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1. 发明授权

US4613619A Anti-arrhythmic amino-alcohols 失效
标题翻译：抗心律失常氨基醇
公开(公告)号：US4613619A
公开(公告)日：1986-09-23
申请号：US704491
申请日：1985-02-22
申请人： Thomas Sleigh , David S. Savage , John K. Clark
发明人： Thomas Sleigh , David S. Savage , John K. Clark
IPC分类号： A61K31/135 , A61K31/165 , A61K31/215 , A61K31/22 , A61P9/06 , C07C1/22 , C07C17/00 , C07C33/38 , C07C43/215 , C07C43/23 , C07C43/285 , C07C43/295 , C07C45/46 , C07C45/65 , C07C49/792 , C07C49/813 , C07C49/84 , C07C67/00 , C07C213/00 , C07C215/44 , C07C217/52 , C07C217/74 , C07C217/76 , C07C217/90 , C07C219/24 , C07C219/26 , A61K31/235 , C07C91/16 , C07C93/24 , C07C93/26
CPC分类号： C07C1/22 , C07C17/35 , C07C33/38 , C07C43/215 , C07C43/23 , C07C43/285 , C07C43/295 , C07C45/46 , C07C45/65 , C07C49/792 , C07C49/813 , C07C49/84 , C07C2101/08 , Y10S514/821
摘要： The invention concerns novel anti-arrhythmic amino-alcohol derivatives, characterized by the general formula (1) ##STR1## or pharmaceutically acceptable salts thereof, wherein R.sub.1, R.sub.2 and R.sub.3 each independently represent hydrogen, alkyl having 1-6 carbon atoms, alkoxy having 1-6 carbon atoms, acyloxy having 1-6 carbon atoms, hydroxy, halogen or optionally alkyl-substituted amino;R.sub.4 represents hydrogen, hydroxy or alkyl having 1-6 carbon atoms,R.sub.5 represents hydrogen or alkyl having 1-6 carbon atoms,R.sub.6 represents hydrogen, acyl having 1-18 carbon atoms or alkyl having 1-6 carbon atoms,R.sub.7 and R.sub.8 each independently represent hydrogen or alkyl having 1-6 carbon atoms,X represents a direct bond or an oxygen atom, andn and m each independently are integers having a value of 1 or 2, whereby the sum of n and m is 2 or 3.
摘要翻译：本发明涉及新型抗心律失常氨基醇衍生物，其特征在于通式（1）其中R1，R2和R3各自独立地代表氢，具有1-6个碳原子的烷基，具有1-6个碳原子的烷氧基，具有1-6个碳原子的酰氧基，羟基，卤素或任选的烷基取代的氨基; R4表示氢，羟基或具有1-6个碳原子的烷基，R5表示氢或1-6个碳原子的烷基，R6表示氢，具有1-18个碳原子的酰基或具有1-6个碳原子的烷基，R7和R8各自独立地表示独立地表示氢或具有1-6个碳原子的烷基，X表示直接键或氧原子，n和m各自独立地为具有1或2的整数，由此n和m的和为2或3。

2. 发明授权

US4801753A Biologically active tricyclic compounds and pharmaceutical compositions containing same 失效
标题翻译：生物活性三环化合物和含有它们的药物组合物
公开(公告)号：US4801753A
公开(公告)日：1989-01-31
申请号：US98203
申请日：1987-09-17
申请人： David S. Savage , Thomas Sleigh , John K. Clark
发明人： David S. Savage , Thomas Sleigh , John K. Clark
IPC分类号： A61K31/13 , A61K31/135 , A61K31/165 , A61P25/24 , A61P25/26 , C07C67/00 , C07C209/00 , C07C211/42 , C07D295/073 , C07D303/32 , C07C87/64
CPC分类号： C07D295/073 , C07D303/32
摘要： The present invention relates to novel biologically active tricyclic compounds, of the general formula I: ##STR1## and salts thereof, in which R.sub.1 represents hydrogen, alkyl of 1-6 carbon atoms, an optionally substituted aralkyl group or an acyl group,R.sub.2 represents hydrogen, alkyl (1-6 C), or an optionally substituted aralkyl group, orR.sub.1 +R.sub.2 together with the nitrogen atom represent a heterocyclic 5- or 6-membered ring, p1 X and Y each represent hydrogen, hydroxy, halogen, alkyl or alkoxy of 1-6 carbon atoms, nitro, CF.sub.3 or an acyloxy group, andthe dotted line signifies an optional extra bond.The compounds of the general formula I have valuable anti-depressant activity without a sustained influence on appetite.
摘要翻译：本发明涉及通式Ⅰ：其中R 1表示氢，1-6个碳原子的烷基，任意取代的芳烷基或酰基的通式Ⅰ及其盐的新型生物活性三环化合物，R2 表示氢，烷基（1-6C）或任选取代的芳烷基，或者R1 + R2与氮原子一起表示杂环的5或6元环，p1 X和Y各自表示氢，羟基，卤素， 1-6个碳原子的烷基或烷氧基，硝基，CF 3或酰氧基，虚线表示任选的额外键。通式I的化合物具有有价值的抗抑郁活性，而对食欲没有持续的影响。

3. 发明授权

US5598708A Phase responsive fluid delivery 失效
标题翻译：相位响应流体输送
公开(公告)号：US5598708A
公开(公告)日：1997-02-04
申请号：US367217
申请日：1995-01-06
申请人： John K. Clark
发明人： John K. Clark
IPC分类号： F17C7/02 , F17C13/02
CPC分类号： F17C13/02 , F17C7/02 , F17C2205/0326 , F17C2205/0335 , F17C2205/0341 , F17C2221/035 , F17C2223/0153 , F17C2223/033 , F17C2250/032 , F17C2250/0447
摘要： A system for delivering fluid, e.g. liquefied petroleum gas or "LPG", through a delivery path (10) under pressure. A delivery control valve (16) is selectably operable to close and open the delivery path (10) and monitors a parameter of the fluid, e.g. dielectric constant, and to sense the presence of vapor or gas phase in the fluid. A control means (30) responsive to the indicating signal from the sensing means (20) causes the delivery control valve (16) to close the delivery path upon sensing the presence of a significant proportion of vapor or gas phase in the fluid. A gas introduction point (35) upstream of the sensing means (20) enables gas to be introduced so as to knowingly expose the sensing means (20) to fluid containing gas phase and thereby enable controlled testing of the correct functioning of the sensing means (20). In the case of the fluid being liquefied gas, pumping means (45) upstream of the sensing means (20) can continue operation after closure of the delivery control valve (16) so that the gas or vapor phase will undergo compression and as a result will liquify and the control means (30) will then cause re-opening of the delivery control valve (16). The closure of the delivery control valve (16) prevents liquefied gas having a significant proportion of gas or vapor phase passing through a metering means (15) downstream of the sensing means (20).
摘要翻译： PCT No.PCT / AU93 / 00402 Sec。 371 1995年1月6日第 102（e）日期1995年1月6日PCT提交1993年8月9日PCT公布。公开号WO94 / 03755 日期1994年2月17日。液化石油气或“LPG”，通过压力下的输送路径（10）。输送控制阀（16）可选择地操作以关闭和打开输送路径（10）并监测流体的参数，例如流体。介电常数，并且感测流体中气相或气相的存在。响应于来自感测装置（20）的指示信号的控制装置（30）使得输送控制阀（16）在检测到流体中存在相当大比例的蒸汽或气相时闭合输送路径。在感测装置（20）上游的气体引入点（35）能够引入气体，从而有意识地将感测装置（20）暴露于含有气相的流体，从而能够对感测装置的正确功能进行受控测试（ 20）。在流体为液化气体的情况下，在传感装置（20）上游的泵送装置（45）可在关闭输送控制阀（16）之后继续运行，使气体或气相经受压缩，结果将液化，并且控制装置（30）将导致输送控制阀（16）的重新打开。输送控制阀（16）的关闭防止具有显着比例的气相或气相的液化气体通过感测装置（20）下游的计量装置（15）。

4. 发明授权

US5006606A Tire with rubber tread 失效
标题翻译：轮胎与橡胶胎面
公开(公告)号：US5006606A
公开(公告)日：1991-04-09
申请号：US500629
申请日：1990-03-28
申请人： John K. Clark
发明人： John K. Clark
IPC分类号： B60C1/00 , C08L9/00 , C08L21/00
CPC分类号： B60C1/0016 , C08L9/00 , C08L7/00 , C08L9/02
摘要： A pneumatic tire with tread composed of a sulfur cured rubber comprised of, based on the rubber (A) cis 1,4-polyisoprene; (B) at least one of isoprene/acrylonitrile rubber and butadiene/acrylonitrile rubber and, optionally; (C) at least one additional rubber which includes cis 1,4-polybutadiene characterized in that the cis 1,4-polybutadiene is a primary rubber constituent.

5. 发明授权

US4926919A Vehicle tire with rib type tread pattern having sipes across the ribs 失效
标题翻译：具有肋状胎面花纹的车辆轮胎具有跨越肋的刀槽花纹
公开(公告)号：US4926919A
公开(公告)日：1990-05-22
申请号：US270598
申请日：1988-11-14
申请人： William M. Hopkins , Robert A. Brightwell , Ray A. Young , John K. Clark , Frederick W. Miller , Richard L. Galante , Terry J. Waibel , Michael A. Kolowski
发明人： William M. Hopkins , Robert A. Brightwell , Ray A. Young , John K. Clark , Frederick W. Miller , Richard L. Galante , Terry J. Waibel , Michael A. Kolowski
IPC分类号： B60C20060101 , B60C9/08 , B60C11/04 , B60C11/11 , B60C11/12
CPC分类号： B60C11/04 , B60C11/0306 , Y10S152/03
摘要： A vehicle tire (10) has a tread (20) with a plurality of ribs (30,31,32) extending circumferentially about the tread. The ribs each have a pair of lateral edges (48,49;60,61) which comprise edge segments placed end to end to present a zigzag configuration. Each rib has grooves (37,38;39,40) therein which intersect the lateral edges of the respective rib and have varying depths at said lateral edges. Preferably, the tread has an all-season configuration.

6. 外观设计

USD338180S Tire tread and buttress 失效
公开(公告)号：USD338180S
公开(公告)日：1993-08-10
申请号：US676225
申请日：1991-03-27
申请人： Rudy E. Consolacion , Randall R. Brayer , John K. Clark , Robert A. Stella
设计人： Rudy E. Consolacion , Randall R. Brayer , John K. Clark , Robert A. Stella

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