01-29
申请号：US531064
申请日：1983-09-12
申请人： Donald F. Loncrini , Thomas E. Haag , Steven R. Freebersyser
发明人： Donald F. Loncrini , Thomas E. Haag , Steven R. Freebersyser
IPC分类号： A01N37/40 , A01N43/50 , A01N37/10
CPC分类号： A01N37/40 , A01N43/50
摘要： A composition having broad spectrum antimicrobial activity and being freeze and heat stable is comprised of a clear solution containing up to approximately 90% by weight of a eutectic mixture of three or more lower alkyl esters of p-hydroxybenzoic acid such as isopropyl p-hydroxybenzoate, isobutyl p-hydroxybenzoate and n-butyl p-hydroxybenzoate in a ratio between approximately 1:1:1 to 4:2:2, respectively, approximately 10% to 90% by weight of a "Glydant" solution (composed of 55% 1,3-bis(hydroxymethyl)-5,5-dimethylhydantoin and 45% water) and at least approximately 0.5% by weight based on the weight of the eutectic mixture and the "Glydant" solution of an anionic surfactant. The latter, for example, may be dioctyl sodium sulfosuccinate, sodium lauryl sulfate or the ammonium or sodium salt of sulfated nonylphenoxypoly(ethyleneoxy) ethanol.
摘要翻译：具有广谱抗微生物活性并具有冷冻和热稳定性的组合物由含有最多约90重量％的三羟
基苯甲酸的低级烷基酯如对羟基苯甲酸异丙酯的共晶混合物，对羟基苯甲酸异丁酯和对羟基苯甲酸正丁酯的比例分别为约1：1：1至4：2：2，约10％至90％重量的“Glydant”溶液（由55％1 ，3-双（羟甲基）-5,5-二甲基乙内酰脲和45％水）和至少约0.5重量％，基于阴离子表面活性剂的共晶混合物和“Glydant”溶液的重量。后者例如可以是二辛基磺基琥珀酸钠，月桂基硫酸钠或硫酸化壬基苯氧基聚（乙烯氧基）乙醇的铵盐或钠盐。

6. 发明授权

US4357258A Stable emulsions of p-hydroxybenzoic acid esters and method of preparation 失效
标题翻译：对羟基苯甲酸酯的稳定乳液及其制备方法
公开(公告)号：US4357258A
公开(公告)日：1982-11-02
申请号：US199718
申请日：1980-10-23
申请人： Thomas E. Haag , Steven R. Freebersyser , Donald F. Loncrini
发明人： Thomas E. Haag , Steven R. Freebersyser , Donald F. Loncrini
IPC分类号： C09K3/00 , A01N25/04 , A01N37/40 , B01F17/00 , B01F17/30 , B01F17/34 , B01F17/42 , B01J13/00
CPC分类号： B01F17/0057 , A01N25/04 , A01N37/40 , B01F17/0021 , B01F17/0028
摘要： A heat and freeze-thaw stable, oil-in-water emulsion is comprised of from approximately 10% to 60% by weight of a eutectic oil containing a mixture of three or more lower alkyl esters of p-hydroxybenzoic acid, from approximately 1.5% to 5.0% by weight of an emulsifying agent which may be gelatin, casein, collagen, glyceryl oleate, the ammonium or sodium salt of sulfated nonylphenoxypoly(ethyleneoxy) ethanol or mixtures thereof, from approximately 3% to 10% by weight of sorbitol and the balance water. The method of preparing such emulsions is also disclosed.
摘要翻译：热和冻融稳定的水包油乳液由约10重量％至60重量％的含有三个或更多个对羟基苯甲酸的低级烷基酯的混合物的共晶油，约1.5重量％至5.0重量％的乳化剂，其可以是明胶，酪蛋白，胶原，油酸甘油酯，硫酸壬基苯氧基聚（乙烯氧基）乙醇或其混合物的铵盐或钠盐，约3重量％至10重量％的山梨醇，平衡水。还公开了制备这种乳液的方法。

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