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1. 发明授权

US06677301B1 Truncated keratinocyte growth factor (KGF) having increased biological activity 失效
标题翻译：截短的角质形成细胞生长因子（KGF）具有增加的生物活性
公开(公告)号：US06677301B1
公开(公告)日：2004-01-13
申请号：US09573068
申请日：2000-05-16
申请人： Denis J. Gospodarowicz , Frank R. Masiarz
发明人： Denis J. Gospodarowicz , Frank R. Masiarz
IPC分类号： C07K1448
CPC分类号： C07K14/50 , A61K38/00 , A61K47/6415 , A61K47/642
摘要： The present invention relates to a keratinocyte growth factor fragment, KGFdes1-23, or an analog thereof that is composed of a portion of an amino acid sequence of mature, full length keratinocyte growth factor, KGF163. The fragment exhibits at least a 2-fold increase in mitogenic activity as compared to a mature, recombinant keratinocyte growth factor, rKGF, but lacks a sequence comprising the first 23 amino acid residues. C-N-D-M-T-P-E-Q-M-A-T-N-V-N-C-S-S-P-E-R-H-T-R- (SEQ ID NO: 2) of the KGF163 N-terminus. The present invention also relates to a DNA molecule encoding KGFdes1-23, an expression vector and a transformed host containing the DNA molecule, and a method of producing KGFdes1-23 by culturing the transformed host. The present invention further relates to a conjugate of KGFdes1-23 and a toxin molecule, and the use thereof for treatment of hyperproliferative disease of the epidermis. Moreover, the present invention relates to a therapeutic composition containing KGFdes1-23 and a pharmaceutically acceptable carrier and the use thereof for wound healing purposes.
摘要翻译：本发明涉及由成熟的全长角质形成细胞生长因子KGF163的氨基酸序列的一部分组成的角质形成细胞生长因子片段KGFdes1-23或其类似物。与成熟的重组角质形成细胞生长因子rKGF相比，该片段显示出促有丝分裂活性的至少2倍的增加，但是缺少包含前23个氨基酸残基的序列。 C-N-D-M-T-P-E-Q-M-A-T-N-V-N-C-S-S-P-E-R-H-T-R-（SEQ ID NO：2）。本发明还涉及编码KGFdes1-23的DNA分子，表达载体和含有DNA分子的转化宿主，以及通过培养转化的宿主生产KGFdes1-23的方法。本发明还涉及KGFdes1-23与毒素分子的结合物及其用于治疗表皮的过度增殖性疾病的用途。此外，本发明涉及含有KGFdes1-23和药学上可接受的载体的治疗组合物及其用于伤口愈合目的的用途。

2. 发明申请

US20090093400A1 Truncated keratinocyte growth factor (KGF) having increased biological activity 审中-公开
标题翻译：截短的角质形成细胞生长因子（KGF）具有增加的生物活性
公开(公告)号：US20090093400A1
公开(公告)日：2009-04-09
申请号：US11811560
申请日：2007-06-11
申请人： Denis J. Gospodarowicz , Frank R. Masiarz
发明人： Denis J. Gospodarowicz , Frank R. Masiarz
IPC分类号： A61K38/18 , C07K14/475 , C07K16/22 , C07H21/00 , C12N1/21 , C12P21/02
CPC分类号： C07K14/50 , A61K38/00 , A61K47/6415 , A61K47/642
摘要： The present invention relates to a keratinocyte growth factor fragment, KGFdes1-23, or an analog thereof that is composed of a portion of an amino acid sequence of mature, full length keratinocyte growth factor, KGF163. The fragment exhibits at least a 2-fold increase in mitogenic activity as compared to a mature, recombinant keratinocyte growth factor, rKGF, but lacks a sequence comprising the first 23 amino acid residues; C-N-D-M-T-P-E-Q-M-A-T-N-V-N-C-S-S-P-E-R-H-T-R- (SEQ ID NO: 2) of the KGF163 N-terminus. The present invention also relates to a DNA molecule encoding KGFdes1-23, an expression vector and a transformed host containing the DNA molecule, and a method of producing KGFdes1-23 by culturing the transformed host. The present invention further relates to a conjugate of KGFdes1-23 and a toxin molecule, and the use thereof for treatment of hyperproliferative disease of the epidermis. Moreover, the present invention relates to a therapeutic composition containing KGFdes1-23 and a pharmaceutically acceptable carrier and the use thereof for wound healing purposes.
摘要翻译：本发明涉及由成熟的全长角质形成细胞生长因子KGF163的氨基酸序列的一部分组成的角质形成细胞生长因子片段KGFdes1-23或其类似物。与成熟的重组角质形成细胞生长因子rKGF相比，该片段表现出促有丝分裂活性的至少2倍的增加，但缺少包含前23个氨基酸残基的序列; C-N-D-M-T-P-E-Q-M-A-T-N-V-N-C-S-S-P-E-R-H-T-R-（SEQ ID NO：2）。本发明还涉及编码KGFdes1-23的DNA分子，表达载体和含有DNA分子的转化宿主，以及通过培养转化的宿主生产KGFdes1-23的方法。本发明还涉及KGFdes1-23与毒素分子的结合物及其用于治疗表皮的过度增殖性疾病的用途。此外，本发明涉及含有KGFdes1-23和药学上可接受的载体的治疗组合物及其用于伤口愈合目的的用途。

3. 发明授权

US07247452B2 Truncated keratinocyte growth factor (KGF) having increased biological activity 失效
标题翻译：截短的角质形成细胞生长因子（KGF）具有增加的生物活性
公开(公告)号：US07247452B2
公开(公告)日：2007-07-24
申请号：US10998425
申请日：2004-11-29
申请人： Denis J. Gospodarowicz , Frank R. Masiarz
发明人： Denis J. Gospodarowicz , Frank R. Masiarz
IPC分类号： C12N15/19 , C12N1/21 , C12N5/10 , C12N15/66 , C07K14/475
CPC分类号： C07K14/50 , A61K38/00 , A61K47/6415 , A61K47/642
摘要： The present invention relates to a keratinocyte growth factor fragment, KGFdes1-23, or an analog thereof that is composed of a portion of an amino acid sequence of mature, full length keratinocyte growth factor, KGF163. The fragment exhibits at least a 2-fold increase in mitogenic activity as compared to a mature, recombinant keratinocyte growth factor, rKGF, but lacks a sequence comprising the first 23 amino acid residues, C-N-D-M-T-P-E-Q-M-A-T-N-V-N-C-S-S-P-E-R-H-T-R- (SEQ ID NO: 2) of the KGF163 N-terminus. The present invention also relates to a DNA molecule encoding KGFdes1-23, an expression vector and a transformed host containing the DNA molecule, and a method of producing KGFdes1-23 by culturing the transformed host. The present invention further relates to a conjugate of KGFdes1-23 and a toxin molecule, and the use thereof for treatment of hyperproliferative disease of the epidermis. Moreover, the present invention relates to a therapeutic composition containing KGFdes1-23 and a pharmaceutically acceptable carrier and the use thereof for wound healing purposes.
摘要翻译：本发明涉及由成熟的全长角质形成细胞生长因子的一部分氨基酸序列组成的角质形成细胞生长因子片段，KGF 或其类似物，KGF _{163 。与成熟的重组角质形成细胞生长因子rKGF相比，该片段显示出促有丝分裂活性的至少2倍的增加，但是缺少包含前23个氨基酸残基的序列CNDMTPEQMATNVNCSSPERH-TR-（SEQ ID NO：2） KGF 163 N末端。本发明还涉及编码KGF Sub1-23的DNA分子，表达载体和含有该DNA分子的转化宿主，以及生产KGF 通过培养转化的宿主。本发明进一步涉及一种KGF Sub1.33和毒素分子的缀合物及其用于治疗表皮过度增殖性疾病的用途。此外，本发明涉及含有KGF和其药学上可接受的载体的治疗组合物及其用于伤口愈合目的的用途。}

4. 发明授权

US07084119B2 Truncated keratinocyte growth factor (KGF) having increased biological activity 失效
标题翻译：截短的角质形成细胞生长因子（KGF）具有增加的生物活性
公开(公告)号：US07084119B2
公开(公告)日：2006-08-01
申请号：US10700653
申请日：2003-11-04
申请人： Denis J. Gospodarowicz , Frank R. Masiarz
发明人： Denis J. Gospodarowicz , Frank R. Masiarz
IPC分类号： A61K38/18 , C07K14/475
CPC分类号： C07K14/50 , A61K38/00 , A61K47/6415 , A61K47/642
摘要： The present invention relates to a keratinocyte growth factor fragment, KGFdes1-23, or an analog thereof that is composed of a portion of an amino acid sequence of mature, full length keratinocyte growth factor, KGF163. The fragment exhibits at least a 2-fold increase in mitogenic activity as compared to a mature, recombinant keratinocyte growth factor, rKGF, but lacks a sequence comprising the first 23 amino acid residues; C-N-D-M-T-P-E-Q-M-A-T-N-V-N-C-S-S-P-E-R-H-T-R- (SEQ ID NO: 2) of the KGF163 N-terminus. The present invention also relates to a DNA molecule encoding KGFdes1-23, an expression vector and a transformed host containing the DNA molecule, and a method of producing KGFdes1-23 by culturing the transformed host. The present invention further relates to a conjugate of KGFdes1-23 and a toxin molecule, and the use thereof for treatment of hyperproliferative disease of the epidermis. Moreover, the present invention relates to a therapeutic composition containing KGFdes1-23 and a pharmaceutically acceptable carrier and the use thereof for wound healing purposes.
摘要翻译：本发明涉及由成熟的全长角质形成细胞生长因子的一部分氨基酸序列组成的角质形成细胞生长因子片段KGF 或其类似物，KGF _{163 。与成熟的重组角质形成细胞生长因子rKGF相比，该片段表现出促有丝分裂活性的至少2倍的增加，但缺少包含前23个氨基酸残基的序列; C-N-D-M-T-P-E-Q-M-A-T-N-V-N-C-S-S-P-E-R-H-T-R-（SEQ ID NO：2）。本发明还涉及编码KGF Sub1-23的DNA分子，表达载体和含有该DNA分子的转化宿主，以及生产KGF 通过培养转化的宿主。本发明进一步涉及一种KGF Sub1.33和毒素分子的缀合物及其用于治疗表皮过度增殖性疾病的用途。此外，本发明涉及含有KGF和其药学上可接受的载体的治疗组合物及其用于伤口愈合目的的用途。}

5. 发明授权

US6074848A Truncated keratinocyte growth factor (KGF) having increased biological activity 失效
标题翻译：截短的角质形成细胞生长因子（KGF）具有增加的生物活性
公开(公告)号：US6074848A
公开(公告)日：2000-06-13
申请号：US74950
申请日：1998-05-08
申请人： Denis J. Gospodarowicz , Frank R. Masiarz
发明人： Denis J. Gospodarowicz , Frank R. Masiarz
IPC分类号： C12N15/09 , A61K38/00 , A61K38/18 , A61K38/22 , A61K47/48 , A61P35/00 , A61P43/00 , C07H21/04 , C07K14/47 , C07K14/50 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/12 , C12N15/19 , C12P21/02 , C12R1/19 , C12R1/91 , C12N15/66
CPC分类号： C07K14/50 , A61K47/48261 , A61K47/48269 , A61K38/00
摘要： The present invention relates to keratinocyte growth factor fragment, KGF.sub.des1-23, or an analog thereof that is composed of a portion of an amino acid sequence of mature, full length keratinocyte growth factor, KGF.sub.163. The fragment exhibits at least a 2-fold increase in mitogenic activity as compared to a mature, recombinant keratonocyte growth factor, rKGF, but lacks a sequence comprising the first 23 amino acid residues, C-N-D-M-T-P-E-Q-M-A-T-N-V-N-C-S-S-P-E-R-H-T-R-(SEQ ID NO: 2) of the KGF.sub.163 N-terminus. The present invention also relates to a DNA molecule encoding KGF.sub.des1-23, an expression vector and a transformed host containing the DNA molecule, and a method of producing KGF.sub.des1-23 by culturing the transformed host. The present invention further relates to a conjugate of KGF.sub.des1-23 and a toxin molecule, and the use thereof for treatment of hyperproliferative disease of the epidermis. Moreover, the present invention relates to a therapeutic composition containing KGF.sub.des1-23 and a pharmaceutically acceptable carrier and the use thereof for wound healing purposes.
摘要翻译：本发明涉及由成熟的全长角质形成细胞生长因子KGF163的一部分氨基酸序列组成的角质形成细胞生长因子片段KGFdes1-23或其类似物。与成熟的重组角质细胞生长因子rKGF相比，该片段显示出促有丝分裂活性的至少2倍的增加，但是缺少包含前23个氨基酸残基的序列CNDMTPEQMATNVNCSSPERH-TR-（SEQ ID NO：2） KGF163 N末端。本发明还涉及编码KGFdes1-23的DNA分子，表达载体和含有DNA分子的转化宿主，以及通过培养转化的宿主生产KGFdes1-23的方法。本发明还涉及KGFdes1-23与毒素分子的结合物及其用于治疗表皮的过度增殖性疾病的用途。此外，本发明涉及含有KGFdes1-23和药学上可接受的载体的治疗组合物及其用于伤口愈合目的的用途。

6. 发明授权

US5863767A Truncated keratinocyte growth factor (KGF) having increased biological activity 失效
标题翻译：截短的角质形成细胞生长因子（KGF）具有增加的生物活性
公开(公告)号：US5863767A
公开(公告)日：1999-01-26
申请号：US467937
申请日：1995-06-06
申请人： Denis J. Gospodarowicz , Frank R. Masiarz
发明人： Denis J. Gospodarowicz , Frank R. Masiarz
IPC分类号： C12N15/09 , A61K38/00 , A61K38/18 , A61K38/22 , A61K47/48 , A61P35/00 , A61P43/00 , C07H21/04 , C07K14/47 , C07K14/50 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/12 , C12N15/19 , C12P21/02 , C12R1/19 , C12R1/91 , C07K14/475 , C12N15/63
CPC分类号： C07K14/50 , A61K47/48261 , A61K47/48269 , A61K38/00
摘要： The present invention relates to a keratinocyte growth factor fragment, KGF.sub.des1-23, or an analog thereof that is composed of a portion of an amino acid sequence of mature, full length keratinocyte growth factor, KGF.sub.163. The fragment exhibits at least a 2-fold increase in mitogenic activity as compared to a mature, recombinant keratinocyte growth factor, rKGF, but lacks a sequence comprising the first 23 amino acid residues, C-N-D-M-T-P-E-Q-M-A-T-N-V-N-C-S-S-P-E-R-H-T-R- (SEQ ID NO: 2) of the KGF.sub.163 N-terminus. The present invention also relates to a DNA molecule encoding KGF.sub.des1-23, an expression vector and a transformed host containing the DNA molecule, and a method of producing KGF.sub.des1-23 by culturing the transformed host. The present invention further relates to a conjugate of KGF.sub.des1-23 and a toxin molecule, and the use thereof for treatment of hyperproliferative disease of the epidermis. Moreover, the present invention relates to a therapeutic composition containing KGF.sub.des1-23 and a pharmaceutically acceptable carrier and the use thereof for wound healing purposes.
摘要翻译：本发明涉及由成熟的全长角质形成细胞生长因子KGF163的氨基酸序列的一部分组成的角质形成细胞生长因子片段KGFdes1-23或其类似物。与成熟的重组角质形成细胞生长因子rKGF相比，该片段显示出促有丝分裂活性的至少2倍的增加，但是缺少包含前23个氨基酸残基的序列CNDMTPEQMATNVNCSSPERH-TR-（SEQ ID NO：2） KGF163 N末端。本发明还涉及编码KGFdes1-23的DNA分子，表达载体和含有DNA分子的转化宿主，以及通过培养转化的宿主生产KGFdes1-23的方法。本发明还涉及KGFdes1-23与毒素分子的结合物及其用于治疗表皮的过度增殖性疾病的用途。此外，本发明涉及含有KGFdes1-23和药学上可接受的载体的治疗组合物及其用于伤口愈合目的的用途。

7. 发明授权

US5843883A Methods of wound healing and treating hyperproliferative diseases of epidermis comprising administering trunicated keratinocyte growh factor (KGF) having increased biological activity 失效
标题翻译：伤口愈合方法及治疗表皮增生性疾病的方法，包括给予具有增加的生物学活性的穿孔角化细胞生长因子（KGF）
公开(公告)号：US5843883A
公开(公告)日：1998-12-01
申请号：US468547
申请日：1995-06-06
申请人： Denis J. Gospodarowicz , Frank R. Masiarz
发明人： Denis J. Gospodarowicz , Frank R. Masiarz
IPC分类号： C12N15/09 , A61K38/00 , A61K38/18 , A61K38/22 , A61K47/48 , A61P35/00 , A61P43/00 , C07H21/04 , C07K14/47 , C07K14/50 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/12 , C12N15/19 , C12P21/02 , C12R1/19 , C12R1/91 , A61K38/16
CPC分类号： C07K14/50 , A61K47/48261 , A61K47/48269 , A61K38/00
摘要： The present invention relates to a keratiniocyte growth factor fragment, KGF.sub.des1-23, or an analog thereof that is composed of a portion of an amino acid sequence of mature, full length keratinlocyte growth factor, KGF.sub.163. The fragment exhibits at least a 2-fold increase in mitogenic activity as compared to a mature, recombinant keratinocyte growth factor, rKGF, but lacks a sequence comprising the first 23 amino acid residues, C-N-D-M-T-P-E-Q-M-A-T-N-V-N-C-S-S-P-E-R-H-T-R- (SEQ ID NO: 2) of the KGF.sub.163 N-terminus. The present invention also relates to a DNA molecule encoding KGF.sub.des1-23, an expression vector and a transformed host containing the DNA molecule, and a method of producing KGF.sub.des1-23 by culturing the transformed host. The present invention further relates to a conjugate of KGF.sub.des1-23 and a toxin molecule, and the use thereof for treatment of hyperproliferative disease of the epidermis. Moreover, the present invention relates to a therapeutic composition containing KGF.sub.des1-23 and a pharmaceutically acceptable carrier and the use thereof for wound healing purposes.
摘要翻译：本发明涉及由成熟的全长角质形成细胞生长因子KGF163的一部分氨基酸序列组成的角质形成细胞生长因子片段KGFdes1-23或其类似物。与成熟的重组角质形成细胞生长因子rKGF相比，该片段显示出促有丝分裂活性的至少2倍的增加，但是缺少包含前23个氨基酸残基的序列CNDMTPEQMATNVNCSSPERH-TR-（SEQ ID NO：2） KGF163 N末端。本发明还涉及编码KGFdes1-23的DNA分子，表达载体和含有DNA分子的转化宿主，以及通过培养转化的宿主生产KGFdes1-23的方法。本发明还涉及KGFdes1-23与毒素分子的结合物及其用于治疗表皮的过度增殖性疾病的用途。此外，本发明涉及含有KGFdes1-23和药学上可接受的载体的治疗组合物及其用于伤口愈合目的的用途。

8. 发明授权

US5773586A Conjugates comprising truncated keratinocyte growth factor (KGF) having increased biological activity and a toxin 失效
标题翻译：包含具有增加的生物活性的截短的角化细胞生长因子（KGF）和毒素的缀合物
公开(公告)号：US5773586A
公开(公告)日：1998-06-30
申请号：US468546
申请日：1995-06-06
申请人： Denis J. Gospodarowicz , Frank R. Masiarz
发明人： Denis J. Gospodarowicz , Frank R. Masiarz
IPC分类号： C12N15/09 , A61K38/00 , A61K38/18 , A61K38/22 , A61K47/48 , A61P35/00 , A61P43/00 , C07H21/04 , C07K14/47 , C07K14/50 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/12 , C12N15/19 , C12P21/02 , C12R1/19 , C12R1/91 , C07K14/475 , C12N15/00
CPC分类号： C07K14/50 , A61K47/48261 , A61K47/48269 , A61K38/00
摘要： The present invention relates to a keratinocyte growth factor fragment, KGF.sub.des1-23, or an analog thereof that is composed of a portion of an amino acid sequence of mature, full length keratinocyte growth factor, KGF.sub.163. The fragment exhibits at least a 2-fold increase in mitogenic activity as compared to a mature, recombinant keratinocyte growth factor, rKGF, but lacks i sequence comprising the first 23 amino acid residues, C-N-D-M-T-P-E-Q-M-A-T-N-V-N-C-S-S-P-E-R-H-T-R-(SEQ ID NO: 2) of the KGF.sub.163 N-terminus. The present invention also relates to a DNA molecule encoding KGF.sub.des1-23, an expression vector and a transformed host containing the DNA molecule, and a method of producing KGF.sub.des1-23 by culturing the transformed host The present invention further relates to a conjugate of KGF.sub.des1-23 and a toxin molecule, and the use thereof for treatment of hyperproliferative disease of the epidermis. Moreover, the present invention relates to a therapeutic composition containing KGF.sub.des1-23 and a pharmaceutically acceptable carrier and the use thereof for wound healing purposes.
摘要翻译：本发明涉及由成熟的全长角质形成细胞生长因子KGF163的氨基酸序列的一部分组成的角质形成细胞生长因子片段KGFdes1-23或其类似物。与成熟的重组角质形成细胞生长因子rKGF相比，该片段显示出促有丝分裂活性的至少2倍的增加，但是缺乏包含前23个氨基酸残基的C序列CNDMTPEQMATNVNCSSPERH-TR-（SEQ ID NO：2） KGF163 N末端。本发明还涉及编码KGFdes1-23的DNA分子，表达载体和含有该DNA分子的转化宿主，以及通过培养转化的宿主生产KGFdes1-23的方法本发明还涉及KGFdes1- 23和毒素分子，以及其用于治疗表皮的过度增殖性疾病的用途。此外，本发明涉及含有KGFdes1-23和药学上可接受的载体的治疗组合物及其用于伤口愈合目的的用途。

9. 发明授权

US5677278A Truncated keratinocyte growth factor (KGF) having increased biological activity 失效
标题翻译：截短的角质形成细胞生长因子（KGF）具有增加的生物活性
公开(公告)号：US5677278A
公开(公告)日：1997-10-14
申请号：US410941
申请日：1995-03-27
申请人： Denis J. Gospodarowicz , Frank R. Masiarz
发明人： Denis J. Gospodarowicz , Frank R. Masiarz
IPC分类号： C12N15/09 , A61K38/00 , A61K38/18 , A61K38/22 , A61K47/48 , A61P35/00 , A61P43/00 , C07H21/04 , C07K14/47 , C07K14/50 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/12 , C12N15/19 , C12P21/02 , C12R1/19 , C12R1/91 , C07K14/475
CPC分类号： C07K14/50 , A61K47/48261 , A61K47/48269 , A61K38/00
摘要： The present invention relates to a keratinocyte growth factor fragment, KGF.sub.des1-23, or an analog thereof that is composed of a portion of an amino acid sequence of mature, full length keratinocyte growth factor, KGF.sub.163. The fragment exhibits at least a 2-fold increase in mitogenic activity as compared to a mature, recombinant keratinocyte growth factor, rKGF, but lacks a sequence comprising the first 23 amino acid residues, C-N-D-M-T-P-E-Q-M-A-T-N-V-N-C-S-S-P-E-R-H-T-R- (SEQ ID NO: 2) of the KGF.sub.163 N-terminus. The present invention also relates to a DNA molecule encoding KGF.sub.des1-23, an expression vector and a transformed host containing the DNA molecule, and a method of producing KGF.sub.des1-23 by culturing the transformed host. The present invention further relates to a conjugate of KGF.sub.des1-23 and a toxin molecule, and the use thereof for treatment of hyperproliferative disease of the epidermis. Moreover, the present invention relates to a therapeutic composition containing KGF.sub.des1-23 and a pharmaceutically acceptable carrier and the use thereof for wound healing purposes.
摘要翻译：本发明涉及由成熟的全长角质形成细胞生长因子KGF163的氨基酸序列的一部分组成的角质形成细胞生长因子片段KGFdes1-23或其类似物。与成熟的重组角质形成细胞生长因子rKGF相比，该片段显示出促有丝分裂活性的至少2倍的增加，但缺少包含前23个氨基酸残基CNDMTPEQMATNVNCSSPERH-TR-（SEQ ID NO：2）的序列 KGF163 N末端。本发明还涉及编码KGFdes1-23的DNA分子，表达载体和含有DNA分子的转化宿主，以及通过培养转化的宿主生产KGFdes1-23的方法。本发明还涉及KGFdes1-23与毒素分子的结合物及其用于治疗表皮的过度增殖性疾病的用途。此外，本发明涉及含有KGFdes1-23和药学上可接受的载体的治疗组合物及其用于伤口愈合目的的用途。

10. 发明授权

US07265089B2 KGF polypeptide compositions 失效
标题翻译： KGF多肽组合物
公开(公告)号：US07265089B2
公开(公告)日：2007-09-04
申请号：US10227185
申请日：2002-08-21
申请人： Denis J. Gospodarowicz , W. Michael Kavanaugh , Kenneth Crawford
发明人： Denis J. Gospodarowicz , W. Michael Kavanaugh , Kenneth Crawford
IPC分类号： A61K38/18 , C07K14/475
CPC分类号： C07K14/50 , A61K38/1825
摘要： Compositions comprising keratinocyte growth factor (KGF) polypeptides and methods of using the same are described. The KGF polypeptides of the present invention display enhanced bioactivity relative to full-length KGF163. Accordingly, the KGF polypeptides of the present invention may be used in compositions in lesser amounts than would be necessary using KGF163.
摘要翻译：描述了包含角质形成细胞生长因子（KGF）多肽的组合物及其使用方法。本发明的KGF多肽相对于全长KGF 163显示增强的生物活性。因此，本发明的KGF多肽可以以比使用KGF 163的必需量少的组合物使用。

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