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    • 3. 发明授权
    • Eyewear storage cases and related methods
    • 眼镜储存箱及相关方法
    • US08590698B1
    • 2013-11-26
    • US13099111
    • 2011-05-02
    • David W. Osborne
    • David W. Osborne
    • A45C11/04
    • A45C11/04A45C3/001A45C11/00A45C2011/002A45C2011/003A45F5/021
    • Eyewear cases and collapsible storage cases for use in storing and polishing or cleaning eyewear or other objects with a scratch sensitive surface are disclosed and described. In some embodiments such a case may include a soft and flexible bag having an opening and an internal space sufficiently sized to receive and store a piece of eyewear or other object, and a soft and flexible cover attached to the bag and providing an enclosure with an opening and cavity sufficiently sized to receive and store the bag when the bag is empty. In practice the bag extends out of the cavity through the cover opening for use in either storing, cleaning, or treating eyewear or other object, and retracts back through the cover opening and substantially into the cavity when not in use for storage.
    • 公开并描述了用于存储和抛光或清洁具有刮擦敏感表面的眼镜或其它物体的眼镜盒和可折叠存储箱。 在一些实施例中,这种情况可以包括具有开口和足够尺寸以容纳和存放一件眼镜或其他物体的开口和内部空间的柔软和柔性的袋子,以及附接到袋子的柔软和柔性的盖子,并提供具有 开口和空腔足够大,以便当袋子空时接收和存放袋子。 在实践中,袋子通过盖开口延伸出空腔,用于储存,清洁或处理眼镜或其他物体,并且在不用于储存时通过盖开口并基本进入空腔。
    • 8. 发明授权
    • Compositions for topical application of therapeutic agents
    • 局部应用治疗剂的组合物
    • US06620435B1
    • 2003-09-16
    • US09236909
    • 1999-01-25
    • David W. Osborne
    • David W. Osborne
    • A61K910
    • A61K9/06Y10S514/859Y10S514/944
    • The present invention generally relates to pharmaceutical compositions that enable control of drug, delivery properties and the development of optimal drug delivery strategies customized for particular drugs and particular diseases. The composition includes a dissolved pharmaceutical that has the capacity to permeate the stratum corneum layer of the epidermis and become available systemically, and a pharmaceutical in a microparticulate state that does not readily cross the stratum corneum of the epidermis. The dissolved and microparticulate pharmaceuticals may be the same or different pharmaceuticals. Methods for the preparation and use of the compositions are also provided. In a preferred embodiment, the invention finds particular use in a formulation for the topical application of dapsone for the treatment of acne. In another preferred embodiment, the invention finds particular use for the treatment of herpes lesions.
    • 本发明一般涉及能够控制药物,递送特性和针对特定药物和特定疾病定制的最佳药物递送策略的开发的药物组合物。 该组合物包括具有渗透表皮角质层的能力的溶解药物,并且可以全身使用,以及微粒状态的药物,其不易于穿过表皮的角质层。 溶解和微粒化的药物可以是相同或不同的药物。 还提供了制备和使用组合物的方法。 在优选的实施方案中,本发明特别用于局部施用氨苯砜以治疗痤疮的制剂。 在另一优选实施方案中,本发明特别用于治疗疱疹病变。
    • 9. 发明授权
    • Compositions and methods for topical application of therapeutic agents
    • 局部应用治疗剂的组合物和方法
    • US6060085A
    • 2000-05-09
    • US201521
    • 1998-11-30
    • David W. Osborne
    • David W. Osborne
    • A61K9/06A61K45/00A61K47/30A61P23/02A61P29/00A61P31/04A61P31/12A61K9/10
    • A61K9/06Y10S514/859Y10S514/944
    • The present invention generally relates to pharmaceutical compositions that enable control of drug delivery properties and the development of optimal drug delivery strategies customized for particular drugs and particular diseases. The composition includes a dissolved pharmaceutical that has the capacity to permeate the stratum corneum layer of the epidermis and become available systemically, and a pharmaceutical in a microparticulate state that does not readily cross the stratum corneum of the epidermis. The dissolved and microparticulate pharmaceuticals may be the same or different pharmaceuticals. Methods for the preparation and use of the compositions are also provided. In a preferred embodiment, the invention finds particular use in a formulation for the topical application of dapsone for the treatment of acne. In another preferred embodiment, the invention finds particular use for the treatment of herpes lesions.
    • 本发明一般涉及药物组合物,其能够控制药物递送性质和开发为特定药物和特定疾病定制的最佳药物递送策略。 该组合物包括具有渗透表皮角质层的能力的溶解药物,并且可以全身使用,以及微粒状态的药物,其不易于穿过表皮的角质层。 溶解和微粒化的药物可以是相同或不同的药物。 还提供了制备和使用组合物的方法。 在优选的实施方案中,本发明特别用于局部施用氨苯砜以治疗痤疮的制剂。 在另一优选实施方案中,本发明特别用于治疗疱疹病变。