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1. 发明申请

US20210177896A1 THERAPEUTIC REGIMENS FOR CHIMERIC ANTIGEN RECEPTOR (CAR)- EXPRESSING CELLS 有权
公开(公告)号：US20210177896A1
公开(公告)日：2021-06-17
申请号：US16305728
申请日：2017-06-02
申请人： David L. Porter , Noelle Frey , Carl H. June , Simon Lacey , Fang Chen , Jan J. Melenhorst , Tetiana Taran , Karen Thudium Mueller , Patricia Wood , Yiyun Zhang , Novartis AG , The Trustees of the University of Pennsylvania
发明人： David L. Porter , Noelle Frey , Carl H. June , Simon Lacey , Fang Chen , Jan J. Melenhorst , Tetiana Taran , Karen Thudium Mueller , Patricia Wood , Yiyun Zhang
IPC分类号： A61K35/17 , A61P35/00 , C07K14/705 , G01N33/50 , G01N33/68 , C07K16/28
摘要： The invention provides a method of treating an adult subject having a hematological cancer, comprising administering to the subject selected dosage regimens comprising a plurality of immune effector cells expressing a CAR molecule.

2. 发明申请

US20180252727A1 BIOMARKERS PREDICTIVE OF CYTOKINE RELEASE SYNDROME 审中-公开
公开(公告)号：US20180252727A1
公开(公告)日：2018-09-06
申请号：US15757123
申请日：2016-09-02
申请人： Alfred Garfall , Alex Ganetsky , Saar Gill , Simon Lacey , Jan J. Melenhorst , David Teachey , The Trustees of the University of Pennsylvania
发明人： Alfred Garfall , Alex Ganetsky , Saar Gill , Simon Lacey , Jan J. Melenhorst , David Teachey
IPC分类号： G01N33/68 , A61K45/06 , A61K39/395 , C07K16/28 , C07K14/705 , C07K14/725 , A61K35/17 , C12Q1/6876 , A61K31/675 , A61P37/00 , A61P29/00
CPC分类号： G01N33/6863 , A61K31/675 , A61K35/17 , A61K39/3955 , A61K45/06 , A61P29/00 , A61P37/00 , C07K14/7051 , C07K14/70578 , C07K16/2803 , C07K2317/622 , C07K2317/76 , C07K2319/02 , C07K2319/03 , C12Q1/6876 , C12Q2600/106 , C12Q2600/158 , G01N33/5047 , G01N33/6866 , G01N33/6869 , G01N33/6893 , G01N2800/24 , G01N2800/50 , G01N2800/52 , G01N2800/7095
摘要： The present disclosure relates to the identification and use of biomarkers (e.g., analytes, analyte profiles, or markers (e.g., gene expression and/or protein expression profiles)) with clinical relevance to cytokine release syndrome (CRS).

3. 发明申请

US20210047405A1 CAR T CELL THERAPIES WITH ENHANCED EFFICACY 有权
公开(公告)号：US20210047405A1
公开(公告)日：2021-02-18
申请号：US17050805
申请日：2019-04-26
申请人： Novartis AG , The Trustees of the University of Pennsylvania
发明人： Christopher Loren Nobles , Frederic Dixon Bushman , Joseph A. Fraietta , Simon Lacey , Jan J. Melenhorst , Carl H. June
IPC分类号： C07K16/28 , A61K35/17 , C12N15/86 , C12N5/0783 , A61P35/02 , C07K14/725 , G01N33/50
摘要： The invention provides methods for manufacturing optimized CAR T cell therapies and uses thereof. Specifically, the invention provides parameters that can be measured, e.g., evaluated, to manufacture CAR T cell therapies with optimized properties. The invention further provides methods of use in connection with said optimized CART cells.

4. 发明申请

US20190151365A1 COMBINATION THERAPIES OF CHIMERIC ANTIGEN RECEPTORS AND PD-1 INHIBITORS 审中-公开
公开(公告)号：US20190151365A1
公开(公告)日：2019-05-23
申请号：US16321322
申请日：2017-07-28
申请人： Novartis AG , The Trustees of the University of Pennsylvania
发明人： Oezlem Anak , Sanela Bilic , Jennifer Brogdon , John Scott Cameron , William Chou , Stephan Grupp , Danny Roland Howard, Jr. , Randi Isaacs , Carl H. June , Simon Lacey , Shannon Maude , Jan J. Melenhorst , Stephen Shuster , Alfonso Quintas-Cardama
IPC分类号： A61K35/17 , C07K14/725 , C07K16/28 , A61P35/00 , G01N33/574
摘要： Provided are compositions and methods for treating diseases, e.g., cancers, e.g., diseases associated with expression of an antigen, e.g., CD 19, comprising administering a cell that expresses a chimeric antigen receptor (CAR) specific to the antigen, e.g., CD19, in combination with a PD-1 inhibitor.

5. 发明申请

US20070026503A1 Polyomavirus cellular epitopes and uses therefor 有权
标题翻译：多瘤病毒细胞表位及其用途
公开(公告)号：US20070026503A1
公开(公告)日：2007-02-01
申请号：US11491542
申请日：2006-07-24
申请人： Simon Lacey
发明人： Simon Lacey
IPC分类号： C12Q1/68 , C12P19/34
CPC分类号： C12Q1/708
摘要： The present invention relates to HLA-A*02-restricted cellular epitopes within the VP1 polypeptide of a human polyomavirus, BK virus, which is associated with polyomavirus-associated nephropathy in kidney transplant patients. Preferred peptides correspond to amino acids residues 107-116, 108-116 and 44-52 of BKV VP1, and are processed in vivo in natural infection with BKV. Effector T cell populations stimulated by the peptides represent functional CTLs as assessed by cytotoxicity and cytokine production, and are reactive against cells presenting both the BKV peptides above and the JC virus homolog sequences.
摘要翻译：本发明涉及在人移植患者中与多瘤病毒相关的肾病相关的人多瘤病毒BK病毒的VP1多肽内的HLA-A * 02限制性细胞表位。优选的肽对应于BKV VP1的氨基酸残基107-116,108-116和44-52，并且在BKV的天然感染中在体内进行处理。由肽刺激的效应物T细胞群体代表通过细胞毒性和细胞因子产生评估的功能性CTL，并且对上述BKV肽和JC病毒同系物序列的细胞具有反应性。

6. 发明授权

US06271465B1 Low cost conformal EMI/RFI shield 有权
标题翻译：低成本适应EMI / RFI屏蔽
公开(公告)号：US06271465B1
公开(公告)日：2001-08-07
申请号：US09386780
申请日：1999-08-31
申请人： Simon Lacey
发明人： Simon Lacey
IPC分类号： H05K900
CPC分类号： H05K9/003 , H05K3/321 , H05K9/0022 , H05K9/0037
摘要： An EMI/RFI shield includes a shell made from a metalized polymeric material with a shape that is predetermined to form within at least one shielded cavity. The shell has sidewalls that terminate in a flange extending at an angle to the sidewalls. The flange has a lower surface for electrically coupling the shell to a predetermined electrical potential and an upper surface for engaging a structure, preferably a protruding rib from a cover, that exerts a compressive force on the top surface for urging the lower surface into an electrical coupling arrangement with an underlying planar conductor carrying the predetermined electrical potential (e.g., ground). The lower surface can include or be placed upon a layer of electrically conductive compliant material, such as a conductive adhesive. At least one of the sidewalls can include a projecting fluted structure having a size and location that is predetermined to engage a side of the structure that exerts the compressive force.
摘要翻译： EMI / RFI屏蔽包括由金属化的聚合物材料制成的壳体，其具有预定的形状以形成在至少一个屏蔽空腔内。壳体具有终止于与侧壁成一定角度延伸的凸缘的侧壁。凸缘具有用于将壳体电耦合到预定电位的下表面和用于接合结构的上表面，优选地，来自盖的突出肋，其在顶表面上施加压缩力，以将下表面推入电耦合布置与承载预定电位（例如，接地）的底层平面导体。下表面可以包括或放置在导电柔性材料层上，例如导电粘合剂。侧壁中的至少一个可以包括突出的凹槽结构，其具有预定的尺寸和位置，以接合施加压缩力的结构的一侧。

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