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2. 发明申请

US20070105810A1 THERAPEUTICS 审中-公开
标题翻译：疗法
公开(公告)号：US20070105810A1
公开(公告)日：2007-05-10
申请号：US11422010
申请日：2006-06-02
申请人： Barry Potter , James Dowden , Antony Galione , Andreas Guse , Alexander Flugel
发明人： Barry Potter , James Dowden , Antony Galione , Andreas Guse , Alexander Flugel
IPC分类号： A61K31/70 , A01N43/04
CPC分类号： A61K31/70
摘要： The present invention relates to the use of a compound of formula (1): wherein: R1 comprises a carbonyl group and R2 is a hydrocarbyl group; optionally wherein said ring is further substituted; or a pharmaceutically acceptable salt thereof; in the manufacture of a medicament for use in one or more of: modulating the release of intracellular calcium from a store controlled by nicotinic acid adenine dinucleotide phosphate; modulating calcium spikes in mammalian cells; treating diseases in one or more of brain, heart, pancreatic cells (e.g. pancreatic acinar and pancreatic beta cells), immune cells, T-cells, haemopoietic cells including phagocytes; treating diseases in one or more of brain, heart, pancreatic cells (e.g. pancreatic acinar and pancreatic beta cells), immune cells, T-cells, haemopoietic cells including phagocytes by modulating the release of intracellular calcium from a store controlled by nicotinic acid adenine dinucleotide phosphate; treating diseases in one or more of brain, heart, and T-cells by modulating calcium spikes in mammalian cells.
摘要翻译：本发明涉及式（1）化合物的用途：其中：R 1包含羰基，R 2是烃基; 任选地，其中所述环进一步被取代; 或其药学上可接受的盐; 在制备用于以下一种或多种中的一种或多种药物中：调节由烟酸腺嘌呤二核苷酸磷酸酯控制的商店释放细胞内钙; 调节哺乳动物细胞中的钙尖峰; 治疗脑，心脏，胰腺细胞（例如胰腺和胰腺β细胞），免疫细胞，T细胞，造血细胞（包括吞噬细胞）中的一种或多种的疾病; 通过调节由烟酸腺嘌呤二核苷酸控制的商店释放细胞内钙，治疗脑，心脏，胰腺细胞（例如胰腺腺泡和胰腺β细胞），免疫细胞，T细胞，造血细胞（包括吞噬细胞）中的一种或多种的疾病磷酸盐通过调节哺乳动物细胞中的钙尖峰来治疗脑，心脏和T细胞中的一种或多种疾病。

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