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1. 发明授权

US06316272B1 Methods of diagnosis of colorectal cancer and methods of screening for colorectal cancer modulators 失效
标题翻译：结直肠癌诊断方法及筛查结肠直肠癌调节剂的方法
公开(公告)号：US06316272B1
公开(公告)日：2001-11-13
申请号：US09268866
申请日：1999-03-15
申请人： David Mack , Kurt C. Gish , Keith E. Wilson
发明人： David Mack , Kurt C. Gish , Keith E. Wilson
IPC分类号： G01N3353
CPC分类号： G01N33/5011 , A61K38/00 , A61K39/00 , C07K14/47 , C07K14/4748 , G01N33/57419
摘要： Described herein are methods that can be used for diagnosis and prognosis of colorectal cancer. Also described herein are methods that can be used to screen candidate bioactive agents for the ability to modulate colorectal cancer. Additionally, molecular targets (genes and their products) for therapeutic intervention in colorectal and other cancers are described.
摘要翻译：本文描述了可用于结肠直肠癌的诊断和预后的方法。本文还描述了可用于筛选候选生物活性剂以调节结肠直肠癌的能力的方法。此外，描述了用于结肠直肠癌和其他癌症治疗性干预的分子靶标（基因及其产物）。

2. 发明授权

US06682890B2 Methods of diagnosing and determining prognosis of colorectal cancer 失效
标题翻译：诊断和确定结肠直肠癌预后的方法
公开(公告)号：US06682890B2
公开(公告)日：2004-01-27
申请号：US09851588
申请日：2001-05-08
申请人： David Mack , Kurt C. Gish , Keith E. Wilson
发明人： David Mack , Kurt C. Gish , Keith E. Wilson
IPC分类号： C12Q168
CPC分类号： A61K49/0008 , C12Q1/6886 , C12Q2600/118 , C12Q2600/136 , C12Q2600/158 , G01N33/5011 , G01N33/57419
摘要： Described herein are methods that can be used for diagnosis and prognosis of colorectal cancer. Also described herein are methods that can be used to screen candidate bioactive agents for the ability to modulate colorectal cancer. Additionally, methods and molecular targets (genes and their products) for therapeutic intervention in colorectal cancer are described.
摘要翻译：本文描述了可用于结肠直肠癌的诊断和预后的方法。本文还描述了可用于筛选候选生物活性剂以调节结肠直肠癌的能力的方法。此外，描述了用于结肠直肠癌治疗性干预的方法和分子靶标（基因及其产物）。

3. 发明授权

US06566502B1 Methods of diagnosing cancer, compositions, and methods of screening for cancer modulators 有权
标题翻译：诊断癌症的方法，组合物和筛选癌症调节剂的方法
公开(公告)号：US06566502B1
公开(公告)日：2003-05-20
申请号：US09608821
申请日：2000-06-30
申请人： David Mack , Kurt C. Gish , Keith E. Wilson
发明人： David Mack , Kurt C. Gish , Keith E. Wilson
IPC分类号： C07K100
CPC分类号： C07K14/47 , A61K38/00 , A61K39/00 , C07K14/4748 , C12Q1/6886 , C12Q2600/136 , C12Q2600/158 , G01N33/5011 , G01N33/57419
摘要： Described herein are methods that can be used for diagnosis and prognosis of breast and/or colorectal cancer. Also described herein are methods that can be used to screen candidate bioactive agents for the ability to modulate breast and/or colorectal cancer. Additionally, methods and molecular targets (genes and their products) for therapeutic intervention in breast and/or colorectal cancer are described.
摘要翻译：本文描述了可用于乳腺和/或结肠直肠癌的诊断和预后的方法。本文还描述了可用于筛选候选生物活性剂以调节乳腺和/或结肠直肠癌的能力的方法。此外，描述了用于乳腺和/或结肠直肠癌治疗干预的方法和分子靶标（基因及其产物）。

4. 发明授权

US06773878B1 Methods of diagnosing of colorectal cancer, compositions, and methods of screening for colorectal cancer modulators 失效
标题翻译：诊断结肠直肠癌的方法，组合物和筛选结肠直肠癌调节剂的方法
公开(公告)号：US06773878B1
公开(公告)日：2004-08-10
申请号：US09435945
申请日：1999-11-09
申请人： David Mack , Kurt C. Gish , Keith E. Wilson
发明人： David Mack , Kurt C. Gish , Keith E. Wilson
IPC分类号： C12Q168
CPC分类号： G01N33/5011 , A61K38/00 , A61K39/00 , C07K14/47 , C07K14/4748 , G01N33/57419
摘要： Described herein are methods that can be used for diagnosis and prognosis of colorectal cancer. Also described herein are methods that can be used to screen candidate bioactive agents for the ability to modulate colorectal cancer. Additionally, methods and molecular targets (genes and their products) for therapeutic intervention in colorectal and other cancers are described.
摘要翻译：本文描述了可用于结肠直肠癌的诊断和预后的方法。本文还描述了可用于筛选候选生物活性剂以调节结肠直肠癌的能力的方法。此外，描述了用于治疗性干预结肠直肠癌和其他癌症的方法和分子靶标（基因及其产物）。

5. 发明授权

US06455668B1 Methods of diagnosing colorectal cancer, compositions, and methods of screening for colorectal cancer modulators 有权
标题翻译：诊断结肠直肠癌的方法，组合物和筛选结肠直肠癌调节剂的方法
公开(公告)号：US06455668B1
公开(公告)日：2002-09-24
申请号：US09656002
申请日：2000-09-06
申请人： David Mack , Kurt C. Gish , Keith E. Wilson
发明人： David Mack , Kurt C. Gish , Keith E. Wilson
IPC分类号： A61K3800
CPC分类号： A61K49/0008 , A61K38/00 , A61K39/00 , C07K14/47 , C07K14/4748 , C12Q1/6886 , C12Q2600/136 , C12Q2600/158 , G01N33/5011 , G01N33/57419
摘要： Described herein are methods that can be used for diagnosis and prognosis of colorectal cancer. Also described herein are methods that can be used to screen candidate bioactive agents for the ability to modulate colorectal cancer. Additionally, methods and molecular targets (genes and their products) for therapeutic intervention in colorectal cancer are described.
摘要翻译：本文描述了可用于结肠直肠癌的诊断和预后的方法。本文还描述了可用于筛选候选生物活性剂以调节结肠直肠癌的能力的方法。此外，描述了用于结肠直肠癌治疗性干预的方法和分子靶标（基因及其产物）。

6. 发明授权

US06294343B1 Methods of diagnosing colorectal cancer, compositions, and methods of screening for colorectal cancer modulators 失效
标题翻译：诊断结肠直肠癌的方法，组合物和筛选结肠直肠癌调节剂的方法
公开(公告)号：US06294343B1
公开(公告)日：2001-09-25
申请号：US09436983
申请日：1999-11-09
申请人： David Mack , Kurt C. Gish , Keith E. Wilson
发明人： David Mack , Kurt C. Gish , Keith E. Wilson
IPC分类号： G01N3353
CPC分类号： G01N33/5011 , A61K38/00 , A61K39/00 , C07K14/47 , C07K14/4748 , G01N33/57419
摘要： Described herein are methods that can be used for diagnosis and prognosis of colorectal cancer. Also described herein are methods that can be used to screen candidate bioactive agents for the ability to modulate colorectal cancer. Additionally, methods and molecular targets (genes and their products) for therapeutic intervention in colorectal and other cancers are described.
摘要翻译：本文描述了可用于结肠直肠癌的诊断和预后的方法。本文还描述了可用于筛选候选生物活性剂以调节结肠直肠癌的能力的方法。此外，描述了用于治疗性干预结肠直肠癌和其他癌症的方法和分子靶标（基因及其产物）。

7. 发明授权

US4913976A Cohesive bonding process for forming a laminate of a wear resistant thermoplastic and a weather resistant rubber 失效
标题翻译：用于形成耐磨热塑性塑料和耐候橡胶的层压材料的粘合粘结工艺
公开(公告)号：US4913976A
公开(公告)日：1990-04-03
申请号：US148247
申请日：1988-01-25
申请人： Mark L. Brooks , Keith E. Wilson
发明人： Mark L. Brooks , Keith E. Wilson
IPC分类号： B32B7/02 , B32B25/08 , B32B25/14 , B32B27/00 , B32B27/32 , B32B37/15 , B60J10/00 , B60J10/06 , B60J10/08
CPC分类号： B32B25/08 , B60J10/17 , B60J10/79 , Y10T428/24198 , Y10T428/31833 , Y10T428/31917
摘要： A polymer laminate produced by crosshead extrusion suitable for wear resistant applications such as a vehicle glass run channel comprises a layer of a weather resistant rubber such as an ethylene-propylenediene (EPDM) rubber and a layer of a wear resistant thermoplastic such as polypropylene. The laminate is passed through an oven at an elevated temperature sufficient to cure the EPDM rubber, for example, at about 375.degree. F., with ambient temperature cooling fluid being blown over the exposed surface of the polypropylene thermoplastic. The interior polypropylene surface or interface is heated by the EPDM rubber which is at a high temperature as a result of the heat of extrusion and heat generated by cure thereof. As a result, the polypropylene interior surface or interface melts and causes it to flow and form a mechanical bond with the EPDM rubber while the exposed surface as well as a substantial portion of the polypropylene is kept from melting by the cooling fluid. The EPDM rubber can be extruded in the form of a channel having a longitudinal web which supports and is bonded to the laminated polypropylene wear strip to form a glass run channel.

8. 发明授权

US5582895A Integrally molded greenhouse trim 失效
标题翻译：整体模制温室装饰
公开(公告)号：US5582895A
公开(公告)日：1996-12-10
申请号：US504162
申请日：1995-07-19
申请人： Ronald E. Dupuy , Keith E. Wilson , Walter D. Hunnicut , Wayne A. Smith
发明人： Ronald E. Dupuy , Keith E. Wilson , Walter D. Hunnicut , Wayne A. Smith
IPC分类号： B29C45/14 , B60J10/00 , B60J10/04 , B60R13/06
CPC分类号： B29C45/14336 , B60J10/16 , B60J10/74 , Y10T428/24198 , Y10T428/2902
摘要： A combined glassrun, greenhouse trim (10) for the window opening of an automotive vehicle comprising an extruded or co-extruded, polymeric glassrun (12) and a greenhouse trim (14). The greenhouse trim (14) is injection molded from a polymeric material against a surface of a flange portion (22) of the glassrun (12). The organic materials selected for the glassrun (12) and the greenhouse trim (14) are such that the greenhouse trim (14) is adhesively joined to the glassrun (12) during the injection molding of the greenhouse trim (14).
摘要翻译：一种用于机动车辆的窗口的组合玻璃瓶，温室装饰件（10），包括挤出或共挤出的聚合玻璃杯（12）和温室装饰板（14）。温室装饰件（14）由聚合物材料注射到玻璃刷（12）的凸缘部分（22）的表面上。选择用于玻璃瓶（12）和温室装饰（14）的有机材料使得在温室装饰件（14）的注射成型期间，温室装饰件（14）被粘合地接合到玻璃瓶（12）。

9. 发明授权

US5034603A Integrated optics wavelength stabilization unit 失效
标题翻译：集成光学波长稳定单元
公开(公告)号：US5034603A
公开(公告)日：1991-07-23
申请号：US432517
申请日：1989-11-06
申请人： Keith E. Wilson
发明人： Keith E. Wilson
IPC分类号： G02F1/225 , H01S5/0687
CPC分类号： G02F1/225 , H01S5/0687
摘要： An integrated-optics wavelength stabilization device for broad-bandwidth optical sources requires small-optical-path-difference interferometers to detect wavelength shifts. The phase retardation between the arms of the interferometer is modulated using small applied AC voltages.
摘要翻译：用于宽带宽光源的集成光学波长稳定装置需要小光程差干涉仪来检测波长偏移。使用小的施加的AC电压来调制干涉仪的臂之间的相位延迟。

10. 发明授权

US5013379A Cohesive bonding process for forming a laminate of a wear resistant thermoplastic and a weather resistant rubber 失效
标题翻译：用于形成耐磨热塑性塑料和耐候橡胶的层压材料的粘合粘结工艺
公开(公告)号：US5013379A
公开(公告)日：1991-05-07
申请号：US464073
申请日：1990-01-12
申请人： Mark L. Brooks , Keith E. Wilson
发明人： Mark L. Brooks , Keith E. Wilson
IPC分类号： B32B25/08 , B60J10/00 , B60J10/06
CPC分类号： B32B25/08 , B60J10/17 , B60J10/79 , Y10T428/24198 , Y10T428/31833 , Y10T428/31917 , Y10T428/31931
摘要： A polymer laminate produced by crosshead extrusion suitable for wear resistant applications such as a vehile glass run channel comprises a layer of a weather resistant rubber such as an ethylene-propylenediene (EPDM) rubber and a layer of a wear resistant thermoplastic such as polypropylene. The laminate is passed through an oven at an elevated temperature sufficient to cure the EPDM rubber, for example, at about 375.degree. F., with ambient temperature cooling fluid being blown over the exposed surface of the polypropylene thermoplastic. The interior polypropylene surface or interface is heated by the EPDM rubber which is at a high temperature as a result of the heat of extrusion and heat generated by cure thereof. As a result, the polypropylene interior surface or interface melts and causes it to flow and form a mechanical bond with the EPDM rubber while the exposed surface as well as a substantial portion of the polypropylene is kept from melting by the cooling fluid. The EPDM rubber can be extruded in the form of a channel having a longitudinal web which supports and is bonded to the laminated polypropylene wear strip to form a glass run channel.
摘要翻译：通过十字头挤出制造的聚合物层压材料，其适用于诸如车辆玻璃运行通道的耐磨应用，包括耐候橡胶层，例如乙烯 - 丙烯二烯（EPDM）橡胶层和耐磨热塑性层如聚丙烯层。层压板在高温下通过烘箱，足以使EPDM橡胶固化，例如在约375°F，环境温度下冷却流体吹过聚丙烯热塑性塑料的暴露表面。内部聚丙烯表面或界面被作为挤出热和其固化产生的热量的高温下的EPDM橡胶加热。结果，聚丙烯内表面或界面熔化并使其流动并与EPDM橡胶形成机械结合，同时暴露的表面以及大部分聚丙烯不被冷却流体熔化。 EPDM橡胶可以以具有纵向腹板的通道的形式挤出，所述纵向腹板支撑并结合到层压的聚丙烯耐磨条上以形成玻璃运行通道。

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