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1. 发明授权

US06239267B1 VANILREP1 polynucleotides and VANILREP1 polypeptides 失效
标题翻译： VANILREP1多核苷酸和VANILREP1多肽
公开(公告)号：US06239267B1
公开(公告)日：2001-05-29
申请号：US09197636
申请日：1998-11-23
申请人： David Malcolm Duckworth , Philip David Hayes , Helen Jane Meadows , John Beresford Davis
发明人： David Malcolm Duckworth , Philip David Hayes , Helen Jane Meadows , John Beresford Davis
IPC分类号： C07H2104
CPC分类号： C07K14/705
摘要： VANILREP1 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing VANILREP1 polypeptides and polynucleotides in therapy, and diagnostic assays for such.
摘要翻译：公开了VANILREP1多肽和多核苷酸以及通过重组技术产生此类多肽的方法。还公开了在治疗中使用VANILREP1多肽和多核苷酸的方法，以及用于其的诊断测定法。

2. 发明授权

US06274380B1 Cacnglike3 polynucleotides and expression systems 失效
标题翻译： Cacnglike3多核苷酸和表达系统
公开(公告)号：US06274380B1
公开(公告)日：2001-08-14
申请号：US09392014
申请日：1999-09-08
申请人： David Malcolm Duckworth , Philip David Hayes
发明人： David Malcolm Duckworth , Philip David Hayes
IPC分类号： C12N1563
CPC分类号： G01N33/6872 , A61K38/00 , C07K14/705 , G01N2500/04
摘要： CACNGLIKE3 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing CACNGLIKE3 are calcium ion channel family members and CACNGLIKE3 polynucleotides encode for these calcium ion family proteins. Polynucleotides comprising the nucleotide sequences of the present invention provide means for production and manipulation of the CACNGLIKE3 polypeptides. The present invention also provides for the use of CACNGLIKE3 polynucleotides in recombinant expression systems.
摘要翻译：公开了CACNGLIKE3多肽和多核苷酸以及通过重组技术产生此类多肽的方法。还公开了使用CACNGLIKE3的方法是钙离子通道家族成员和编码这些钙离子家族蛋白的CACNGLIKE3多核苷酸。包含本发明核苷酸序列的多核苷酸提供了生产和操作CACNGLIKE3多肽的方法。本发明还提供了CACNGLIKE3多核苷酸在重组表达系统中的用途。

3. 发明授权

US5990133A Indole derivatives as 5-HT receptor antagonist 失效
标题翻译：吲哚衍生物作为5-HT受体拮抗剂
公开(公告)号：US5990133A
公开(公告)日：1999-11-23
申请号：US875506
申请日：1997-10-16
申请人： Laramie Mary Gaster , Paul Adrian Wyman , Keith Raymond Mulholland , David Thomas Davies , David Malcolm Duckworth , Ian Thomson Forbes , Graham Elgin Jones
发明人： Laramie Mary Gaster , Paul Adrian Wyman , Keith Raymond Mulholland , David Thomas Davies , David Malcolm Duckworth , Ian Thomson Forbes , Graham Elgin Jones
IPC分类号： A61K31/40 , A61K31/44 , A61K31/4427 , A61K31/443 , A61K31/4433 , A61K31/475 , A61K31/495 , A61K31/50 , A61K31/505 , A61P25/00 , A61P25/30 , A61P43/00 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D409/14 , C07D413/12 , C07D417/14 , C07D401/10 , C07D403/10
CPC分类号： C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D409/14 , C07D413/12 , C07D417/14
摘要： A compound of formula (I) or a salt thereof: ##STR1## wherein: P.sup.1 is pyridyl;P.sup.2 is phenyl;A is a bond or a chain of 1 to 5 atoms optionally substituted by C.sub.1-6 alkyl;R.sup.1 and R.sup.2 groups are each independently hydrogen, C.sub.1-6 alkyl optionally substituted by NR.sup.12 R.sup.13, C.sub.2-6 alkenyl, C.sub.2-6 alkynyl, cyano, halogen, CF.sub.3, NR.sup.12 R.sup.13, CHO, OCF.sub.3, COR.sup.14, CH.sub.2 OR.sup.14 or OR.sup.14 where R.sup.12, R.sup.13 and R.sup.14 are independently hydrogen or C.sub.1-6 alkyl;n and m are independently 0, 1 or 2;R.sup.3 is hydrogen or C.sub.1-6 alkyl;R.sup.4 is a group of formula (i): ##STR2## in which: R.sup.6 and R.sup.7 are independently hydrogen, C.sub.1-6 alkyl optionally substituted by one or more fluorine atoms, C.sub.1-6 alkylthio, C.sub.1-6 alkoxy or halogen.
摘要翻译： PCT No.PCT / EP96 / 00368 Sec。 371日期：1997年10月16日 102（e）1997年10月16日PCT PCT 1996年1月26日PCT公布。公开号WO96 / 23783 日期：1996年8月8日A式（I）化合物或其盐：其中：P1为吡啶基; P2是苯基; A是任选被C 1-6烷基取代的1至5个原子的键或链; R1和R2各自独立地为氢，任选被NR 12 R 13，C 2-6烯基，C 2-6炔基，氰基，卤素，CF 3，NR 12 R 13，CHO，OCF 3，COR 14，CH 2 OR 14或OR 14取代的C 1-6烷基，其中R 12，R 13和R 14独立地为氢或C 1-6烷基; n和m独立地为0,1或2; R3是氢或C1-6烷基; R4是式（ⅰ）的基团：其中：R6和R7独立地是氢，任意被一个或多个氟原子取代的C 1-6烷基，C 1-6烷硫基，C 1-6烷氧基或卤素。

4. 发明授权

US06426197B1 Polynucleotides encoding a human potassium channel 失效
标题翻译：编码人类钾通道的多核苷酸
公开(公告)号：US06426197B1
公开(公告)日：2002-07-30
申请号：US09432470
申请日：1999-11-03
申请人： David Malcolm Duckworth , Conrad Gerald Chapman
发明人： David Malcolm Duckworth , Conrad Gerald Chapman
IPC分类号： C12N510
CPC分类号： C07K14/705 , G01N33/6872
摘要： h-TRAAK polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing h-TRAAK polypeptides and polynucleotides in diagnostic assays.
摘要翻译：公开了通过重组技术制备这种多肽的h-TRAAK多肽和多核苷酸和方法。还公开了在诊断测定中利用h-TRAAK多肽和多核苷酸的方法。

5. 发明授权

US5834471A Amide derivatives as 5HT.sub.1D receptor antagonists 失效
标题翻译：酰胺衍生物作为5HT1D受体拮抗剂
公开(公告)号：US5834471A
公开(公告)日：1998-11-10
申请号：US591553
申请日：1996-02-02
申请人： David Malcolm Duckworth , Sarah Margaret Jenkins , Andrew John Jennings
发明人： David Malcolm Duckworth , Sarah Margaret Jenkins , Andrew John Jennings
IPC分类号： C07D249/08 , A61K31/38 , A61K31/381 , A61K31/44 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/443 , A61K31/4433 , A61K31/495 , A61P43/00 , C07D213/82 , C07D231/12 , C07D233/61 , C07D295/12 , C07D295/135 , C07D295/185 , C07D295/205 , C07D333/24 , C07D333/38 , C07D405/04 , C07D409/04 , C07D521/00 , C07D295/155 , C07D407/14 , C07D409/14
CPC分类号： C07D213/82 , C07D231/12 , C07D233/56 , C07D249/08 , C07D295/135 , C07D295/185 , C07D295/205 , C07D333/24 , C07D405/04 , C07D409/04 , C07C2101/14
摘要： Novel amide derivatives, processes for their preparation, and pharmaceutical compositions containing them are disclosed.
摘要翻译： PCT No.PCT / EP94 / 02492 Sec。 371日期：1996年2月2日 102（e）日期1996年2月2日PCT提交1994年7月26日PCT公布。公开号WO95 / 04729 日期1995年2月16日公开了新型酰胺衍生物，其制备方法和含有它们的药物组合物。

6. 发明授权

US06235758B1 Indole derivatives as 5-HT receptor antagonist 失效
标题翻译：吲哚衍生物作为5-HT受体拮抗剂
公开(公告)号：US06235758B1
公开(公告)日：2001-05-22
申请号：US09359606
申请日：1999-07-23
申请人： Laramie Mary Gaster , Paul Adrian Wyman , Keith Raymond Mulholland , David Thomas Davies , David Malcolm Duckworth , Ian Thomson Forbes , Graham Elgin Jones
发明人： Laramie Mary Gaster , Paul Adrian Wyman , Keith Raymond Mulholland , David Thomas Davies , David Malcolm Duckworth , Ian Thomson Forbes , Graham Elgin Jones
IPC分类号： C07D40104
CPC分类号： C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D409/14 , C07D413/12 , C07D417/14
摘要： A compound of formula (I) or a salt thereof: wherein: P1 is pyridiyl; P2 is phenyl; A is a bond or a chain of 1 to 5 atoms optionally substituted by C1-6 alkyl; R1 and R2 groups are each independently hydrogen, C1-6alkyl optionally substituted by NR12R13, C2-6alkenyl, C2-6alkynyl, cyano, halogen, CF3, NR12R13, CHO, OCF3, COR14, CH2OR14 or OR14 where R12, R13 and R14 are independently hydrogen or C1-6alkyl; n and m are independently 0, 1 or 2; R3 is hydrogen or C1-6 alkyl; R4 is a group of formula (i): in which: R6 and R7 are independently hydrogen, C1-6 alkyl optionally substituted by one or more fluorine atoms, C1-6alkylthio, C1-6alkoxy or halogen.
摘要翻译：式（I）化合物或其盐：其中：P1为吡啶基; P2为苯基; A为任选被C 1-6烷基取代的1至5个原子的键或链; R 1和R 2基团各自独立地为氢任选被NR 12 R 13，C 2-6烯基，C 2-6炔基，氰基，卤素，CF 3，NR 12 R 13，CHO，OCF 3，COR 14，CH 2 OR 14或OR 14取代的C 1-6烷基，其中R 12，R 13和R 14独立地为氢或C 1-6烷基; n和 m独立地是0,1或2; R 3是氢或C 1-6烷基; R 4是式（ⅰ）的基团：其中：R 6和R 7独立地是氢，被一个或多个氟原子任意取代的C 1-6烷基，C 1-6烷硫基，C 1-6烷氧基或卤素。

7. 发明授权

US6165752A Polynucleotides and expression systems for HSSCRG1 失效
标题翻译： HSSCRG1的多核苷酸和表达系统
公开(公告)号：US6165752A
公开(公告)日：2000-12-26
申请号：US181487
申请日：1998-10-28
申请人： David Malcolm Duckworth
发明人： David Malcolm Duckworth
IPC分类号： C12N15/09 , A61K31/00 , A61K31/70 , A61K38/00 , A61K45/00 , A61K48/00 , A61P25/00 , C07K14/47 , C07K16/18 , C07K19/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/12 , C12P21/02 , C12Q1/02 , C12Q1/68 , C07H21/00 , C12N1/00 , C12N15/79
CPC分类号： C07K14/47 , A61K38/00
摘要： The HSSCRG1 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing HSSCRG1 polypeptides and polynucleotides in therapy, and diagnostic assays for such.
摘要翻译：公开了HSSCRG1多肽和通过重组技术产生这种多肽的多核苷酸和方法。还公开了在治疗中利用HSSCRG1多肽和多核苷酸的方法，以及用于其的诊断测定法。

8. 发明授权

US5696122A Indole and indoline derivatives as 5HT.sub.1D receptor antagonists 失效
标题翻译：吲哚和二氢吲哚衍生物作为5HT1D受体拮抗剂
公开(公告)号：US5696122A
公开(公告)日：1997-12-09
申请号：US605022
申请日：1996-02-26
申请人： Laramie Mary Gaster , David Malcolm Duckworth , Sarah Margaret Jenkins , Paul Adrian Wyman
发明人： Laramie Mary Gaster , David Malcolm Duckworth , Sarah Margaret Jenkins , Paul Adrian Wyman
IPC分类号： A61K31/495 , A61K31/496 , A61P1/00 , A61P9/08 , A61P9/12 , A61P25/00 , A61P25/24 , A61P25/26 , A61P43/00 , C07D209/08 , C07D401/10 , C07D409/06 , C07D413/10 , C07D403/10 , C07D403/14 , C07D413/14
CPC分类号： C07D401/10 , C07D209/08 , C07D409/06 , C07D413/10
摘要： The present invention provides novel indole and indoline derivatives according to formula (I) below, processes for their preparation, pharmaceutical compositions containing them and their use as medicaments. The present indole and indoline derivatives are compounds of formula (I) or a salt thereof: ##STR1## in which R is a group of formula (i): ##STR2## in which P.sup.1 is a phenyl or a 5 to 7-membered heterocyclic ring containing 1 to 3 heteroatoms selected from oxygen, nitrogen or sulphur; and R.sup.1 and R.sup.2 are independently hydrogen, halogen, C.sub.1-6 alkyl, C.sub.1-6 alkoxy, hydroxyC.sub.1-6 alkyl, acyl, nitro, trifluoromethyl, cyano, SR.sup.5, SOR.sup.5, SO.sub.2 R.sup.5, SO.sub.2 NR.sup.5 R.sup.6, CO.sub.2 R.sup.5, CONR.sup.5 R.sup.6, CONR.sup.5 (CH.sub.2).sub.x CO.sub.2 R.sup.6, NR.sup.5 R.sup.6, NR.sup.5 CO.sub.2 R.sup.6, CR.sup.5 =NOR.sup.6, where R.sup.5 and R.sup.6 are independently hydrogen or C.sub.1-6 alkyl and x is 1 to 3; or R is a group of formula (ii): ##STR3## in which P.sup.2 is phenyl or biphenyl; P.sub.3 is phenyl or a 5 to 7-membered heterocyclic ring containing 1 to 3 heteroatoms selected from oxygen, nitrogen or sulphur; A is a bond or a group (CH.sub.2).sub.p --R.sup.8 --(CH.sub.2).sub.q where R.sup.8 is oxygen, S(O).sub.m where m is 0 to 2, carbonyl, CO.sub.2 or CH.sub.2 and p and q are independently 0 to 3; and R.sup.1 and R.sup.2 are as defined above in formula (i); R.sup.3 is hydrogen, halogen, hydroxy, C.sub.1-6 alkyl or C.sub.1-6 alkoxy;n is 1 or 2; R.sup.4 is hydrogen or C.sub.1-6 alkyl; and B is --CHR.sup.9 CHR.sup.10 -- or --CR.sup.9 .dbd.CR.sup.10 -- where R.sup.9 and R.sup.10 are independently hydrogen or C.sub.1-6 alkyl. C.sub.1-6 alkyl groups, whether alone or as part of another group, may be straight chain or branched. The groups P.sub.1, P.sub.2, and P.sub.3 can be aromatic or saturated heterocyclic rings.
摘要翻译： PCT No.PCT / EP94 / 02663 371日期1996年2月26日 102（e）日期1996年2月26日PCT 1994年8月9日PCT公布。公开号WO95 / 06637 日期1995年3月9日本发明提供了下述式（I）的新型吲哚和二氢吲哚衍生物，其制备方法，含有它们的药物组合物及其作为药物的用途。本发明的吲哚和二氢吲哚衍生物是式（I）化合物或其盐：其中R是式（i）的基团：其中P1是苯基或含有1至3个选自氧，氮或硫的杂原子的5至7元杂环; 酰基，硝基，三氟甲基，氰基，SR5，SOR5，SO2R5，SO2NR5R6，CO2R5，CONR5R6，CONR5（CH2）xCO2R6，NR5R6， NR5CO2R6，CR5 = NOR6，其中R5和R6独立地为氢或C1-6烷基，x为1至3; 或R为式（ⅱ）的基团：其中P2为苯基或联苯基;（ⅱ） P3是苯基或含有1至3个选自氧，氮或硫的杂原子的5至7元杂环; A是键或基团（CH 2）p -R 8 - （CH 2）q，其中R 8是氧，S（O）m，其中m是0至2，羰基，CO 2或CH 2，p和q独立地是0至3; 并且R 1和R 2如上述式（ⅰ）中所定义; R3是氢，卤素，羟基，C1-6烷基或C1-6烷氧基; n为1或2; R4是氢或C1-6烷基; 且B为-CHR 9 CHR 10 - 或-CR 9 = CR 10 - 其中R 9和R 10独立地为氢或C 1-6烷基。不管是单独还是作为另一基团的一部分，C 1-6烷基可以是直链或支链的。基团P1，P2和P3可以是芳族或饱和的杂环。

9. 发明授权

US06638953B2 Indole derivatives as 5-HT receptor antagonist 失效
公开(公告)号：US06638953B2
公开(公告)日：2003-10-28
申请号：US09767245
申请日：2001-01-22
申请人： Laramie Mary Gaster , Paul Adrian Wyman , Keith Raymond Mulholland , David Thomas Davies , David Malcolm Duckworth , Ian Thomson Forbes , Graham Elgin Jones
发明人： Laramie Mary Gaster , Paul Adrian Wyman , Keith Raymond Mulholland , David Thomas Davies , David Malcolm Duckworth , Ian Thomson Forbes , Graham Elgin Jones
IPC分类号： A61K3144
CPC分类号： C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D409/14 , C07D413/12 , C07D417/14
摘要： The invention relates to heterocyclic compounds having pharmacological activity, processes for their preparation, to compositions containing them and to their use in the treatment of CNS disorders such as anxiety.

10. 发明授权

US06187562B1 Polynucleotides encoding human sphingosine Lyase 失效
标题翻译：编码人类鞘氨醇裂解酶的多核苷酸
公开(公告)号：US06187562B1
公开(公告)日：2001-02-13
申请号：US09238373
申请日：1999-01-27
申请人： David Malcolm Duckworth , Robert James Godden , Tania Tamson Testa
发明人： David Malcolm Duckworth , Robert James Godden , Tania Tamson Testa
IPC分类号： C12P2106
CPC分类号： C12N9/88
摘要： SPHINGLY polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing SPHINGLY polypeptides and polynucleotides in therapy, and diagnostic assays for such.
摘要翻译：公开了通过重组技术制备此类多肽的SPHINGLY多肽和多核苷酸和方法。还公开了在治疗中使用SPHINGLY多肽和多核苷酸的方法，以及用于其的诊断测定。

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