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1. 发明授权

US06403776B1 Synthesis of carbamate ketolide antibiotics 失效
标题翻译：氨基甲酸酯酮内酯抗生素的合成
公开(公告)号：US06403776B1
公开(公告)日：2002-06-11
申请号：US09610057
申请日：2000-07-05
申请人： David H. B. Ripin , Brian C. Vanderplas , Takushi Kaneko , William T. McMillen , Robert W. McLaughlin
发明人： David H. B. Ripin , Brian C. Vanderplas , Takushi Kaneko , William T. McMillen , Robert W. McLaughlin
IPC分类号： C07H100
CPC分类号： C07H17/08
摘要： The invention relates to a method of preparing a macrolide antibiotic of the formula wherein R1, R2, R3, R4, R5 are defined above. These antibiotics are useful as antibacterial and antiprotozoal agents in mammals, including man, as well as in fish and birds. The invention also includes novel compounds made by the preparation of the macrolide antibiotic.
摘要翻译：本发明涉及制备式（Ⅳ）的大环内酯抗生素的方法，其中R 1，R 2，R 3，R 4，R 5如上所定义。这些抗生素在哺乳动物，包括人以及鱼和鸟类中都可用作抗细菌和抗原虫药。本发明还包括通过制备大环内酯类抗生素制备的新化合物。

2. 发明授权

US06833444B2 Ketolide antibiotics 失效
标题翻译：酮内酯抗生素
公开(公告)号：US06833444B2
公开(公告)日：2004-12-21
申请号：US10116969
申请日：2002-04-05
申请人： William T. McMillen , Takushi Kaneko
发明人： William T. McMillen , Takushi Kaneko
IPC分类号： C07H1708
CPC分类号： C07H17/08
摘要： This invention relates to compounds of the formula 1: and to pharmaceutically acceptable salts and solvates thereof wherein X1, X2, R2, R8, R9, R10 and R11 are as defined herein. The compounds of formula 1 are antibacterial and antiprotozoal agents that may be used to treat various bacterial and protozoal infections and disorders related to such infections. The invention also relates to pharmaceutical compositions containing the compounds of formula 1 and to methods of treating bacterial and protozoal infections by administering the compounds of formula 1.
摘要翻译：本发明涉及式1化合物及其药学上可接受的盐和溶剂化物，其中X 1，X 2，R 2，R 8，R 9，R 10和R <11>如本文所定义。式1的化合物是可用于治疗各种细菌和原生动物感染的抗细菌剂和抗原虫药，以及与这种感染有关的疾病。本发明还涉及含有式1化合物的药物组合物和通过施用式1化合物来治疗细菌和原生动物感染的方法。

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