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1. 发明授权

US06716823B1 Noninvasive genetic immunization, expression products therefrom, and uses thereof 有权
公开(公告)号：US06716823B1
公开(公告)日：2004-04-06
申请号：US09533149
申请日：2000-03-23
申请人： De-chu C. Tang , Donald H. Marks , David T. Curiel , Zhongkai Shi
发明人： De-chu C. Tang , Donald H. Marks , David T. Curiel , Zhongkai Shi
IPC分类号： A61K3170
CPC分类号： A61K39/00 , A61K39/0011 , A61K39/08 , A61K39/12 , A61K39/145 , A61K48/00 , A61K2039/53 , A61K2039/54 , A61K2039/541 , A61K2039/542 , A61K2039/543 , A61K2039/55522 , A61K2039/55555 , A61K2039/60 , C12N2710/10043 , C12N2760/16134 , C12N2760/16171
摘要： Disclosed and claimed are methods of non-invasive genetic immunization in an animal and/or methods of inducing a systemic immune or therapeutic response in an animal, products therefrom and uses for the methods and products therefrom. The methods can include contacting skin of the animal with a vector in an amount effective to induce the systemic immune or therapeutic response in the animal. The vector can include and express an exogenous nucleic acid molecule encoding an epitope or gene product of interest. The systemic immune response can be to or from the epitope or gene product. The nucleic acid molecule can encode an epitope of interest and/or an antigen of interest and/or a nucleic acid molecule that stimulates and/or modulates an immunological response and/or stimulates and/or modulates expression, e.g., transcription and/or translation, such as transcription and/or translation of an endogenous and/or exogenous nucleic acid molecule; e.g., one or more of influenza hemagglutinin, influenza nuclear protein, influenza M2, tetanus toxin C-fragment, anthrax protective antigen, anthrax lethal factor, rabies glycoprotein, HBV surface antigen, HIV gp 120, HIV gp 160, human carcinoembryonic antigen, malaria CSP, malaria SSP, malaria MSP, malaria pfg, and mycobacterium tuberculosis HSP; and/or a therapeutic, an immunomodulatory gene, such as co-stimulatory gene and/or a cytokine gene. The immune response can be induced by the vector expressing the nucleic acid molecule in the animal's cells. The animal's cells can be epidermal cells. The immune response can be against a pathogen or a neoplasm. A prophylactic vaccine or a therapeutic vaccine or an immunological composition can include the vector. The animal can be a vertebrate, e.g., a mammal, such as human, a cow, a horse, a dog, a cat, a goat, a sheep or a pig; or fowl such as turkey, chicken or duck. The vector can be one or more of a viral vector, including viral coat, e.g., with some or all viral genes deleted therefrom, bacterial, protozoan, transposon, retrotransposon, and DNA vector, e.g., a recombinant vector; for instance, an adenovirus, such as an adenovirus defective in its E1 and/or E3 and/or E4 region(s). The method can encompass applying a delivery device including the vector to the skin of the animal, as well as such a method further including disposing the vector in and/or on the delivery device. The vector can have all viral genes deleted therefrom. The vector can induce a therapeutic and/or an anti-tumor effect in the animal, e.g., by expressing an oncogene, a tumor-suppressor gene, or a tumor-associated gene. Immunological products generated by the expression, e.g., antibodies, cells from the methods, and the expression products, are likewise useful in in vitro and ex vivo applications, and such immunological and expression products and cells and applications are disclosed and claimed. Methods for expressing a gene product in vivo and products therefor and therefrom including mucosal and/or intranasal administration of an adenovirus, advantageously an E1 and/or E3 and/or E4 defective or deleted adenovirus, such as a human adenovirus or canine adenovirus, are also disclosed and claimed.

2. 发明授权

US06348450B1 Noninvasive genetic immunization, expression products therefrom and uses thereof 有权
标题翻译：无创遗传免疫，其表达产物及其用途
公开(公告)号：US06348450B1
公开(公告)日：2002-02-19
申请号：US09563826
申请日：2000-05-03
申请人： De-chu C. Tang , Donald H. Marks , David T. Curiel , Zhongkai Shi , Kent Rigby van Kampen
发明人： De-chu C. Tang , Donald H. Marks , David T. Curiel , Zhongkai Shi , Kent Rigby van Kampen
IPC分类号： A61K4800
CPC分类号： A61K39/08 , A61K39/00 , A61K39/0011 , A61K39/12 , A61K39/145 , A61K48/00 , A61K2039/53 , A61K2039/54 , A61K2039/541 , A61K2039/542 , A61K2039/543 , A61K2039/55555 , A61K2039/60 , C12N2710/10343 , C12N2760/16134
摘要： Disclosed and claimed are methods of non-invasive genetic immunization in an animal and/or methods of inducing a systemic immune or therapeutic response in an animal, products therefrom and uses for the methods and products therefrom. The methods can include contacting skin of the animal with a vector in an amount effective to induce the systemic immune or therapeutic response in the animal. The vector can include and express an exogenous nucleic acid molecule encoding an epitope or gene product of interest. The systemic immune response can be to or from the epitope or gene product. The nucleic acid molecule can encode an epitope of interest and/or an antigen of interest and/or a nucleic acid molecule that stimulates and/or modulates an immunological response and/or stimulates and/or modulates expression, e.g., transcription and/or translation, such as transcription and/or translation of an endogenous and/or exogenous nucleic acid molecule; e.g., one or more of influenza hemagglutinin, influenza nuclear protein, tetanus toxin C-fragment, anthrax protective antigen, HIV gp 120, human carcinoembryonic antigen, and/or a therapeutic, an immunomodulatory gene, such as co-stimulatory gene and/or a cytokine gene. The immune response can be induced by the vector expressing the nucleic acid molecule in the animal's cells. The immune response can be against a pathogen or a neoplasm. A prophylactic vaccine or a therapeutic vaccine or an immunological composition can include the vector.
摘要翻译：公开和要求的是在动物中非侵入性遗传免疫的方法和/或在动物中诱导全身性免疫或治疗反应的方法，其产品及其用途。所述方法可以包括使动物的皮肤与有效诱导动物体内免疫或治疗反应的量的载体接触。载体可以包括并表达编码感兴趣的表位或基因产物的外源核酸分子。全身免疫应答可以来自表位或基因产物。核酸分子可以编码感兴趣的表位和/或感兴趣的抗原和/或刺激和/或调节免疫应答和/或刺激和/或调节表达的核酸分子，例如转录和/或翻译，例如内源和/或外源核酸分子的转录和/或翻译; 例如流感血凝素，流感核蛋白，破伤风毒素C片段，炭疽保护性抗原，HIV gp120，人癌胚抗原和/或治疗性免疫调节基因中的一种或多种，例如共刺激基因和/或细胞因子基因。可以通过在动物细胞中表达核酸分子的载体诱导免疫应答。免疫应答可以针对病原体或肿瘤。预防性疫苗或治疗性疫苗或免疫组合物可以包括载体。

3. 发明授权

US06706693B1 Vaccination by topical application of genetic vectors 有权
标题翻译：通过局部应用遗传载体接种疫苗
公开(公告)号：US06706693B1
公开(公告)日：2004-03-16
申请号：US09402527
申请日：2000-01-03
申请人： De-chu Tang , Donald H. Marks , David T. Curiel , Zhongkai Shi
发明人： De-chu Tang , Donald H. Marks , David T. Curiel , Zhongkai Shi
IPC分类号： A61K4800
CPC分类号： A61K39/0011 , A61K39/00 , A61K2039/54 , A61K2039/55516 , A61K2039/55522 , A61K2039/55555 , A61K2039/57 , C12N2799/02 , C12N2799/022
摘要： The present invention provides a method of inducing an immune response in a non-invasive mode, comprising the step of: contacting skin of an individual in need of such treatment topically by applying to said skin an immunologically effective concentration of a genetic vector encoding a gene of interest. Also provided is a method of inducing an anti-tumor immune response in an animal in need of such treatment, comprising the step of: contacting skin of said animal topically by applying to said skin an immunologically effective concentration of a vector encoding a gene which encodes an antigen which induces an anti-tumor effect in said animal following administration. The genetic vector may include adenovirus recombinants, DNA/adenovirus complexes, DNA/liposome complexes, or any other vectors capable of expressing transgenes. Topical application of geneticvectors may preferably include a device as designed therein.
摘要翻译：本发明提供以非侵入性模式诱导免疫应答的方法，其包括以下步骤：通过向所述皮肤施用免疫有效浓度的编码基因的遗传载体，接触需要这种治疗的个体的皮肤，出于兴趣。还提供了在需要这种治疗的动物中诱导抗肿瘤免疫应答的方法，包括以下步骤：通过向所述皮肤施用免疫有效浓度的编码编码的基因的载体来局部接触所述动物的皮肤在给药后在所述动物中诱导抗肿瘤作用的抗原。遗传载体可以包括腺病毒重组体，DNA /腺病毒复合物，DNA /脂质体复合物或能够表达转基因的任何其他载体。遗传医生的局部应用可以优选地包括其中设计的装置。

4. 发明申请

US20140112951A1 Vaccine and drug delivery by topical application of vectors and vector extracts 有权
标题翻译：通过局部应用载体和载体提取物进行疫苗和药物递送
公开(公告)号：US20140112951A1
公开(公告)日：2014-04-24
申请号：US13961439
申请日：2013-08-07
申请人： De-Chu C. Tang , Zhongkai Shi , Kent Rigby van Kampen
发明人： De-Chu C. Tang , Zhongkai Shi , Kent Rigby van Kampen
IPC分类号： A61K39/145 , A61K39/08
CPC分类号： A61K39/145 , A61K38/1774 , A61K38/193 , A61K38/27 , A61K39/00 , A61K39/0011 , A61K39/08 , A61K39/12 , A61K39/39 , A61K2039/521 , A61K2039/522 , A61K2039/523 , A61K2039/5254 , A61K2039/5256 , A61K2039/53 , A61K2039/54 , A61K2039/541 , A61K2039/542 , A61K2039/543 , A61K2039/55516 , A61K2039/55522 , A61K2039/55555 , A61M11/008 , A61M11/02 , A61M15/009 , A61M15/08 , A61M2210/0618 , C12N7/00 , C12N2710/10043 , C12N2710/10343 , C12N2760/16034 , C12N2760/16071 , C12N2760/16134 , C12N2799/022 , Y02A50/412 , A61K2300/00
摘要： Disclosed and claimed is a method of non-invasive immunization in an animal and/or a method of inducing a systemic immune response or systemic therapeutic response to a gene product. The skin of the animal is contacted with a non-replicative vector chosen from the group of bacterium, virus, and fungus, wherein the vector comprises and expresses a nucleic acid molecule encoding the gene product, in an amount effective to induce the response.
摘要翻译：公开并要求保护的是在动物中非侵入性免疫的方法和/或诱导针对基因产物的全身免疫应答或全身治疗反应的方法。使动物的皮肤与选自细菌，病毒和真菌的非复制载体接触，其中载体以有效诱导反应的量包含并表达编码基因产物的核酸分子。

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