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1. 发明授权

US06197172B1 Electrochemical sensor with gelled membrane and method of making 有权
标题翻译：具凝胶膜的电化学传感器及其制造方法
公开(公告)号：US06197172B1
公开(公告)日：2001-03-06
申请号：US09162478
申请日：1998-09-28
申请人： David H. Dicks , Handani Winarta , John Hiti , Nicole Pouliot , Jeffrey C. Chien , Chung Chang Young
发明人： David H. Dicks , Handani Winarta , John Hiti , Nicole Pouliot , Jeffrey C. Chien , Chung Chang Young
IPC分类号： G01N27333
CPC分类号： G01N27/40
摘要： An electrochemical sensor with a gelled membrane for prolonging the useful life of an ion-selective electrode. The gelled membrane is a hydrophilic membrane having a specially-formulated gel layer coated on one side. The gel-coated side of the gelled membrane is in intimate contact with the ion-selective membrane and separates the ion-selective membrane from the test samples and the calibration and cleaning fluids. The gelled membrane is a semi-permeable barrier which allows passage of the species to be measured while inhibiting the passage of surfactant and proteinaceous material into the polymeric ion-selective membrane.
摘要翻译：具有凝胶膜的电化学传感器，用于延长离子选择性电极的使用寿命。凝胶膜是具有一面涂布特殊配制的凝胶层的亲水膜。凝胶膜的凝胶涂层与离子选择膜紧密接触，并将离子选择性膜与测试样品和校准和清洁液分离。凝胶膜是半透性屏障，其允许待测量的物质通过，同时抑制表面活性剂和蛋白质物质进入聚合物离子选择性膜。

2. 发明申请

US20090223834A1 Biosensor and method 审中-公开
标题翻译：生物传感器和方法
公开(公告)号：US20090223834A1
公开(公告)日：2009-09-10
申请号：US12466767
申请日：2009-05-15
申请人： Xiaohua Cai , Handani Winarta , Chung Chang Young
发明人： Xiaohua Cai , Handani Winarta , Chung Chang Young
IPC分类号： G01N27/26
CPC分类号： C12Q1/34 , C12Q1/004 , C12Q1/006 , C12Q1/26 , C12Q1/28 , Y10T29/49002
摘要： A method of compensating for the presence of hematocrit in a blood sample when measuring a blood analyte using a disposable sensor strip. The method includes disposing a blood sample onto a working electrode and a reference electrode of the disposable sensor strip to obtain a concentration of an analyte in the blood sample, measuring a resistance value of the blood sample between the reference electrode and the working electrode, and calculating a corrected concentration of the analyte using the resistance value and a hematocrit equation to correct for the presence of hematocrit in the blood sample.
摘要翻译：当使用一次性传感器条测量血液分析物时，补偿血液样品中血细胞比容存在的方法。该方法包括将血液样本设置在一次性传感器条的工作电极和参考电极上，以获得血液样品中的分析物的浓度，测量参考电极和工作电极之间的血液样本的电阻值，以及使用电阻值和血细胞比容方程计算校正的分析物浓度以校正血液样品中血细胞比容的存在。

3. 发明申请

US20080006530A1 Capillary Flow Control in a Flow Channel 审中-公开
标题翻译：流道中的毛细管流量控制
公开(公告)号：US20080006530A1
公开(公告)日：2008-01-10
申请号：US11425001
申请日：2006-06-19
申请人： Handani Winarta , Chung Chang Young , Andy Vo , Yu-Tao Chuang , Yu-Feng Chang
发明人： Handani Winarta , Chung Chang Young , Andy Vo , Yu-Tao Chuang , Yu-Feng Chang
IPC分类号： G01N33/487
CPC分类号： G01N27/3272 , G01N33/54386 , G01N33/558
摘要： A sensor strip with capillary flow control has a base layer having a plurality of conductive paths delineated thereon, an electrode forming layer disposed on the base layer, the electrode forming layer having a first opening forming a working electrode, a second opening forming a reference electrode, and a flow-control mechanism, a spacer layer disposed on the electrode forming layer, and a cover layer with a vent opening disposed on the spacer layer and forming a substantially flat sample channel with walls formed by the electrode forming layer, the spacer layer and the cover layer, the substantially flat sample chamber having a sample inlet adjacent a proximal end and the vent opening adjacent a distal end where the substantially flat sample chamber contains the working electrode, the reference electrode and the flow-control mechanism.
摘要翻译：具有毛细管流控制的传感器条带具有其上描绘的多个导电路径的基底层，设置在基底层上的电极形成层，电极形成层具有形成工作电极的第一开口，形成参考电极的第二开口，以及流动控制机构，设置在电极形成层上的间隔层，以及设置在间隔层上的排气孔的盖层，并形成具有由电极形成层形成的壁的基本平坦的样品通道，间隔层覆盖层，基本上平坦的样品室具有邻近近端的样品入口和邻近远端的通气口，其中基本上平坦的样品室包含工作电极，参考电极和流量控制机构。

4. 发明授权

US06287451B1 Disposable sensor and method of making 有权
标题翻译：一次性传感器及其制作方法
公开(公告)号：US06287451B1
公开(公告)日：2001-09-11
申请号：US09324443
申请日：1999-06-02
申请人： Handani Winarta , Xiaohua Cai , Fung Seto , Chung Chang Young
发明人： Handani Winarta , Xiaohua Cai , Fung Seto , Chung Chang Young
IPC分类号： G01N2726
CPC分类号： C12Q1/002
摘要： A disposable electrode strip for testing a fluid sample including a laminated strip with a first and second end, a reference electrode embedded in the laminated strip proximate to the first end, at least two working electrodes embedded in the laminated strip proximate to the first end and the reference electrode, an open path for receiving a fluid sample beginning from the first end and being sufficiently long to expose the reference electrode and the working electrodes to the fluid sample, and conductive contacts located at the second end of the laminated strip. The laminated strip has a base layer with a conductive coating, a reagent holding layer, a channel forming layer and a cover. One of the working electrodes contains a reagent substantially similar to the reagent of the reference electrode and a second working electrode contains a reagent having an enzyme.
摘要翻译：一种用于测试流体样品的一次性电极条，包括具有第一和第二端的层压条，附接到第一端的层压条中的参考电极，嵌入层叠带中的至少两个工作电极，靠近第一端，参考电极，用于从第一端开始接收流体样品并且足够长以将参考电极和工作电极暴露于流体样品的开放路径，以及位于层压条的第二端处的导电触点。层叠带具有带有导电涂层的底层，试剂保持层，通道形成层和盖。其中一个工作电极含有与参考电极的试剂基本相似的试剂，第二工作电极含有具有酶的试剂。

5. 发明授权

US06767441B1 Biosensor with peroxidase enzyme 有权
标题翻译：具有过氧化物酶的生物传感器
公开(公告)号：US06767441B1
公开(公告)日：2004-07-27
申请号：US09919126
申请日：2001-07-31
申请人： Xiaohua Cai , Handani Winarta , Chung Chang Young
发明人： Xiaohua Cai , Handani Winarta , Chung Chang Young
IPC分类号： G01N27327
CPC分类号： C12Q1/34 , C12Q1/004 , C12Q1/006 , C12Q1/26 , C12Q1/28 , Y10T29/49002
摘要： An improved biosensor having at least a first working electrode and a first electrode material disposed on the first working electrode. The first electrode material is a mixture made by combining at least one enzyme where the at least one enzyme is a capable of reacting with the analyte to be measured, a redox mediator capable of reacting with a product of an enzymatic reaction or a series of enzymatic reactions involving the at least one enzyme, a peroxidase capable of catalyzing a reaction involving the redox mediator where the redox mediator is oxidized, a binder and a surfactant.
摘要翻译：一种改进的生物传感器，具有至少第一工作电极和设置在第一工作电极上的第一电极材料。第一电极材料是通过将至少一种酶与待测分析物反应的至少一种酶，能够与酶反应或一系列酶反应的产物反应的氧化还原介体涉及至少一种酶的反应物，能够催化涉及氧化还原介体被氧化的氧化还原介体的反应的过氧化物酶，粘合剂和表面活性剂。

6. 发明授权

US08617366B2 Disposable urea sensor and system for determining creatinine and urea nitrogen-to-creatinine ratio in a single device 有权
公开(公告)号：US08617366B2
公开(公告)日：2013-12-31
申请号：US11164935
申请日：2005-12-12
申请人： Handani Winarta , Jianhong Pei , Mary Lauro , Chung Chang Young , Xiaohua Cai
发明人： Handani Winarta , Jianhong Pei , Mary Lauro , Chung Chang Young , Xiaohua Cai
IPC分类号： G01N33/487
CPC分类号： C12Q1/005 , G01N27/3271
摘要： A disposable urea sensor has a laminated body having a fluid sample inlet end and an electrical contact end, a fluid sample inlet, a substantially flat sample chamber in communication between the fluid sample inlet and a vent opening, the sample chamber being adapted to collect a fluid sample through the fluid sample inlet, a working electrode and a reference electrode within the sample chamber, and a reagent matrix disposed on the working electrode wherein the reagent matrix contains urease.

7. 发明授权

US06837976B2 Disposable sensor with enhanced sample port inlet 有权
标题翻译：一次性传感器，具有增强的样品口入口
公开(公告)号：US06837976B2
公开(公告)日：2005-01-04
申请号：US10126819
申请日：2002-04-19
申请人： Xiaohua Cai , Handani Winarta , Andy Vo , Chung Chang Young
发明人： Xiaohua Cai , Handani Winarta , Andy Vo , Chung Chang Young
IPC分类号： G01N27/327 , C12M1/34 , C12M1/40 , C12Q1/00 , G01N27/30 , G01N27/416 , G01N33/487
CPC分类号： C12Q1/001 , G01N27/3272
摘要： A disposable biosensor for testing a fluid sample including a laminated strip with a first and second end, a reference electrode embedded in the laminated strip proximate to the first end, at least one working electrode embedded in the laminated strip proximate to the first end and the reference electrode, an open path for receiving a fluid sample beginning from the first end and connecting to a vent spaced from the first end, the open path being sufficiently long to expose the reference electrode and the working electrode to the fluid sample, and conductive contacts located at the second end of the laminated strip. The laminated strip has a base layer with a conductive coating, a reagent holding layer, a channel forming layer and a cover having an inlet notch at the first end. The working electrode contains a reagent having an enzyme.

8. 发明授权

US06258229B1 Disposable sub-microliter volume sensor and method of making 有权
标题翻译：一次性亚微升体积传感器及其制作方法
公开(公告)号：US06258229B1
公开(公告)日：2001-07-10
申请号：US09324493
申请日：1999-06-02
申请人： Handani Winarta , Xiaohua Cai , Fung Seto , Chung Chang Young
发明人： Handani Winarta , Xiaohua Cai , Fung Seto , Chung Chang Young
IPC分类号： G01N2726
CPC分类号： C12Q1/006 , C12Q1/004
摘要： A disposable electrode strip for testing a fluid sample including a laminated strip with a first and second end, a vent, an open path for receiving a fluid sample of less than one microliter beginning from the first end and connecting to the vent, a working electrode, a reference electrode and a pseudo-working electrode embedded in the laminated strip within the open path and proximate to the first end, a reagent matrix coextensive within the open path and covering the three electrodes, and conductive contacts located at the second end of the laminated strip.
摘要翻译：一种用于测试流体样品的一次性电极条，包括具有第一和第二端的层压条，通气口，用于接收从第一端开始并连接到通风口的小于1微升的流体样品的开放路径，工作电极，参考电极和伪工作电极，其嵌入在开放路径内并且靠近第一端的层压条中，在开放路径内共同延伸并覆盖三个电极的试剂基体和位于第二端的导电触点层压带。

9. 发明授权

US09039874B2 Disposable urea sensor and system for determining creatinine and urea nitrogen-to-creatinine ratio in a single device 有权
标题翻译：一次性尿素传感器和用于测定单个装置中肌酐和尿素氮对肌酐比例的系统
公开(公告)号：US09039874B2
公开(公告)日：2015-05-26
申请号：US14077620
申请日：2013-11-12
申请人： Handani Winarta , Jianhong Pei , Mary Lauro , Chung Chang Young , Xiaohua Cai
发明人： Handani Winarta , Jianhong Pei , Mary Lauro , Chung Chang Young , Xiaohua Cai
IPC分类号： C12Q1/00 , G01N27/327
CPC分类号： C12Q1/005 , G01N27/3271
摘要： A disposable urea sensor has a laminated body having a fluid sample inlet end and an electrical contact end, a fluid sample inlet, a substantially flat sample chamber in communication between the fluid sample inlet and a vent opening, the sample chamber being adapted to collect a fluid sample through the fluid sample inlet, a working electrode and a reference electrode within the sample chamber, and a reagent matrix disposed on the working electrode wherein the reagent matrix contains urease.
摘要翻译：一次性尿素传感器具有层压体，其具有流体样品入口端和电接触端，流体样品入口，在流体样品入口和通气口之间连通的基本平坦的样品室，样品室适于收集流体样品通过流体样品入口，样品室内的工作电极和参比电极，以及设置在工作电极上的试剂基质，其中试剂基质含有脲酶。

10. 发明申请

US20140069823A1 Disposable urea sensor and system for determining creatinine and urea nitrogen-to-creatinine ratio in a single device 审中-公开
标题翻译：一次性尿素传感器和用于测定单个装置中肌酐和尿素氮对肌酐比例的系统
公开(公告)号：US20140069823A1
公开(公告)日：2014-03-13
申请号：US14077620
申请日：2013-11-12
申请人： Handani Winarta , Jianhong Pei , Mary Lauro , Chung Chang Young , Xiaohua Cai
发明人： Handani Winarta , Jianhong Pei , Mary Lauro , Chung Chang Young , Xiaohua Cai
IPC分类号： C12Q1/00
CPC分类号： C12Q1/005 , G01N27/3271
摘要： A disposable urea sensor has a laminated body having a fluid sample inlet end and an electrical contact end, a fluid sample inlet, a substantially flat sample chamber in communication between the fluid sample inlet and a vent opening, the sample chamber being adapted to collect a fluid sample through the fluid sample inlet, a working electrode and a reference electrode within the sample chamber, and a reagent matrix disposed on the working electrode wherein the reagent matrix contains urease.
摘要翻译：一次性尿素传感器具有层压体，其具有流体样品入口端和电接触端，流体样品入口，在流体样品入口和通气口之间连通的基本平坦的样品室，样品室适于收集流体样品通过流体样品入口，样品室内的工作电极和参比电极，以及设置在工作电极上的试剂基质，其中试剂基质含有脲酶。

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