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1. 发明授权

US06277334B1 Chemical synthesis apparatus employing a droplet generator 有权
公开(公告)号：US06277334B1
公开(公告)日：2001-08-21
申请号：US09313403
申请日：1999-05-18
申请人： David J. Ecker , Oscar Acevedo , Normand Hebert , Peter W. Davis , Jacqueline R. Wyatt , John S. Kiely
发明人： David J. Ecker , Oscar Acevedo , Normand Hebert , Peter W. Davis , Jacqueline R. Wyatt , John S. Kiely
IPC分类号： B01L300
CPC分类号： B01L3/0268 , B01J19/0046 , B01J2219/00315 , B01J2219/00333 , B01J2219/00351 , B01J2219/00378 , B01J2219/00527 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00617 , B01J2219/00621 , B01J2219/00626 , B01J2219/0063 , B01J2219/00637 , B01J2219/00641 , B01J2219/00659 , B01J2219/0072 , B01J2219/00722 , B01J2219/00725 , B01J2219/00729 , C07B2200/11 , C07H21/00 , C07K1/047 , C12P19/34 , C40B40/06 , C40B40/10 , C40B60/14
摘要： Chemical reaction apparatus, materials and methods are provided for the automatable, efficient synthesis of chemical species and libraries. In accordance with preferred embodiments, chemical droplet generation and direction techniques are employed to prepare oligomers and libraries of chemical species. Reaction assemblies adapted for efficient synthetic employment and for improved collection are also disclosed.

2. 发明授权

US5925732A Chemical reaction apparatus for performing multiple reaction on a surface and collecting the product 失效
标题翻译：用于在表面上进行多次反应并收集产品的化学反应装置
公开(公告)号：US5925732A
公开(公告)日：1999-07-20
申请号：US778876
申请日：1997-01-02
申请人： David J. Ecker , Oscar Acevedo , Normand Hebert , Peter W. Davis , Jacqueline R. Wyatt , John S. Kiely
发明人： David J. Ecker , Oscar Acevedo , Normand Hebert , Peter W. Davis , Jacqueline R. Wyatt , John S. Kiely
IPC分类号： B01J19/00 , B01L3/02 , C07B61/00 , C07H21/00 , C07K1/04 , C12P19/34 , C40B40/06 , C40B40/10 , C40B60/14 , G01N33/53 , C12Q1/68
CPC分类号： B01L3/0268 , B01J19/0046 , C07H21/00 , C07K1/047 , C12P19/34 , B01J2219/00315 , B01J2219/00333 , B01J2219/00351 , B01J2219/00378 , B01J2219/00527 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00617 , B01J2219/00621 , B01J2219/00626 , B01J2219/0063 , B01J2219/00637 , B01J2219/00641 , B01J2219/00659 , B01J2219/0072 , B01J2219/00722 , B01J2219/00725 , B01J2219/00729 , C07B2200/11 , C40B40/06 , C40B40/10 , C40B60/14
摘要： Chemical reaction apparatus, materials and methods are provided for the automatable, efficient synthesis of chemical species and libraries. In accordance with preferred embodiments, chemical droplet generation and direction techniques are employed to prepare oligomers and libraries of chemical species. Reaction assemblies adapted for efficient synthetic employment and for improved collection are also disclosed.
摘要翻译：提供化学反应装置，材料和方法用于化学物质和文库的可自动化，有效的合成。根据优选实施方案，采用化学液滴产生和方向技术来制备化学物质的低聚物和文库。还公开了适于高效合成使用和改进收集的反应组件。

3. 发明授权

US06558633B1 Chemical reaction apparatus and methods 失效
标题翻译：化学反应装置及方法
公开(公告)号：US06558633B1
公开(公告)日：2003-05-06
申请号：US08309925
申请日：1994-09-21
申请人： David J. Ecker , Oscar Acevedo , Normand Hebert , Peter W. Davis , Jacqueline R. Wyatt , John S. Kiely
发明人： David J. Ecker , Oscar Acevedo , Normand Hebert , Peter W. Davis , Jacqueline R. Wyatt , John S. Kiely
IPC分类号： C12M118
CPC分类号： B01L3/0268 , B01J19/0046 , B01J2219/00315 , B01J2219/00333 , B01J2219/00351 , B01J2219/00378 , B01J2219/00527 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00617 , B01J2219/00621 , B01J2219/00626 , B01J2219/0063 , B01J2219/00637 , B01J2219/00641 , B01J2219/00659 , B01J2219/0072 , B01J2219/00722 , B01J2219/00725 , B01J2219/00729 , C07B2200/11 , C07H21/00 , C07K1/047 , C12P19/34 , C40B40/06 , C40B40/10 , C40B60/14
摘要： Chemical reaction apparatus, materials and methods are provided for the automatable, efficient synthesis of chemical species and libraries. In accordance with preferred embodiments, chemical droplet generation and direction techniques are employed to prepare oligomers and libraries of chemical species. Reaction assemblies adapted for efficient synthetic employment and for improved collection are also disclosed.
摘要翻译：提供化学反应装置，材料和方法用于化学物质和文库的可自动化，有效的合成。根据优选实施方案，采用化学液滴产生和方向技术来制备化学物质的低聚物和文库。还公开了适于高效合成使用和改进收集的反应组件。

4. 发明授权

US5637684A Phosphoramidate and phosphorothioamidate oligomeric compounds 失效
标题翻译：氨基磷酸酯和硫代酰胺酯低聚物
公开(公告)号：US5637684A
公开(公告)日：1997-06-10
申请号：US200638
申请日：1994-02-23
申请人： Phillip D. Cook , Oscar Acevedo , Normand Hebert
发明人： Phillip D. Cook , Oscar Acevedo , Normand Hebert
IPC分类号： C12N9/99 , A61K31/66 , A61K31/70 , A61K31/7028 , A61K31/7088 , A61P29/00 , A61P31/00 , A61P43/00 , C07F9/09 , C07F9/24 , C07H15/00 , C07H21/00 , C08G79/02 , C08G79/04 , C12Q1/68 , C07D239/00 , C07H21/02 , C07H21/04
CPC分类号： C07H21/00 , C07F9/091
摘要： Compounds are provided having the structure: ##STR1## wherein the L groups are spanner or linker units, the Y and T group are functional groups for interacting with target molecules of interest, the X groups are oxygen or sulfur and the E groups are H, conjugate groups or intermediate groups used during the synthesis of the compounds are prepared using H phosphonate type chemistry wherein the functional groups are added during an oxidization step.
摘要翻译：提供具有以下结构的化合物：其中L基团是扳手或连接体单元，Y和T基团是与目的靶分子相互作用的官能团，X基团是氧或硫，E基团是H，在化合物合成期间使用的共轭基团或中间体使用H膦酸酯型化学制备，其中在氧化步骤期间加入官能团。

5. 发明授权

US5717083A Phosphoramidate and phosphorothiomidate oligomeric compounds 失效
标题翻译：氨基磷酸酯和硫代磷酸酯低聚化合物
公开(公告)号：US5717083A
公开(公告)日：1998-02-10
申请号：US693112
申请日：1996-08-19
申请人： Phillip Dan Cook , Oscar Acevedo , Normand Hebert
发明人： Phillip Dan Cook , Oscar Acevedo , Normand Hebert
IPC分类号： C12N9/99 , A61K31/66 , A61K31/70 , A61K31/7028 , A61K31/7088 , A61P29/00 , A61P31/00 , A61P43/00 , C07F9/09 , C07F9/24 , C07H15/00 , C07H21/00 , C08G79/02 , C08G79/04 , C12Q1/68 , C07D239/00
CPC分类号： C07H21/00 , C07F9/091
摘要： Compounds are provided having structure (I), wherein the L groups are backbone segments, the Y and T groups are functional groups for interacting with target molecules of interest, the X groups are oxygen or sulfur and the E groups are H, conjugate groups or intermediate groups used during the synthesis of the compounds and wherein the compounds are prepared using H phosphonate type chemistry wherein the functional groups are added during an oxidation step or during a coupling step. ##STR1##
摘要翻译： PCT No.PCT / US95 / 02267 Sec。 371日期：1996年8月19日 102（e）日期1996年8月19日PCT提交1995年2月23日PCT公布。公开号WO95 / 23160 日期1995年8月31日提供具有结构（I）的化合物，其中L基是骨架链段，Y和T基团是与目的靶分子相互作用的官能团，X基团是氧或硫，E基团是 H，在化合物合成期间使用的共轭基团或中间体，并且其中使用H膦酸盐型化学制备所述化合物，其中所述官能团在氧化步骤期间或在偶联步骤期间加入。（一）

6. 发明授权

US06698040B1 Retractable bed 失效
标题翻译：伸缩床
公开(公告)号：US06698040B1
公开(公告)日：2004-03-02
申请号：US10198907
申请日：2002-07-19
申请人： Oscar Acevedo
发明人： Oscar Acevedo
IPC分类号： A47C1700
CPC分类号： A47C17/84
摘要： A retractable bed for mounting in a ceiling of a room. The retractable bed includes a cap member for mounting on mounting rafters of a framed section in a ceiling and has a cap cavity. The cap member comprises a top wall, and a pair of cap side walls and cap end walls that are attached to and extend away from the top wall to define the cap cavity. A base member holds a bed and in a bed cavity. The base member comprises a bottom wall, and a pair of base side walls and base end walls being attached to and extending away from the bottom wall to define the bed cavity. The base member is selectively positionable in the cap cavity. A moving means selectively moves the base member between a retracted position and an extended position. A switch allows a user to actuate the moving means, thereby controlling the positioning of the bed.
摘要翻译：一个用于安装在房间天花板上的伸缩床。可伸缩床包括盖构件，用于安装在天花板中的框架部分的安装椽上并具有帽腔。帽构件包括顶壁和一对帽侧壁和帽端壁，其连接到顶壁并且远离顶壁延伸以限定帽腔。一个基座部件保持一个床并在一个床腔中。基部构件包括底壁，并且一对底侧壁和基端壁附接到底壁并且远离底壁延伸以限定床腔。基座构件可选择性地定位在帽腔中。移动装置选择性地在缩回位置和延伸位置之间移动基座构件。开关允许用户致动移动装置，从而控制床的定位。

7. 发明授权

US5459243A Apparatus and processes for the large scale generation and transfer of diazomethane 失效
标题翻译：用于大规模生成和转移重氮甲烷的装置和方法
公开(公告)号：US5459243A
公开(公告)日：1995-10-17
申请号：US209154
申请日：1994-03-10
申请人： Oscar Acevedo , Bruce Ross , Robert S. Andrews , Robert Springer , Phillip D. Cook
发明人： Oscar Acevedo , Bruce Ross , Robert S. Andrews , Robert Springer , Phillip D. Cook
IPC分类号： C07C245/14 , C07C245/16 , C07C245/12
CPC分类号： C07C245/16 , C07C245/14
摘要： For large scale preparation of pyrimidine ribonucleosides, the intermediate 2-O-methyl-(or ethyl)-1,3,5-tri-O-benzoyl-.alpha.-D-ribose can be prepared using a diazomethane (or diazoethane) reaction that is controlled via an inert solvent transferring system. This transfer system allows for large scale preparations of the pyrimidine ribonucleosides.
摘要翻译：对于嘧啶核糖核苷的大规模制备，中间体2-O-甲基 - （或乙基）-1,3,5-三-O-苯甲酰-α-D-核糖可以使用重氮甲烷（或重氮乙烷）反应制备，通过惰性溶剂转移系统进行控制。该转移系统允许嘧啶核糖核苷的大规模制备。

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