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    • 2. 发明授权
    • Cosmetic composition and method
    • 化妆品成分及方法
    • US06713074B2
    • 2004-03-30
    • US09896566
    • 2001-06-29
    • David S. LernerGregory Schultz
    • David S. LernerGregory Schultz
    • A61K700
    • A61Q19/00A61K8/492A61K8/63A61K8/97A61K31/404A61K2800/782A61Q19/08
    • The cosmetic topical formulation of this invention is directed toward diminishing skin wrinkling, fine line, improving skin tone, and combinations thereof. Preferably, the topical formulation contains a matrix metalloproteinase inhibitor, MMPI, and advantageously includes a natural estrogen, e.g., a true estrogen compound, such as 17-beta estradiol, or an estrogen-like steroid, (such as various phytoestrogens found in herbal preparations), as opposed to a synthetic estrogen. Other forms of the cosmetic topical formulation of this invention include combinations of synthetic estrogen and MMP inhibitor. Exemplary synthetic estrogens include, but are not limited to, ethinyl estradiol and clomiphine citrate. The cosmetic topical formulation is safe and effective diminishing wrinkling, and improving skin tone. Certain compositions of this invention are useful for minimizing photodamage to skin, while in other embodiments, the composition according to this invention is useful to prevent or minimize the adverse effects on skin induced by cigarette smoking.
    • 本发明的化妆品局部制剂旨在减少皮肤皱纹,细纹,改善肤色及其组合。 优选地,局部制剂含有基质金属蛋白酶抑制剂MMPI,并且有利地包括天然雌激素,例如真正的雌激素化合物,例如17-β雌二醇或雌激素样类固醇(例如在草药制剂中发现的各种植物雌激素 ),而不是合成雌激素。 本发明的其它形式的化妆品局部制剂包括合成雌激素和MMP抑制剂的组合。 示例性合成的雌激素包括但不限于乙炔雌二醇和柠檬酸氯霉素。 化妆品局部制剂安全有效地减少皱纹,改善肤色。 本发明的某些组合物可用于使对皮肤的光损伤最小化,而在其它实施方案中,根据本发明的组合物可用于预防或最小化由吸烟引起的对皮肤的不利影响。
    • 6. 发明申请
    • Method for minimizing or avoiding adverse effects of vesicants
    • 减少或避免发泡剂不良反应的方法
    • US20080139512A1
    • 2008-06-12
    • US11343024
    • 2006-01-30
    • David S. LernerGregory Schultz
    • David S. LernerGregory Schultz
    • A61K31/665A61K31/573A61K31/405A61K31/137A61K31/095
    • A61K31/095A61K31/137A61K31/405A61K31/573A61K31/665A61K2300/00
    • The invention pertains to compositions and methods to treat the adverse effects of mustard chemicals and other toxic compounds, such as chemical warfare agents, exposure to which normally induces vesicating type response in mammals. In a rodent eye model at fixed concentrations of such a vesicant, compositions comprising a matrix metalloproteinase inhibitor, MMPI, a significant reduction in morbidity is achieved. with increased concentrations of the compositions of this invention, as compared with vehicle alone. Furthermore, compositions comprising the MMPI and in addition, an anti-inflammatory compound, in a vehicle appropriate to the type of tissue damage to be protected against from vesicant exposure, achieves both reduction in total tissue damage and inflammation, as compared with anti-inflammatory composition alone. Chemicals having more than one property, such as MMPI and AIA properties, are also disclosed.
    • 本发明涉及治疗芥子化学物质和其它有毒化合物(例如化学战剂)的不良反应的组合物和方法,其通常在哺乳动物中诱导发泡型反应。 在固定浓度的这种发泡剂的啮齿动物眼模型中,包含基质金属蛋白酶抑制剂MMPI的组合物达到显着降低发病率。 与本发明的组合物的浓度增加,与单独的载体相比。 此外,与抗炎剂相比,包含MMPI的组合物和除了抗炎化合物之外的组合物适合于防止发生泡沫暴露的组织损伤类型的赋形剂,与抗炎剂相比,减少了总组织损伤和炎症 单独组合 还公开了具有多于一种性质的化学品,例如MMPI和AIA性质。