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1. 发明授权

US07312324B2 Regulatory elements for delivery to the liver 有权
标题翻译：用于输送到肝脏的调节元件
公开(公告)号：US07312324B2
公开(公告)日：2007-12-25
申请号：US10139763
申请日：2002-05-06
申请人： David W. Souza , Donna Armentano , Samuel C. Wadsworth
发明人： David W. Souza , Donna Armentano , Samuel C. Wadsworth
IPC分类号： C07H21/04 , C07H21/02 , A01N63/00 , A01N65/00 , A01N43/04 , A01N31/70
CPC分类号： C12N15/86 , A61K48/00 , A61K48/0058 , C12N15/85 , C12N2710/10343 , C12N2799/022 , C12N2830/008 , C12N2830/15 , C12N2830/85
摘要： The invention is directed to novel combinations of liver specific enhancers and promoter elements for achieving persistent transgene expression in the liver. The liver specific enhancer elements may be derived from either the human serum albumin, prothrombin, α-1microglobulin or aldolase genes in single copies or in multimerized form linked to elements derived from the cytomegalovirus intermediate early (CMV), α-1-antitrypsin or albumin promoters. In a preferred embodiment of the invention, an adenoviral vector comprising a liver specific enhancer/promoter combination operably linked to a transgene is administered to recipient cells. In other embodiments of the invention, adeno-associated viral vectors, retroviral vectors, lentiviral vectors or a plasmid comprising the liver specific enhancer/promoter combination linked to a transgene is administered to recipient cells. Also within the scope of the invention are promoter elements derived from the human prothrombin gene and the β-fibrinogen gene.
摘要翻译：本发明涉及用于实现肝脏中持续转基因表达的肝特异性增强子和启动子元件的新型组合。肝脏特异性增强子元件可以来源于与来自巨细胞病毒中间体早期（CMV），α-1-抗胰蛋白酶或白蛋白的元件连接的单拷贝或多聚化形式的人血清白蛋白，凝血酶原，α-1微球蛋白或醛缩酶基因发起人。在本发明的优选实施方案中，向受体细胞施用包含可操作地连接到转基因的肝特异性增强子/启动子组合的腺病毒载体。在本发明的其它实施方案中，将腺相关病毒载体，逆转录病毒载体，慢病毒载体或包含与转基因连接的肝特异性增强子/启动子组合的质粒施用于受体细胞。也在本发明范围内的是源自人凝血酶原基因和β-纤维蛋白原基因的启动子元件。

2. 发明授权

US4560092A Variable quantity dispensing device for granular material 失效
标题翻译：颗粒材料可变量分配装置
公开(公告)号：US4560092A
公开(公告)日：1985-12-24
申请号：US607735
申请日：1984-05-07
申请人： David W. Souza
发明人： David W. Souza
IPC分类号： G01F11/24 , G01F11/10
CPC分类号： G01F11/24
摘要： A device for dispensing a selectively variable measured quantity of granular material from a container includes a cup-shaped first member and a hollow cylindrical dispensing member having a sidewall disposed concentrically within the first member. The dispensing member includes a handle, an open bottom, a closed top panel, and a pair of radially extending side panels depending from the top panel to define a measuring chamber. The volume of the measuring chamber may be varied by means of an adjustment member having a lateral panel disposed in a recess in the top of the dispensing member and a depending panel which forms a sidewall of the measuring chamber. The dispensing member is rotatable about a tubular projection extending from the first member, so that the measuring chamber may be moved from alignment with an intake port in the bottom panel of a reservoir supported above the first member to alignment with a discharge port in the bottom of the first member. A post having a plurality of radially extending rods extends through the first member and the dispensing member. In one embodiment, the post rotates with the dispensing member to stir the granular material. In a second embodiment, the post is rotationaly immobilized with respect to the first member, while the reservoir and the dispensing member rotate together around it.
摘要翻译：用于从容器中分配选择性可变量的粒状材料的装置包括杯状第一构件和具有同心地设置在第一构件内的侧壁的中空圆柱形分配构件。分配构件包括手柄，开口底部，封闭顶板以及从顶板悬垂以限定测量室的一对径向延伸的侧板。测量室的体积可以通过调节构件来改变，调节构件具有设置在分配构件的顶部中的凹部中的侧面板和形成测量室的侧壁的悬垂面板。分配构件可围绕从第一构件延伸的管状突起旋转，使得测量室可以与支撑在第一构件上方的储存器的底板中的进气口对准地移动，以与底部中的排出口对准的第一个成员。具有多个径向延伸杆的柱延伸穿过第一构件和分配构件。在一个实施例中，柱随着分配构件旋转以搅拌颗粒材料。在第二实施例中，柱相对于第一构件旋转固定，同时储存器和分配构件围绕其一起旋转。

3. 发明授权

US4345700A Variable quantity dispensing device for granular material 失效
标题翻译：颗粒材料可变量分配装置
公开(公告)号：US4345700A
公开(公告)日：1982-08-24
申请号：US144226
申请日：1980-04-28
申请人： David W. Souza
发明人： David W. Souza
IPC分类号： B65D47/20 , G01F11/46
CPC分类号： G01F11/46
摘要： A device for dispensing a selectively variable measured quantity of granular material from a container includes a cap adapted to be secured to the open end of the container, the cap including a generally cup-like coffer disposed in the neck of the container. A disk-like lid is rotatably secured to the cap in coaxial fashion, and includes a discharge port subtending a small angle therein. The cap includes a boss projecting radially inwardly in the coffer and disposed directly adjacent to an inlet port in the inner end wall of the coffer. An adjustment member is rotatably received in the coffer, and includes a radially extending wall parallel to the axis which is selectively variably spaced from the boss to define a chamber of variable volume communicating with the inlet port. A disk-like bottom cover includes an inlet opening therein, and is secured to the inner end of the cap and adapted for rotation in concert with the lid. With the container in the inverted position, granular material therein will fall gravitally through the opening in the bottom cover and the inlet port in the cap to fill the chamber in the coffer thereof to the extent permitted by the position of the wall of the adjustment member. The lid is rotated so that the bottom cover occludes the inlet port, after which the discharge port in the lid comes into registration with the chamber. The contents of the chamber fall gravitally through the discharge port, and spring means return the lid and bottom cover to their original angular positions.
摘要翻译：用于从容器中分配选择性可变量的粒状材料的装置包括适于固定到容器的开口端的盖，所述盖包括设置在容器的颈部中的大致杯状的保险箱。盘状盖以同轴方式可旋转地固定到盖上，并且包括在其中对着小角度的排出口。该盖包括在保险箱中径向向内突出并且直接邻近保险箱的内端壁中的入口设置的凸台。调节构件可旋转地容纳在保险箱中，并且包括平行于轴线的径向延伸的壁，该径向选择性地可选地与凸台间隔开，以限定与入口连通的可变容积室。盘形底盖在其中包括入口开口，并且固定到盖的内端并适于与盖一致地旋转。在容器处于倒置位置时，其中的颗粒材料将通过底盖中的开口和盖中的入口重力下落，以将其在其保险箱中的室填充到调节构件的壁的位置所允许的程度。旋转盖子使得底盖封闭入口，此后盖子中的排出口与腔室对准。腔室的内容物通过排出口重力下降，弹簧装置将盖子和底盖返回原来的角度位置。

4. 发明授权

US4770451A Security lock for hinged entry doors and the like 失效
标题翻译：铰链入口门等的安全锁
公开(公告)号：US4770451A
公开(公告)日：1988-09-13
申请号：US933245
申请日：1986-11-20
申请人： David W. Souza
发明人： David W. Souza
IPC分类号： E05C19/18
CPC分类号： E05C19/182 , Y10T292/28 , Y10T292/34 , Y10T292/37
摘要： Multiple embodiments of a security lock for hinged entry doors or the like are disclosed, each having a strike plate adapted for mounting on the door jamb with a lock element being selectively operable for locking the door and being opened inwardly. In one embodiment, the lock element is engaged with a slotted extension of the strike plate for locking the door and with an offset plate portion for storing the lock element in an unlocked position out of engagement with the door. In another embodiment, the lock element is connected to an offset portion of the plate by an elongated flexible element such as a chain. In yet another embodiment, the lock element is an elongated hook member which is rotatably attached to the plate and extends inwardly of the door in its closed position, the hook member being rotatable into either a locking position for engaging the door after it is opened a short distance from the jamb or an unlocked position. In a further embodiment, the lock element is supported in an unlocked position upon a portion of the plate by a magnet. In a still further embodiment, the lock element is attached to a key for the door. Various combinations of these embodiments are also contemplated.
摘要翻译：公开了用于铰接入口门等的安全锁的多个实施例，每个具有适于安装在门边框上的冲击板，其中锁定元件选择性地可操作地用于锁定门并向内打开。在一个实施例中，锁定元件与撞击板的带槽的延伸部接合，用于锁定门，并具有用于将锁定元件存储在与门接合的解锁位置的偏移板部分。在另一个实施例中，锁定元件通过诸如链条的细长柔性元件连接到板的偏移部分。在另一个实施例中，锁定元件是细长的钩构件，其可旋转地附接到板并且在门的内部向其延伸的关闭位置，钩构件可旋转到用于在打开门之后接合门的锁定位置距离边框短距离或解锁位置。在另一实施例中，锁定元件通过磁体支撑在板的一部分上的解锁位置。在又一实施例中，锁定元件附接到门的钥匙。也考虑了这些实施例的各种组合。

5. 发明授权

US4257541A Dispensing device for granular material 失效
标题翻译：粒状物料分配装置
公开(公告)号：US4257541A
公开(公告)日：1981-03-24
申请号：US71885
申请日：1979-09-04
申请人： David W. Souza
发明人： David W. Souza
IPC分类号： A47G19/34 , G01F11/24
CPC分类号： A47G19/34 , G01F11/24
摘要： A device for dispensing a measured quantity of granular material from a container includes a cap adapted to be secured to the open end of the container, and a generally cup-like housing secured to the interior surface of the cap. A dispensing member is disposed within the housing, and is adapted to be rotated about the axis of the cap and housing by a lever which extends outwardly from the cap. The dispensing member includes a cylindrical chamber extending therethrough parallel to the axis thereof, and adapted to be rotated to register with an intake port in the housing to be filled with granular material. The dispensing member may be rotated to bring the chamber into registration with a discharge port extending through the cap.
摘要翻译：用于从容器分配测量量的颗粒材料的装置包括适于固定到容器的开口端的盖，以及固定到盖的内表面的大致杯状的壳体。分配构件设置在壳体内，并且适于通过从盖向外延伸的杆围绕盖和壳体的轴线旋转。分配构件包括平行于其轴线延伸穿过的圆柱形室，并且适于旋转以与壳体中的进料口对准以填充颗粒材料。分配构件可以旋转以使腔室与延伸穿过盖子的排出口对准。

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