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1. 发明授权

US08983594B2 Electronic control of drug delivery system 有权
标题翻译：药物输送系统的电子控制
公开(公告)号：US08983594B2
公开(公告)日：2015-03-17
申请号：US12648726
申请日：2009-12-29
申请人： David Saar , Bogdan Mariusz Baudis , Rainuka Gupta , Vaishali Vilas Kamat , Matthew Kent Reich , Rajagopalan Srinivasan
发明人： David Saar , Bogdan Mariusz Baudis , Rainuka Gupta , Vaishali Vilas Kamat , Matthew Kent Reich , Rajagopalan Srinivasan
IPC分类号： A61N1/30 , A61N1/04 , A61N1/32
CPC分类号： A61N1/325 , A61N1/0436 , A61N1/0448 , A61N1/303
摘要： In an exemplary embodiment, a drug delivery device for driving an electrotransport current through a body surface of a user is provided. The device includes a patch with two electrodes and one or more reservoirs storing a therapeutic agent. The one or more reservoirs release the therapeutic agent into the body surface of the user when the reservoirs are positioned over the electrodes to form an electrical path for the electrotransport current. The device includes a controller which controls a controllable power supply to drive the electrotransport current through the body surface of the user in a predetermined profile.
摘要翻译：在一个示例性实施例中，提供了用于驱动通过用户的身体表面的电输送电流的药物递送装置。该装置包括具有两个电极的贴片和一个或多个存储治疗剂的储存器。当储存器位于电极上方时，一个或多个储存器将治疗剂释放到使用者的身体表面中，以形成用于电输送电流的电路径。该装置包括控制器，该控制器控制可控电源以预定的轮廓驱动穿过使用者的身体表面的电输送电流。

2. 发明申请

US20100262066A1 ELECTRONIC CONTROL OF DRUG DELIVERY SYSTEM 有权
标题翻译：药物输送系统的电子控制
公开(公告)号：US20100262066A1
公开(公告)日：2010-10-14
申请号：US12648726
申请日：2009-12-29
申请人： David Saar , Bogdan Mariusz Baudis , Rainuka Gupta , Vaishali Vilas Kamat , Matthew Kent Reich , Rajagopalan Srinivasan
发明人： David Saar , Bogdan Mariusz Baudis , Rainuka Gupta , Vaishali Vilas Kamat , Matthew Kent Reich , Rajagopalan Srinivasan
IPC分类号： A61N1/30
CPC分类号： A61N1/325 , A61N1/0436 , A61N1/0448 , A61N1/303
摘要： In an exemplary embodiment, a drug delivery device for driving an electrotransport current through a body surface of a user is provided. The device includes a patch with two electrodes and one or more reservoirs storing a therapeutic agent. The one or more reservoirs release the therapeutic agent into the body surface of the user when the reservoirs are positioned over the electrodes to form an electrical path for the electrotransport current. The device includes a controller which controls a controllable power supply to drive the electrotransport current through the body surface of the user in a predetermined profile.
摘要翻译：在一个示例性实施例中，提供了用于驱动通过用户的身体表面的电输送电流的药物递送装置。该装置包括具有两个电极的贴片和一个或多个存储治疗剂的储存器。当储存器位于电极上方时，一个或多个储存器将治疗剂释放到使用者的身体表面中，以形成用于电输送电流的电路径。该装置包括控制器，该控制器控制可控电源以预定的轮廓驱动穿过使用者的身体表面的电输送电流。

3. 发明授权

US07736312B2 Acoustic monitoring system 有权
标题翻译：声学监控系统
公开(公告)号：US07736312B2
公开(公告)日：2010-06-15
申请号：US10762963
申请日：2004-01-22
申请人： Terri K. Taylor , Meir Rosenberg , Rainuka Gupta , Stephen Ferrer Wilson , Pierre S. Ostiguy , Bertil Romner , Alan J. Dextradeur
发明人： Terri K. Taylor , Meir Rosenberg , Rainuka Gupta , Stephen Ferrer Wilson , Pierre S. Ostiguy , Bertil Romner , Alan J. Dextradeur
IPC分类号： A61B8/00
CPC分类号： A61B7/005 , A61B2562/0204
摘要： An acoustic monitoring system that is able to verify the success or failure of the positional adjustment of a valve without the need for additional energy during non-invasive reprogramming is provided. The acoustic monitoring system includes a programmer for generating a sequence of commands to adjust the valve mechanism, and for receiving acoustic signals for analysis, a transmitter to implement the command and adjust the valve, and a sensor for detecting an acoustic signal generated from the valve during execution of the commands. A method for using the acoustic monitoring system is also provided.
摘要翻译：提供一种声学监测系统，其能够在非侵入式重新编程期间验证阀的位置调整的成功或失败，而不需要额外的能量。声学监测系统包括一个编程器，用于产生一系列命令以调节阀门机构，并且用于接收用于分析的声学信号，发射器来实现该指令并调整阀门;以及传感器，用于检测从阀门产生的声学信号在执行命令期间。还提供了一种使用声学监测系统的方法。

4. 发明授权

US07040485B2 Method and apparatus for packaging a drug-device combination product 有权
标题翻译：用于包装药物装置组合产品的方法和装置
公开(公告)号：US07040485B2
公开(公告)日：2006-05-09
申请号：US11174115
申请日：2005-07-01
申请人： Rainuka Gupta , Alan J. Dextradeur
发明人： Rainuka Gupta , Alan J. Dextradeur
IPC分类号： B65D73/00
CPC分类号： A61L2/206 , A61L2/07 , A61L2/14 , A61L2/18 , A61L2/20 , B65D33/01
摘要： A package for a drug-device combination product includes an outer package including a first gas impermeable sheet and a second gas impermeable sheet hermetically sealed there to on three sides. A gas permeable header is attached to an unsealed side of the first sheet and sealed to the second sheet on two sides. The first and second gas impermeable sheets and the header form an interior and an opening communicating with the interior. A gas permeable inner package is disposed within the outer package. A product is sealed within the inner package. The inner package is placed within the outer package and a top end of the header is sealed to the second sheet. The outer package is then sealed by sealing the first gas impermeable sheet to the second gas impermeable sheet at a seal point below the point where the header attaches to the first sheet.
摘要翻译：用于药物装置组合产品的包装包括外包装，其包括第一不透气片和在三面上气密密封的第二不透气片。气体可渗透的头部附接到第一片的未密封侧并且在两侧密封到第二片。第一和第二气体不可渗透片材和头部形成与内部连通的内部和开口。气体可渗透的内包装设置在外包装内。产品密封在内包装内。内包装被放置在外包装内，并且头部的顶端被密封到第二片。然后通过在头部附接到第一片材的点下方的密封点处将第一不透气片材密封到第二不透气片材上来密封外包装。

5. 发明授权

US07094214B2 System and method for clearing an implanted catheter that is connected to a shunt 有权
标题翻译：用于清除连接到分流器的植入导管的系统和方法
公开(公告)号：US07094214B2
公开(公告)日：2006-08-22
申请号：US10607692
申请日：2003-06-27
申请人： Alan J. Dextradeur , Terri Kelcourse Taylor , Rainuka Gupta
发明人： Alan J. Dextradeur , Terri Kelcourse Taylor , Rainuka Gupta
IPC分类号： A61M5/00
CPC分类号： A61N1/08 , A61M25/0068 , A61M25/007 , A61M27/006 , A61M2025/0019 , A61N1/0529 , A61N1/0551
摘要： A shunt has a housing and a base. The base has a first set of electrodes extending across the base. A catheter is connected to the housing. The catheter has a longitudinal length, a proximal end, and a distal end. The catheter has a second set of electrodes extending along the longitudinal length of the catheter. At least two of the electrodes of said first set are electrically connected to two of the electrodes of the second set. The housing including a self sealing, needle penetrable outer housing wall. The system includes a probe assembly that is selectively penetratable through an outer housing wall.
摘要翻译：分流器有一个外壳和一个底座。底座具有延伸穿过基座的第一组电极。导管连接到外壳。导管具有纵向长度，近端和远端。导管具有沿着导管的纵向长度延伸的第二组电极。所述第一组的至少两个电极电连接到第二组的两个电极。外壳包括一个自密封，可穿透的外壳壁。该系统包括可以通过外部壳体壁选择性地穿透的探针组件。

6. 发明申请

US20050241981A1 Method and apparatus for packaging a drug-device combination product 有权
标题翻译：用于包装药物装置组合产品的方法和装置
公开(公告)号：US20050241981A1
公开(公告)日：2005-11-03
申请号：US11174115
申请日：2005-07-01
申请人： Rainuka Gupta , Alan Dextradeur
发明人： Rainuka Gupta , Alan Dextradeur
IPC分类号： B65D81/24 , A61J1/00 , A61J1/03 , A61J1/14 , A61L2/07 , A61L2/14 , A61L2/18 , A61L2/20 , B65D33/01 , B65D77/04 , B65D83/04
CPC分类号： A61L2/206 , A61L2/07 , A61L2/14 , A61L2/18 , A61L2/20 , B65D33/01
摘要： A package for a drug-device combination product includes an outer package including a first gas impermeable sheet and a second gas impermeable sheet hermetically sealed there to on three sides. A gas permeable header is attached to an unsealed side of the first sheet and sealed to the second sheet on two sides. The first and second gas impermeable sheets and the header form an interior and an opening communicating with the interior. A gas permeable inner package is disposed within the outer package. A product is sealed within the inner package. The inner package is placed within the outer package and a top end of the header is sealed to the second sheet. The outer package is then sealed by sealing the first gas impermeable sheet to the second gas impermeable sheet at a seal point below the point where the header attaches to the first sheet.
摘要翻译：用于药物装置组合产品的包装包括外包装，其包括第一不透气片和在三面上气密密封的第二不透气片。气体可渗透的头部附接到第一片的未密封侧并且在两侧密封到第二片。第一和第二气体不可渗透片材和头部形成与内部连通的内部和开口。气体可渗透的内包装设置在外包装内。产品密封在内包装内。内包装被放置在外包装内，并且头部的顶端被密封到第二片。然后通过在头部附接到第一片材的点下方的密封点处将第一不透气片材密封到第二不透气片材上来密封外包装。

7. 发明申请

US20050067312A1 Method for improving stability and effectivity of a drug-device combination product 有权
标题翻译：提高药物组合产品的稳定性和有效性的方法
公开(公告)号：US20050067312A1
公开(公告)日：2005-03-31
申请号：US10676333
申请日：2003-09-30
申请人： Rainuka Gupta , Alan Dextradeur
发明人： Rainuka Gupta , Alan Dextradeur
IPC分类号： B65D81/24 , A61J1/00 , A61J1/03 , A61J1/14 , A61L2/07 , A61L2/14 , A61L2/18 , A61L2/20 , B65D33/01 , B65D77/04 , B65D73/00 , B65D85/84
CPC分类号： A61L2/206 , A61L2/07 , A61L2/14 , A61L2/18 , A61L2/20 , B65D33/01
摘要： A package for a drug-device combination product includes an outer package including a first gas impermeable sheet and a second gas impermeable sheet hermetically sealed there to on three sides. A gas permeable header is attached to an unsealed side of the first sheet and sealed to the second sheet on two sides. The first and second gas impermeable sheets and the header form an interior and an opening communicating with the interior. A gas permeable inner package is disposed within the outer package. A product is sealed within the inner package. The inner package is placed within the outer package and a top end of the header is sealed to the second sheet. The outer package is then sealed by sealing the first gas impermeable sheet to the second gas impermeable sheet at a seal point below the point where the header attaches to the first sheet.
摘要翻译：用于药物装置组合产品的包装包括外包装，其包括第一不透气片和在三面上气密密封的第二不透气片。气体可渗透的头部附接到第一片的未密封侧并且在两侧密封到第二片。第一和第二气体不可渗透片材和头部形成与内部连通的内部和开口。气体可渗透的内包装设置在外包装内。产品密封在内包装内。内包装被放置在外包装内，并且头部的顶端被密封到第二片。然后通过在头部附接到第一片材的点下方的密封点处将第一不透气片材密封到第二不透气片材上来密封外包装。

8. 发明授权

US06996952B2 Method for improving stability and effectivity of a drug-device combination product 有权
标题翻译：提高药物组合产品的稳定性和有效性的方法
公开(公告)号：US06996952B2
公开(公告)日：2006-02-14
申请号：US10676333
申请日：2003-09-30
申请人： Rainuka Gupta , Alan J. Dextradeur
发明人： Rainuka Gupta , Alan J. Dextradeur
IPC分类号： B65B31/06 , B65B55/18
CPC分类号： A61L2/206 , A61L2/07 , A61L2/14 , A61L2/18 , A61L2/20 , B65D33/01
摘要： A package for a drug-device combination product includes an outer package including a first gas impermeable sheet and a second gas impermeable sheet hermetically sealed there to on three sides. A gas permeable header is attached to an unsealed side of the first sheet and sealed to the second sheet on two sides. The first and second gas impermeable sheets and the header form an interior and an opening communicating with the interior. A gas permeable inner package is disposed within the outer package. A product is sealed within the inner package. The inner package is placed within the outer package and a top end of the header is sealed to the second sheet. The outer package is then sealed by sealing the first gas impermeable sheet to the second gas impermeable sheet at a seal point below the point where the header attaches to the first sheet.
摘要翻译：用于药物装置组合产品的包装包括外包装，其包括第一不透气片和在三面上气密密封的第二不透气片。气体可渗透的头部附接到第一片的未密封侧并且在两侧密封到第二片。第一和第二气体不可渗透片材和头部形成与内部连通的内部和开口。气体可渗透的内包装设置在外包装内。产品密封在内包装内。内包装被放置在外包装内，并且头部的顶端被密封到第二片。然后通过在头部附接到第一片材的点下方的密封点处将第一不透气片材密封到第二不透气片材上来密封外包装。

9. 发明申请

US20050004460A1 Acoustic monitoring system 有权
标题翻译：声学监控系统
公开(公告)号：US20050004460A1
公开(公告)日：2005-01-06
申请号：US10762963
申请日：2004-01-22
申请人： Terri Taylor , Meir Rosenberg , Rainuka Gupta , Stephen Wilson , Pierre Ostiguy , Bertil Romner , Alan Dextradeur
发明人： Terri Taylor , Meir Rosenberg , Rainuka Gupta , Stephen Wilson , Pierre Ostiguy , Bertil Romner , Alan Dextradeur
IPC分类号： A61M1/00 , A61B7/00 , A61B8/00
CPC分类号： A61B7/005 , A61B2562/0204
摘要： An acoustic monitoring system that is able to verify the success or failure of the positional adjustment of a valve without the need for additional energy during non-invasive reprogramming is provided. The acoustic monitoring system includes a programmer for generating a sequence of commands to adjust the valve mechanism, and for receiving acoustic signals for analysis, a transmitter to implement the command and adjust the valve, and a sensor for detecting an acoustic signal generated from the valve during execution of the commands. A method for using the acoustic monitoring system is also provided.
摘要翻译：提供一种声学监测系统，其能够在非侵入式重新编程期间验证阀的位置调整的成功或失败，而不需要额外的能量。声学监测系统包括一个编程器，用于产生一系列命令以调节阀门机构，并且用于接收用于分析的声学信号，发射器来实现该指令并调整阀门;以及传感器，用于检测从阀门产生的声学信号在执行命令期间。还提供了一种使用声学监测系统的方法。

10. 发明授权

US07771381B2 Shunt valve locking mechanism 有权
标题翻译：分流阀锁定机构
公开(公告)号：US07771381B2
公开(公告)日：2010-08-10
申请号：US12029818
申请日：2008-02-12
申请人： Daniel McCusker , Alan J. Dextradeur , Rainuka Gupta , Carleton Bryan Southworth
发明人： Daniel McCusker , Alan J. Dextradeur , Rainuka Gupta , Carleton Bryan Southworth
IPC分类号： A61M5/00 , F16K31/12 , F16K35/00
CPC分类号： F16K35/025 , A61M27/006 , F16K35/04 , Y10T70/5615 , Y10T137/7069 , Y10T137/7225 , Y10T137/7256
摘要： A locking assembly is provided to simply and effectively prevent any unintentional adjustment of the adjustable valve mechanism in a fluid flow control device, without compromising the function of the device. The locking assembly generally includes at least one gripping arm for frictionally engaging at least a portion of the adjustable valve mechanism, and an actuating mechanism for controlling the deployment and release of the gripping arm. The locking assembly prevents unintentional adjustments that can adversely affect the pressure settings of the fluid flow control device. In particular, the locking assembly prevents unintentional adjustment, such as may be caused by the presence of a strong external magnetic field. The locking assembly can be easily disengaged, such as through the application or removal of an external mechanical force, to allow a clinician to adjust the pressure settings of the fluid flow control device as necessary.
摘要翻译：提供了一种锁定组件，以简单且有效地防止流体流量控制装置中的可调节阀机构的任何无意的调节，而不会影响装置的功能。锁定组件通常包括至少一个夹紧臂，用于摩擦地接合可调节阀机构的至少一部分，以及用于控制夹持臂的展开和释放的致动机构。锁定组件防止可能不利地影响流体流量控制装置的压力设置的意外调整。特别地，锁定组件防止无意的调整，例如可能由于存在强的外部磁场而引起。锁定组件可以容易地脱离，例如通过施加或移除外部机械力，以允许临床医生根据需要调节流体流量控制装置的压力设置。

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