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1. 发明申请

US20200015786A1 METHOD FOR GENERATING AN ENHANCED IMAGE OF A VOLUME OF TISSUE 审中-公开
公开(公告)号：US20200015786A1
公开(公告)日：2020-01-16
申请号：US16368986
申请日：2019-03-29
申请人： Delphinus Medical Technologies, Inc.
发明人： Nebojsa Duric , Peter LITTRUP , Cuiping LI
IPC分类号： A61B8/08 , A61B8/00 , G06T5/00 , A61B8/14 , A61B8/15
摘要： A method and system for generating an enhanced image of a volume of tissue, comprising: emitting acoustic waveforms toward the volume of tissue; detecting acoustic signals derived from acoustic waveforms interacting with the volume of tissue; generating a reflection rendering of a region of the volume of tissue; generating at least one of a sound speed map and an attenuation map of the region of the volume of tissue; generating a transfer map derived from a set of sound speed parameter values of the sound speed map and/or a set of acoustic attenuation parameter values of the acoustic attenuation map, the set of sound speed parameter values and the set of acoustic attenuation parameters associated with the set of elements of the region of the volume of tissue; and rendering an enhanced image of the volume of tissue, derived from processing of the reflection rendering with the transfer map.

2. 发明授权

US10368831B2 Waveform enhanced reflection and margin boundary characterization for ultrasound tomography 有权
公开(公告)号：US10368831B2
公开(公告)日：2019-08-06
申请号：US15829748
申请日：2017-12-01
申请人： Delphinus Medical Technologies, Inc.
发明人： Nebojsa Duric , Peter J. Littrup , Gursharan Singh Sandhu , Mark Krycia , Mark Sak
IPC分类号： A61B8/13 , A61B8/08 , A61B8/00 , G06T5/00 , A61B8/15
摘要： The present invention provides improved methods and systems for generating enhanced images of a volume of tissue. In an aspect, the method comprises receiving from a transducer, a plurality of acoustic signals derived from acoustic waveforms transmitted through the volume of tissue; generating from the acoustic signals, a first reflection rendering that characterizes sound reflection, the first reflection rendering comprising a first distribution of reflection values across a region of the volume of tissue; generating from the acoustic signals, a sound speed rendering that characterizes sound speed, the sound speed rendering comprising a distribution of sound speed values across the region; generating from the sound speed rendering, a second reflection rendering that characterizes sound reflection, the second reflection rendering comprising a second distribution of reflection values across the region; and rendering one or more combined images, based on the first reflection rendering and the second reflection rendering.

3. 发明申请

US20130303895A1 System and Method for Performing an Image-Guided Biopsy 审中-公开
标题翻译：执行图像导向活检的系统和方法
公开(公告)号：US20130303895A1
公开(公告)日：2013-11-14
申请号：US13894202
申请日：2013-05-14
申请人： Delphinus Medical Technologies, Inc.
发明人： Peter John Littrup , Nebojsa Duric , Gerrit Lee Littrup
IPC分类号： A61B19/00
CPC分类号： A61B34/20 , A61B8/0825 , A61B8/0841 , A61B8/403 , A61B8/406 , A61B17/3403 , A61B90/17 , A61B2017/3411 , A61B2017/3413
摘要： A system and method for performing an image-guided biopsy of a target mass of a volume of tissue comprising: a transducer array comprising a set of ultrasound emitters and a set of ultrasound receivers configured to generate a set of acoustic data based upon acoustic waveforms received from the volume of tissue, wherein the transducer array is configured to enable determination of a location of the target mass based on the set of acoustic data; a base proximate to the transducer array; a fixation plate coupled to the base and cooperating with the base and the transducer array to at least partially define an adjustable receiving space configured to receive the volume of tissue; and a guiding module coupled to the base and comprising an aperture configured to align a biopsy tool with the location of the target mass.
摘要翻译：一种用于对组织体积的目标质量进行图像引导的活组织检查的系统和方法，包括：包括一组超声波发射器的一组换能器阵列和被配置成基于所接收的声波产生一组声学数据的一组超声波接收器其中所述换能器阵列被配置为能够基于所述声学数据集合来确定所述目标质量块的位置; 靠近换能器阵列的基座; 耦合到所述基座并与所述基座和所述换能器阵列配合的固定板，以至少部分地限定被配置为接收所述体积的组织的可调节接收空间; 以及引导模块，其联接到所述基座并且包括孔，所述孔被配置为将活检工具与所述目标块的位置对准。

4. 发明授权

US10231696B2 Method of characterizing tissue of a patient 有权
公开(公告)号：US10231696B2
公开(公告)日：2019-03-19
申请号：US15731000
申请日：2017-10-12
申请人： Delphinus Medical Technologies, Inc.
发明人： Nebojsa Duric , Peter John Littrup
IPC分类号： A61B8/08 , A61B8/00 , G06T7/00 , G06F19/00 , A61B8/06
摘要： A method for characterizing tissue of a patient, including receiving acoustic data derived from the interaction between the tissue and the acoustic waves irradiating the tissue; generating a morphology rendering of the tissue from the acoustic data, in which the rendering represents at least one biomechanical property of the tissue; determining a prognostic parameter for a region of interest in the rendering, in which the prognostic parameter incorporates the biomechanical property; and analyzing the prognostic parameter to characterize the region of interest. In some embodiment, the method further includes introducing a contrast agent into the tissue; generating a set of enhanced morphology renderings of the tissue after introducing the contrast agent; determining an enhanced prognostic parameter from the enhanced morphology renderings; and analyzing the enhanced prognostic parameter.

5. 发明申请

US20160030000A1 ULTRASOUND WAVEFORM TOMOGRAPHY METHOD AND SYSTEM 审中-公开
标题翻译：超声波波形图法和系统
公开(公告)号：US20160030000A1
公开(公告)日：2016-02-04
申请号：US14817470
申请日：2015-08-04
申请人： Delphinus Medical Technologies, Inc.
发明人： Gursharan Singh Sandhu , Cuiping Li , Olivier Roy , Steven Schmidt , Nebojsa Duric
IPC分类号： A61B8/15 , A61B8/08 , A61B8/00
CPC分类号： A61B8/15 , A61B8/0825 , A61B8/4494 , A61B8/5207 , G06T11/006 , G06T2211/424
摘要： A method and system for generating an enhanced image of a volume of tissue, the method comprising: emitting acoustic waveforms toward the volume of tissue; detecting a set of acoustic signals derived from acoustic waveforms interacting with the volume of tissue; generating, from the set of acoustic signals, an initial model representing a distribution of an acoustomechanical parameter across a region of the volume of tissue; extracting a set of frequency components, from the set of acoustic signals; generating a first simulated wavefield with a first frequency component of the set of frequency components; generating an updated model of the initial model with the first simulated wavefield; iteratively refining the updated model with a set of simulated wavefields associated with the set of frequency components until a threshold condition is satisfied, thereby producing a final model; and generating the enhanced image from the final model of the volume of tissue.
摘要翻译：一种用于产生组织体积的增强图像的方法和系统，所述方法包括：向所述组织体积发射声波形; 检测从与组织体积相互作用的声波导出的一组声信号; 从所述声学信号集合生成表示组织体积的区域上的声学参数分布的初始模型; 从所述一组声信号中提取一组频率分量; 产生具有所述一组频率分量的第一频率分量的第一模拟波场; 用第一个模拟波场生成初始模型的更新模型; 使用与该组频率分量相关联的一组模拟波场迭代地更新更新的模型，直到满足阈值条件，从而产生最终模型; 并从组织体积的最终模型生成增强图像。

6. 发明申请

US20150359508A1 METHOD OF CHARACTERIZING THE PATHOLOGICAL RESPONSE OF TISSUE TO A TREATMENT PLAN 审中-公开
标题翻译：表征治疗方案组织病理学反应的方法
公开(公告)号：US20150359508A1
公开(公告)日：2015-12-17
申请号：US14835349
申请日：2015-08-25
申请人： Delphinus Medical Technologies, Inc.
发明人： Peter John Littrup , Nebojsa Duric
IPC分类号： A61B8/08 , A61B8/00 , A61B5/00
CPC分类号： A61B8/085 , A61B5/4312 , A61B5/4848 , A61B8/0825 , A61B8/0833 , A61B8/406 , A61B8/461 , A61B8/466 , A61B8/469 , A61B8/483 , A61B8/5207 , A61B8/5223 , A61B8/5238 , G06T7/0014 , G06T2207/10136 , G06T2207/30068
摘要： A method of characterizing the pathological response of tissue to a treatment plan, including: obtaining a set of sequential morphology renderings of the tissue, wherein each rendering corresponds to a particular point in time during the treatment plan; generating a set of representative values of a biomechanical property of the tissue for the set of renderings, wherein each representative value is based on a corresponding rendering; determining a trend of the biomechanical property based on the set of representative values; and predicting response of the tissue to the treatment plan based on the trend of the biomechanical property.
摘要翻译：一种表征组织对治疗计划的病理反应的方法，包括：获得组织的一系列连续形态呈现，其中每个呈现对应于治疗计划期间的特定时间点; 生成用于所述一组渲染的所述组织的生物力学属性的一组代表值，其中每个代表值基于相应的呈现; 基于一组代表性值确定生物力学性质的趋势; 并根据生物力学性质的趋势预测组织对治疗计划的反应。

7. 发明申请

US20130204137A1 Method and System for Denoising Acoustic Travel Times and Imaging a Volume of Tissue 审中-公开
标题翻译：去噪声旅行时间的方法和系统和成像体积的组织
公开(公告)号：US20130204137A1
公开(公告)日：2013-08-08
申请号：US13756864
申请日：2013-02-01
申请人： DELPHINUS MEDICAL TECHNOLOGIES, INC.
发明人： Olivier Roy , Cuiping Li , Nebojsa Duric
IPC分类号： A61B8/15
CPC分类号： A61B8/15 , A61B8/0825 , A61B8/406 , A61B8/5207 , A61B8/5269 , G01S7/52077 , G01S15/8922 , G01S15/8977
摘要： A method and system for denoising acoustic travel times and imaging a volume of tissue comprising receiving a dataset representative of acoustic waveforms originating from an array of ultrasound emitters and received with an array of ultrasound receivers; for each ultrasound emitter in the array of ultrasound emitters, forming an empirical relative travel time matrix, from the dataset, including a set of relative empirical travel times, each relative empirical travel time corresponding to a pair of ultrasound receivers receiving an acoustic waveform, generating a denoised empirical relative travel time matrix, and extracting a set of denoised absolute travel times from the denoised empirical relative travel time matrix; and rendering an image of the volume of tissue based on an acoustomechanical parameter and the set of denoised absolute travel times corresponding to each ultrasound emitter in the array of ultrasound emitters.
摘要翻译：一种用于去噪声学旅行时间并对组织体积进行成像的方法和系统，包括接收代表由超声波发射器阵列产生并由超声波接收器阵列接收的声波的数据集; 对于超声波发射器阵列中的每个超声发射器，从数据集形成经验相对行进时间矩阵，包括一组相对经验旅行时间，对应于接收声波形的一对超声波接收器的每个相对经验行进时间，产生去噪的经验相对旅行时间矩阵，以及从去噪的经验相对旅行时间矩阵中提取一组去噪的绝对旅行时间; 以及基于声学参数和对应于超声发射器阵列中的每个超声发射器的一组去噪的绝对行进时间来渲染组织体积的图像。

8. 发明申请

US20230089236A1 METHOD OF CHARACTERIZING TISSUE OF A PATIENT 有权
公开(公告)号：US20230089236A1
公开(公告)日：2023-03-23
申请号：US17851650
申请日：2022-06-28
申请人： Delphinus Medical Technologies, Inc.
发明人： Nebojsa Duric , Peter John Littrup
IPC分类号： A61B8/08 , A61B8/00 , G06T7/00
摘要： A method for characterizing tissue of a patient, including receiving acoustic data derived from the interaction between the tissue and the acoustic waves irradiating the tissue; generating a morphology rendering of the tissue from the acoustic data, in which the rendering represents at least one biomechanical property of the tissue; determining a prognostic parameter for a region of interest in the rendering, in which the prognostic parameter incorporates the biomechanical property; and analyzing the prognostic parameter to characterize the region of interest. In some embodiment, the method further includes introducing a contrast agent into the tissue; generating a set of enhanced morphology renderings of the tissue after introducing the contrast agent; determining an enhanced prognostic parameter from the enhanced morphology renderings; and analyzing the enhanced prognostic parameter.

9. 发明授权

US11147537B2 Method for representing tissue stiffness 有权
公开(公告)号：US11147537B2
公开(公告)日：2021-10-19
申请号：US16182715
申请日：2018-11-07
申请人： Delphinus Medical Technologies, Inc.
发明人： Nebojsa Duric , Peter Littrup , Cuiping Li , Olivier Roy , Steven Schmidt
IPC分类号： A61B8/00 , A61B5/00 , A61B8/08 , A61B8/15
摘要： A method and system for analyzing stiffness in a volume of tissue, the method including: emitting acoustic waveforms toward the volume of tissue with an array of ultrasound transmitters; detecting, with an array of ultrasound receivers, a set of acoustic signals derived from acoustic waveforms transmitted through the volume of tissue; generating, from the set of acoustic signals, a sound speed map and an acoustic attenuation map of a region of the volume of tissue, generating a stiffness map derived from combination of a set of sound speed parameter values of the sound speed map and a corresponding set of acoustic attenuation parameter values of the acoustic attenuation map, the stiffness map representing the distribution of the stiffness parameter across the region; and at a display in communication with the computer processor, rendering a stiffness image of the volume of tissue, based upon the stiffness map.

10. 发明授权

US11064974B2 Patient interface system 有权
公开(公告)号：US11064974B2
公开(公告)日：2021-07-20
申请号：US16155276
申请日：2018-10-09
申请人： Delphinus Medical Technologies, Inc.
发明人： James Szpak , Nebojsa Duric , Peter Littrup , Roman Janer , Mike Tesic
IPC分类号： A61B8/00 , A61B8/08 , A61B8/14
摘要： A patient interface system for scanning a volume of tissue protruding from a patient, the system comprising: a base including a planar portion configured to support the patient in a prone configuration, and a frustoconical portion extending from the planar portion and defining a base aperture configured to receive the volume of tissue; and a support assembly configured to couple to the base, including a frame and a membrane retained in tension within the frame at a peripheral portion of the membrane, wherein the membrane defines a membrane aperture configured to align with the base aperture, and wherein the membrane is configured to deflect into the frustoconical portion of the base in response to the patient's weight. The system can further include an electrical subsystem including a pressure sensor array configured to generate signals in response to a pressure distribution resulting from the patient's weight at the patient interface system.

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