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1. 发明授权

US4803272A S-modified adenosyl-1,8-diamino-3-thiooctane derivatives 失效
标题翻译： S-修饰的腺苷-1,8-二氨基-3-硫辛烷衍生物
公开(公告)号：US4803272A
公开(公告)日：1989-02-07
申请号：US17889
申请日：1987-02-24
申请人： David L. Anton , Bruce D. Korant , Chia-Lin J. Wang
发明人： David L. Anton , Bruce D. Korant , Chia-Lin J. Wang
IPC分类号： C07D473/00 , A61K31/52 , C07D473/34
CPC分类号： C07D473/00
摘要： S-Modified Adenosyl-1,8-Diamino-3-Thiooctane derivatives which are useful as interferon potentiators and polyamine biosynthesis inhibitors are disclosed.
摘要翻译：公开了可用作干扰素增强剂和多胺生物合成抑制剂的S-修饰的腺苷-1,8-二氨基-3-硫辛烷衍生物。

2. 发明授权

US5593871A Process for the preparation of enantiometric 2-alkanoic acid amides from nitriles 失效
标题翻译：从腈制备对映异构2-链烷酸酰胺的方法
公开(公告)号：US5593871A
公开(公告)日：1997-01-14
申请号：US388921
申请日：1995-02-15
申请人： David L. Anton , Robert D. Fallon , Barry Stieglitz , Vincent G. Witterholt
发明人： David L. Anton , Robert D. Fallon , Barry Stieglitz , Vincent G. Witterholt
IPC分类号： C12P13/02 , C12P17/00 , C12P17/10 , C12P17/18 , C12P41/00 , C12P17/14
CPC分类号： C12R1/38 , C12P13/02 , C12P17/00 , C12P17/10 , C12P17/18 , C12P41/006
摘要： This invention relates to the enantioselective biologically-catalyzed hydrolysis of certain racemic nitriles to the corresponding R- or S-amides, chemically or biologically-catalyzed hydrolysis of the amides to the corresponding R- or S-acids in a batch process or in a continuous process that employs racemization and recycling of enantiomeric nitrile intermediates, the racemic nitriles being selected from the group, A--C(R.sup.1)(R.sup.2)CN, wherein A, R.sup.1 and R.sup.2 are as defined in the text, as well as certain biological materials employed to catalyze the process.
摘要翻译：本发明涉及某些外消旋腈与相应的R-或S-酰胺的对映选择性生物催化水解，在分批方法或连续的方法中将酰胺化学或生物催化水解成相应的R-或S-酸外消旋腈选自AC（R 1）（R 2）CN，其中A，R 1和R 2如本文所定义的那些外消旋腈以及某些生物材料用于催化过程。

3. 发明授权

US5219745A Production of glyoxylic acid from glycolic acid 失效
标题翻译：从乙醇酸生产乙醛酸
公开(公告)号：US5219745A
公开(公告)日：1993-06-15
申请号：US705419
申请日：1991-05-24
申请人： David L. Anton , Robert DiCosimo , Lawrence W. Gosser
发明人： David L. Anton , Robert DiCosimo , Lawrence W. Gosser
IPC分类号： C12P7/40
CPC分类号： C12P7/40
摘要： A process for the production of glyoxylic acid involving the enzymatic oxidation of glycolic acid. The process provides a commercially practical method involving the reaction of glycolic acid in an aqueous solution at a starting concentration range of 200 mM to 2,500 mM in the presence of oxygen, glycolate oxidase and catalase at a pH of 7 to 10 and in the presence of an amine such as ethylenediamine, or tris(hydroxymethyl)-methylamine.
摘要翻译：涉及乙醇酸酶促氧化的乙醛酸的生产方法。该方法提供了一种商业上实用的方法，其涉及在氧气，乙醇酸氧化酶和过氧化氢酶的存在下，在pH为7至10的条件下，以200mM至2,500mM的起始浓度范围的乙醇酸反应，胺如乙二胺或三（羟甲基） - 甲基胺。

4. 发明授权

US5538875A Process for the preparation of pyruvic acid using permeabilized transformants of H. polymorha and P. pastoris which express glycolate oxidase and catalase 失效
标题翻译：使用表达乙醇酸氧化酶和过氧化氢酶的多形态聚合酶和巴斯德毕赤酵母的透化转化体制备丙酮酸的方法
公开(公告)号：US5538875A
公开(公告)日：1996-07-23
申请号：US493446
申请日：1995-06-22
申请人： David L. Anton , Robert Dicosimo , Vincent G. Witterholt
发明人： David L. Anton , Robert Dicosimo , Vincent G. Witterholt
IPC分类号： C12P7/40 , C12N1/14
CPC分类号： C12P7/40
摘要： A process for the production of pyruvic acid involving the enzymatic reaction of L-lactic acid and oxygen in an aqueous solution in the presence of catalysts glycolate oxidase ((S)-2-hydroxy-acid oxidase, EC 1.1.3.15) and catalase (EC 1.11.1.6). High yields of pyruvate at high purity can be achieved at commercially acceptable concentration without substantial product inhibition of the enzyme.
摘要翻译：在催化剂乙醇酸氧化酶（（S）-2-羟基酸氧化酶，EC 1.1.3.15）和过氧化氢酶（（S）-2-羟基酸氧化酶）的存在下，涉及L-乳酸和氧在水溶液中的酶反应的丙酮酸的生产方法 EC 1.11.1.6）。高纯度丙酮酸的高产率可以在商业上可接受的浓度下实现，而对酶没有实质的产物抑制。

5. 发明授权

US5439813A Production of glyoxylic acid with glycolate oxidase and catalase immobilized on oxirane acrylic beads 失效
标题翻译：用羟乙酸氧化酶和过氧化氢酶固定在环氧乙烷丙烯酸珠上生产乙醛酸
公开(公告)号：US5439813A
公开(公告)日：1995-08-08
申请号：US253812
申请日：1994-06-03
申请人： David L. Anton , Robert DiCosimo , John E. Gavagan
发明人： David L. Anton , Robert DiCosimo , John E. Gavagan
IPC分类号： C12P7/40 , C12N9/04 , C12N9/08
CPC分类号： C12P7/40
摘要： A process for the production of glyoxylic acid by reacting glycolic acid with oxygen in an aqueous solution in the presence of an amine buffer capable of forming a chemical adduct with glyoxylic acid, and glycolate oxidase and catalase immobilized or co-immobilized on an insoluble support is disclosed. The reaction is carried out at a pH of 7 to 10, preferably 8 to 9.5, an initial concentration of glycolic acid of 200 to 2500 mM, a concentration of amine wherein the initial mole ratio of amine to glycolic acid is within the range of 1.0 to 3.0, a concentration of immobilized catalase of 50 to 100,00 IU/mL, preferably 350 to 14,000 IU/mL, an oxygen pressure of up to 50 atmospheres, preferably 15 atmospheres, an immobilized glycolate oxidase concentration of about 0.01 to 10 IU/mL, preferably about 0.1 to 4 IU/mL, and a temperature of 0.degree. to 40.degree. C. preferably 5.degree. to 15.degree. C. Preferred insoluble immobilization supports are Eupergit C-250L and Eupergit C (Oxirane acrylic beads).
摘要翻译：在能够与乙醛酸形成化学加合物的胺缓冲剂存在下，在水溶液中使乙醇酸与氧反应生成乙醛酸的方法，以及固定或共固定在不溶性载体上的乙醇酸氧化酶和过氧化氢酶，披露该反应在pH为7至10，优选8至9.5，乙醇酸的初始浓度为200至2500mM，其中胺与乙醇酸的初始摩尔比在1.0的范围内的胺浓度进行至3.0，固定化过氧化氢酶的浓度为50至100,00IU / mL，优选为350至14,000IU / mL，氧气压力高达50大气压，优选15个大气压，固定化的乙醇酸氧化酶浓度为约0.01至10IU / mL，优选约0.1〜4IU / mL，温度为0〜40℃，优选为5〜15℃。优选的不溶性固定载体为Eupergit C-250L和Eupergit C（Oxirane acrylic beads）。

6. 发明授权

US5221621A Production of glyoxylic acid from glycolic acid 失效
标题翻译：从乙醇酸生产乙醛酸
公开(公告)号：US5221621A
公开(公告)日：1993-06-22
申请号：US705420
申请日：1991-05-24
申请人： David L. Anton , Robert DiCosimo , Lawrence W. Gosser
发明人： David L. Anton , Robert DiCosimo , Lawrence W. Gosser
IPC分类号： C12P7/40
CPC分类号： C12P7/40
摘要： A process or the production of glyoxylic acid involving the enzymatic oxidation of glycolic acid. The process provides a commercially practical method involving the reaction of glycolic acid in an aqueous solution at a starting concentration range of 200 mM to 2,500 mM in the presence of oxygen, glycolate oxidase and catalase at a pH of 7 to 10.
摘要翻译：涉及乙醇酸的酶氧化的方法或生产乙醛酸。该方法提供商业实用的方法，其涉及在氧气，乙醇酸氧化酶和过氧化氢酶的存在下，在pH为7至10的情况下，以200mM至2,500mM的起始浓度范围的乙醇酸反应。

7. 发明授权

US5559020A Process for preparing glyoxylic acid/dialkyl aminomethylphosphonate mixtures 失效
标题翻译：制备乙醛酸/二烷基氨基甲基膦酸酯混合物的方法
公开(公告)号：US5559020A
公开(公告)日：1996-09-24
申请号：US385260
申请日：1995-02-08
申请人： David L. Anton , Robert Dicosimo
发明人： David L. Anton , Robert Dicosimo
IPC分类号： C07F9/38 , C12N1/19 , C12P7/40 , C12P13/04 , C12R1/78 , C12R1/84 , C07F9/22 , C12P7/42 , C12P13/00
CPC分类号： C12P13/04 , C07F9/3813 , C12P7/40
摘要： The invention provides a process for producing mixtures of glyoxylate and a dialkyl aminomethylphosphonate and the subsequent production of N-(phosphonomethyl)glycine, also known as glyphosate. The process comprises preparing in situ a mixture of glyoxylate and a dialkyl aminomethylphosphonate (DEAMPA) by enzymatically reacting glycolic acid (glycolate) and oxygen in an aqueous solution in the presence of a dialkyl aminomethylphosphonate and catalysts consisting of glycolate oxidase and catalase. The resulting mixture can be hydrogenated and then subjected to hydrolysis to produce N-(phosphonomethyl)glycine, a post-emergent phytotoxicant and herbicide.
摘要翻译：本发明提供了一种生产乙醛酸盐和氨基甲基膦酸二烷基酯混合物的方法，随后生产N-（膦酰基甲基）甘氨酸，也称为草甘膦。该方法包括在二烷基氨基甲基膦酸二烷基酯和由乙醇酸氧化酶和过氧化氢酶组成的催化剂的存在下，使乙醇酸（乙醇酸）和氧在水溶液中酶促反应，原位制备乙醛酸和二烷基氨基甲基膦酸二乙酯（DEAMPA）的混合物。所得混合物可以氢化，然后进行水解以产生N-（膦酰基甲基）甘氨酸，芽后植物毒素和除草剂。

8. 发明授权

US5541094A Glyoxylic acid/aminomethylphosphonic acid mixtures prepared using a microbial transformant 失效
标题翻译：使用微生物转化体制备的乙醛酸/氨基甲基膦酸混合物
公开(公告)号：US5541094A
公开(公告)日：1996-07-30
申请号：US253823
申请日：1994-06-03
申请人： David L. Anton , Robert DiCosimo
发明人： David L. Anton , Robert DiCosimo
IPC分类号： C07F9/38 , C12N9/04 , C12N9/08 , C12P7/40 , C12P13/04 , C12P13/00
CPC分类号： C12P13/04 , C07F9/3813 , C12N9/0006 , C12N9/0065 , C12P7/40
摘要： An improved enzymatic process for reacting glycolic acid and oxygen in an aqueous solution in the presence of aminomethylphosphonic acid wherein the improvement comprises using a microbial cell catalyst that expresses glycolate oxidase (e.g., Pichia pastoris, Hansenula polymorpha, Aspergillus nidulans, or Escherichia coli) and endogenous catalase; soluble catalase may also be included. The resulting mixtures are useful intermediates in the production of N-(phosphonomethyl)glycine.
摘要翻译：一种在氨基甲基膦酸存在下使乙醇酸和氧在水溶液中反应的改进的酶法，其中改进包括使用表达乙醇酸氧化酶的微生物细胞催化剂（例如巴斯德毕赤酵母，多形汉逊酵母，构巢曲霉或大肠埃希氏菌）和内源性过氧化氢酶; 也可以包括可溶性过氧化氢酶。所得混合物是制备N-（膦酰基甲基）甘氨酸的有用中间体。

9. 发明授权

US5371001A Esters of unsymmetrically 2-substituted glycolic acid dimers 失效
标题翻译：不对称2-取代乙醇酸二聚体的酯
公开(公告)号：US5371001A
公开(公告)日：1994-12-06
申请号：US85783
申请日：1993-07-06
申请人： David L. Anton , Charles E. Nakamura
发明人： David L. Anton , Charles E. Nakamura
IPC分类号： C07C69/675 , C07C69/68 , C12P7/62
CPC分类号： C12P7/62 , C07C69/675 , C07C69/68
摘要： This invention concerns esters of unsymmetrically 2-substituted glycolic acid dimers, a process for their preparation and their use in the preparation of unsymmetrically 3,6-substituted 1,4-dioxane-2,5-diones.
摘要翻译：本发明涉及不对称2-取代的乙醇酸二聚体的酯，其制备方法及其在制备不对称的3,6-取代的1,4-二恶烷-2,5-二酮的用途。

10. 发明授权

US5262314A Enzymatic oxidation of glycolic acid in the presence of non-enzymatic catalyst for decomposing hydrogen peroxide 失效
标题翻译：在用于分解过氧化氢的非酶催化剂的存在下乙醇酸的酶催化氧化
公开(公告)号：US5262314A
公开(公告)日：1993-11-16
申请号：US755925
申请日：1991-09-06
申请人： David L. Anton , Anthony J. Arduengo, III , Robert DiCosimo
发明人： David L. Anton , Anthony J. Arduengo, III , Robert DiCosimo
IPC分类号： C07C51/235 , C12P7/40 , C07C51/16
CPC分类号： C12P7/40 , C07C51/235
摘要： A process for the production of glyoxylic acid by reacting glycolic acid and oxygen in an aqueous solution at pH 7-10 in the presence of the enzyme glycolate oxidase and a non-enzymatic catalyst for the decomposition of hydrogen peroxide, and an amine buffer capable of forming a chemical adduct with glyoxylic acid.
摘要翻译：在乙醇酸和氧气在pH7-10的水溶液中，在乙醇酸氧化酶的酶和用于分解过氧化氢的非酶催化剂的存在下反应生产乙醛酸的方法，以及能够与乙醛酸形成化学加合物。

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