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1. 发明申请

US20060020393A1 Methods for quantification and de novo polypeptide sequencing by mass spectrometry 审中-公开
公开(公告)号：US20060020393A1
公开(公告)日：2006-01-26
申请号：US11004570
申请日：2004-12-02
申请人： David Goodlett , Andrew Keller
发明人： David Goodlett , Andrew Keller
IPC分类号： G01N33/53
CPC分类号： G01N33/6848
摘要： The invention provides a method of determining an amino acid sequence of a parent polypeptide. The method consists of: (a) obtaining mass spectra of two or more differentially labeled polypeptide fragments of a parent polypeptide; (b) assigning a mass and a weighting characteristic to two or more paired signals having a difference in mass corresponding to an integer value of said differential label, the weighting characteristic combining properties of each signal within said paired signals; (c) selecting from the mass spectra a paired signal having the assigned mass and a weighting characteristic distinguishable from non-peptide signals, the assigned mass indicating the mass of a polypeptide fragment within the spectra; (d) determining the difference in mass of the polypeptide fragments; (e) assigning the mass differences a satisfying amino acid name, and (f) orienting the assigned amino acid names. Also provided is a method of determining the amino acid sequence of a polypeptide. The method consists of: (a) constructing a graph from mass spectra of two or more differentially labeled polypeptides, the graph comprising a node with mass m, number of labels n, intensity i, and mass differential of labels δ; (b) creating a node corresponding to a paired signal having masses of about m and about m+nδ, and (c) adding a labeled weighted directed edge to the graph between any two nodes corresponding to a mass of an amino acid, the labeled weighted directed edge combining properties of the paired signals.

2. 发明授权

US06829539B2 Methods for quantification and de novo polypeptide sequencing by mass spectrometry 有权
标题翻译：通过质谱法进行定量和从头多肽测序的方法
公开(公告)号：US06829539B2
公开(公告)日：2004-12-07
申请号：US09835072
申请日：2001-04-13
申请人： David R. Goodlett , Andrew Keller
发明人： David R. Goodlett , Andrew Keller
IPC分类号： G01N3348
CPC分类号： G01N33/6848
摘要： The invention provides a method of determining an amino acid sequence of a parent polypeptide. The method consists of: (a) obtaining mass spectra of two or more differentially labeled polypeptide fragments of a parent polypeptide; (b) assigning a mass and a weighting characteristic to two or more paired signals having a difference in mass corresponding to an integer value of said differential label, the weighting characteristic combining properties of each signal within said paired signals; (c) selecting from the mass spectra a paired signal having the assigned mass and a weighting characteristic distinguishable from non-peptide signals, the assigned mass indicating the mass of a polypeptide fragment within the spectra; (d) determining the difference in mass of the polypeptide fragments; (e) assigning the mass differences a satisfying amino acid name, and (f) orienting the assigned amino acid names. Also provided is a method of determining the amino acid sequence of a polypeptide. The method consists of: (a) constructing a graph from mass spectra of two or more differentially labeled polypeptides, the graph comprising a node with mass m, number of labels n, intensity i, and mass differential of labels &dgr;; (b) creating a node corresponding to a paired signal having masses of about m and about m+n&dgr;, and (c) adding a labeled weighted directed edge to the graph between any two nodes corresponding to a mass of an amino acid, the labeled weighted directed edge combining properties of the paired signals.
摘要翻译：本发明提供了确定亲本多肽的氨基酸序列的方法。该方法包括：（a）获得母体多肽的两个或更多个差异标记的多肽片段的质谱; （b）将质量和加权特性分配给具有与所述差分标签的整数值相对应的质量差异的两个或多个配对信号，所述加权特征组合所述成对信号内的每个信号的特性; （c）从质谱中选择具有分配质量的配对信号和与非肽信号可区分的加权特征，指定的质量指示光谱内的多肽片段的质量; （d）确定多肽片段的质量差异; （e）将质量差异指定为令人满意的氨基酸名称，和（f）定向所分配的氨基酸名称。还提供了确定多肽的氨基酸序列的方法。该方法包括：（a）从两个或更多个差异标记的多肽的质谱图构建图，该图包括质量m，标记数n，强度i和标记δ的质量差的节点; （b）创建对应于具有大约m和大约m + ndelta的质量的成对信号的节点，以及（c）在对应于氨基酸质量的任何两个节点之间的图表中添加标记的加权有向边缘，配对信号的加权有向边组合属性。

3. 发明授权

US4020266A Oriented crystallization of polymers 失效
标题翻译：聚合物的定向结晶
公开(公告)号：US4020266A
公开(公告)日：1977-04-26
申请号：US543355
申请日：1975-01-23
申请人： Frederick Charles Frank , Andrew Keller , Malcolm Robert Mackley
发明人： Frederick Charles Frank , Andrew Keller , Malcolm Robert Mackley
IPC分类号： C08F6/06 , D01D5/40
CPC分类号： D01D5/40 , C08F6/06
摘要： Crystalline polymer fibrils having a highly ordered crystalline core surrounded by less ordered crystalline polymer are produced by causing a solution of the polymer to flow through a gauze. The solution is at a temperature below the dissolution temperature of the polymer but above the temperature at which the polymer will crystallize spontaneously in an unstirred solution. The flow rate is selected in relation to the gauze dimensions to impart a sufficiently high longitudinal velocity gradient to the solution flowing through the gauze, preferably about 10.sup.2 sec.sup..sup.-1 or greater.
摘要翻译：通过使聚合物的溶液流过纱布来制备具有由较有序结晶聚合物包围的高度有序结晶核的结晶聚合物原纤维。该溶液的温度低于聚合物的溶解温度，但高于聚合物在未搅拌溶液中自发结晶的温度。相对于纱布尺寸选择流速，以使流动纱布的溶液具有足够高的纵向速度梯度，优选为约102sec -1或更大。

4. 发明授权

US3990829A Oriented crystallization of polymers 失效
标题翻译：聚合物的定向结晶
公开(公告)号：US3990829A
公开(公告)日：1976-11-09
申请号：US480938
申请日：1974-06-19
申请人： Frederick Charles Frank , Andrew Keller , Malcolm Robert Mackley
发明人： Frederick Charles Frank , Andrew Keller , Malcolm Robert Mackley
IPC分类号： B29B7/00 , B29C47/00 , B29C47/12 , B29C47/54 , B29C47/92 , D01D5/08 , D01F6/04 , B29F3/06
CPC分类号： B29C47/0004 , D01D5/08 , D01F6/04 , B29C47/0014
摘要： Molten crystallizable polymer is extruded through an orifice. Opposite the orifice on the upstream side is a fixed surface arranged so as to provide in the molten polymer a line of uniaxial extension or a plane of pure shear passing through the orifice. The polymer is extruded at a temperature and flow rate such as to cause a core of crystalline polymer to form in the melt along said line or plane. It is particularly suitable for extruding a continuous filament having a highly crystalline core in a generally less crystalline matrix of the polymer.
摘要翻译：熔融的可结晶聚合物通过孔挤出。在上游侧的孔口相对的是固定表面，其布置成在熔融聚合物中提供单轴延伸线或通过孔口的纯剪切平面。聚合物在温度和流速下挤出，使得在沿着所述线或平面的熔体中形成结晶聚合物芯。特别适用于在聚合物的通常较少结晶的基质中挤出具有高度结晶的芯的连续长丝。

5. 发明授权

US5001206A Oriented polyolfins 失效
标题翻译：定向聚糖
公开(公告)号：US5001206A
公开(公告)日：1991-03-19
申请号：US492433
申请日：1990-03-07
申请人： Zahir Bashir , Andrew Keller , Jeffrey A. Odell
发明人： Zahir Bashir , Andrew Keller , Jeffrey A. Odell
IPC分类号： B29C47/00 , B29C55/00 , B29C55/30 , B29K23/00 , C08F2/00 , C08F8/00 , C08F10/00 , D01F6/04 , D01F6/30
CPC分类号： D01F6/04 , B29C55/00 , B29K2023/00
摘要： The present invention relates to an orientated polyolefin composition comprising an olefin (co)polymer having a weight average molecular weight (Mw) from 30,000 to 1,000,000 and a high molecular weight tail extending to molecular weights above 1,000,000, and has a microstructure which is substantially parallel chain extended cores of the component polymer(s) and associated lamellar overgrowths extending in planes normal to the cores. The lamellar overgrowths an adjacent cores intermesh and are capable of sustaining a haul off tension of at least 10 MPa without breaking during its extrusion.The orientated polyolefin composition is produced by extruding an olefin copolymer through a die under a pressure of about 5-10 MPa, at a temperature above the self-blocking temperature thereof and by hauling off the extrudate at a tension of at least 10 MPa without breaking. The extrudates so produced have a high modulus.

6. 发明申请

US20220004257A1 HEADWARE FOR COMPUTER CONTROL 有权
公开(公告)号：US20220004257A1
公开(公告)日：2022-01-06
申请号：US17364180
申请日：2021-06-30
申请人： Andrew Keller , Alexander Aziz Castillo Alvarez , Samuel Stephen Holland
发明人： Andrew Keller , Alexander Aziz Castillo Alvarez , Samuel Stephen Holland
IPC分类号： G06F3/01 , G08B6/00 , G06F1/16
摘要： A headware for computer control includes a body portion. A first arm is pivotally coupled to the body portion and a second arm is pivotably coupled to the body portion. The first arm and the second arm define a central region therebetween. A pivoting mechanism is coupled to the first arm or the second arm and the body portion. The pivoting mechanism pivots the first arm or the second arm towards or away from the central region. The pivoting mechanism includes a pivot pin securing the first arm or the second arm to the body portion. A biasing member biases the first arm or the second arm toward the central region when the first arm or the second arm is pivoted away from the central region.

7. 发明授权

US4948545A Extrusion process for preparing orientated polyolefins 失效
标题翻译：制备取向聚烯烃的挤出方法
公开(公告)号：US4948545A
公开(公告)日：1990-08-14
申请号：US418992
申请日：1989-10-06
申请人： Zahir Bashir , Andrew Keller , Jeffrey A. Odell
发明人： Zahir Bashir , Andrew Keller , Jeffrey A. Odell
IPC分类号： B29C47/00 , B29C55/00 , B29C55/30 , B29K23/00 , C08F2/00 , C08F8/00 , C08F10/00 , D01F6/04 , D01F6/30
CPC分类号： D01F6/04 , B29C55/00 , B29K2023/00
摘要： An orientated polyolefin composition comprising an olefin (co)polymer having a weight average molecular weight (Mw) from 30,000 to 1,000,000 and a high molecular weight tail extending to molelcular weights above 1,000,000, and has a microstructure which is substantially parallel chain extended cores of the component polymer(s) and associated lamellar overgrowths extending in planes normal to the cores in which the lamellar overgrowths on adjacent cores intermesh and are capable of sustaining a haul off tension of at least 10 MPa without breaking during its extrusion, is produced by extruding an olefin copolymer through a die under a pressure of about 5-10 MPa, at a temperature above the self-blocking temperature thereof and by hauling off the extrudate at a tension of at least 10 MPa without breaking. The extrudates so produced have a high modulus.
摘要翻译：一种取向的聚烯烃组合物，其包含重均分子量（Mw）为30,000至1,000,000的烯烃（共）聚合物和延伸至高于1,000,000的摩尔重量的高分子量尾部，并且具有基本平行的链延伸芯的微结构组分聚合物和相关的层状过度生长在垂直于芯的平面中延伸，其中在相邻芯上的层状过度生长相互啮合并且能够在其挤出期间能够承受至少10MPa的牵引张力而不断裂，通过挤出烯烃共聚物通过模具在约5-10MPa的压力下，在高于其自身阻塞温度的温度下，并且以至少10MPa的张力牵引挤出物而不破裂。如此制造的挤出物具有高模量。

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