专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US4360527A 9-(Hydroxy, lower alkoxy or lower alkanoyloxy)-2-(1H-tetrazol-5-yl)naphtho-(2,1-b)-pyran-1-ones and anti-allergic use thereof 失效
标题翻译： 9-（羟基，低级烷氧基或低级烷酰氧基）-2-（1H-四唑-5-基）萘并（2,1-b） - 吡喃-1-酮及其抗过敏用途
公开(公告)号：US4360527A
公开(公告)日：1982-11-23
申请号：US144509
申请日：1980-04-28
申请人： David T. Connor , Patricia A. Young , Maximilian von Strandtmann
发明人： David T. Connor , Patricia A. Young , Maximilian von Strandtmann
IPC分类号： C07D311/92 , C07F5/04 , A61K31/41 , C07D405/02
CPC分类号： C07F5/04 , C07D311/92
摘要： This invention relates to Compounds of formula II: ##STR1## wherein Y is formyl, carboxylic acid, acrylic acid, cyano or tetrazolo; X is hydrogen, lower alkanoyl or lower alkyl, and their non-toxic, pharmaceutically acceptable salts are disclosed. These compounds are useful in the prevention of allergic and asthmatic reactions.
摘要翻译：本发明涉及式II化合物：其中Y是甲酰基，羧酸，丙烯酸，氰基或四唑; X是氢，低级烷酰基或低级烷基，及其无毒的药学上可接受的盐。这些化合物可用于预防过敏和哮喘反应。

2. 发明授权

US4076716A Substituted 3-(2-pyridinyl)-4(1H)-quinolinone N-oxides 失效
标题翻译：取代的3-（2-吡啶基）-4（1H） - 喹啉酮N-氧化物
公开(公告)号：US4076716A
公开(公告)日：1978-02-28
申请号：US699911
申请日：1976-06-25
申请人： David T. Connor , Patricia A. Young , Maximilian VON Strandtmann
发明人： David T. Connor , Patricia A. Young , Maximilian VON Strandtmann
IPC分类号： C07D401/04
CPC分类号： C07D401/04 , Y10S514/826
摘要： Substituted 3-(2-pyridinyl)-4(1H)-quinolinone N-oxides having the formula I: ##STR1## wherein R.sub.1 is hydrogen, halogen, lower alkyl, hydroxy or alkoxy; R.sub.2 is hydrogen or lower alkyl; R.sub.3 is hydrogen or --CH.sub.2 OH; the dotted line indicates the possible presence of a double bond at the 2,3-position of the quinoline ring; the pharmaceutically acceptable acid addition salts thereof; and a process for the preparation thereof, are described. The compounds of the invention are useful for the treatment of hyperacidity and for the prevention of allergic and asthmatic reactions.
摘要翻译：取代的具有式I的3-（2-吡啶基）-4（1H） - 喹啉酮N-氧化物：其中R 1是氢，卤素，低级烷基，羟基或烷氧基; R2是氢或低级烷基; R3是氢或-CH2OH; 虚线表示在喹啉环的2,3位可能存在双键; 其药学上可接受的酸加成盐; 并描述其制备方法。本发明的化合物可用于治疗过酸和预防过敏和哮喘反应。

3. 发明授权

US4056619A 1-Substituted-2-(2-pyridinyl)ethanone N-oxides 失效
标题翻译： 1-取代的2-（2-吡啶基）乙酮N-氧化物
公开(公告)号：US4056619A
公开(公告)日：1977-11-01
申请号：US611282
申请日：1975-09-08
申请人： David T. Connor , Patricia A. Young , Maximilian VON Strandtmann
发明人： David T. Connor , Patricia A. Young , Maximilian VON Strandtmann
IPC分类号： C07D213/89 , A61K31/44
CPC分类号： C07D213/89
摘要： 1-Substituted-2-(2-pyridinyl)ethanone N-oxides having the formula I or II: ##STR1## wherein R.sub.1 is hydrogen or lower alkyl; R.sub.2 and R.sub.3 are each hydrogen, halogen, hydroxy, lower alkyl, lower alkoxy, or benzyloxy; R.sub.4 is halogen, hydroxy, lower alkyl, lower alkoxy, benzyloxy, ortho-amino, ortho-lower alkylamino, ortho-alkanoylamino or ortho-benzoylamino; and R.sub.5 is hydrogen, halogen, hydroxy, lower alkyl, lower alkoxy or benzyloxy; the pharmaceutically acceptable acid addition salts thereof, and a process for the preparation thereof, are described. The compounds of this invention are useful for the treatment of allergic conditions and for the treatment of hyperacidity.
摘要翻译： 1-取代的2-（2-吡啶基）乙酮具有式I或II的N-氧化物：其中R 1是氢或低级烷基; R2和R3各自为氢，卤素，羟基，低级烷基，低级烷氧基或苄氧基; R4是卤素，羟基，低级烷基，低级烷氧基，苄氧基，邻氨基，邻 - 低级烷基氨基，邻 - 烷酰氨基或邻 - 苯甲酰基氨基; R5是氢，卤素，羟基，低级烷基，低级烷氧基或苄氧基; 其药学上可接受的酸加成盐及其制备方法。本发明的化合物可用于治疗过敏症状和治疗过酸。

4. 发明授权

US4225722A Process for the production of 2-(1H-tetrazol-5-yl)-9-hydroxy-1-oxo-1H-naphtho-(2,1-b) pyran and intermediates therefor 失效
标题翻译：制备2-（1H-四唑-5-基）-9-羟基-1-氧代-1H-萘并（2,1-b）吡喃及其中间体的方法
公开(公告)号：US4225722A
公开(公告)日：1980-09-30
申请号：US841782
申请日：1977-10-13
申请人： David T. Connor , Patricia A. Young , Maximilian Von Strandtmann
发明人： David T. Connor , Patricia A. Young , Maximilian Von Strandtmann
IPC分类号： C07D311/92 , C07F5/04 , C07D405/04
CPC分类号： C07D311/92 , C07F5/04
摘要： This invention relates to Compounds of formula II: ##STR1## wherein Y is formyl, carboxylic acid, acrylic acid, cyano or tetrazolo; X is hydrogen, lower alkanoyl or lower alkyl, and their non-toxic, pharmaceutically acceptable salts are disclosed. These compounds are useful in the prevention of allergic and asthamatic reactions.
摘要翻译：本发明涉及式II化合物：其中Y是甲酰基，羧酸，丙烯酸，氰基或四唑; X是氢，低级烷酰基或低级烷基，及其无毒的药学上可接受的盐。这些化合物可用于预防过敏和哮喘反应。

5. 发明授权

US4123536A Dialkyl ({[3-(alkoxycarbonyl)-1,4-dihydro-4-oxo-8-quinolinyl]amino}methylene)pro panedioates 失效
标题翻译：二烷基（{55 {8-（烷氧基羰基）-1,4-二氢-4-氧代-8-喹啉基{9氨基{56亚甲基）丙二酸二
公开(公告)号：US4123536A
公开(公告)日：1978-10-31
申请号：US860526
申请日：1977-12-14
申请人： David T. Connor , Patricia A. Young , Maximilian Von Strandtmann
发明人： David T. Connor , Patricia A. Young , Maximilian Von Strandtmann
IPC分类号： C07D215/56 , C07D471/04 , A61K31/47
CPC分类号： C07D471/04 , C07D215/56
摘要： The present invention relates to dialkyl ({[3-(alkoxy-carbonyl)-1,4-dihydro-4-oxo-8-quinolinyl]amino}methylene)-propanedioates having the following structural formula: ##STR1## wherein R.sub.1 is lower alkyl; and R.sub.2 is hydrogen, halogen, lower alkyl or nitro.These compounds exhibit antibacterial activity against gram positive and gram negative bacteria and are therefore useful in the treatment of bacterial infections caused by these organisms.
摘要翻译：本发明涉及具有以下结构式的（{[3-（烷氧基 - 羰基）-1,4-二氢-4-氧代-8-喹啉基]氨基}亚甲基） - 丙二酸二烷基酯低级烷基并且R 2是氢，卤素，低级烷基或硝基。

6. 发明授权

US3973020A 3-(2-Pyridinyl)-4(1H)-cinnolinone N-oxides 失效
标题翻译： 3-（2-吡啶基）-4（1H） - 噌啉酮N-氧化物
公开(公告)号：US3973020A
公开(公告)日：1976-08-03
申请号：US611120
申请日：1975-09-08
申请人： David T. Connor , Patricia A. Young , Maximilian VON Strandtmann
发明人： David T. Connor , Patricia A. Young , Maximilian VON Strandtmann
IPC分类号： C07D401/04 , A61K31/495 , C07D237/28
CPC分类号： C07D401/04 , Y10S514/819
摘要： 3-(2-Pyridinyl)-4(1H)-cinnolinone N-oxides of the formula I: ##SPC1##wherein R is hydrogen, halogen, lower alkyl, hydroxy or alkoxy; the pharmaceutically acceptable acid addition salts thereof; and a process for the preparation thereof, are described. The compounds of the invention are useful for the treatment of hyperacidity.
摘要翻译： 3-（2-吡啶基）-4（1H） - 噌啉酮式I的N-氧化物：

7. 发明授权

US4076720A 1-Substituted-2-(2-pyridinyl)ethanone N-oxides 失效
标题翻译： 1-取代的2-（2-吡啶基）乙酮N-氧化物
公开(公告)号：US4076720A
公开(公告)日：1978-02-28
申请号：US762549
申请日：1977-01-25
申请人： David T. Connor , Patricia A. Young , Maximilian VON Strandtmann
发明人： David T. Connor , Patricia A. Young , Maximilian VON Strandtmann
IPC分类号： C07D213/89 , C07D213/50
CPC分类号： C07D213/89
摘要： 1-Substituted-2-(2-pyridinyl)ethanone N-oxides having the formula I or II: ##STR1## wherein R.sub.1 is hydrogen or lower alkyl; R.sub.2 and R.sub.3 are each hydrogen, halogen, hydroxy, lower alkyl, lower alkoxy, or benzyloxy; R.sub.4 is halogen, hydroxy, lower alkyl, lower alkoxy, benzyloxy, ortho-amino, ortho-lower alkylamino, ortho-alkanoylamino or ortho-benzoylamino; and R.sub.5 is hydrogen, halogen, hydroxy, lower alkyl, lower alkoxy or benzyloxy; the pharmaceutically acceptable acid addition salts thereof, and a process for the preparation thereof, are described. The compounds of this invention are useful for the treatment of allergic conditions and for the treatment of hyperacidity.This is a division of application Ser. No. 611,282 filed Sept. 8, 1975.
摘要翻译： 1-取代的2-（2-吡啶基）乙酮具有式I或II的N-氧化物：其中R 1是氢或低级烷基; R2和R3各自为氢，卤素，羟基，低级烷基，低级烷氧基或苄氧基; R4是卤素，羟基，低级烷基，低级烷氧基，苄氧基，邻氨基，邻 - 低级烷基氨基，邻 - 烷酰氨基或邻 - 苯甲酰基氨基; R5是氢，卤素，羟基，低级烷基，低级烷氧基或苄氧基; 其药学上可接受的酸加成盐及其制备方法。本发明的化合物可用于治疗过敏症状和治疗过酸。

8. 发明授权

US4018781A 2-Aryl substituted isoxazolo(2,3-alpha)pyridinyl halides 失效
标题翻译： 2-芳基取代的异恶唑（2,3-α）吡啶基卤化物
公开(公告)号：US4018781A
公开(公告)日：1977-04-19
申请号：US690478
申请日：1976-05-27
申请人： David T. Connor , Patricia A. Young , Maximilian VON Strandtmann
发明人： David T. Connor , Patricia A. Young , Maximilian VON Strandtmann
IPC分类号： C07D498/04 , C07D498/00
CPC分类号： C07D498/04
摘要： 2-Aryl substituted isoxazolo[2,3-a]pyridinyl halides having the formula I: ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 are each hydrogen, halogen, hydroxy, lower alkyl, lower alkoxy or lower alkanoyl; R.sub.4 is hydrogen or lower alkyl; X is a bromide, chloride or iodide salt; the pharmaceutically acceptable, acid addition salts thereof; and processes for the preparation thereof, are described. The compounds of the invention are useful as anti-inflammatory agents and for the treatment of hyperacidity.
摘要翻译：具有式I的2-芳基取代的异恶唑并[2,3-a]吡啶基卤化物：其中R 1，R 2和R 3各自为氢，卤素，羟基，低级烷基，低级烷氧基或低级烷酰基; R4是氢或低级烷基; X是溴化物，氯化物或碘化物盐; 其药学上可接受的酸加成盐; 并描述其制备方法。本发明的化合物可用作抗炎剂和用于治疗胃酸过多。

9. 发明授权

US3983237A 2-Aryl substituted isoxazolo[2,3-a]pyridinyl halides 失效
标题翻译： 2-芳基取代的异恶唑并[8，2,3-a {9吡啶基卤化物
公开(公告)号：US3983237A
公开(公告)日：1976-09-28
申请号：US611281
申请日：1975-09-08
申请人： David T. Connor , Patricia A. Young , Maximilian VON Strandtmann
发明人： David T. Connor , Patricia A. Young , Maximilian VON Strandtmann
IPC分类号： C07D498/04 , A61K31/44
CPC分类号： C07D498/04
摘要： 2-Aryl substituted isoxazolo[2,3-a]pyridinyl halides having the formula I: ##SPC1##wherein R.sub.1, R.sub.2 and R.sub.3 are each hydrogen, halogen, hydroxy, lower alkyl, lower alkoxy or lower alkanoyl; R.sub.4 is hydrogen or lower alkyl; X is a bromide, chloride or iodide salt; and processes for the preparation thereof, are described. The compounds of the invention are useful as anti-inflammatory agents and for the treatment of hyperacidity.
摘要翻译：具有式I的2-芳基取代的异恶唑并[2,3-a]吡啶基卤化物：

10. 发明授权

US4104274A 1-Substituted-2-(2-pyridinyl)ethanone N-oxides 失效
标题翻译： 1-取代的2-（2-吡啶基）乙酮N-氧化物
公开(公告)号：US4104274A
公开(公告)日：1978-08-01
申请号：US825011
申请日：1977-08-16
申请人： David T. Connor , Patricia A. Young , Maximilian VON Strandtmann
发明人： David T. Connor , Patricia A. Young , Maximilian VON Strandtmann
IPC分类号： C07D213/89
CPC分类号： C07D213/89
摘要： 1-Substituted-2-(2-pyridinyl)ethanone N-oxides having the formula I or II: ##STR1## wherein R.sub.1 is hydrogen or lower alkyl; R.sub.2 and R.sub.3 are each hydrogen, halogen, hydroxy, lower alkyl, lower alkoxy, or benzyloxy; R.sub.4 is halogen, hydroxy, lower alkyl, lower alkoxy, benzyloxy, ortho-amino, ortho-lower alkylamino, ortho-alkanoylamino or ortho benzoylamino; and R.sub.5 is hydrogen, halogen, hydroxy, lower alkyl, lower alkoxy or benzyloxy; the pharmaceutically acceptable acid addition salts thereof, and a process for the preparation thereof, are described. The compounds of this invention are useful for the treatment of allergic conditions and for the treatment of hyperacidity.
摘要翻译： 1-取代的2-（2-吡啶基）乙酮具有式I或II的N-氧化物：其中R 1是氢或低级烷基; R2和R3各自为氢，卤素，羟基，低级烷基，低级烷氧基或苄氧基; R4是卤素，羟基，低级烷基，低级烷氧基，苄氧基，邻氨基，邻 - 低级烷基氨基，邻 - 烷酰氨基或邻苯甲酰氨基; R5是氢，卤素，羟基，低级烷基，低级烷氧基或苄氧基; 其药学上可接受的酸加成盐及其制备方法。本发明的化合物可用于治疗过敏症状和治疗过酸。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式