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1. 发明申请

US20060286636A1 VEGF variants 审中-公开
标题翻译： VEGF变体
公开(公告)号：US20060286636A1
公开(公告)日：2006-12-21
申请号：US11414724
申请日：2006-04-28
申请人： David Shima , Anthony Adamis , Gregory Robinson , Yin-Shan Ng , Kazuaki Nishijima , Dominik Krilleke
发明人： David Shima , Anthony Adamis , Gregory Robinson , Yin-Shan Ng , Kazuaki Nishijima , Dominik Krilleke
IPC分类号： C07K14/475 , C07H21/04 , C12P21/06 , A61K38/18
CPC分类号： C07K14/475 , A61K38/00 , C07K14/52 , G01N2500/00 , G01N2800/168 , G01N2800/32
摘要： Applicants have defined the pro-inflammatory domain of the Vascular Endothelial Growth Factor VEGF164(165) protein molecule using VEGF164 protein mutants in which the heparin binding domain is inactivated through alanine scanning, site directed mutagenesis. The invention provides novel VEGF variants having a modified heparin binding domain. The VEGF variants modified heparin binding function compared to native VEGF while maintaining receptor binding function. The invention provides compositions and methods for treating disorders relating to angiogenesis and inflammation.
摘要翻译：申请人使用VEGF164蛋白突变体定义了血管内皮生长因子VEGF164（165）蛋白分子的促炎域，其中肝素结合结构域通过丙氨酸扫描，定点诱变失活。本发明提供具有修饰的肝素结合结构域的新型VEGF变体。 VEGF变体修饰的肝素结合功能与天然VEGF相比，同时保持受体结合功能。本发明提供了治疗与血管生成和炎症有关的疾病的组合物和方法。

2. 发明申请

US20050260651A1 Enhanced biologically active conjugates 审中-公开
标题翻译：增强的生物活性缀合物
公开(公告)号：US20050260651A1
公开(公告)日：2005-11-24
申请号：US11105279
申请日：2005-04-13
申请人： Pericles Calias , Gary Cook , David Shima , Anthony Adamis , Yin-Shan Ng , Gregory Robinson , David Turner , Mary Ganley
发明人： Pericles Calias , Gary Cook , David Shima , Anthony Adamis , Yin-Shan Ng , Gregory Robinson , David Turner , Mary Ganley
IPC分类号： A61K31/716 , A61K31/785 , A61K47/48 , A61K49/00 , C08G63/48 , C12Q1/68
CPC分类号： A61K49/0002 , A61K47/60 , A61K47/61
摘要： The invention provides compositions and methods for making and using sterically enhanced antagonist aptamer conjugates that include a nucleic acid sequence having a specific affinity for a target molecule and a soluble, high molecular weight steric group that augments or facilitates the inhibition of binding to, or interaction with, the target molecule binding partner by the target molecule when bound to the aptamer conjugate. The present invention also provides methods and formulations for ocular delivery of a biologically active molecule by attaching a charged moiety to the biologically active molecule and delivering the biologically active molecule by iontophoresis. Iontophoresis of a biologically active molecule that is conjugated to a high molecular weight neutral moiety, in enhanced by substituting the high molecular weight neutral moiety with a charged molecule of comparable size.
摘要翻译：本发明提供了制备和使用空间增强的拮抗剂适体缀合物的组合物和方法，其包括对靶分子具有特异性亲和力的核酸序列和增加或促进抑制结合或相互作用的可溶性高分子量空间基团当靶分子与适配体缀合物结合时，靶分子结合配偶体。本发明还提供了通过将带电部分附着到生物活性分子并通过离子电渗递送生物活性分子来生物活性分子的眼部递送的方法和制剂。通过与具有相当大小的带电分子取代高分子量中性部分来增强与高分子量中性部分缀合的生物活性分子的离子电渗疗法。

3. 发明申请

US20060019298A1 Sequencing of modified nucleic acid molecules 审中-公开
标题翻译：修饰核酸分子的测序
公开(公告)号：US20060019298A1
公开(公告)日：2006-01-26
申请号：US11184240
申请日：2005-07-19
申请人： David Shima , Pericles Calias , Gregory Robinson , Yin-Shan Ng , Francine Wincott , Corinna Krinos
发明人： David Shima , Pericles Calias , Gregory Robinson , Yin-Shan Ng , Francine Wincott , Corinna Krinos
IPC分类号： C12Q1/68 , C12P19/34
CPC分类号： C12N15/1096 , C12N2310/322 , C12P19/34 , C12Q1/6869 , C12Q2525/113
摘要： Modified nucleic acids are used for many purposes in research, diagnostic, and treatment protocols. However, direct sequencing of such molecules is generally considered to require special conditions. Methods of making a cDNA using a modified nucleic acid molecule and sequencing methods of sequencing a modified nucleic acid molecule are described.
摘要翻译：修饰的核酸在研究，诊断和治疗方案中用于许多目的。然而，这种分子的直接测序通常被认为需要特殊的条件。描述了使用修饰的核酸分子制备cDNA的方法和测序修饰的核酸分子的测序方法。

4. 发明申请

US20070178476A1 Detection of oligonucleotides by dual hybridization 失效
标题翻译：通过双杂交检测寡核苷酸
公开(公告)号：US20070178476A1
公开(公告)日：2007-08-02
申请号：US11186660
申请日：2005-07-21
申请人： David Shima , Pericles Calias , Gregory Robinson , John Wing , Lori Mullin , Lillian Smith , Ervin Sinani
发明人： David Shima , Pericles Calias , Gregory Robinson , John Wing , Lori Mullin , Lillian Smith , Ervin Sinani
IPC分类号： C12Q1/68 , C12P19/34
CPC分类号： C12Q1/6837 , C12Q1/6816 , C12Q2561/125 , C12Q2561/101 , C12Q2525/205 , C12Q2533/107 , C12Q2537/125 , C12Q2531/113 , C12Q2525/155
摘要： The invention provides methods and compositions for detecting and/or quantifying modified nucleic acid oligonucleotides. These methods and compositions are useful for detecting and quantifying diagnostic and/or therapeutic synthetic modified oligonucleotides, such as aptamers, RNAi, siRNA, antisense oligonucleotides or ribozymes in a biological sample.
摘要翻译：本发明提供了用于检测和/或定量修饰的核酸寡核苷酸的方法和组合物。这些方法和组合物可用于检测和定量诊断和/或治疗合成修饰的寡核苷酸，例如生物样品中的适体，RNAi，siRNA，反义寡核苷酸或核酶。

5. 发明申请

US20070141637A1 Marker for fenestrae 审中-公开
标题翻译：开窗的标记
公开(公告)号：US20070141637A1
公开(公告)日：2007-06-21
申请号：US11274800
申请日：2005-11-15
申请人： David Shima , Sofia Ioannidou , Gregory Robinson , Heming Xing
发明人： David Shima , Sofia Ioannidou , Gregory Robinson , Heming Xing
IPC分类号： G01N33/567 , C12Q1/37
CPC分类号： G01N33/56966 , G01N33/5064 , G01N33/6803 , G01N33/6842
摘要： The invention relates to a plasma membrane marker for identifying fenestrae. The invention also relates to a method of visualizing fenestrae utilizing a plasma membrane marker and light microscopy. The invention also relates to a method of identifying a plasma membrane marker for fenestrae. In particular, the invention relates to the characterization of moesin as a component of fenestrae sieve plates. More particularly, the invention relates to the use of moesin as a plasma membrane marker. Moesin may be used as a plasma membrane marker for the identification of fenestrae or permeability of endothelial cells.
摘要翻译：本发明涉及用于识别窗孔的质膜标记物。本发明还涉及利用质膜标记物和光学显微镜观察窗口的方法。本发明还涉及一种鉴定门窗的质膜标记物的方法。特别地，本发明涉及作为窗筛板的组分的moesin的表征。更具体地说，本发明涉及moesin作为质膜标记物的用途。 Moesin可用作鉴定眼内膜或内皮细胞通透性的质膜标记物。

6. 发明申请

US20220174948A1 MULTI-PURPOSE DISINFECTANT, DEGREASER, CLEANER AND HERBICIDE 有权
公开(公告)号：US20220174948A1
公开(公告)日：2022-06-09
申请号：US17117082
申请日：2020-12-09
申请人： Gregory Robinson
发明人： Gregory Robinson
IPC分类号： A01N33/12 , A01N25/30 , C11D3/48 , C11D3/30 , C11D3/18 , C11D1/835 , C11D3/12
摘要： A natural cleaning and herbicide composition having an quaternary ammonium compound, one or more additional amine-based surfactants, and an herbicidally active limonene component, that synergistically creates an effective COVID-19 disinfectant in wipes, an effective clearer for bulk cleaning applications, as well as an impressive gross soils remover following EPA protocol. The composition may further contain sodium silicate, tetrasodium iminodisuccinate, an ethanolamine, caustic potash, and/or water. A formulation of the present disclosure comprises a mixture of about 74% soft water, about 1% Tetrasodium Iminodisuccinate, about 0.5% Monoethanolamine, about 0.5% Sodium Silicate, about 2% alkali surfactant, about 12% Ethoxylated Amine, about 1% Amine Oxide, about 1% Quaternary Amine, and about 6% Limonene.

7. 发明授权

US11008211B2 System and method for distributing scented, color-coded, or color scented dilution ratios of disinfectants, disinfectant based cleaning concentrates and ready to use foaming and non foaming hard surface, soft surface and skin cleaning concentrates that are diluted into ready to use form products 有权
公开(公告)号：US11008211B2
公开(公告)日：2021-05-18
申请号：US16554137
申请日：2019-08-28
申请人： Gregory Robinson
发明人： Gregory Robinson
IPC分类号： B67D7/74 , B67D7/02 , C11D13/08 , C11D13/10 , C11D11/00
摘要： A system and method for distributing color-coded dilution ratios of cleaning concentrates at different dilution ratios and flow rates. The system mixes a concentrated cleaning composition with different quantities of water to produce diluted concentrates. A plurality of separate dyes or scented dyes are added to the diluted concentrates, with each color of dye correlating to a unique diluted concentrate. This provides a visual indication of the dilution ratio of the diluted concentrate. A plurality of metering devices selectively dispense the dyed diluted concentrates at different dilution ratios and at multiple flow rates. The metering devices are labeled with identification markings, indicating dilution ratios and flow rates. The dilution ratio and the flow rate are selected based on the type of cleaning that is required, and the type of dispensing means used for cleaning. A plurality of lines carry the concentrated cleaning composition, water, dyes, and dyed diluted concentrate.

8. 发明申请

US20210061639A1 SYSTEM AND METHOD FOR DISTRIBUTING SCENTED, COLOR-CODED, OR COLOR SCENTED DILUTION RATIOS OF DISINFECTANTS, DISINFECTANT BASED CLEANING CONCENTRATES AND READY TO USE FOAMING AND NON FOAMING HARD SURFACE, SOFT SURFACE AND SKIN CLEANING CONCENTRATES THAT ARE DILUTED INTO READY TO USE FORM PRODUCTS 有权
公开(公告)号：US20210061639A1
公开(公告)日：2021-03-04
申请号：US16554137
申请日：2019-08-28
申请人： Gregory Robinson
发明人： Gregory Robinson
IPC分类号： B67D7/74 , B67D7/02 , C11D11/00 , C11D13/10 , C11D13/08
摘要： A system and method for distributing color-coded dilution ratios of cleaning concentrates at different dilution ratios and flow rates. The system mixes a concentrated cleaning composition with different quantities of water to produce diluted concentrates. A plurality of separate dyes or scented dyes are added to the diluted concentrates, with each color of dye correlating to a unique diluted concentrate. This provides a visual indication of the dilution ratio of the diluted concentrate. A plurality of metering devices selectively dispense the dyed diluted concentrates at different dilution ratios and at multiple flow rates. The metering devices are labeled with identification markings, indicating dilution ratios and flow rates. The dilution ratio and the flow rate are selected based on the type of cleaning that is required, and the type of dispensing means used for cleaning. A plurality of lines carry the concentrated cleaning composition, water, dyes, and dyed diluted concentrate.

9. 发明申请

US20060048846A1 Instrumentation control software 有权
标题翻译：仪表控制软件
公开(公告)号：US20060048846A1
公开(公告)日：2006-03-09
申请号：US11217084
申请日：2005-08-31
申请人： Luke Roenneburg , Gregory Robinson , Kirby Reed , Christian Zander
发明人： Luke Roenneburg , Gregory Robinson , Kirby Reed , Christian Zander
IPC分类号： B65B43/42
CPC分类号： G01N35/00584 , G01N30/88 , G01N2030/8804 , G01N2035/0091
摘要： A controller controls a sequence of actions at a device. The controller includes computer instructions that receive a plurality of user inputs and command information associated with an action for the device to perform. The first user input defines a target in a bed layout of the device. The second user input assigns the target to a first zone of the bed layout. The third user input assigns the target to a second zone of the bed layout. The fourth user input indicates an operational mode for controlling performance of the action. The operational mode includes a non-validation mode defining a state of operation wherein a device limitation is not imposed to restrict the action. The command information includes a command name identifying the action and a device identifier. A unique command method corresponding to the device identifier and to the command name is identified and executed to control operation of the device as it performs the action at the defined target without imposing the device limitation if the fourth user input indicates the non-validation mode.
摘要翻译：控制器控制设备上的一系列动作。控制器包括接收多个用户输入的计算机指令和与该设备执行的动作相关联的命令信息。第一个用户输入定义了设备的床布局中的目标。第二用户输入将目标分配给床布局的第一区域。第三用户输入将目标分配给床布局的第二区域。第四用户输入指示用于控制动作的操作的操作模式。操作模式包括定义操作状态的非验证模式，其中不施加设备限制来限制动作。命令信息包括识别动作的命令名称和设备标识符。识别并执行对应于设备标识符和命令名称的唯一命令方法，以在第四用户输入指示非验证模式时执行设备的操作，以控制设备的操作，而不施加设备限制。

10. 发明公开

US20240158052A1 Combination Fishing Net Mud Spike 审中-公开
公开(公告)号：US20240158052A1
公开(公告)日：2024-05-16
申请号：US18389215
申请日：2023-11-13
申请人： Gregory Robinson
发明人： Gregory Robinson
IPC分类号： B63B21/00 , A01K75/00
CPC分类号： B63B21/00 , A01K75/00 , B63B2021/003
摘要： A combination fishing net mud spike may attach or clamp to a variety of types of personal watercraft (PWC) including, but not limited to, bass boats, pontoon boats, canoes, and/or kayaks, to secure the PWC while fishing. The mud spike may be used to secure the PWC in shallow waters for fishing. Further, the ring portion of the combination fishing net mud spike may be used to secure around a tree. Accordingly, the mud spike and/or the ring portion may be used to hold the PWC in place for fishing or other water activities, and the combination fishing net mud spike does not require being near a dock/pier or piling to be used. However, the combination fishing net mud spike may be secured to a dock/pier. The ring portion may include slots or other securing mechanisms to receive a fishing net.

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