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    • 7. 发明申请
    • Measurement of bioactive hepcidins
    • 生物活性肝素的测定
    • US20060019339A1
    • 2006-01-26
    • US11119293
    • 2005-04-28
    • Xavier LauthMark WestermanVaughn OstlandJason StannardMichael Pennington
    • Xavier LauthMark WestermanVaughn OstlandJason StannardMichael Pennington
    • C12P21/06C07K14/47
    • C07K14/461C07K16/26
    • The present invention concerns a method for the oxidative refolding of a hepcidin polypeptide to a form that is mature, bioactive and folded as in the native configuration and molecular mass; a method for measuring the level of native, bioactive hepcidin in a vertebrate animal; a method for measuring the level of hepcidin gene expression in a vertebrate animal; and a method for regulating the production of native, bioactive hepcidin in a vertebrate animal in vivo. The present invention also concerns an antibody or fragment thereof that specifically binds to a continuous, discontinuous, and/or conformational epitope of a mature and bioactive hepcidin folded as in the native configuration; and a pharmaceutical composition that includes the antibody or a hepcidin polypeptide and that provides antimicrobial, agonistic, or antagonistic activities in vivo in a vertebrate animal.
    • 本发明涉及一种将铁调素多肽氧化重折叠成为天然构型和分子质量的成熟,生物活性和折叠形式的方法; 用于测量脊椎动物中天然的,生物活性的铁调素的水平的方法; 测定脊椎动物中铁调素基因表达水平的方法; 以及用于调节脊椎动物体内天然生物活性铁调素的产生的方法。 本发明还涉及特异性结合如天然构型折叠的成熟和生物活性铁调素的连续,不连续和/或构象表位的抗体或其片段; 以及包含抗体或铁调素多肽并且在脊椎动物体内提供抗微生物,激动或拮抗活性的药物组合物。