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1. 发明授权

US07544683B2 Cyclohexyl derivatives 失效
标题翻译：环己基衍生物
公开(公告)号：US07544683B2
公开(公告)日：2009-06-09
申请号：US12136093
申请日：2008-06-10
申请人： Delphine Gaufreteau , Matthias Nettekoven , Jean-Marc Plancher , Olivier Roche , Sebastien Schmitt , Tadakatsu Takahashi
发明人： Delphine Gaufreteau , Matthias Nettekoven , Jean-Marc Plancher , Olivier Roche , Sebastien Schmitt , Tadakatsu Takahashi
IPC分类号： A61K31/5377 , A61K31/496 , C07D295/185 , C07D417/12
CPC分类号： C07D403/12 , C07D401/12 , C07D413/12 , C07D417/12
摘要： The present invention relates to compounds of formula I wherein R1 and R2 are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prevention of diseases which are associated with the modulation of H3 receptors.
摘要翻译：本发明涉及式I化合物，其中R 1和R 2如说明书和权利要求书中所定义，及其药学上可接受的盐。该化合物可用于治疗和/或预防与H3受体的调节相关的疾病。

2. 发明申请

US20090005380A1 CYCLOHEXYL DERIVATIVES 失效
标题翻译：环辛基衍生物
公开(公告)号：US20090005380A1
公开(公告)日：2009-01-01
申请号：US12136093
申请日：2008-06-10
申请人： Delphine Gaufreteau , Matthias Nettekoven , Jean-Marc Plancher , Olivier Roche , Sebastien Schmitt , Tadakatsu Takahashi
发明人： Delphine Gaufreteau , Matthias Nettekoven , Jean-Marc Plancher , Olivier Roche , Sebastien Schmitt , Tadakatsu Takahashi
IPC分类号： A61K31/5377 , C07D241/04 , A61K31/495 , A61K31/496 , C07D401/02 , C07D413/02
CPC分类号： C07D403/12 , C07D401/12 , C07D413/12 , C07D417/12
摘要： The present invention relates to compounds of formula I wherein R1 and R2 are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prevention of diseases which are associated with the modulation of H3 receptors.
摘要翻译：本发明涉及式I化合物，其中R 1和R 2如说明书和权利要求书中所定义，及其药学上可接受的盐。该化合物可用于治疗和/或预防与H3受体的调节相关的疾病。

3. 发明授权

US06693116B2 Adenosine receptor ligands 失效
标题翻译：腺苷受体配体
公开(公告)号：US06693116B2
公开(公告)日：2004-02-17
申请号：US10246551
申请日：2002-09-18
申请人： Matthias Heinrich Nettekoven , Sebastien Schmitt
发明人： Matthias Heinrich Nettekoven , Sebastien Schmitt
IPC分类号： A61K31437
CPC分类号： C07D471/04
摘要： The present application relates to compounds of the formula wherein R1 is hydrogen, halogen or lower alkoxy; R2 is hydrogen or is —C(O)-lower alkyl or —C(O)-phenyl, wherein the phenyl ring is unsubstituted or substituted by one or two substituents selected from the group consisting of halogen, lower alkyl, lower alkoxy and trifluoromethyl, or is —C(O)-furanyl or —C(O)-thiophenyl, wherein the rings are unsubstituted or substituted by halogen; or a pharmaceutically acceptable salt thereof. The compounds are useful in the treatment of diseases associated with the adenosine A2 receptor.
摘要翻译：本申请涉及式I的化合物，R 1是氢，卤素或低级烷氧基; R 2是氢或是-C（O） - 低级烷基或-C（O） - 苯基，其中苯环是未取代或被一个或两个选自卤素，低级烷基，低级烷氧基和三氟甲基的取代基取代或被-C（O） - 呋喃基或-C（O） - 噻吩基取代，其中环是未取代的或被卤素;或其药学上可接受的盐。该化合物可用于治疗与腺苷A2受体相关的疾病。

4. 发明授权

US06689790B2 Substituted triazolopyridine compounds 失效
标题翻译：取代的三唑并吡啶化合物
公开(公告)号：US06689790B2
公开(公告)日：2004-02-10
申请号：US10265957
申请日：2002-10-07
申请人： Matthias Heinrich Nettekoven , Sebastien Schmitt
发明人： Matthias Heinrich Nettekoven , Sebastien Schmitt
IPC分类号： A61K31437
CPC分类号： C07D471/04 , A61K31/437
摘要： A compound of formula wherein R1 is —NR′R″, wherein R′ and R″ are independently selected from the group consisting of lower alkyl, —(CH2)n—C(O)NRaRb, —(CH2)n,-heteroaryl, —(CH2)n-aryl, —(CH2)n—CN, —(CH2)n—O-lower alkyl or —(CH2)n-cycloalkyl, or R′ and R″ form together with the N-atom a five or six-membered non-aromatic ring, containing no or one additional heteroatom selected from the group consiting of O and S, and said ring being unsubstituted or substituted by one or two substituents, selected from the group consisting of lower alkyl, —C(O)NRaRb and —(CH2)n—O-lower alkyl, and RaRb are independently from each other hydrogen or lower alkyl; R2 is aryl or heteroaryl, unsubstituted or substituted by lower alkyl or halogen; and n is 0, 1, 2 or 3; or a pharmaceutically acceptable salt thereof. Compounds of formula I are useful in the treatment of disease associated with the adenosine A2 receptor.
摘要翻译：式（Ⅳ）的化合物是-NR'R“，其中R'和R”独立地选自低级烷基， - （CH 2）n C（O）NR a R b， - （CH 2）n - 杂芳基， - （CH 2）n - 芳基， - （CH 2）n -CN， - （CH 2）n O-低级烷基或 - （CH 2）n - 环烷基或R'和R“ 与N原子一起为五或六元非芳族环，其不含或一个另外的选自O和S的杂原子的杂原子，所述环是未取代的或被一个或两个取代基取代，所述取代基选自的低级烷基，-C（O）NR a R b和 - （CH 2）n O-低级烷基，R a R b彼此独立地为氢或低级烷基; R 2为是未取代的或被低级烷基或卤素取代的芳基或杂芳基; 和n为0,1,2或3;或其药学上可接受的盐。式I化合物可用于治疗与腺苷A2受体相关的疾病。

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