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1. 发明授权

US06234997B1 System and method for mixing and delivering intravenous drugs 有权
标题翻译：静脉注射药物混合体系及方法
公开(公告)号：US06234997B1
公开(公告)日：2001-05-22
申请号：US09359237
申请日：1999-07-22
申请人： Dean L. Kamen , Charles M. Grinnell , Marc A. Mandro , Dennis Gilbreath , Kevin Grant , Jason A. Demers , William T. Larkins , Robert Manning , Richard Lanigan
发明人： Dean L. Kamen , Charles M. Grinnell , Marc A. Mandro , Dennis Gilbreath , Kevin Grant , Jason A. Demers , William T. Larkins , Robert Manning , Richard Lanigan
IPC分类号： A61M3700
CPC分类号： A61M5/142 , A61M5/1409 , A61M5/1413 , A61M5/14224 , A61M5/16809 , A61M5/16827 , A61M5/16831 , A61M5/16854 , A61M5/16877 , A61M5/365 , A61M5/5086 , A61M39/24 , A61M2005/1402 , A61M2005/1403 , A61M2005/14208 , A61M2205/123 , A61M2205/128 , A61M2205/35 , A61M2205/8206 , A61M2206/22 , F16K5/0414 , F16K5/0478
摘要： A bedside-pharmacy system for the preparation and delivery of intravenous drugs. The system includes a liquid inlet for connection to a liquid supply, vial receptacles, and a liquid outlet for providing the intravenous drug in mixed, liquid form to the patient. The system may include a chamber having a variable volume, and a valve mechanism, which may be actuated to control flow between the liquid outlet, the variable-volume chamber, the vial receptacles and the liquid inlet. The system induces change in the volume of the variable-volume chamber and actuates the valve mechanism, so as to introduce liquid from the liquid inlet into the vials and reconstitute or dilute the drugs and so as to deliver the drugs to the patient. In a preferred embodiment, the liquid inlet, the vial receptacles, the variable-volume chamber, the liquid outlet and the valve mechanism (in other words, all components that come into contact with the liquid) are located in a disposable cassette, which may be received in a control unit. The system may include means for changing the chamber volume and actuating the valves so as to move the liquid repeatedly between a vial and the chamber. After the drug has been reconstituted, the system may cause the drug to be further diluted by providing an additional volume of liquid to be mixed with the drug. The system may further include a second chamber for delivery of the drug to the patient in precise quantities.
摘要翻译：用于制备和输送静脉注射药物的床旁药房系统。该系统包括用于连接到液体供应器，小瓶容器和液体出口的液体入口，用于向患者提供混合的液体形式的静脉内药物。该系统可以包括具有可变容积的腔室和阀机构，其可以被致动以控制液体出口，可变体积腔室，小瓶容器和液体入口之间的流动。该系统引起可变容积腔体积的变化并致动阀机构，从而将液体从液体入口引入小瓶中，并重新构建或稀释药物并将药物输送给患者。在优选实施例中，液体入口，瓶容器，可变容积室，液体出口和阀机构（换句话说，与液体接触的所有部件）位于一次性盒中，在控制单元中接收。该系统可以包括用于改变腔体积并致动阀的装置，以便在小瓶和腔室之间重复移动液体。药物重建后，系统可能通过提供额外体积的与药物混合的液体而使药物进一步稀释。该系统还可以包括用于以精确量将药物递送到患者的第二腔室。

2. 发明授权

US08968244B2 System and method for drug preparation and delivery 有权
标题翻译：药物制备和给药的系统和方法
公开(公告)号：US08968244B2
公开(公告)日：2015-03-03
申请号：US13594374
申请日：2012-08-24
申请人： Dean L. Kamen , Charles M. Grinnell , Marc A. Mandro , Dennis Gilbreath , Kevin Grant , Jason A. Demers , William T. Larkins , Robert Manning , Richard Lanigan
发明人： Dean L. Kamen , Charles M. Grinnell , Marc A. Mandro , Dennis Gilbreath , Kevin Grant , Jason A. Demers , William T. Larkins , Robert Manning , Richard Lanigan
IPC分类号： A61M1/00 , A61M5/14 , A61M5/142 , A61M5/168 , A61M5/36 , A61M39/24 , F16K5/04
CPC分类号： A61M5/142 , A61M5/1409 , A61M5/1413 , A61M5/14224 , A61M5/16809 , A61M5/16827 , A61M5/16831 , A61M5/16854 , A61M5/16877 , A61M5/365 , A61M5/5086 , A61M39/24 , A61M2005/1402 , A61M2005/1403 , A61M2005/14208 , A61M2205/123 , A61M2205/128 , A61M2205/35 , A61M2205/8206 , A61M2206/22 , F16K5/0414 , F16K5/0478
摘要： A disposable cassette for mixing a drug in a vial includes a liquid inlet for connection to a liquid supply, a first vial spike, a second vial spike, a chamber and a valve mechanism. The chamber, the first and second vial spikes, and the liquid inlet are in fluid communication with each other. The valve mechanism may be actuated to control flow between the chamber, the vial receptacles and the liquid inlet.
摘要翻译：用于在小瓶中混合药物的一次性盒包括用于连接到液体供应源的液体入口，第一小瓶尖峰，第二小瓶尖峰，室和阀机构。腔室，第一和第二小瓶尖头和液体入口彼此流体连通。可以致动阀机构以控制腔室，药瓶容器和液体入口之间的流动。

3. 发明申请

US20130178831A1 System and Method for Drug Preparation and Delivery 有权
标题翻译：药物制备和给药系统和方法
公开(公告)号：US20130178831A1
公开(公告)日：2013-07-11
申请号：US13594374
申请日：2012-08-24
申请人： Dean L. Kamen , Charles M. Grinnell , Marc A. Mandro , Dennis Gilbreath , Kevin Grant , Jason A. Demers , William T. Larkins , Robert Manning , Richard Lanigan
发明人： Dean L. Kamen , Charles M. Grinnell , Marc A. Mandro , Dennis Gilbreath , Kevin Grant , Jason A. Demers , William T. Larkins , Robert Manning , Richard Lanigan
IPC分类号： A61M5/14
CPC分类号： A61M5/142 , A61M5/1409 , A61M5/1413 , A61M5/14224 , A61M5/16809 , A61M5/16827 , A61M5/16831 , A61M5/16854 , A61M5/16877 , A61M5/365 , A61M5/5086 , A61M39/24 , A61M2005/1402 , A61M2005/1403 , A61M2005/14208 , A61M2205/123 , A61M2205/128 , A61M2205/35 , A61M2205/8206 , A61M2206/22 , F16K5/0414 , F16K5/0478
摘要： A disposable cassette for mixing a drug in a vial includes a liquid inlet for connection to a liquid supply, a first vial spike, a second vial spike, a chamber and a valve mechanism. The chamber, the first and second vial spikes, and the liquid inlet are in fluid communication with each other. The valve mechanism may be actuated to control flow between the chamber, the vial receptacles and the liquid inlet.
摘要翻译：用于在小瓶中混合药物的一次性盒包括用于连接到液体供应源的液体入口，第一小瓶尖峰，第二小瓶尖峰，室和阀机构。腔室，第一和第二小瓶尖头和液体入口彼此流体连通。可以致动阀机构以控制腔室，药瓶容器和液体入口之间的流动。

4. 发明授权

US06726656B2 System for controlling flow through a line during intravenous drug delivery 有权
标题翻译：用于控制静脉内药物输送期间通过线路的流动的系统
公开(公告)号：US06726656B2
公开(公告)日：2004-04-27
申请号：US10266997
申请日：2002-10-08
申请人： Dean L. Kamen , Charles M. Grinnell , Marc A. Mandro , Dennis Gilbreath , Kevin Grant , Jason A. Demers , William T. Larkins , Robert Manning , Richard Lanigan
发明人： Dean L. Kamen , Charles M. Grinnell , Marc A. Mandro , Dennis Gilbreath , Kevin Grant , Jason A. Demers , William T. Larkins , Robert Manning , Richard Lanigan
IPC分类号： A61M3700
CPC分类号： A61M5/142 , A61M5/1409 , A61M5/1413 , A61M5/14224 , A61M5/16809 , A61M5/16827 , A61M5/16831 , A61M5/16854 , A61M5/16877 , A61M5/365 , A61M5/5086 , A61M39/24 , A61M2005/1402 , A61M2005/1403 , A61M2005/14208 , A61M2205/123 , A61M2205/128 , A61M2205/35 , A61M2205/8206 , A61M2206/22 , F16K5/0414 , F16K5/0478
摘要： A system and method for the preparation and delivery of intravenous drugs includes a liquid inlet for connection to a liquid supply and vial receptacles. The system may also include a liquid outlet for providing the intravenous drug in mixed, liquid form to the patient. The system may include a chamber having a variable volume, and a valve mechanism, which may be actuated to control flow between the liquid outlet, the variable-volume chamber, the vial receptacles and the liquid inlet. The liquid inlet, the vial receptacles, the variable-volume chamber, the liquid outlet and the valve mechanism may be located in a disposable cassette, which may be received in a control unit.
摘要翻译：用于制备和递送静脉内药物的系统和方法包括用于连接到液体供应源和小瓶容器的液体入口。该系统还可以包括用于将静脉内药物以混合的液体形式提供给患者的液体出口。该系统可以包括具有可变容积的腔室和阀机构，其可以被致动以控制液体出口，可变体积腔室，小瓶容器和液体入口之间的流动。液体入口，瓶容器，可变容积室，液体出口和阀机构可以位于可以被接收在控制单元中的一次性盒中。

5. 发明授权

US06464667B1 Method and cassette for delivering intravenous drugs 有权
标题翻译：用于递送静脉注射药物的方法和药盒
公开(公告)号：US06464667B1
公开(公告)日：2002-10-15
申请号：US09359232
申请日：1999-07-22
申请人： Dean L. Kamen , Charles M. Grinnell , Marc A. Mandro , Dennis Gilbreath , Kevin Grant , Jason A. Demers , William T. Larkins , Robert Manning , Richard Lanigan
发明人： Dean L. Kamen , Charles M. Grinnell , Marc A. Mandro , Dennis Gilbreath , Kevin Grant , Jason A. Demers , William T. Larkins , Robert Manning , Richard Lanigan
IPC分类号： A61M3700
CPC分类号： A61M5/142 , A61M5/1409 , A61M5/1413 , A61M5/14224 , A61M5/16809 , A61M5/16827 , A61M5/16831 , A61M5/16854 , A61M5/16877 , A61M5/365 , A61M5/5086 , A61M39/24 , A61M2005/1402 , A61M2005/1403 , A61M2005/14208 , A61M2205/123 , A61M2205/128 , A61M2205/35 , A61M2205/8206 , A61M2206/22 , F16K5/0414 , F16K5/0478
摘要： A bedside-pharmacy system for the preparation and delivery of intravenous drugs. The system includes a liquid inlet for connection to a liquid supply, vial receptacles, and a liquid outlet for providing the intravenous drug in mixed, liquid form to the patient. The system may include a chamber having a variable volume, and a valve mechanism, which may be actuated to control flow between the liquid outlet, the variable-volume chamber, the vial receptacles and the liquid inlet. The system induces change in the volume of the variable-volume chamber and actuates the valve mechanism, so as to introduce liquid from the liquid inlet into the vials and reconstitute or dilute the drugs and so as to deliver the drugs to the patient. In a preferred embodiment, the liquid inlet, the vial receptacles, the variable-volume chamber, the liquid outlet and the valve mechanism (in other words, all components that come into contact with the liquid) are located in a disposable cassette, which may be received in a control unit. The system may include means for changing the chamber volume and actuating the valves so as to move the liquid repeatedly between a vial and the chamber. After the drug has been reconstituted, the system may cause the drug to be further diluted by providing an additional volume of liquid to be mixed with the drug. The system may further include a second chamber for delivery of the drug to the patient in precise quantities.
摘要翻译：用于制备和输送静脉注射药物的床旁药房系统。该系统包括用于连接到液体供应器，小瓶容器和液体出口的液体入口，用于向患者提供混合的液体形式的静脉内药物。该系统可以包括具有可变容积的腔室和阀机构，其可以被致动以控制液体出口，可变体积腔室，小瓶容器和液体入口之间的流动。该系统引起可变容积腔体积的变化并致动阀机构，从而将液体从液体入口引入小瓶中，并重新构建或稀释药物并将药物输送给患者。在优选实施例中，液体入口，瓶容器，可变容积室，液体出口和阀机构（换句话说，与液体接触的所有部件）位于一次性盒中，在控制单元中接收。该系统可以包括用于改变腔体积并致动阀的装置，以便在小瓶和腔室之间重复移动液体。药物重建后，系统可能通过提供额外体积的与药物混合的液体而使药物进一步稀释。该系统还可以包括用于以精确量将药物递送到患者的第二腔室。

6. 发明授权

US06210361B1 System for delivering intravenous drugs 有权
标题翻译：递送静脉注射药物的系统
公开(公告)号：US06210361B1
公开(公告)日：2001-04-03
申请号：US09137025
申请日：1998-08-20
申请人： Dean L. Kamen , Charles M. Grinnell , Marc A. Mandro , Dennis Gilbreath , Kevin Grant , Jason A. Demers , William T. Larkins , Robert Manning , Richard Lanigan
发明人： Dean L. Kamen , Charles M. Grinnell , Marc A. Mandro , Dennis Gilbreath , Kevin Grant , Jason A. Demers , William T. Larkins , Robert Manning , Richard Lanigan
IPC分类号： A61M3700
CPC分类号： A61M5/142 , A61M5/1409 , A61M5/1413 , A61M5/14224 , A61M5/16809 , A61M5/16827 , A61M5/16831 , A61M5/16854 , A61M5/16877 , A61M5/365 , A61M5/5086 , A61M39/24 , A61M2005/1402 , A61M2005/1403 , A61M2005/14208 , A61M2205/123 , A61M2205/128 , A61M2205/35 , A61M2205/8206 , A61M2206/22 , F16K5/0414 , F16K5/0478
摘要： A bedside-pharmacy systen for the preparation and delivery of intravenous drugs. The system includes a liquid inlet for connection to a liquid supply, vial receptacles, and a liquid outlet for providing the intravenous drug in mixed, liquid form to the patient. The system may include a chamber having a variable volume, and a valve mechanism, which may be actuated to control flow between the liquid outlet, the variable-volume chamber, the vial receptacles and the liquid inlet. The system induces change in the volume of the variable-volume chamber and actuates the valve mechanism, so as to introduce liquid from the liquid inlet into the vials and reconstitute or dilute the drugs and so as to deliver the drugs to the patient. In a preferred embodiment, the liquid inlet, the vial receptacles, the variable-volume chamber, the liquid outlet and the valve mechanism (in other words, all components that come into contact with the liquid) are located in a disposable cassette, which may be received in a control unit. The system may include means for changing the chamber volume and actuating the valves so as to move the liquid repeatedly between a vial and the chamber. After the drug has been reconstituted, the system may cause the drug to be further diluted by providing an additional volume of liquid to be mixed with the drug. The system may further include a second chamber for delivery of the drug to the patient in precise quantities.
摘要翻译：用于制备和递送静脉注射药物的床旁药房系统。该系统包括用于连接到液体供应器，小瓶容器和液体出口的液体入口，用于向患者提供混合的液体形式的静脉内药物。该系统可以包括具有可变容积的腔室和阀机构，其可以被致动以控制液体出口，可变体积腔室，小瓶容器和液体入口之间的流动。该系统引起可变容积腔体积的变化并致动阀机构，从而将液体从液体入口引入小瓶中，并重新构建或稀释药物并将药物输送给患者。在优选实施例中，液体入口，瓶容器，可变容积室，液体出口和阀机构（换句话说，与液体接触的所有部件）位于一次性盒中，在控制单元中接收。该系统可以包括用于改变腔体积并致动阀的装置，以便在小瓶和腔室之间重复移动液体。药物重建后，系统可能通过提供额外体积的与药物混合的液体而使药物进一步稀释。该系统还可以包括用于以精确量将药物递送到患者的第二腔室。

7. 发明授权

US07214210B2 Cassette and method for drug preparation and delivery 有权
标题翻译：药盒和药物制备和递送方法
公开(公告)号：US07214210B2
公开(公告)日：2007-05-08
申请号：US10803049
申请日：2004-03-16
申请人： Dean Kamen , Charles M. Grinnell , Marc A. Mandro , Dennis Gilbreath , Kevin Lee Grant , Jason A. Demers , William T. Larkins , Robert Manning , Richard J. Lanigan
发明人： Dean Kamen , Charles M. Grinnell , Marc A. Mandro , Dennis Gilbreath , Kevin Lee Grant , Jason A. Demers , William T. Larkins , Robert Manning , Richard J. Lanigan
IPC分类号： A61M37/00
CPC分类号： A61M5/142 , A61M5/1409 , A61M5/1413 , A61M5/14224 , A61M5/16809 , A61M5/16827 , A61M5/16831 , A61M5/16854 , A61M5/16877 , A61M5/365 , A61M5/5086 , A61M39/24 , A61M2005/1402 , A61M2005/1403 , A61M2005/14208 , A61M2205/123 , A61M2205/128 , A61M2205/35 , A61M2205/8206 , A61M2206/22 , F16K5/0414 , F16K5/0478
摘要： A disposable cassette for mixing an intravenous drug in a vial to a patient includes a liquid inlet for connection to a liquid supply, a first vial spike, a second vial spike and a chamber. The chamber, the first and second vial spikes, and the liquid inlet are in fluid communication with each other. A valve mechanism may be actuated to control flow between the chamber, the vial receptacles and the liquid inlet.
摘要翻译：用于将小瓶中的静脉内药物混合到患者的一次性盒包括用于连接到液体供应源的液体入口，第一小瓶尖峰，第二小瓶尖峰和室。腔室，第一和第二小瓶尖头和液体入口彼此流体连通。可以致动阀机构以控制腔室，药瓶容器和液体入口之间的流动。

8. 发明授权

US07798997B2 Cassette and method for drug preparation and delivery 有权
标题翻译：药盒和药物制备和递送方法
公开(公告)号：US07798997B2
公开(公告)日：2010-09-21
申请号：US11455494
申请日：2006-06-19
申请人： Dean Kamen , Jason A. Demers , Dennis Gilbreath , Kevin Lee Grant , Charles M. Grinnell , Richard J. Lanigan , William T. Larkins , Marc A. Mandro , Robert Manning
发明人： Dean Kamen , Jason A. Demers , Dennis Gilbreath , Kevin Lee Grant , Charles M. Grinnell , Richard J. Lanigan , William T. Larkins , Marc A. Mandro , Robert Manning
IPC分类号： A61M37/00 , B65B1/30
CPC分类号： A61M5/142 , A61M5/1409 , A61M5/1413 , A61M5/14224 , A61M5/16809 , A61M5/16827 , A61M5/16831 , A61M5/16854 , A61M5/16877 , A61M5/365 , A61M5/5086 , A61M39/24 , A61M2005/1402 , A61M2005/1403 , A61M2005/14208 , A61M2205/123 , A61M2205/128 , A61M2205/35 , A61M2205/8206 , A61M2206/22 , F16K5/0414 , F16K5/0478
摘要： A disposable cassette for mixing a drug in a vial includes a liquid inlet for connection to a liquid supply, a first vial spike, a second vial spike, a chamber and a valve mechanism. The chamber, the first and second vial spikes, and the liquid inlet are in fluid communication with each other. The valve mechanism may be actuated to control flow between the chamber, the vial receptacles and the liquid inlet.
摘要翻译：用于在小瓶中混合药物的一次性盒包括用于连接到液体供应源的液体入口，第一小瓶尖峰，第二小瓶尖峰，室和阀机构。腔室，第一和第二小瓶尖头和液体入口彼此流体连通。可以致动阀机构以控制腔室，药瓶容器和液体入口之间的流动。

9. 发明授权

US06321597B1 System and method for measuring volume of liquid in a chamber 有权
标题翻译：用于测量腔室中液体体积的系统和方法
公开(公告)号：US06321597B1
公开(公告)日：2001-11-27
申请号：US09322477
申请日：1999-05-28
申请人： Jason A. Demers , Marc A. Mandro
发明人： Jason A. Demers , Marc A. Mandro
IPC分类号： G01F2300
CPC分类号： G01F22/02
摘要： Methods and systems for measuring the volume of a liquid in a subject chamber, such as the mixing chamber in a system for mixing and delivering drugs, for example. A volume of a control gas in communication with the subject chamber is isolated, such that the total volume of the control gas and the liquid is held constant, and the initial pressure of the control gas is measured. Then, a known volume of liquid is moved into or out of the subject chamber. This known volume may be exchanged between the subject chamber and a measurement chamber, in order to determine this volume. The final pressure of the control gas is also measured after the reference volume has been removed from or added to the chamber and while the volume of control gas remains otherwise isolated. The volume of liquid in the chamber may then be measured based on (a) the initial pressure, (b) the final pressure, (c) the reference volume and (d) the volume of gas in the subject chamber when the subject chamber is empty of liquid.
摘要翻译：用于测量本体室中的液体的体积的方法和系统，例如用于混合和递送药物的系统中的混合室。与被检体室连通的控制气体的体积被隔离，使得控制气体和液体的总体积保持恒定，并且测量控制气体的初始压力。然后，将已知体积的液体移入或移出对象室。这个已知体积可以在本体室和测量室之间进行交换，以确定该体积。控制气体的最终压力也是在将参考体积从室中除去或加入到室中之后测量的，而控制气体的体积保持另外分离。然后可以基于（a）初始压力，（b）最终压力，（c）参考体积和（d）当主体室是当前室时气体的体积来测量腔室中的液体体积空的液体。

10. 发明授权

US08251953B2 System and method for drug preparation and delivery 有权
标题翻译：药物制备和给药的系统和方法
公开(公告)号：US08251953B2
公开(公告)日：2012-08-28
申请号：US12886235
申请日：2010-09-20
申请人： Dean Kamen , Marc A. Mandro , Jason A. Demers
发明人： Dean Kamen , Marc A. Mandro , Jason A. Demers
IPC分类号： A61M37/00
CPC分类号： A61M5/142 , A61M5/1409 , A61M5/1413 , A61M5/14224 , A61M5/16809 , A61M5/16827 , A61M5/16831 , A61M5/16854 , A61M5/16877 , A61M5/365 , A61M5/5086 , A61M39/24 , A61M2005/1402 , A61M2005/1403 , A61M2005/14208 , A61M2205/123 , A61M2205/128 , A61M2205/35 , A61M2205/8206 , A61M2206/22 , F16K5/0414 , F16K5/0478
摘要： A disposable cassette for mixing a drug in a vial includes a liquid inlet for connection to a liquid supply, a first vial spike, a second vial spike, a chamber and a valve mechanism. The chamber, the first and second vial spikes, and the liquid inlet are in fluid communication with each other. The valve mechanism may be actuated to control flow between the chamber, the vial receptacles and the liquid inlet.
摘要翻译：用于在小瓶中混合药物的一次性盒包括用于连接到液体供应源的液体入口，第一小瓶尖峰，第二小瓶尖峰，室和阀机构。腔室，第一和第二小瓶尖头和液体入口彼此流体连通。可以致动阀机构以控制腔室，药瓶容器和液体入口之间的流动。

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