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1. 发明授权

US4663383A Silica coated olefin-acid copolymer molding pellets 失效
标题翻译：二氧化硅涂覆的烯烃 - 共聚物成型颗粒
公开(公告)号：US4663383A
公开(公告)日：1987-05-05
申请号：US832726
申请日：1986-02-25
申请人： David J. Lowe , Richard J. Powell , Malcolm S. Smith
发明人： David J. Lowe , Richard J. Powell , Malcolm S. Smith
IPC分类号： C08J3/00 , C08J3/12 , C08K3/34 , C08K3/36 , C08L23/00 , C08L23/02 , C08L23/08 , C08L33/00 , C08L33/02 , C08L101/00
CPC分类号： C08J3/124 , C08K3/36 , C08J2323/08
摘要： Ethylene copolymers or terpolymers containing repeating units derived from ethylenically unsaturated carboxylic acids which have been surface treated with from 0.005 to 2 wt. % silica to reduce surface tackiness are disclosed.
摘要翻译：含有衍生自烯键式不饱和羧酸的重复单元的乙烯共聚物或三元共聚物，其已经用0.005-2重量％公开了用于降低表面粘性的二氧化硅。

2. 发明授权

US5276135A Stabilized copolymers of ethylene with ethylenically unsaturated carboxylic acids 失效
标题翻译：乙烯与烯属不饱和羧酸的稳定共聚物
公开(公告)号：US5276135A
公开(公告)日：1994-01-04
申请号：US3819
申请日：1993-01-11
申请人： Richard J. Powell
发明人： Richard J. Powell
IPC分类号： C08J3/00 , C08F6/26 , C08K3/20 , C08F6/00
CPC分类号： C08F6/26 , C08K3/20
摘要： The viscosity stability of a copolymer of ethylene with at least one comonomer which is an ethylenically unsaturated carboxylic acid is improved by exposing the isolated copolymer to moisture for a sufficient period to cause the copolymer to retain at least 20 weight percent more water than it would retain if it were purged with air or nitrogen heated to a temperature at least 5.degree. C. above ambient, which air or nitrogen has not been humidified after it has been heated to such temperature.
摘要翻译：乙烯与至少一种作为烯键式不饱和羧酸的共聚单体的共聚物的粘度稳定性通过将分离的共聚物暴露于水分足够长的时间来改善，使共聚物保留比保留的水多至少20重量％如果用空气或氮气吹扫，加热到高于环境温度至少5摄氏度的温度，哪些空气或氮气在加热到这样的温度之后没有被加湿。

3. 发明授权

US5399401A Flexible, low haze chlorine-free ethylene copolymer article 失效
标题翻译：柔性低雾无氯乙烯共聚物制品
公开(公告)号：US5399401A
公开(公告)日：1995-03-21
申请号：US200809
申请日：1994-02-22
申请人： Richard J. Powell
发明人： Richard J. Powell
IPC分类号： A61L29/04 , A61L29/14 , C08K5/20 , C08L23/08
CPC分类号： A61L29/041 , A61L29/14 , C08K5/20 , C08L23/0869 , Y10T428/139
摘要： Highly flexible articles having wall thickness of at least 0.01 inches are made from chlorine-free direct ethylene copolymers containing small amounts of selected known slip additives. Articles in the form of tubes or tubing have particular utility for replacement of PVC based tubing used in medical applications.
摘要翻译：具有至少0.01英寸的壁厚度的高度柔性制品由含有少量选定的已知滑动添加剂的无氯直接乙烯共聚物制成。管或管道形式的物品具有用于医疗应用中使用的PVC基管的替代物的特殊用途。

4. 发明授权

US07510714B2 Methods for modulating angiogenesis 有权
标题翻译：调节血管生成的方法
公开(公告)号：US07510714B2
公开(公告)日：2009-03-31
申请号：US11668663
申请日：2007-01-30
申请人： Mary Jo Mulligan-Kehoe , Richard J. Powell
发明人： Mary Jo Mulligan-Kehoe , Richard J. Powell
IPC分类号： A61K38/16 , A61K38/17
CPC分类号： A61K38/57
摘要： Recombinant plasminogen activator inhibitor-1 (PAI-1) isoforms which lack the reactive center loop and contain the complete heparin-binding domain or lack at least a portion of the heparin-binding domain are described. The rPAI-1 isoforms disclosed herein may be used to modulate angiogenesis through blocking release of VEGF from a VEGF-heparin complex. Furthermore, the rPAI-1 proteins may be used to inhibit cell proliferation and migration, induce apoptosis, and produce proteolytic fragments corresponding to angiostatin kringles 1-3 and kringles 1-4. A truncated proteolytic plasmin protein of 34 kDa is also provided.
摘要翻译：描述了缺乏反应中心环并含有完整的肝素结合结构域或缺乏至少一部分肝素结合结构域的重组纤溶酶原激活物抑制剂-1（PAI-1）异构体。本文公开的rPAI-1同种型可用于通过从VEGF-肝素复合物阻断VEGF的释放来调节血管生成。此外，rPAI-1蛋白可用于抑制细胞增殖和迁移，诱导细胞凋亡，并产生对应于血管抑素三酮1-3和三环1-4的蛋白水解片段。还提供了34kDa的截短的蛋白水解纤溶酶蛋白。

5. 发明授权

US07241446B2 Methods for modulating angiogenesis via VEGF 有权
标题翻译：通过VEGF调节血管生成的方法
公开(公告)号：US07241446B2
公开(公告)日：2007-07-10
申请号：US10506225
申请日：2003-04-01
申请人： Mary Jo Mulligan-Kehoe , Richard J. Powell
发明人： Mary Jo Mulligan-Kehoe , Richard J. Powell
IPC分类号： A61K39/00 , A61K38/16 , A61K38/17
CPC分类号： A61K38/57
摘要： Recombinant plasminogen activator inhibitor-1 (PAI-1) isoforms which lack the reactive center loop and contain the complete heparin-binding domain or lack at least a portion of the heparin-binding domain are described. The rPAI-1 isoforms disclosed herein may be used to modulate angiogenesis through blocking release of VEGF from a VEGF-heparin complex. Furthermore the rPAI-1 proteins may be used to inhibit cell proliferation and migration, induce apoptosis, and produce proteolytic fragments corresponding to angiostatin kringles 1–3 and kringles 1–4.
摘要翻译：描述了缺乏反应中心环并含有完整的肝素结合结构域或缺乏至少一部分肝素结合结构域的重组纤溶酶原激活物抑制剂-1（PAI-1）异构体。本文公开的rPAI-1同种型可用于通过从VEGF-肝素复合物阻断VEGF的释放来调节血管生成。此外，rPAI-1蛋白可用于抑制细胞增殖和迁移，诱导细胞凋亡，并产生对应于血管抑素三酮1-3和三酮酮1-4的蛋白水解片段。

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