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1. 发明授权

US5846765A Identification of novel substrates 失效
标题翻译：鉴定新基质
公开(公告)号：US5846765A
公开(公告)日：1998-12-08
申请号：US441871
申请日：1995-05-16
申请人： David J. Matthews , James A. Wells , Mark J. Zoller
发明人： David J. Matthews , James A. Wells , Mark J. Zoller
IPC分类号： C12N15/10 , C40B40/02 , C12P21/06 , C12N15/00 , C12Q1/00
CPC分类号： C40B40/02 , C12N15/1037 , C07K2319/00 , C07K2319/02 , C07K2319/735 , C07K2319/75
摘要： A method for identifying and selecting novel substrates for enzymes is provided. The method comprises constructing a gene fusion comprising DNA encoding a polypeptide fused to DNA encoding a substrate peptide, which in turn is fused to DNA encoding at least a portion of a phage coat protein. The DNA encoding the substrate peptide is mutated at one or more codons thereby generating a family of mutants. The fusion protein is expressed on the surface of a phagemid particle and subjected to chemical or enzymatic modification of the substrate peptide. Those phagemid particles which have been modified are then separated from those that have not.
摘要翻译：提供了用于鉴定和选择酶的新基质的方法。该方法包括构建包含编码与编码底物肽的DNA融合的多肽的DNA的基因融合物，其又与编码至少一部分噬菌体外壳蛋白质的DNA融合。编码底物肽的DNA以一个或多个密码子突变，从而产生突变体家族。融合蛋白在噬菌粒的表面上表达并进行底物肽的化学或酶修饰。然后将已经被修饰的那些噬菌粒颗粒与那些未被修饰的噬菌粒分离出来。

2. 发明授权

US5780279A Method of selection of proteolytic cleavage sites by directed evolution and phagemid display 失效
标题翻译：通过定向进化和噬菌粒展示来选择蛋白水解切割位点的方法
公开(公告)号：US5780279A
公开(公告)日：1998-07-14
申请号：US418928
申请日：1995-04-05
申请人： David J. Matthews , James A. Wells , Mark J. Zoller
发明人： David J. Matthews , James A. Wells , Mark J. Zoller
IPC分类号： C12N15/10 , C40B40/02 , C07K14/435 , C12N15/12
CPC分类号： C40B40/02 , C12N15/1037 , C07K2319/00 , C07K2319/02 , C07K2319/735 , C07K2319/75
摘要： A method for identifying and selecting novel substrates for enzymes is provided. The method comprises constructing a gene fusion comprising DNA encoding a polypeptide fused to DNA encoding a substrate peptide, which in turn is fused to DNA encoding at least a portion of a phage coat protein. The DNA encoding the substrate peptide is mutated at one or more codons thereby generating a family of mutants. The fusion protein is expressed on the surface of a phagemid particle and subjected to chemical or enzymatic modification of the substrate peptide. Those phagemid particles which have been modified are then separated from those that have not.
摘要翻译：提供了用于鉴定和选择酶的新基质的方法。该方法包括构建包含编码与编码底物肽的DNA融合的多肽的DNA的基因融合物，其又与编码至少一部分噬菌体外壳蛋白质的DNA融合。编码底物肽的DNA以一个或多个密码子突变，从而产生突变体家族。融合蛋白在噬菌粒的表面上表达并进行底物肽的化学或酶修饰。然后将已经被修饰的那些噬菌粒颗粒与那些未被修饰的噬菌粒分离出来。

3. 发明授权

US6040136A Enrichment method for variant proteins with altered binding properties 失效
标题翻译：具有改变的结合特性的变体蛋白质的富集方法
公开(公告)号：US6040136A
公开(公告)日：2000-03-21
申请号：US923854
申请日：1997-09-03
申请人： Lisa J. Garrard , Dennis J. Henner , Steven Bass , Ronald Greene , Henry B. Lowman , James A. Wells , David J. Matthews
发明人： Lisa J. Garrard , Dennis J. Henner , Steven Bass , Ronald Greene , Henry B. Lowman , James A. Wells , David J. Matthews
IPC分类号： A61K47/48 , C07K14/01 , C07K14/47 , C07K14/575 , C07K14/61 , C07K19/00 , C12N5/10 , C12N15/10 , C12N15/11 , C12N15/62 , C12N15/85 , C12Q1/68 , C40B40/02 , G01N33/554 , G01N33/566 , G01N33/74 , C12Q1/70 , C07H17/00 , C07K14/00 , C12P21/06
CPC分类号： C40B40/02 , C07K14/005 , C07K14/575 , C07K14/61 , C12N15/1037 , C12N15/62 , G01N33/6845 , G01N33/74 , C07K2319/00 , C07K2319/02 , C07K2319/735 , C07K2319/75 , C12N2750/00011 , C12N2795/14022 , C12N2795/14122 , G01N2333/61 , Y10S436/802 , Y10S930/12
摘要： A method for selecting novel proteins such as growth hormone and antibody fragment variants having altered binding properties for their respective receptor molecules is provided. The method comprises fusing a gene encoding a protein of interest to the carboxy terminal domain of the gene III coat protein of the filamentous phage M13. The gene fusion is mutated to form a library of structurally related fusion proteins that are expressed in low quantity on the surface of a phagemid particle. Biological selection and screening are employed to identify novel ligands useful as drug candidates. Disclosed are preferred phagemid expression vectors and selected human growth hormone variants.
摘要翻译：提供了选择新型蛋白质如生长激素和具有改变其各自受体分子的结合特性的抗体片段变体的方法。该方法包括将编码目的蛋白质的基因融合到丝状噬菌体M13的基因III外壳蛋白的羧基末端结构域上。基因融合突变以形成在噬菌粒粒子表面上以低量表达的结构相关融合蛋白的文库。使用生物选择和筛选来鉴定可用作候选药物的新型配体。公开了优选的噬菌粒表达载体和选择的人生长激素变体。

4. 发明申请

US20100035236A1 ENRICHMENT METHOD FOR VARIANT PROTEINS WITH ALTERED BINDING PROPERTIES 审中-公开
标题翻译：具有改变的结合性质的变体蛋白的富集方法
公开(公告)号：US20100035236A1
公开(公告)日：2010-02-11
申请号：US12508859
申请日：2009-07-24
申请人： Lisa J. GARRARD , Dennis J. Henner , Steven Bass , Ronald Greene , Henry B. Lowman , James A. Wells , David J. Matthews
发明人： Lisa J. GARRARD , Dennis J. Henner , Steven Bass , Ronald Greene , Henry B. Lowman , James A. Wells , David J. Matthews
IPC分类号： C12Q1/70 , C07K14/61 , C12N7/00
CPC分类号： C40B40/02 , C07K14/005 , C07K14/575 , C07K14/61 , C07K2319/00 , C07K2319/02 , C07K2319/735 , C07K2319/75 , C12N15/1037 , C12N15/62 , C12N2750/00011 , C12N2795/14022 , C12N2795/14122 , G01N33/6845 , G01N33/74 , G01N2333/61 , Y10S436/802 , Y10S930/12
摘要： A method for selecting novel proteins such as growth hormone and antibody fragment variants having altered binding properties for their respective receptor molecules is provided. The method comprises fusing a gene encoding a protein of interest to the carboxy terminal domain of the gene III coat protein of the filamentous phage M13. The gene fusion is mutated to form a library of structurally related fusion proteins that are expressed in low quantity on the surface of a phagemid particle. Biological selection and screening are employed to identify novel ligands useful as drug candidates. Disclosed are preferred phagemid expression vectors and selected human growth hormone variants.
摘要翻译：提供了选择新型蛋白质如生长激素和具有改变其各自受体分子的结合特性的抗体片段变体的方法。该方法包括将编码目的蛋白质的基因融合到丝状噬菌体M13的基因III外壳蛋白的羧基末端结构域上。基因融合突变以形成在噬菌粒粒子表面上以低量表达的结构相关融合蛋白的文库。使用生物选择和筛选来鉴定可用作候选药物的新型配体。公开了优选的噬菌粒表达载体和选择的人生长激素变体。

5. 发明授权

US5821047A Monovalent phage display 失效
标题翻译：单价噬菌体展示
公开(公告)号：US5821047A
公开(公告)日：1998-10-13
申请号：US463587
申请日：1995-06-05
申请人： Lisa J. Garrard , Dennis J. Henner , Steven Bass , Ronald Greene , Henry B. Lowman , James A. Wells , David J. Matthews
发明人： Lisa J. Garrard , Dennis J. Henner , Steven Bass , Ronald Greene , Henry B. Lowman , James A. Wells , David J. Matthews
IPC分类号： A61K47/48 , C07K14/01 , C07K14/47 , C07K14/575 , C07K14/61 , C07K19/00 , C12N5/10 , C12N15/10 , C12N15/11 , C12N15/62 , C12N15/85 , C12Q1/68 , C40B40/02 , G01N33/554 , G01N33/566 , G01N33/74 , C12Q1/70 , C07K16/00 , C12N7/02 , C12N15/63
CPC分类号： C40B40/02 , C07K14/005 , C07K14/575 , C07K14/61 , C12N15/1037 , C12N15/62 , G01N33/6845 , G01N33/74 , C07K2319/00 , C07K2319/02 , C07K2319/735 , C07K2319/75 , C12N2750/00011 , C12N2795/14022 , C12N2795/14122 , G01N2333/61 , Y10S436/802 , Y10S930/12
摘要： A method for selecting novel proteins such as growth hormone and antibody fragment variants having altered binding properties for their respective receptor molecules is provided. The method comprises fusing a gene encoding a protein of interest to the carboxy terminal domain of the gene III coat protein of the filamentous phage M13. The gene fusion is mutated to form a library of structurally related fusion proteins that are expressed in low quantity on the surface of a phagemid particle. Biological selection and screening are employed to identify novel ligands useful as drug candidates. Disclosed are preferred phagemid expression vectors and selected human growth hormone variants.
摘要翻译：提供了选择新型蛋白质如生长激素和具有改变其各自受体分子的结合特性的抗体片段变体的方法。该方法包括将编码目的蛋白质的基因融合到丝状噬菌体M13的基因III外壳蛋白的羧基末端结构域上。基因融合突变以形成在噬菌粒粒子表面上以低量表达的结构相关融合蛋白的文库。使用生物选择和筛选来鉴定可用作候选药物的新型配体。公开了优选的噬菌粒表达载体和选择的人生长激素变体。

6. 发明授权

US5750373A Enrichment method for variant proteins having altered binding properties, M13 phagemids, and growth hormone variants 失效
标题翻译：具有改变的结合特性的变体蛋白质的富集方法，M13噬菌粒和生长激素变体
公开(公告)号：US5750373A
公开(公告)日：1998-05-12
申请号：US50058
申请日：1993-04-30
申请人： Lisa J. Garrard , Dennis J. Henner , Steven Bass , Ronald Greene , Henry B. Lowman , James A. Wells , David J. Matthews
发明人： Lisa J. Garrard , Dennis J. Henner , Steven Bass , Ronald Greene , Henry B. Lowman , James A. Wells , David J. Matthews
IPC分类号： A61K47/48 , C07K14/01 , C07K14/47 , C07K14/575 , C07K14/61 , C07K19/00 , C12N5/10 , C12N15/10 , C12N15/11 , C12N15/62 , C12N15/85 , C12Q1/68 , C40B40/02 , G01N33/554 , G01N33/566 , G01N33/74 , C12P21/06 , C12N15/63
CPC分类号： C40B40/02 , C07K14/005 , C07K14/575 , C07K14/61 , C12N15/1037 , C12N15/62 , G01N33/6845 , G01N33/74 , C07K2319/00 , C07K2319/02 , C07K2319/735 , C07K2319/75 , C12N2750/00011 , C12N2795/14022 , C12N2795/14122 , G01N2333/61 , Y10S436/802 , Y10S930/12
摘要： A method for selecting novel proteins such as growth hormone and antibody fragment variants having altered binding properties for their respective receptor molecules is provided. The method comprises fusing a gene encoding a protein of interest to the carboxy terminal domain of the gene III coat protein of the filamentous phage M13. The gene fusion is mutated to form a library of structurally related fusion proteins that are expressed in low quantity on the surface of a phagemid particle. Biological selection and screening are employed to identify novel ligands useful as drug candidates. Disclosed are preferred phagemid expression vectors and selected human growth hormone variants.
摘要翻译： PCT No.PCT / US91 / 09133 Sec。 371日期：1993年04月30日 102（e）日期1993年4月30日PCT 1991年12月3日提交了一种选择具有改变其各自受体分子结合特性的生长激素和抗体片段变体的新蛋白质的方法。该方法包括将编码目的蛋白质的基因融合到丝状噬菌体M13的基因III外壳蛋白的羧基末端结构域上。基因融合突变以形成在噬菌粒粒子表面上以低量表达的结构相关融合蛋白的文库。使用生物选择和筛选来鉴定可用作候选药物的新型配体。公开了优选的噬菌粒表达载体和选择的人生长激素变体。

7. 发明申请

US20140088103A1 (FUSED RING ARYLAMINO AND HETEROCYCLYLAMINO) PYRIMIDINYL AND 1,3,5-TRIAZINYL BENZIMIDAZOLES, PHARMACEUTICAL COMPOSITIONS THEREOF, AND THEIR USE IN TREATING PROLIFERATIVE DISEASES 审中-公开
标题翻译：（熔融芳族亚胺基和杂环基亚氨基）吡啶基和1,3,5-三嗪基苯并咪唑，其药物组合物及其在治疗增殖性疾病中的应用
公开(公告)号：US20140088103A1
公开(公告)日：2014-03-27
申请号：US14007629
申请日：2012-03-27
申请人： S. David Brown , David J. Matthews
发明人： S. David Brown , David J. Matthews
IPC分类号： C07D403/04
CPC分类号： C07D403/04
摘要： Provided herein are (fused ring arylamino and heterocyclylamino) pyrimidinyl and 1,3,5-triazinyl benzimidazoles, e.g., a compound of Formula (I), and their pharmaceutical compositions, preparation, and use as agents or drugs for treating proliferative diseases.
摘要翻译：本文提供的是（稠环芳基氨基和杂环基氨基）嘧啶基和1,3,5-三嗪基苯并咪唑，例如式（I）的化合物及其药物组合物，制备和用作治疗增殖性疾病的药物或药物。

8. 发明授权

US08397474B2 Methods of making slide-zippered reclosable packages on horizontal form-fill-seal machines 有权
公开(公告)号：US08397474B2
公开(公告)日：2013-03-19
申请号：US10883369
申请日：2004-07-01
申请人： Michael J. McMahon , Art Malin , Steve Ausnit , Donald L. Crevier , Joel Johnson , David J. Matthews
发明人： Michael J. McMahon , Art Malin , Steve Ausnit , Donald L. Crevier , Joel Johnson , David J. Matthews
IPC分类号： B65B61/18
CPC分类号： B65B43/50 , B31B50/81 , B31B70/8132 , B65B9/04 , B65B9/093 , B65B61/188 , Y10T24/45168 , Y10T428/1303
摘要： Methods of making slide-zippered reclosable packages are provided. In one embodiment, a pair of opposing film extensions are provided on each package between which a zipper and slider are attached. In another embodiment, sliders are inserted on to zippered packages output from a form-fill-seal machine or the like. In yet another embodiment, during package formation a reclosable zipper is sealed to each package and then a slider is inserted on to the zipper. In yet another embodiment, during package formation a reclosable zipper is sealed to each package and a slider is inserted on to each zipper, either before or after zipper sealing.

9. 发明申请

US20120252802A1 (ALPHA-SUBSTITUTED ARALKYLAMINO AND HETEROARYLALKYLAMINO) PYRIMIDINYL AND 1,3,5-TRIAZINYL BENZIMIDAZOLES, PHARMACEUTICAL COMPOSITIONS THEREOF, AND THEIR USE IN TREATING PROLIFERATIVE DISEASES 有权
标题翻译：（ALPHA-取代的ARALKYLAMINO和HETEROARYLALKYLAMINO）吡咯烷酮和1,3,5-三嗪基苯并咪唑，其药物组合物及其在治疗增殖性疾病中的用途
公开(公告)号：US20120252802A1
公开(公告)日：2012-10-04
申请号：US13431716
申请日：2012-03-27
申请人： S. David Brown , David J. Matthews
发明人： S. David Brown , David J. Matthews
IPC分类号： A61K31/5377 , C12N9/99 , A61P29/00 , C07D413/14
CPC分类号： A61K31/5377 , C07D401/14 , C07D403/04 , C07D403/14 , C07D413/14 , C12N9/1205
摘要： Provided herein are (alpha-substituted aralkylamino or heteroarylalkylamino) pyrimidinyl and 1,3,5-triazinyl benzimidazoles, e.g., a compound of Formula I, and their pharmaceutical compositions, preparation, and use as agents or drugs for treating proliferative diseases.
摘要翻译：本文提供的是（α-取代的芳烷基氨基或杂芳基烷基氨基）嘧啶基和1,3,5-三嗪基苯并咪唑，例如式I的化合物及其药物组合物，制备和用作治疗增殖性疾病的药物或药物。

10. 发明授权

US08204824B2 System and method of account reconciliation for electronic transactions 失效
标题翻译：电子交易账户对账系统和方法
公开(公告)号：US08204824B2
公开(公告)日：2012-06-19
申请号：US12272325
申请日：2008-11-17
申请人： W. Jeffrey Knowles , David J. Matthews , Russell Hales Day
发明人： W. Jeffrey Knowles , David J. Matthews , Russell Hales Day
IPC分类号： G06Q40/00
CPC分类号： G06Q20/04 , G06Q20/102 , G06Q20/12 , G06Q20/24 , G06Q20/381 , G06Q40/025 , G06Q40/12
摘要： A transaction process system (10) provides for data transactions between parties. In a credit card transaction, the parties are the merchant (20), acquiring bank (24), card association (34), issuing bank (14), and cardholder (12). A transaction processing center (30) is positioned between the acquiring bank and the card association. The transaction processing center provides data processing channels for message-based processing (72) and filed-based processing (76). The file-based processing uses an incoming queue (80) and outgoing queue (84) to simplify the interface. The transaction processing center also provides for currency conversions and account reconciliation on a per transaction basis. The transaction processing center uses a scheduler (160) to efficiently manage the data processing resources and an account reconciliation processor (200) to identify discrepancies and initiate corrective action.
摘要翻译：交易处理系统（10）提供各方之间的数据交易。在信用卡交易中，双方是商户（20），收款银行（24），卡片协会（34），开证行（14）和持卡人（12）。交易处理中心（30）位于采集银行和卡片关联之间。事务处理中心提供用于基于消息的处理（72）和基于归档的处理（76）的数据处理通道。基于文件的处理使用传入队列（80）和传出队列（84）来简化接口。交易处理中心还提供每笔交易的货币兑换和账户对账。事务处理中心使用调度器（160）来有效地管理数据处理资源和帐户对帐处理器（200）以识别差异并启动纠正措施。

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