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1. 发明申请

US20070058412A1 System and method for improved low flow medical pump delivery 有权
标题翻译：改善低流量医用泵输送的系统和方法
公开(公告)号：US20070058412A1
公开(公告)日：2007-03-15
申请号：US11510106
申请日：2006-08-25
申请人： David Wang , Peter Scaramuzzi , Mansour Saleki , Robert Cousineau , Kent Abrahamson , Michael Lawless , Marwan Fathallah , Brian Kidd , Robert Boyd , Howard Greene , Eric Navin , Lori Lucke , Benjamin Mullin
发明人： David Wang , Peter Scaramuzzi , Mansour Saleki , Robert Cousineau , Kent Abrahamson , Michael Lawless , Marwan Fathallah , Brian Kidd , Robert Boyd , Howard Greene , Eric Navin , Lori Lucke , Benjamin Mullin
IPC分类号： G11C13/00
CPC分类号： A61M5/14224 , A61M5/16809 , A61M5/16854 , A61M5/172 , A61M2205/128 , A61M2205/3331
摘要： A medical pump with an improved continuity low flow delivery system and method for use with a pumping chamber, for example in a cassette, is disclosed. The pump includes a pump drive for exerting a force on the pumping chamber and a sensor for sensing the force/pressure exerted by the pump drive on the pumping chamber. The pump drive position sensor senses the position of the pump drive. The medical pump also includes a processing unit and a memory having a programming code adapted to calculate the rate of change of the sensed force/pressure values and determine whether the rate of change of the sensed force/pressure values meets a rate of change threshold. Once the rate of change threshold is met, the programming code is adapted to calculate a remaining pump drive travel value for determining how much farther the pump drive should travel before the end of an effective pump cycle. The programming code is further adapted to trigger one or more signals to drive the pump drive for the remainder of the effective pump cycle using the remaining pump drive travel value.
摘要翻译：公开了一种具有改进的连续性低流量输送系统的医疗泵以及用于例如在盒中的泵送室的方法。泵包括用于在泵送室上施加力的泵驱动器和用于感测泵驱动器在泵送室上施加的力/压力的传感器。泵驱动位置传感器检测泵驱动器的位置。医疗泵还包括处理单元和具有适于计算检测到的力/压力值的变化率的编程代码的存储器，并且确定检测到的力/压力值的变化率是否满足变化率阈值。一旦满足了变化率阈值，编程代码就适用于计算剩余的泵驱动行程值，用于确定泵驱动器在有效泵循环结束之前要行进的距离。编程代码还适用于使用剩余的泵驱动行程值来触发一个或多个信号来驱动泵驱动器的剩余有效泵循环。

2. 发明申请

US20050214129A1 Medical infusion pump with closed loop stroke feedback system and method 有权
标题翻译：具有闭环行程反馈系统和方法的医用输液泵
公开(公告)号：US20050214129A1
公开(公告)日：2005-09-29
申请号：US10810123
申请日：2004-03-26
申请人： Howard Greene , Robert Boyd , Michael Lawless , Marwan Fathallah , Mansour Saleki , Brian Kidd , Kent Abrahamson , Robert Cousineau
发明人： Howard Greene , Robert Boyd , Michael Lawless , Marwan Fathallah , Mansour Saleki , Brian Kidd , Kent Abrahamson , Robert Cousineau
IPC分类号： A61M5/142 , A61M5/168 , A61M5/172 , F04B49/00 , F04B43/08
CPC分类号： A61M5/14224 , A61M5/16809 , A61M5/16854 , A61M5/172 , A61M2205/128 , A61M2205/3331
摘要： A medical pump with a closed loop stroke feedback system and method, for use with a pumping chamber, for example in a cassette, is disclosed. The pump includes a pumping element that intermittently pressurizes a pumping chamber during a pumping cycle. A pressure sensor detects the pressure exerted by the pumping element on the pumping chamber. A position sensor detects the position of the pumping element. A processing unit processes pressure data from the pressure sensor and position data from the position sensor to determine a calculated stroke volume of the pump for a pump cycle, and to adjust a stroke frequency of the pump to compensate for variation in the stroke volume.
摘要翻译：公开了一种具有闭环行程反馈系统和方法的医用泵，其用于例如在盒中的泵送室。泵包括泵送元件，其在泵送循环期间间歇地加压泵送室。压力传感器检测泵送元件在泵送室上施加的压力。位置传感器检测泵送元件的位置。处理单元处理来自压力传感器的压力数据和来自位置传感器的位置数据，以确定用于泵循环的泵的计算行程量，并且调节泵的行程频率以补偿行程体积的变化。

3. 发明申请

US20070088897A1 Interactive mapping method and system 有权
标题翻译：交互式映射方法和系统
公开(公告)号：US20070088897A1
公开(公告)日：2007-04-19
申请号：US11581145
申请日：2006-10-13
申请人： Thomas Wailes , Gareth Finucane , Michael Lawless , Mark Wehner , Rodney Fernandez
发明人： Thomas Wailes , Gareth Finucane , Michael Lawless , Mark Wehner , Rodney Fernandez
IPC分类号： G06F12/08
CPC分类号： G06F17/30241 , G01C21/343 , G01C21/3676 , G09B29/007 , G09B29/106
摘要： Method and computer program product for presenting a set of address locations in a browser window of a user device via the Internet are disclosed. The method includes receiving a set of address locations in a given order, presenting the set of address locations as a list of directions, and presenting the set of address locations graphically on a map, where the map includes a route connecting the set of address locations according to the given order and a marker for each of the address locations. The method further includes creating a new order of the set of address locations from the given order by dragging an address location from the map to a different position in the list of directions, updating the list of directions according to the new order of the set of address locations, and updating the map according to the new order of the set of address locations.
摘要翻译：公开了用于经由因特网在用户设备的浏览器窗口中呈现一组地址位置的方法和计算机程序产品。该方法包括以给定的顺序接收一组地址位置，将一组地址位置呈现为方向列表，并以地图形式在地图上呈现一组地址位置，其中地图包括连接该组地址位置的路线根据给定的顺序和每个地址位置的标记。该方法还包括通过将地址位置从地图拖动到方向列表中的不同位置来创建来自给定顺序的一组地址位置的新顺序，根据该组的新顺序更新方向列表地址位置，并根据地址位置集合的新顺序更新地图。

4. 发明申请

US20070156332A1 Method and system for navigating a map 有权
标题翻译：用于导航地图的方法和系统
公开(公告)号：US20070156332A1
公开(公告)日：2007-07-05
申请号：US11580776
申请日：2006-10-13
申请人： Thomas Wailes , Gareth Finucane , Michael Lawless , Mark Wehner , Rodney Fernandez
发明人： Thomas Wailes , Gareth Finucane , Michael Lawless , Mark Wehner , Rodney Fernandez
IPC分类号： G01C21/32
CPC分类号： G06F17/30241 , G01C21/343 , G01C21/3676 , G09B29/007 , G09B29/106
摘要： Method and computer program product for navigating a map in a browser window of a user device via the Internet are disclosed. The method includes providing a first map for showing geographic context of a general area, providing a second map for showing geographic context of a portion of the general area, superimposing the second map onto the first map, wherein the second map is represented by a highlighted area in the first map, and navigating the first map using the highlighted area. The method further includes displaying points of interest inside the highlighted area of the first map and in the second map for assisting a user in navigating to the points of interest, and displaying additional points of interest outside the shaded area of the first map for assisting a user in navigating to the additional points of interest.
摘要翻译：公开了用于通过因特网在用户设备的浏览器窗口中导航地图的方法和计算机程序产品。该方法包括提供用于显示一般区域的地理上下文的第一地图，提供用于显示一般区域的一部分的地理上下文的第二地图，将第二地图叠加到第一地图上，其中第二地图由高亮显示区域，并使用突出显示的区域导航第一个地图。该方法还包括在第一地图的突出显示的区域内和第二地图中显示兴趣点，以帮助用户导航到兴趣点，并且在第一地图的阴影区域外显示额外的兴趣点以辅助用户导航到其他兴趣点。

5. 发明申请

US20060004197A1 Sulfonamide-based compounds as protein tyrosine kinase inhibitors 审中-公开
标题翻译：磺酰胺类化合物作为蛋白酪氨酸激酶抑制剂
公开(公告)号：US20060004197A1
公开(公告)日：2006-01-05
申请号：US10884113
申请日：2004-07-02
申请人： Thomas Thrash , Michael Lawless , Julian Smith , Richard Foster , Qian Liu , Raymond Budde
发明人： Thomas Thrash , Michael Lawless , Julian Smith , Richard Foster , Qian Liu , Raymond Budde
IPC分类号： C07D279/12 , C07D213/53 , C07D241/04 , C07C311/31
CPC分类号： C07C311/21 , C07C233/80 , C07C309/73 , C07C311/18 , C07C311/29 , C07C311/46 , C07C311/51 , C07C317/14 , C07C317/34 , C07C323/42 , C07C323/49 , C07C2601/14 , C07D213/75 , C07D295/26
摘要： Various sulfonamide-based compounds are able to selectively inhibit the Src family of tyrosine kinases. These compounds are useful in the treatment of various diseases including hyperproliferative diseases, hematologic diseases, osteoporosis, neurological diseases, autoimmune diseases, allergic/immunological diseases, or viral infections.
摘要翻译：各种磺酰胺类化合物能够选择性地抑制酪氨酸激酶的Src家族。这些化合物可用于治疗各种疾病，包括过度增生性疾病，血液病，骨质疏松症，神经系统疾病，自身免疫性疾病，过敏性/免疫性疾病或病毒性感染。

6. 发明授权

US06503914B1 Thienopyrimidine-based inhibitors of the Src family 有权
标题翻译：基于噻吩并嘧啶的Src家族抑制剂
公开(公告)号：US06503914B1
公开(公告)日：2003-01-07
申请号：US09694145
申请日：2000-10-23
申请人： Michele A. Benish , Michael Lawless , Raymond J. A. Budde
发明人： Michele A. Benish , Michael Lawless , Raymond J. A. Budde
IPC分类号： C07D49504
CPC分类号： C07D495/04 , A61K31/519
摘要： Various thienopyrimidine-based analog compounds that selectively inhibit the Src family of tyrosine kinases. These compounds are thienopyrimidines and contain a hydrozone bridge created by heating a thienopyrimidine hydrazine with an aldehyde in ethanol at reflux. Such compounds are useful in the treatment of various diseases including hyperproliferative diseases, hematologic diseases, osteoporosis, neurological diseases, autoimmune diseases, allergic/immunological diseases, or viral infections.
摘要翻译：选择性抑制酪氨酸激酶的Src家族的各种噻吩并嘧啶类似物化合物。这些化合物是噻吩并嘧啶并且含有通过在乙醇中回流加热噻吩并嘧啶肼与醛在乙醇中产生的氢环桥。这些化合物可用于治疗各种疾病，包括过度增生性疾病，血液病，骨质疏松症，神经系统疾病，自身免疫性疾病，过敏性/免疫性疾病或病毒性感染。

7. 发明授权

US4950244A Pressure sensor assembly for disposable pump cassette 失效
标题翻译：用于一次性泵盒的压力传感器组件
公开(公告)号：US4950244A
公开(公告)日：1990-08-21
申请号：US45949
申请日：1987-05-01
申请人： George H. Fellingham , Michael Lawless
发明人： George H. Fellingham , Michael Lawless
IPC分类号： A61B5/0215 , A61M5/168 , G01L7/00
CPC分类号： A61M5/16854
摘要： A pressure sensor assembly includes two spacedly positioned flexible supports which support an elongated rod, with one end of the elongated rod contacting a pressure detector section on a disposable pumping cassette; the pressure sensor assembly can detect pressures in the cassette both above and below atmospheric (i.e., zero psig); when pressure changes in the cassette, the pressure detection section causes axial movement of the rod and the rod, in turn, flexes the two flexible supports. Position detection means associated with one of the two supports monitors the flexural movement of the one support, providing an indication of the pressure within the cassette.

8. 发明授权

US4944191A Ultrasonic detector 失效
标题翻译：超声波检测仪
公开(公告)号：US4944191A
公开(公告)日：1990-07-31
申请号：US307489
申请日：1989-03-07
申请人： John Pastrone , George H. Fellingham , Michael Lawless
发明人： John Pastrone , George H. Fellingham , Michael Lawless
IPC分类号： A61B8/06 , A61M5/36 , G01N29/032 , G01N29/036 , G01N29/22 , G01N29/24 , G01N29/28 , G01N29/34 , G01N29/46 , G01S15/88
CPC分类号： G01N29/223 , A61M5/365 , G01N29/032 , G01N29/036 , G01N29/24 , G01N29/28 , G01N29/348 , G01N29/46 , G01N2291/02433 , G01N2291/102
摘要： An ultrasonic sound generator and receiver are spaced apart from each other so as to receive a projecting portion of a cassette in which a liquid carrying passage is defined by a flexible membrane. The liquid carrying passage in the projecting portion fits between the ultrasonic sound generator and receiver, with opposite sides of the flexible membrane in contact with the sound generator and sound receiver. The sound generator and sound receiver each comprise a substrate having a layer of conducting material. Two electrically isolated regions are defined on the conductive layer, and a piezoelectric chip is electrically connected between the two regions. An electrical signal applied between the first and second regions excites the piezoelectric chip on the sound generator, causing it to generate an ultrasonic signal, which is transmitted through the liquid carrying passage. If liquid is present in the passage, the amplitude of the ultrasonic sound signal received by the piezoelectric chip on the sound receiver is substantially greater than when liquid is absent in the passage. The ultrasonic detector thus produces a signal indicative of liquid in the liquid carrying passage.

9. 发明授权

US4821558A Ultrasonic detector 失效
标题翻译：超声波检测仪
公开(公告)号：US4821558A
公开(公告)日：1989-04-18
申请号：US45951
申请日：1987-05-01
申请人： John Pastrone , George H. Fellingham , Michael Lawless
发明人： John Pastrone , George H. Fellingham , Michael Lawless
IPC分类号： A61B8/06 , A61M5/36 , G01N29/032 , G01N29/036 , G01N29/22 , G01N29/24 , G01N29/28 , G01N29/34 , G01N29/46 , G01S15/88 , G01N7/00
CPC分类号： G01N29/223 , A61M5/365 , G01N29/032 , G01N29/036 , G01N29/24 , G01N29/28 , G01N29/348 , G01N29/46 , G01N2291/02433 , G01N2291/102
摘要： An ultrasonic detector for detecting air in a fluid. A fluid pumping cassette includes an elastomeric member that defines three sides of a fluid passageway, a base of the cassette defining the other side. Resilient lobes on the elastomeric member extend outwardly in opposite directions on each side of the passageway, directly contacting an ultrasonic sound generator on one side and a piezoelectric sound receiver on the opposite side, the direct contact enhancing transmission of an ultrasound signal through the elastomeric member to facilitate detection of an air bubble in the fluid passage.

10. 发明申请

US20110071899A1 Creating, Managing and Optimizing Online Advertising 审中-公开
标题翻译：创建，管理和优化在线广告
公开(公告)号：US20110071899A1
公开(公告)日：2011-03-24
申请号：US12832568
申请日：2010-07-08
申请人： Niel Robertson , Chris Burton , Tom Guzik , Jeff Osborn , Michael Lawless , Bill Quinn , Seth Levine , Matt Hessler , David Mitchell
发明人： Niel Robertson , Chris Burton , Tom Guzik , Jeff Osborn , Michael Lawless , Bill Quinn , Seth Levine , Matt Hessler , David Mitchell
IPC分类号： G06Q30/00
CPC分类号： G06Q30/02 , G06Q30/0244 , G06Q30/0249
摘要： Systems and methods for creating, managing and optimizing online advertising campaigns include groups of independent human resources working through a marketplace to suggest and optimize appropriate choices for how, where and how much to pay for online advertising. Optimization is achieved through the use of market-based incentives that pay participants based on the quality, quantity and efficiency of the results of their suggestions. The systems and methods enable a marketplace that leverages the inherent knowledge of a large group of people to come up with all search terms, placements, targeting and advertisements that might be relevant to a product, and determine the optimal auction prices for these search terms, placements, targeting and ads on the search engine systems.
摘要翻译：用于创建，管理和优化在线广告活动的系统和方法包括通过市场工作的独立人力资源群体，以建议和优化针对在线广告的支付方式，在哪里和多少方面的适当选择。通过使用基于市场的激励措施来实现优化，这些激励措施是根据其建议的结果的质量，数量和效率来支付参与者。系统和方法使市场能够利用大群人的固有知识来获得与产品相关的所有搜索字词，展示位置，定位和广告，并确定这些搜索字词的最佳拍卖价格，搜索引擎系统上的展示位置，定位和广告。

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