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1. 发明授权

US07244843B2 Modulators of serotonin receptors 有权
标题翻译：血清素受体的调节剂
公开(公告)号：US07244843B2
公开(公告)日：2007-07-17
申请号：US10958325
申请日：2004-10-05
申请人： Dean A. Wacker , Jeffrey G. Varnes
发明人： Dean A. Wacker , Jeffrey G. Varnes
IPC分类号： C07D245/00 , C07D487/00 , C07D243/10 , C07D273/00 , C07D241/36
CPC分类号： C07D471/04 , C07D487/04 , C07D513/04
摘要： The present invention provides modulators of serotonin receptors, pharmaceutical compositions containing such modulators and methods for treating various diseases, conditions and disorders associated with modulation of serotonin receptors such as, for example: metabolic diseases, which includes but is not limited to obesity, diabetes, diabetic complications, atherosclerosis, impared glucose tolerance and dyslipidemia; central nervous system diseases which includes but is not limited to, anxiety, depression, obsessive compulsive disorder, panic disorder, psychosis, schizophrenia, sleep disorder, sexual disorder and social phobias; cephalic pain; migraine; and gastrointestinal disorders using such compounds and compositions.
摘要翻译：本发明提供5-羟色胺受体的调节剂，含有这些调节剂的药物组合物和用于治疗与调节血清素受体相关的各种疾病，病症和病症的方法，所述调节剂包括但不限于肥胖，糖尿病，糖尿病并发症，动脉粥样硬化，葡萄糖耐量异常和血脂异常; 包括但不限于焦虑，抑郁，强迫症，惊恐障碍，精神病，精神分裂症，睡眠障碍，性障碍和社交恐惧症的中枢神经系统疾病; 头痛偏头痛和使用这些化合物和组合物的胃肠道疾病。

2. 发明授权

US06906066B2 N-ureidoalkyl-piperidines as modulators of chemokine receptor activity 有权
公开(公告)号：US06906066B2
公开(公告)日：2005-06-14
申请号：US10465191
申请日：2003-06-19
申请人： Soo S. Ko , George V. Delucca , John V. Duncia , Joseph B. Santella, III , Dean A. Wacker , Paul S. Watson , Jeffrey G. Varnes , Wenqing Yao
发明人： Soo S. Ko , George V. Delucca , John V. Duncia , Joseph B. Santella, III , Dean A. Wacker , Paul S. Watson , Jeffrey G. Varnes , Wenqing Yao
IPC分类号： A61P11/06 , A61P29/00 , C07D207/06 , C07D207/08 , C07D211/14 , C07D211/18 , C07D211/34 , C07D211/52 , C07D401/06 , C07D401/12 , C07D403/12 , C07D405/06 , C07D405/12 , C07D413/12 , C07D417/12 , C07D471/10 , C07D211/08 , A61K31/44
CPC分类号： C07D207/08 , C07D207/06 , C07D211/14 , C07D211/18 , C07D211/34 , C07D211/52 , C07D401/06 , C07D401/12 , C07D403/12 , C07D405/06 , C07D405/12 , C07D413/12 , C07D417/12 , C07D471/10
摘要： The present application describes modulators of CCR3 of formula (I): or pharmaceutically acceptable salt forms thereof, useful for the prevention of asthma and other allergic diseases.

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