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1. 发明申请

US20130211049A1 IMMUNOTOXIN FUSION PROTEINS AND MEANS FOR EXPRESSION THEREOF 有权
标题翻译：免疫蛋白融合蛋白及其表达手段
公开(公告)号：US20130211049A1
公开(公告)日：2013-08-15
申请号：US13443779
申请日：2012-04-10
申请人： David M. Neville, JR. , Jerry T. Thompson , Huaizhong Hu , Jung-Hee Woo , Shenglin Ma , Jonathan Mark Hexham , Mary Ellen Digan
发明人： David M. Neville, JR. , Jerry T. Thompson , Huaizhong Hu , Jung-Hee Woo , Shenglin Ma , Jonathan Mark Hexham , Mary Ellen Digan
IPC分类号： C07K19/00
CPC分类号： C07K19/00 , A61K47/6829 , A61K47/6849 , C07K5/1008 , C07K7/06 , C07K7/08 , C07K14/34 , C07K16/2809 , C07K2317/24 , C07K2317/622 , C07K2319/00
摘要： The present invention described and shown in the specification and drawings provides novel recombinant DT-based immunotoxins, and, more specifically anti-T cell immunotoxin fusion proteins. Also provided are immunotoxins that can be ex-pressed in bacterial, yeast, or mammalian cells. The invention also provides means for expression of the immunotoxin fusion protein. It is emphasized that this abstract is provided to comply with the rules requiring an abstract that will allow a searcher or other reader to quickly ascertain the subject matter of the technical disclosure. It is submitted with the understanding that it will not be used to interpret or limit the scope or meaning of the claims.
摘要翻译：在说明书和附图中描述和示出的本发明提供了新的重组DT-基免疫毒素，更具体地，提供了抗T细胞免疫毒素融合蛋白。还提供了可以在细菌，酵母或哺乳动物细胞中进行表达的免疫毒素。本发明还提供了表达免疫毒素融合蛋白的方法。要强调的是，该摘要被提供以符合要求抽象的规则，允许搜索者或其他读者快速确定技术公开内容的主题。提交它的理解是，它不会用于解释或限制权利要求的范围或含义。

2. 发明授权

US08987426B2 Immunotoxin fusion proteins and means for expression thereof 有权
标题翻译：免疫毒素融合蛋白及其表达方法
公开(公告)号：US08987426B2
公开(公告)日：2015-03-24
申请号：US13443779
申请日：2012-04-10
申请人： David M. Neville, Jr. , Jerry T. Thompson , Huaizhong Hu , Jung-Hee Woo , Shenglin Ma , Jonathan Mark Hexham , Mary Ellen Digan
发明人： David M. Neville, Jr. , Jerry T. Thompson , Huaizhong Hu , Jung-Hee Woo , Shenglin Ma , Jonathan Mark Hexham , Mary Ellen Digan
IPC分类号： C07K19/00 , A61K47/48 , C07K5/103 , C07K7/06 , C07K7/08 , C07K14/34 , C07K16/28
CPC分类号： C07K19/00 , A61K47/6829 , A61K47/6849 , C07K5/1008 , C07K7/06 , C07K7/08 , C07K14/34 , C07K16/2809 , C07K2317/24 , C07K2317/622 , C07K2319/00
摘要： The present invention described and shown in the specification and drawings provides novel recombinant DT-based immunotoxins, and, more specifically anti-T cell immunotoxin fusion proteins. Also provided are immunotoxins that can be expressed in bacterial, yeast, or mammalian cells. The invention also provides means for expression of the immunotoxin fusion protein. It is emphasized that this abstract is provided to comply with the rules requiring an abstract that will allow a searcher or other reader to quickly ascertain the subject matter of the technical disclosure. It is submitted with the understanding that it will not be used to interpret or limit the scope or meaning of the claims.
摘要翻译：在说明书和附图中描述和示出的本发明提供了新的重组DT-基免疫毒素，更具体地，提供了抗T细胞免疫毒素融合蛋白。还提供了可以在细菌，酵母或哺乳动物细胞中表达的免疫毒素。本发明还提供了表达免疫毒素融合蛋白的方法。要强调的是，该摘要被提供以符合要求抽象的规则，允许搜索者或其他读者快速确定技术公开内容的主题。提交它的理解是，它不会用于解释或限制权利要求的范围或含义。

3. 发明授权

US07696338B2 Immunotoxin fusion proteins and means for expression thereof 有权
标题翻译：免疫毒素融合蛋白及其表达方法
公开(公告)号：US07696338B2
公开(公告)日：2010-04-13
申请号：US10296085
申请日：2001-05-18
申请人： David M. Neville, Jr. , Jerry T. Thompson , Huaizhong Hu , Jung-Hee Woo , Shenglin Ma , Jonathan Mark Hexham , Mary Ellen Digan
发明人： David M. Neville, Jr. , Jerry T. Thompson , Huaizhong Hu , Jung-Hee Woo , Shenglin Ma , Jonathan Mark Hexham , Mary Ellen Digan
IPC分类号： C07H21/04
CPC分类号： C07K19/00 , A61K47/6829 , A61K47/6849 , C07K5/1008 , C07K7/06 , C07K7/08 , C07K14/34 , C07K16/2809 , C07K2317/24 , C07K2317/622 , C07K2319/00
摘要： The present invention described and shown in the specification and drawings provides novel recombinant DT-based immunotoxins, and, more specifically anti-T cell immunotoxin fusion proteins. Also provided are immunotoxins that can be expressed in bacterial, yeast, or mammalian cells. The invention also provides means for expression of the immunotoxin fusion protein.
摘要翻译：在说明书和附图中描述和示出的本发明提供了新的重组DT-基免疫毒素，更具体地，提供了抗T细胞免疫毒素融合蛋白。还提供了可以在细菌，酵母或哺乳动物细胞中表达的免疫毒素。本发明还提供了表达免疫毒素融合蛋白的方法。

4. 发明申请

US20110086416A1 IMMUNOTOXIN FUSION PROTEINS AND MEANS FOR EXPRESSION THEREOF 有权
标题翻译：免疫蛋白融合蛋白及其表达手段
公开(公告)号：US20110086416A1
公开(公告)日：2011-04-14
申请号：US12718673
申请日：2010-03-05
申请人： David M. Neville, Jr. , Jerry Todd Thompson , Huaizhong Hu , Jung-Hee Woo , Shenglin Ma , Jonathan Mark Hexham , Mary Ellen Digan
发明人： David M. Neville, Jr. , Jerry Todd Thompson , Huaizhong Hu , Jung-Hee Woo , Shenglin Ma , Jonathan Mark Hexham , Mary Ellen Digan
IPC分类号： C12N1/21 , C07H21/04 , C12N15/63
CPC分类号： C07K19/00 , A61K47/6829 , A61K47/6849 , C07K5/1008 , C07K7/06 , C07K7/08 , C07K14/34 , C07K16/2809 , C07K2317/24 , C07K2317/622 , C07K2319/00
摘要： The present invention described and shown in the specification and drawings provides novel recombinant DT-based immunotoxins, and, more specifically anti-T cell immunotoxin fusion proteins. Also provided are immunotoxins that can be expressed in bacterial, yeast, or mammalian cells. The invention also provides means for expression of the immunotoxin fusion protein. It is emphasized that this abstract is provided to comply with the rules requiring an abstract that will allow a searcher or other reader to quickly ascertain the subject matter of the technical disclosure. It is submitted with the understanding that it will not be used to interpret or limit the scope or meaning of the claims.
摘要翻译：在说明书和附图中描述和示出的本发明提供了新的重组DT-基免疫毒素，更具体地，提供了抗T细胞免疫毒素融合蛋白。还提供了可以在细菌，酵母或哺乳动物细胞中表达的免疫毒素。本发明还提供了表达免疫毒素融合蛋白的方法。要强调的是，该摘要被提供以符合要求抽象的规则，允许搜索者或其他读者快速确定技术公开内容的主题。提交它的理解是，它不会用于解释或限制权利要求的范围或含义。

5. 发明授权

US08217158B2 Immunotoxin fusion proteins and means for expression thereof 有权
标题翻译：免疫毒素融合蛋白及其表达方法
公开(公告)号：US08217158B2
公开(公告)日：2012-07-10
申请号：US12718673
申请日：2010-03-05
申请人： David M. Neville, Jr. , Jerry Todd Thompson , Huaizhong Hu , Jung-Hee Woo , Shenglin Ma , Jonathan Mark Hexham , Mary Ellen Digan
发明人： David M. Neville, Jr. , Jerry Todd Thompson , Huaizhong Hu , Jung-Hee Woo , Shenglin Ma , Jonathan Mark Hexham , Mary Ellen Digan
IPC分类号： C07H21/04
CPC分类号： C07K19/00 , A61K47/6829 , A61K47/6849 , C07K5/1008 , C07K7/06 , C07K7/08 , C07K14/34 , C07K16/2809 , C07K2317/24 , C07K2317/622 , C07K2319/00
摘要： The present invention described and shown in the specification and drawings provides novel recombinant DT-based immunotoxins, and, more specifically anti-T cell immunotoxin fusion proteins. Also provided are immunotoxins that can be expressed in bacterial, yeast, or mammalian cells. The invention also provides means for expression of the immunotoxin fusion protein. It is emphasized that this abstract is provided to comply with the rules requiring an abstract that will allow a searcher or other reader to quickly ascertain the subject matter of the technical disclosure. It is submitted with the understanding that it will not be used to interpret or limit the scope or meaning of the claims.
摘要翻译：在说明书和附图中描述和示出的本发明提供了新的重组DT-基免疫毒素，更具体地，提供了抗T细胞免疫毒素融合蛋白。还提供了可以在细菌，酵母或哺乳动物细胞中表达的免疫毒素。本发明还提供了表达免疫毒素融合蛋白的方法。要强调的是，该摘要被提供以符合要求抽象的规则，允许搜索者或其他读者快速确定技术公开内容的主题。提交它的理解是，它不会用于解释或限制权利要求的范围或含义。

6. 发明授权

US06423512B1 Fusion polypeptides 失效
标题翻译：融合多肽
公开(公告)号：US06423512B1
公开(公告)日：2002-07-23
申请号：US08897956
申请日：1997-07-21
申请人： Mary Ellen Digan , Philip Lake , Hermann Gram
发明人： Mary Ellen Digan , Philip Lake , Hermann Gram
IPC分类号： A61K3817
CPC分类号： C07K14/765 , A61K38/00 , C07K2319/00 , C07K2319/30 , Y10S530/868
摘要： Fusion polypeptides and salts thereof comprising at least one IgE-binding domain fused to at least one human serum albumin component, optionally via a peptide linker, and in particular, dimeric fusion polypeptides comprising HSA protein fused, at each of its amino and carboxy termini, to an extracellular domain of the &agr;-chain of the human high affinity receptor for IgE (Fc&egr;RI&agr;); process for the preparation thereof, functionally equivalent polypeptides which are intermediates in their preparation, and polynucleotide and oligonucleotide intermediates and vectors therefor. They are indicated for use in the prevention and/or treatment of IgE-mediated allergic diseases and related disorders such as atopic dermatitis, atopic asthma and chronic urticaria.
摘要翻译：融合多肽及其盐包含与至少一种人血清白蛋白组分融合的至少一个IgE结合结构域，任选经由肽接头，特别是包含在其氨基和羧基末端各自融合的HSA蛋白的二聚融合多肽，到人IgE（FcepsiRIalpha）的人高亲和力受体的α链的细胞外结构域; 其制备方法，作为其制备中的中间体的功能等同多肽，以及多核苷酸和寡核苷酸中间体及其载体。它们被用于预防和/或治疗IgE介导的过敏性疾病和相关疾病如特应性皮炎，特应性哮喘和慢性荨麻疹。

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