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1. 发明授权

US08338447B2 Pyrido[3,4-B]indoles and methods of use 有权
标题翻译：吡啶并[3,4-B]吲哚和使用方法
公开(公告)号：US08338447B2
公开(公告)日：2012-12-25
申请号：US12410407
申请日：2009-03-24
申请人： David T. Hung , Andrew Asher Protter , Sarvajit Chakravarty , Rajendra P. Jain , Sundeep Dugar
发明人： David T. Hung , Andrew Asher Protter , Sarvajit Chakravarty , Rajendra P. Jain , Sundeep Dugar
IPC分类号： C07D471/14 , C07D471/22 , A61K31/437 , A61K31/438 , A61P25/28
CPC分类号： C07D471/14 , C07D471/04
摘要： This disclosure relates to new heterocyclic compounds that may be used to modulate a histamine receptor in an individual. Compounds of formula (I) are described, as are pharmaceutical compositions comprising the compounds and methods of using the compounds in a variety of therapeutic applications, including the treatment of a cognitive disorder, psychotic disorder, neurotransmitter-mediated disorder and/or a neuronal disorder.
摘要翻译：本公开涉及可用于调节个体中组胺受体的新杂环化合物。描述了式（I）化合物，以及包含该化合物的药物组合物以及在各种治疗应用中使用该化合物的方法，包括治疗认知障碍，精神病性障碍，神经递质介导的病症和/或神经元病症。

2. 发明授权

US08338408B2 Tetracyclic compounds 有权
标题翻译：四环化合物
公开(公告)号：US08338408B2
公开(公告)日：2012-12-25
申请号：US12259234
申请日：2008-10-27
申请人： David T. Hung , Andrew A. Protter , Rajendra P. Jain , Sundeep Dugar , Sarvajit Chakravarty , Sergey O. Bachurin , Anatoly K. Ustinov , Bogdan K. Beznosko , Nadezhda Sergeevna Beznosko, legal representative , Elena F. Shevtsova , Vladimir V. Grigoriev
发明人： David T. Hung , Andrew A. Protter , Rajendra P. Jain , Sundeep Dugar , Sarvajit Chakravarty , Sergey O. Bachurin , Anatoly K. Ustinov , Bogdan K. Beznosko , Elena F. Shevtsova , Vladimir V. Grigoriev
IPC分类号： A61K31/541 , A61K31/496 , A61K31/506 , A61K31/519 , A61K31/4439 , A61K31/437 , C07D279/12 , C07D401/06 , C07D471/04 , C07D471/14
CPC分类号： C07D471/04 , A61K31/437 , A61K31/4375 , A61K31/444 , A61K31/4545 , A61K31/496 , A61K31/4985 , A61K31/506 , A61K31/519 , A61K31/5377 , A61K31/541 , C07D417/10 , C07D471/10 , C07D471/14
摘要： This disclosure relates to new tetracyclic compounds that may be used to modulate a histamine receptor in an individual. The compounds in one embodiment are tetracyclic [4,3-b]indoles. Pharmaceutical compositions comprising the compounds are also provided, as are methods of using the compounds in a variety of therapeutic applications, including the treatment of a cognitive disorder, psychotic disorder, neurotransmitter-mediated disorder and/or a neuronal disorder.
摘要翻译：本公开涉及可用于调节个体中组胺受体的新四环化合物。一个实施方案中的化合物是四环[4,3-b]吲哚。还提供了包含化合物的药物组合物，以及在多种治疗应用中使用化合物的方法，包括治疗认知障碍，精神病性障碍，神经递质介导的病症和/或神经元病症。

3. 发明授权

US08569287B2 Azepino[4,5-B]indoles and methods of use 失效
标题翻译： Azepino [4,5-B]吲哚和使用方法
公开(公告)号：US08569287B2
公开(公告)日：2013-10-29
申请号：US12610152
申请日：2009-10-30
申请人： David T. Hung , Andrew Asher Protter , Rajendra Parasmal Jain , Sarvajit Chakravarty
发明人： David T. Hung , Andrew Asher Protter , Rajendra Parasmal Jain , Sarvajit Chakravarty
IPC分类号： A61K31/55 , C07D401/06
CPC分类号： C07D487/04 , A61K31/55 , C07D471/04
摘要： This disclosure relates to new azepino[4,5-b]indole compounds that may be used to modulate a histamine receptor in an individual. Novel compounds are described, including new 1,2,3,4,5,6-tetrahydroazepino[4,5-b]indoles. Pharmaceutical compositions are also provided.
摘要翻译：本公开涉及可用于调节个体中组胺受体的新的氮杂环[4,5-b]吲哚化合物。描述了新的化合物，包括新的1,2,3,4,5,6-四氮杂吖庚因[4,5-b]吲哚。还提供药物组合物。

4. 发明申请

US20100022580A1 NEW 2,3,4,5-TETRAHYDRO-1H-PYRIDO[4,3-B]INDOLE COMPOUNDS AND METHODS OF USE THEREOF 有权
标题翻译：新的2,3,4,5-四氢-1H-吡咯并[4,3-B]吲哚化合物及其使用方法
公开(公告)号：US20100022580A1
公开(公告)日：2010-01-28
申请号：US12360061
申请日：2009-01-26
申请人： David T. Hung , Andrew Asher Protter , Sarvajit Chakravarty , Rajendra Parasmal Jain
发明人： David T. Hung , Andrew Asher Protter , Sarvajit Chakravarty , Rajendra Parasmal Jain
IPC分类号： A61K31/437 , C07D471/04 , A61P25/28
CPC分类号： C07D487/14 , C07D471/04 , C07D471/14 , C07D487/04
摘要： This disclosure relates to new tricyclic compounds that may be used to modulate a histamine receptor in an individual. Compounds are described, including new 2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole compounds. Pharmaceutical compositions comprising the compounds are also provided, as are methods of using the compounds in a variety of therapeutic applications, including the treatment of a cognitive disorder, psychotic disorder, neurotransmitter-mediated disorder and/or a neuronal disorder.
摘要翻译：本公开涉及可用于调节个体中组胺受体的新型三环化合物。描述了化合物，包括新的2,3,4,5-四氢-1H-吡啶并[4,3-b]吲哚化合物。还提供了包含化合物的药物组合物，以及在多种治疗应用中使用化合物的方法，包括治疗认知障碍，精神病性障碍，神经递质介导的病症和/或神经元病症。

5. 发明授权

US08907097B2 Pyrido[4,3-b]indoles containing rigid moieties 有权
标题翻译：含有刚性部分的吡啶并[4,3-b]吲哚
公开(公告)号：US08907097B2
公开(公告)日：2014-12-09
申请号：US12610217
申请日：2009-10-30
申请人： David T. Hung , Andrew Asher Protter , Rajendra Parasmal Jain , Sarvajit Chakravarty
发明人： David T. Hung , Andrew Asher Protter , Rajendra Parasmal Jain , Sarvajit Chakravarty
IPC分类号： C07D401/00 , A61K31/445 , C07D401/14 , C07D471/04
CPC分类号： C07D471/04 , C07D401/14
摘要： This disclosure is directed to pyrido[4,3-b]indoles having rigid moieties. The compounds in one embodiment are pyrido[4,3-b]indoles having an unsaturated hydrocarbon moiety. The compounds in another embodiment are pyrido[4,3-b]indoles having a cycloalkyl, cycloalkenyl or heterocyclyl moiety. Pharmaceutical compositions comprising the compounds are also provided, as are methods of using the compounds in a variety of therapeutic applications, including the treatment of a cognitive disorder, psychotic disorder, neurotransmitter-mediated disorder and/or a neuronal disorder.
摘要翻译：本公开涉及具有刚性部分的吡啶并[4,3-b]吲哚。一个实施方案中的化合物是具有不饱和烃部分的吡啶并[4,3-b]吲哚。另一个实施方案中的化合物是具有环烷基，环烯基或杂环基部分的吡啶并[4,3-b]吲哚。还提供了包含化合物的药物组合物，以及在多种治疗应用中使用化合物的方法，包括治疗认知障碍，精神病性障碍，神经递质介导的病症和/或神经元病症。

6. 发明授权

US09115137B2 2,3,4,5-tetrahydro-1H-pyrido[4,3-B]indole compounds and methods of use thereof 有权
标题翻译： 2,3,4,5-四氢-1H-吡啶并[4,3-B]吲哚化合物及其使用方法
公开(公告)号：US09115137B2
公开(公告)日：2015-08-25
申请号：US12360061
申请日：2009-01-26
申请人： David T. Hung , Andrew Asher Protter , Sarvajit Chakravarty , Rajendra Parasmal Jain
发明人： David T. Hung , Andrew Asher Protter , Sarvajit Chakravarty , Rajendra Parasmal Jain
IPC分类号： A61K31/44 , C07D487/14 , C07D471/04 , C07D471/14 , C07D487/04
CPC分类号： C07D487/14 , C07D471/04 , C07D471/14 , C07D487/04
摘要： Provided are new tricyclic compounds that may be used to modulate a histamine receptor in an individual. Compounds are described, including new 2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole compounds. Pharmaceutical compositions comprising the compounds are also provided, as are methods of using the compounds in a variety of therapeutic applications, including the treatment of a cognitive disorder, psychotic disorder, neurotransmitter-mediated disorder and/or a neuronal disorder.
摘要翻译：提供可用于调节个体中组胺受体的新的三环化合物。描述了化合物，包括新的2,3,4,5-四氢-1H-吡啶并[4,3-b]吲哚化合物。还提供了包含化合物的药物组合物，以及在多种治疗应用中使用化合物的方法，包括治疗认知障碍，精神病性障碍，神经递质介导的病症和/或神经元病症。

7. 发明授权

US08546381B2 Bridged heterocyclic compounds and methods of use 失效
公开(公告)号：US08546381B2
公开(公告)日：2013-10-01
申请号：US12410425
申请日：2009-03-24
申请人： David T. Hung , Andrew Asher Protter , Sarvajit Chakravarty , Rajendra Parasmal Jain
发明人： David T. Hung , Andrew Asher Protter , Sarvajit Chakravarty , Rajendra Parasmal Jain
IPC分类号： A61K31/54
CPC分类号： C07D451/00 , C07D471/08 , C07D471/18
摘要： This disclosure relates to new compounds that may be used to modulate a histamine receptor in an individual. Novel compounds are described, including new bridged heterocyclic [4,3-b]indole compounds. Pharmaceutical compositions are also provided. Pharmaceutical compositions comprising the compounds are also provided, as are methods of using the compounds in a variety of therapeutic applications, including the treatment of a cognitive disorder, psychotic disorder, neurotransmitter-mediated disorder and/or a neuronal disorder.

8. 发明申请

US20100152163A1 AZEPINO[4,5-B]INDOLES AND METHODS OF USE 失效
标题翻译： AZEPINO [4,5-B]吲哚和使用方法
公开(公告)号：US20100152163A1
公开(公告)日：2010-06-17
申请号：US12610152
申请日：2009-10-30
申请人： David T. Hung , Andrew Asher Protter , Rajendra Parasmal Jain , Sarvajit Chakravarty
发明人： David T. Hung , Andrew Asher Protter , Rajendra Parasmal Jain , Sarvajit Chakravarty
IPC分类号： A61K31/55 , C07D487/04 , A61P25/00
CPC分类号： C07D487/04 , A61K31/55 , C07D471/04
摘要： This disclosure relates to new azepino[4,5-b]indole compounds that may be used to modulate a histamine receptor in an individual. Novel compounds are described, including new 1,2,3,4,5,6-tetrahydroazepino[4,5-b]indoles. Pharmaceutical compositions are also provided.
摘要翻译：本公开涉及可用于调节个体中组胺受体的新的氮杂环[4,5-b]吲哚化合物。描述了新的化合物，包括新的1,2,3,4,5,6-四氮杂吖庚因[4,5-b]吲哚。还提供药物组合物。

9. 发明申请

US20100152108A1 METHODS AND COMBINATION THERAPIES FOR TREATING ALZHEIMER'S DISEASE 审中-公开
标题翻译：治疗阿尔茨海默病的方法和组合治疗
公开(公告)号：US20100152108A1
公开(公告)日：2010-06-17
申请号：US12447448
申请日：2007-10-26
申请人： David T. Hung , Andrew Asher Protter
发明人： David T. Hung , Andrew Asher Protter
IPC分类号： A61K38/18 , A61K31/437 , A61P25/28 , A61K31/55
CPC分类号： A61K31/437 , A61K31/445 , A61K45/06 , A61K2300/00
摘要： The invention provides methods and combination therapies for treating and/or preventing and/or slowing the onset and/or development of Alzheimer's disease using a hydrogenated pyrido (4,3-b) indole (e.g., dimebon) in conjunction with another compound, pharmaceutically acceptable salt thereof or therapy for Alzheimer's disease.
摘要翻译：本发明提供了使用氢化吡啶并（4,3-b）吲哚（例如，二甲氧基）与另一种化合物结合治疗和/或预防和/或预防和/或预防和/或减缓阿尔茨海默氏病的发病和/或发展的方法和组合疗法可接受的盐或阿尔茨海默氏病的治疗。

10. 发明申请

US20100178277A1 METHODS AND COMPOSITIONS FOR STIMULATING CELLS 审中-公开
标题翻译：刺激细胞的方法和组合物
公开(公告)号：US20100178277A1
公开(公告)日：2010-07-15
申请号：US12602090
申请日：2008-05-23
申请人： David T. Hung , Andrew Asher Protter
发明人： David T. Hung , Andrew Asher Protter
IPC分类号： A61K35/12 , A61K31/437 , C12N5/07 , C12N5/079 , A61P25/00
CPC分类号： A61K31/44
摘要： The invention provides compositions and methods for treating, preventing, delaying the onset, and/or delaying the development of a disease or condition for which the activation, differentiation, and/or proliferation of one or more cell types is beneficial. These compositions and methods include, for example, a hydrogenated pyrido[4,3-b]indole such as dimebon and/or a cell that has been incubated with a hydrogenated pyrido[4,3-b]indole such as dimebon. In some embodiments, the compositions and methods also include a growth factor and/or an anti-cell death compound. The invention also provides methods of activating a cell, promoting the differentiation of a cell, and/or promoting the proliferation of a cell by incubating the cell with one or more hydrogenated pyrido[4,3-b]indoles or pharmaceutically acceptable salts thereof. In some embodiments, the cell is also incubated with one or more growth factors and/or anti-cell death compounds.
摘要翻译：本发明提供用于治疗，预防，延缓发作和/或延缓一种或多种细胞类型的活化，分化和/或增殖有益的疾病或病症的发展的组合物和方法。这些组合物和方法包括例如氢化吡啶并[4,3-b]吲哚如二甲氧基和/或已经与氢化吡啶并[4,3-b]吲哚（如二甲氧基）孵育的细胞。在一些实施方案中，组合物和方法还包括生长因子和/或抗细胞死亡化合物。本发明还提供了通过将细胞与一种或多种氢化吡啶并[4,3-b]吲哚或其药学上可接受的盐一起孵育来激活细胞，促进细胞分化和/或促进细胞增殖的方法。在一些实施方案中，细胞还与一种或多种生长因子和/或抗细胞死亡化合物一起温育。

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