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1. 发明授权

US08207202B2 Benzamide compounds useful as histone deacetylase inhibitors 有权
标题翻译：可用作组蛋白脱乙酰酶抑制剂的苯甲酰胺化合物
公开(公告)号：US08207202B2
公开(公告)日：2012-06-26
申请号：US12090611
申请日：2006-10-17
申请人： David Michael Andrews , Elaine Sophie Elizabeth Stokes , Andrew Turner , Michael James Waring
发明人： David Michael Andrews , Elaine Sophie Elizabeth Stokes , Andrew Turner , Michael James Waring
IPC分类号： A61K31/454 , C07D401/06
CPC分类号： C07D401/06
摘要： The invention concerns benzamide compounds of formula (I), wherein R1 is a C-linked pyrazole ring, which is optionally substituted by one or more groups selected from C1-4alkyl, C3-4cycloalkyl, C1-4alkoxy and C3-4cycloalkoxy; or a pharmaceutically acceptable salt or pro-drug form thereof. The invention also concerns processes for the preparation of such compounds, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use as an antiproliferative agent in the prevention or treatment of tumors or other proliferative conditions, which are sensitive to the inhibition of histone deacetylase (HDAC).
摘要翻译：本发明涉及式（I）的苯甲酰胺化合物，其中R 1是C连接的吡唑环，其任选被一个或多个选自C 1-4烷基，C 3-4环烷基，C 1-4烷氧基和C 3-4环烷氧基的基团取代; 或其药学上可接受的盐或前药形式。本发明还涉及制备此类化合物的方法，含有它们的药物组合物及其在制备用于预防或治疗肿瘤或其它增殖性病症中的药物中的用途，所述肿瘤或其它增殖性病症对抑制组蛋白脱乙酰酶（HDAC）。

2. 发明申请

US20080269294A1 Benzamide Compounds Useful as Histone Deacetylase Inhibitors 有权
标题翻译：用作组蛋白脱乙酰酶抑制剂的苯甲酰胺化合物
公开(公告)号：US20080269294A1
公开(公告)日：2008-10-30
申请号：US12090611
申请日：2005-10-17
申请人： David Michael Andrews , Elaine Sophie Elizabeth Stokes , Andrew Turner , Michael James Waring
发明人： David Michael Andrews , Elaine Sophie Elizabeth Stokes , Andrew Turner , Michael James Waring
IPC分类号： A61K31/454 , C07D401/06 , C07D211/32 , A61P35/04
CPC分类号： C07D401/06
摘要： The invention concerns benzamide compounds of formula (I), wherein R1 is a C-linked pyrazole ring, which is optionally substituted by one or more groups selected from C1-4alkyl, C3-4cycloalkyl, C1-4alkoxy and C3-4cycloalkoxy; or a pharmaceutically acceptable salt or pro-drug form thereof. The invention also concerns processes for the preparation of such compounds, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use as an antiproliferative agent in the prevention or treatment of tumours or other proliferative conditions, which are sensitive to the inhibition of histone deacetylase (HDAC).
摘要翻译：本发明涉及式（I）的苯甲酰胺化合物，其中R 1是C连接的吡唑环，其任选被一个或多个选自C 1-4的基团取代烷基，C 3-4环烷基，C 1-4烷氧基和C 3-4环烷氧基; 或其药学上可接受的盐或前药形式。本发明还涉及制备此类化合物的方法，含有它们的药物组合物及其在制备用于预防或治疗肿瘤或其它增殖性病症中的药物中的用途，所述肿瘤或其它增殖性病症对抑制组蛋白脱乙酰酶（HDAC）。

3. 发明授权

US08735429B2 Benzamide compounds useful as histone deacetylase inhibitors 有权
标题翻译：可用作组蛋白脱乙酰酶抑制剂的苯甲酰胺化合物
公开(公告)号：US08735429B2
公开(公告)日：2014-05-27
申请号：US13472095
申请日：2012-05-15
申请人： David Michael Andrews , Elaine Sophie Elizabeth Stokes , Andrew Turner , Michael James Waring
发明人： David Michael Andrews , Elaine Sophie Elizabeth Stokes , Andrew Turner , Michael James Waring
IPC分类号： A61K31/445
CPC分类号： C07D401/06
摘要： The invention concerns benzamide compounds of formula (I): compound of formula (I): wherein R1 is a C-linked pyrazole ring, which is optionally substituted by one or more groups selected from C1-4alkyl, C3-4cycloalkyl, C1-4alkoxy and C3-4cycloalkoxy; or a pharmaceutically acceptable salt or pro-drug form thereof. The invention also concerns processes for the preparation of such compounds, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use as an antiproliferative agent in the prevention or treatment of tumors or other proliferative conditions, which are sensitive to the inhibition of histone deacetylase (HDAC).
摘要翻译：本发明涉及式（I）的苯甲酰胺化合物：式（I）化合物：其中R 1是C连接的吡唑环，其任选被一个或多个选自C 1-4烷基，C 3-4环烷基，C 1-4烷氧基和C3-4环烷氧基; 或其药学上可接受的盐或前药形式。本发明还涉及制备此类化合物的方法，含有它们的药物组合物及其在制备用于预防或治疗肿瘤或其它增殖性病症中的药物中的用途，所述肿瘤或其它增殖性病症对抑制组蛋白脱乙酰酶（HDAC）。

4. 发明申请

US20120225907A1 BENZAMIDE COMPOUNDS USEFUL AS HISTONE DEACETYLASE INHIBITORS 有权
标题翻译：苯甲酸化合物有效用作脱乙酰壳多糖酶抑制剂
公开(公告)号：US20120225907A1
公开(公告)日：2012-09-06
申请号：US13472095
申请日：2012-05-15
申请人： David Michael Andrews , Elaine Sophie Elizabeth Stokes , Andrew Turner , Michael James Waring
发明人： David Michael Andrews , Elaine Sophie Elizabeth Stokes , Andrew Turner , Michael James Waring
IPC分类号： A61K31/415 , A61P35/00 , A61P35/02 , A61K31/454
CPC分类号： C07D401/06
摘要： The invention concerns benzamide compounds of formula (I): compound of formula (I): wherein R1 is a C-linked pyrazole ring, which is optionally substituted by one or more groups selected from C1-4alkyl, C3-4cycloalkyl, C1-4alkoxy and C3-4cycloalkoxy; or a pharmaceutically acceptable salt or pro-drug form thereof. The invention also concerns processes for the preparation of such compounds, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use as an antiproliferative agent in the prevention or treatment of tumours or other proliferative conditions, which are sensitive to the inhibition of histone deacetylase (HDAC).
摘要翻译：本发明涉及式（I）的苯甲酰胺化合物：式（I）化合物：其中R 1是C连接的吡唑环，其任选被一个或多个选自C 1-4烷基，C 3-4环烷基，C 1-4烷氧基和C3-4环烷氧基; 或其药学上可接受的盐或前药形式。本发明还涉及制备此类化合物的方法，含有它们的药物组合物及其在制备用于预防或治疗肿瘤或其它增殖性病症中的药物中的用途，所述肿瘤或其它增殖性病症对抑制组蛋白脱乙酰酶（HDAC）。

5. 外观设计

USD933973S1 Frame or mat 有权
公开(公告)号：USD933973S1
公开(公告)日：2021-10-26
申请号：US29646847
申请日：2018-05-08
申请人： Andrew Turner
设计人： Andrew Turner

6. 发明申请

US20190069492A1 MACHINE FOR FORMING AND WRAPPING SQUARE BALES 审中-公开
公开(公告)号：US20190069492A1
公开(公告)日：2019-03-07
申请号：US16118819
申请日：2018-08-31
申请人： James Mathes , Justin Mathes , Andrew Turner
发明人： James Mathes , Justin Mathes , Andrew Turner
IPC分类号： A01F15/08 , A01F15/04
摘要： A combination baling and wrapping machine is provided to enclose harvested material in a protective layer to eliminate or minimize spoilage. The machine includes a bale forming station or compartment with vertical and horizontal compactors to form the bales, and a downstream wrapping station with a first zone for wrapping the bale in a first direction and a second zone for wrapping the bale in a transverse direction, such that the bale is completely enclosed by the wrap material. The machine can be operated while moving through a field or while sitting in a stationery position.

7. 发明授权

US08324531B2 Positioning means and method of use thereof 有权
标题翻译：定位方法及其使用方法
公开(公告)号：US08324531B2
公开(公告)日：2012-12-04
申请号：US12596913
申请日：2008-04-28
申请人： Andrew Turner
发明人： Andrew Turner
IPC分类号： B23K9/00
CPC分类号： B23K9/127 , B23K9/296 , B23K9/32
摘要： A positioning device (13) for producing a light signal (32) to position a robot tool (2) relative to a workpiece (14) is provided. The positioning device (13) comprises a frame (16) and a pair of light sources (22, 24) mounted at the free end of the frame and arranged to direct a pair of light beams (28, 30) therefrom in converging directions which intersect with each other and provide a light signal (32) at a predetermined distance from the free end of the frame (16). The positioning device (13) can include two pairs of light sources to generate two pairs of intersecting light beams (28, 30; 29, 31, ). The two pairs of light sources can be arranged so that the two pairs of light beams (28, 30; 29, 31) are located substantially 90 degrees apart.
摘要翻译：提供了一种用于产生相对于工件（14）定位机器人工具（2）的光信号（32）的定位装置（13）。定位装置（13）包括框架（16）和安装在框架的自由端处的一对光源（22,24），并且布置成从一个光束（28,30）的会聚方向引导一对光束彼此相交并且提供距离框架（16）的自由端预定距离的光信号（32）。定位装置（13）可以包括两对光源，以产生两对相交的光束（28,30; 29,31）。两对光源可以布置成使得两对光束（28,30; 29,31）分开大致90度。

8. 发明申请

US20070287173A9 Albumin fusion proteins 有权
公开(公告)号：US20070287173A9
公开(公告)日：2007-12-13
申请号：US11078663
申请日：2005-03-14
申请人： Craig Rosen , Homayoun Sadeghi , Christopher Prior , Andrew Turner
发明人： Craig Rosen , Homayoun Sadeghi , Christopher Prior , Andrew Turner
IPC分类号： A61K38/17 , C07H21/04 , C12P21/04
CPC分类号： A61K38/4846 , A01K2217/05 , A61K9/0019 , A61K38/21 , A61K38/212 , A61K38/38 , A61K47/42 , A61K47/65 , A61K48/00 , A61K2039/54 , C07K14/56 , C07K14/61 , C07K14/62 , C07K14/65 , C07K14/705 , C07K14/7151 , C07K14/76 , C07K14/765 , C07K2319/00 , C07K2319/21 , C07K2319/31 , C07K2319/50 , C07K2319/75 , C12N9/96 , C12N15/62 , Y02A50/386 , Y02A50/401 , Y02A50/412
摘要： The present invention encompasses albumin fusion proteins. Nucleic acid molecules encoding the albumin fusion proteins of the invention are also encompassed by the invention, as are vectors containing these nucleic acids, host cells transformed with these nucleic acids vectors, and methods of making the albumin fusion proteins of the invention and using these nucleic acids, vectors, and/or host cells. Additionally the present invention encompasses pharmaceutical compositions comprising albumin fusion proteins and methods of treating, preventing, or ameliorating diseases, disorders or conditions using albumin fusion proteins of the invention.

9. 发明申请

US20070114134A1 Recovery process 有权
标题翻译：恢复过程
公开(公告)号：US20070114134A1
公开(公告)日：2007-05-24
申请号：US10516217
申请日：2003-05-09
申请人： Stuart Legg , Christopher Jones , Andrew Turner
发明人： Stuart Legg , Christopher Jones , Andrew Turner
IPC分类号： C25C3/00 , C25B9/00
CPC分类号： G21F9/04 , G21F9/06 , G21F9/28 , G21F9/30
摘要： The present invention provides a process for the recovery of radiolabelled isotopes from organic substances labelled or contaminated with one or more radiolabelled isotopes, which process comprises: i) adding organic substances labelled or contaminated with a radiolabelled isotope to an acidic aqueous electrolyte containing silver ions as an electrochemically regenerable primary oxidising species; ii) subjecting the acidic aqueous electrolyte to an electric potential; and iii) recovering the radiolabelled isotope from the products of the electrochemical process resulting from the application of the electric potential; wherein the process is carried out at a slight pressure depression.
摘要翻译：本发明提供了从被一种或多种放射性同位素标记或污染的有机物质中回收放射性标记的同位素的方法，该方法包括：i）将标记或被放射性标记的同位素污染的有机物质加入到含有银离子的酸性含水电解质中电化学可再生的初级氧化物种; ii）使酸性水性电解质经受电位; 和iii）从施加电位而产生的电化学过程的产物中回收放射性标记的同位素; 其中所述方法在轻微的压力下进行。

10. 发明申请

US20060114127A1 CROSS-TALK LINEARITY CONNECTION 有权
标题翻译：交叉线性连接
公开(公告)号：US20060114127A1
公开(公告)日：2006-06-01
申请号：US11330779
申请日：2006-01-12
申请人： Andrew Turner
发明人： Andrew Turner
IPC分类号： H03M1/22
CPC分类号： H04N5/359 , G01J3/2803 , G01N2021/3595 , G02B21/008
摘要： An array of photoconductive elements comprises an array of radiation detectors; an electrical lead connected to the array of radiation detectors; at least one amplifier receptive of an output signal of the array of radiation detectors; a summation device receptive of an output signal of the at least one amplifier; and a positive feedback loop for reducing crosstalk by directing an output signal of the summation device to the at least one amplifier. A circuit processes the outputs of the array of radiation detectors. The photoconductive elements may be operated in a constant voltage mode or a constant current mode.
摘要翻译：光电导元件阵列包括辐射探测器阵列; 连接到辐射探测器阵列的电引线; 接收放射线检测器阵列的输出信号的至少一个放大器; 接收所述至少一个放大器的输出信号的求和装置; 以及用于通过将求和装置的输出信号引导到至少一个放大器来减少串扰的正反馈回路。 A电路处理辐射探测器阵列的输出。光电导元件可以以恒定电压模式或恒定电流模式工作。

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