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1. 发明授权

US07137975B2 Method for increasing the battery life of an alternating current iontophoresis device using a barrier-modifying agent 失效
公开(公告)号：US07137975B2
公开(公告)日：2006-11-21
申请号：US10014741
申请日：2001-12-10
申请人： David J. Miller , William I. Higuchi , Kevin Li , Gordon L. Flynn
发明人： David J. Miller , William I. Higuchi , Kevin Li , Gordon L. Flynn
IPC分类号： A61M31/00 , A61N1/30
CPC分类号： A61N1/044 , A61N1/0448 , A61N1/325
摘要： An iontophoretic method for transporting compounds of interest across a body tissue is provided. The method utilizes an AC signal in conjunction with a barrier-modifying agent such as a fatty acid, fatty alcohol, bile acid, surfactant, or the like. The method enables the maintenance of a substantially constant electrical state in a localized region of the tissue through which transport occurs, thereby allowing a compound of interest to be transported across the tissue in a controlled and predictable manner. The barrier-modifying agent reduces the time as well as the voltage level required to achieve a target electrical resistance, thereby reducing patient discomfort and increasing the battery life of the iontophoresis device.

2. 发明授权

US06801804B2 Device and method for monitoring and controlling electrical resistance at a tissue site undergoing iontophoresis 失效
标题翻译：用于监测和控制经历离子电渗疗法的组织部位的电阻的装置和方法
公开(公告)号：US06801804B2
公开(公告)日：2004-10-05
申请号：US10138723
申请日：2002-05-03
申请人： David J. Miller , William I. Higuchi , Kevin Li , Matthew S. Hastings
发明人： David J. Miller , William I. Higuchi , Kevin Li , Matthew S. Hastings
IPC分类号： A61N130
CPC分类号： A61N1/08 , A61N1/30
摘要： The invention provides a device for iontophoretically transporting a compound through a localized region of an individual's body tissue. The device comprises first and second iontophoretic electrodes, a reference electrode, a current source, and a monitoring means. The first electrode is placed in ion-conducting relation with the localized region to allow iontophoretic transport of a compound therethrough. The second and transport electrodes are each placed in contact with the individual's body tissue, and all electrodes are spaced apart from each other. The current source is electrically connected to the first and second electrodes and applies a current to the localized region of body tissue to effect iontophoretic transport. The monitoring means monitors the electrical resistance of the localized region by measuring any voltage difference between the reference electrode and the first and/or second electrodes. Methods for using a reference electrode to monitor and control iontophoresis are also provided.
摘要翻译：本发明提供了一种用于离子电渗转运化合物通过个体身体组织的局部区域的装置。该装置包括第一和第二离子电渗电极，参比电极，电流源和监测装置。第一电极与局部区域处于离子导电关系，以允许化合物离子电渗转运通过。第二和输送电极各自放置成与个体的身体组织接触，并且所有电极彼此间隔开。电流源电连接到第一和第二电极，并将电流施加到身体组织的局部区域以实现离子电渗疗法输送。监测装置通过测量参考电极和第一和/或第二电极之间的任何电压差来监视局部区域的电阻。还提供了使用参比电极监测和控制离子电渗疗法的方法。

3. 发明申请

US20110066101A1 NON-INVASIVE OCULAR DRUG DELIVERY 审中-公开
标题翻译：非入侵性OCULAR药物递送
公开(公告)号：US20110066101A1
公开(公告)日：2011-03-17
申请号：US12872701
申请日：2010-08-31
申请人： David J. Miller , S. Kevin Li , William I. Higuchi
发明人： David J. Miller , S. Kevin Li , William I. Higuchi
IPC分类号： A61N1/30 , A61K9/00 , A61K9/127 , A61K9/14 , A61K31/56 , A61K39/395 , A61K31/7088 , A61K38/00 , A61K38/43 , A61K31/5377 , A61P31/00 , A61P27/02 , A61P35/00 , A61P29/00 , A61N7/00
CPC分类号： A61K31/137 , A61K9/0051
摘要： The present invention is drawn to a pharmaceutical compound for the treatment of posterior retinal diseases through topical application of the compound. The compound includes an effective amount of a therapeutic compound, and at least one additional agent that helps to prolong the residence time of the therapeutic compound within the extraocular space, or increase the transport of the therapeutic compound across a tissue of an eye toward and into a posterior ocular region, or both. The invention is additionally drawn to a device and method for delivering the compound.
摘要翻译：本发明涉及用于通过局部施用化合物治疗后视网膜疾病的药物化合物。该化合物包括有效量的治疗化合物和至少一种另外的有助于延长治疗化合物在眼外空间内的停留时间的另外的药剂，或者增加治疗化合物在眼睛组织中的转运和进入后眼部或两者。本发明另外涉及用于递送化合物的装置和方法。

4. 发明授权

US06553255B1 Use of background electrolytes to minimize flux variability during iontophoresis 失效
标题翻译：使用背景电解质来减少离子电渗时的通量变化
公开(公告)号：US06553255B1
公开(公告)日：2003-04-22
申请号：US09698697
申请日：2000-10-27
申请人： David J. Miller , Kevin Li , William I. Higuchi
发明人： David J. Miller , Kevin Li , William I. Higuchi
IPC分类号： A61N130
CPC分类号： A61N1/0416 , A61N1/0432 , A61N1/30 , A61N1/325
摘要： A device and method are provided that minimize the changes in flux encountered during iontophoresis and reduce inter-subject variability. For drug delivery, the active agent to be delivered is administered in conjunction with at least one background ion having a hindrance factor that changes at a faster rate than the hindrance factor of the active agent when an electrical current is applied. For analyte extraction, the extraction reservoir contains at least one background ion having a hindrance factor that changes at a faster rate than the hindrance factor of the background ions of the analyte in the tissue when an electrical current is applied.
摘要翻译：提供了一种装置和方法，其使离子电渗疗法中遇到的通量变化最小化并减少受试者间变异性。对于药物递送，待施用的活性剂与至少一种背景离子一起施用，所述背景离子具有当施加电流时以比活性剂的阻碍因子更快的速率变化的阻碍因子。对于分析物提取，提取储存器包含至少一种具有阻碍因子的背景离子，当施加电流时，阻碍因子以比组织中分析物的背景离子的阻碍因子更快的速率变化。

5. 发明授权

US07785578B2 Non-invasive ocular drug delivery 失效
标题翻译：非侵入性眼药物递送
公开(公告)号：US07785578B2
公开(公告)日：2010-08-31
申请号：US10269911
申请日：2002-10-11
申请人： David J. Miller , S. Kevin Li , William Higuchi
发明人： David J. Miller , S. Kevin Li , William Higuchi
IPC分类号： A61K31/74
CPC分类号： A61K31/137 , A61K9/0051
摘要： The present invention is drawn to a pharmaceutical compound for the treatment of posterior retinal diseases through topical application of the compound. The compound includes an effective amount of a therapeutic compound, and at least one additional agent that helps to prolong the residence time of the therapeutic compound within the extraocular space, or increase the transport of the therapeutic compound across a tissue of an eye toward and into a posterior ocular region, or both. The invention is additionally drawn to a device and method for delivering the compound.
摘要翻译：本发明涉及用于通过局部施用化合物治疗后视网膜疾病的药物化合物。该化合物包括有效量的治疗化合物和至少一种另外的有助于延长治疗化合物在眼外空间内的停留时间的另外的药剂，或者增加治疗化合物在眼睛组织中的转运和进入后眼部或两者。本发明另外涉及用于递送化合物的装置和方法。

6. 发明申请

US20170202520A1 METHOD FOR PREDICTING THE DEVELOPMENT OF ARTHRITIS IN INDIVIDUALS PRIOR TO RADIOGRAPHIC OR SYMPTOMATIC PRESENTATION 审中-公开
公开(公告)号：US20170202520A1
公开(公告)日：2017-07-20
申请号：US15476615
申请日：2017-03-31
申请人： Kenneth L. Urish , Matthew G. Keffalas , Timothy J. Mosher , David J. Miller
发明人： Kenneth L. Urish , Matthew G. Keffalas , Timothy J. Mosher , David J. Miller
IPC分类号： A61B5/00 , A61B5/055
CPC分类号： A61B5/7275 , A61B5/055 , A61B5/4514 , A61B5/4528 , A61B5/4571 , A61B5/4576 , A61B5/458 , A61B5/4585 , A61B5/459 , A61B5/4595 , A61B5/7264 , A61B5/7267 , G01R33/50 , G01R33/5608 , G16H30/40 , G16H50/20 , G16H50/30
摘要： A method for detecting symptomatic osteoarthritis in a human patient who is otherwise asymptomatic comprises: taking a plurality of magnetic resonance (MR) image signal features from MR sequences in a joint of the patient; submitting the MR image signal features to a classifier for performing a feature reduction for redundant or unnecessary features; calculating a signal texture index (STI) value from the remaining image features; comparing that STI value against the STI values of one group of individuals suspected of being vulnerable to developing osteoarthritis at the first point in time; and the same group of individuals years later; predicting from that comparison of STI values a likelihood of the patient developing osteoarthritis; and treating the patient accordingly.

7. 发明授权

US09421341B2 Laryngeal tube 有权
标题翻译：喉管
公开(公告)号：US09421341B2
公开(公告)日：2016-08-23
申请号：US13580978
申请日：2011-02-26
申请人： David J. Miller , Thomas W. McGrail , Benje Boedeker , Volker Bertram
发明人： David J. Miller , Thomas W. McGrail , Benje Boedeker , Volker Bertram
IPC分类号： A61M16/04 , A61M16/00
CPC分类号： A61M16/0463 , A61M16/0434 , A61M16/0459 , A61M16/0479 , A61M16/0484 , A61M16/0486 , A61M16/0495 , A61M2016/0027 , A61M2016/0413 , A61M2205/18 , A61M2205/44 , A61M2205/581 , A61M2205/584
摘要： A laryngeal tube comprising a tubular component and a nozzle having a central cavity, an anterior opening and a tongue at least partially covering the central cavity. In one example, the laryngeal tube has a first lumen to deliver gases to a patient and a fluid barrier supported by the nozzle. In other examples, the laryngeal tube may include additional lumens including a service lumen to perform a function associated with the thorax and an inflation lumen to inflate the fluid barrier.
摘要翻译：一种喉管，其包括管状部件和具有至少部分地覆盖中心空腔的中心腔，前开口和舌部的喷嘴。在一个示例中，喉管具有将气体输送到患者的第一腔和由喷嘴支撑的流体屏障。在其他示例中，喉管可以包括另外的腔，包括执行与胸部相关联的功能的服务腔和充气腔以使流体屏障膨胀。

8. 发明授权

US09247952B2 Devices and methods for tissue access 有权
标题翻译：用于组织进入的装置和方法
公开(公告)号：US09247952B2
公开(公告)日：2016-02-02
申请号：US12984162
申请日：2011-01-04
申请人： Jeffery L. Bleich , Edwin J. Hlavka , Vahid Saadat , David J. Miller , James R. Yurchenco
发明人： Jeffery L. Bleich , Edwin J. Hlavka , Vahid Saadat , David J. Miller , James R. Yurchenco
IPC分类号： A61B17/00 , A61B17/32 , A61B17/16 , A61B17/29 , A61B17/3205 , A61B17/3207 , A61B17/34 , A61B19/00 , A61F2/00 , A61B5/00 , A61B17/295 , A61B18/02 , A61B18/08 , A61B18/14 , A61B18/18 , A61B18/20 , A61B17/14 , A61B18/00 , A61N1/36 , A61N7/02
CPC分类号： A61B17/320016 , A61B5/4893 , A61B17/149 , A61B17/1671 , A61B17/29 , A61B17/295 , A61B17/32002 , A61B17/32053 , A61B17/320758 , A61B17/3401 , A61B17/3403 , A61B17/3421 , A61B17/3496 , A61B18/02 , A61B18/082 , A61B18/1477 , A61B18/1487 , A61B18/1815 , A61B18/20 , A61B90/04 , A61B2017/00261 , A61B2017/00287 , A61B2017/003 , A61B2017/00867 , A61B2017/320004 , A61B2017/320044 , A61B2017/32006 , A61B2017/3445 , A61B2017/3447 , A61B2018/00577 , A61B2018/00595 , A61B2018/1407 , A61B2018/1425 , A61B2034/2063 , A61B2090/061 , A61B2090/08021 , A61B2090/374 , A61B2090/376 , A61B2090/3762 , A61F2/0045 , A61N1/36017 , A61N7/02
摘要： Methods and apparatus are provided for selective surgical removal of tissue, e.g., for enlargement of diseased spinal structures, such as impinged lateral recesses and pathologically narrowed neural foramen. In some embodiments, a surgical tissue removal device includes a flexible elongate body that is adapted to conform with the target anatomy and a guidewire connector at the distal end region of the flexible elongate body configured to removably connect to the end of a guidewire so that the guidewire and flexible elongate body can be pulled distally. The body may have at least one blade edge, and the flexible elongate body may be a thin, flat, ribbon shaped flexible body that includes a profile having a width that is substantially greater than a height.
摘要翻译：提供了用于选择性手术去除组织的方法和装置，例如用于扩大患病的脊柱结构，例如冲击的侧向凹陷和病理变窄的神经孔。在一些实施例中，手术组织去除装置包括适于与目标解剖结构一致的柔性细长主体和在柔性细长主体的远端区域处的导丝连接器，其构造成可移除地连接到导丝的端部，使得导丝和柔性细长体可以向远侧拉。主体可以具有至少一个叶片边缘，并且柔性细长主体可以是薄的，扁平的带状柔性主体，其包括具有基本上大于高度的宽度的轮廓。

9. 发明授权

US09179831B2 Visualization instrument 有权
标题翻译：可视化仪器
公开(公告)号：US09179831B2
公开(公告)日：2015-11-10
申请号：US12874035
申请日：2010-09-01
申请人： Thomas W. McGrail , Michael S. Pargett , David J. Miller , Yun Siung Tony Yeh , Randal B. Chinnock , George Grubner , Elizabeth Powell Goodrich , Richard L. Miller , Gary Vincent Palladino , Brian Hack
发明人： Thomas W. McGrail , Michael S. Pargett , David J. Miller , Yun Siung Tony Yeh , Randal B. Chinnock , George Grubner , Elizabeth Powell Goodrich , Richard L. Miller , Gary Vincent Palladino , Brian Hack
IPC分类号： A61B1/267 , A61B1/00 , A61B1/05 , G02B23/24 , A61B1/018
CPC分类号： A61B1/267 , A61B1/00016 , A61B1/00052 , A61B1/00103 , A61B1/00105 , A61B1/018 , A61B1/05 , G02B23/2423 , G02B23/2446
摘要： A visualization instrument comprising a display support component removably coupled to a component insertable into a target space. The insertable component includes a camera providing images of the target space. The images are presented in a display device supported by the display support component. The insertable component may be discarded after a permitted number of uses.
摘要翻译：一种可视化仪器，包括可拆卸地联接到可插入到目标空间中的部件的显示器支撑部件。可插入部件包括提供目标空间的图像的相机。图像显示在由显示支持组件支持的显示设备中。可插入组件可以在允许的使用次数之后丢弃。

10. 发明授权

US08609296B2 Processing methods and systems for assembling fuel cell perimeter gaskets 有权
标题翻译：用于组装燃料电池周边垫圈的加工方法和系统
公开(公告)号：US08609296B2
公开(公告)日：2013-12-17
申请号：US13611103
申请日：2012-09-12
申请人： Daniel M. Pierpont , Eric J. Hanson , Michael T. Hicks , Eric J. Iverson , David J. Miller , Scott A. Ripley
发明人： Daniel M. Pierpont , Eric J. Hanson , Michael T. Hicks , Eric J. Iverson , David J. Miller , Scott A. Ripley
IPC分类号： H01M8/00 , H01M8/02 , H01M8/10
CPC分类号： B32B38/0004 , B32B37/025 , B32B37/203 , B32B2457/18 , H01M8/0273 , H01M8/0284 , H01M2008/1095 , Y02P70/56 , Y10T156/1056 , Y10T156/1304
摘要： A method and apparatus for making fuel cell components via a roll to roll process are described. Spaced apart apertures are cut in first and second gasket webs that each include adhesives. The first and second gasket webs are transported to a bonding station on conveyers. A membrane web that includes at least an electrolyte membrane is also transported to the bonding station. At the bonding station, a gasketed membrane web is formed by attaching the first and second gasket webs to the membrane web. The first gasket web is attached to a first surface of the membrane web via the adhesive layer of the first gasket web. The second gasket web is attached to a second surface of the membrane web via the adhesive layer of the second gasket web.
摘要翻译：描述了一种通过卷绕工艺制造燃料电池部件的方法和装置。在第一和第二垫片腹板上切割间隔开的孔，每个包括粘合剂。第一和第二垫圈腹板被输送到输送机上的粘结站。至少包括电解质膜的膜网也被输送到粘合台。在粘结站处，通过将第一和第二垫圈网连接到膜网而形成垫圈的膜腹板。第一垫圈腹板通过第一垫片腹板的粘合剂层附着到膜腹板的第一表面上。第二垫圈腹板通过第二垫圈腹板的粘合剂层附着到膜腹板的第二表面上。

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