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1. 发明申请

US20120129735A1 NON-AQUEOUS DRILLING ADDITIVE USEFUL TO PRODUCE A FLAT TEMPERATURE-RHEOLOGY PROFILE 审中-公开
标题翻译：非水性钻孔添加剂有助于生产平坦温度 - 流变学特征
公开(公告)号：US20120129735A1
公开(公告)日：2012-05-24
申请号：US12950164
申请日：2010-11-19
申请人： David Dino , Yanhui Chen , Jeffrey Thompson
发明人： David Dino , Yanhui Chen , Jeffrey Thompson
IPC分类号： C09K8/34
CPC分类号： C09K8/32 , C09K8/36
摘要： A method of providing a substantially constant equivalent circulating density of a drilling fluid over a temperature range of about 120° F. to about 40° F. includes adding a drilling fluid additive to the drilling fluid, wherein the drilling fluid additive includes the reaction product of a carboxylic acid with a single carboxylic moiety; and a polyamine having at least two primary amino functionalities and optionally at least one secondary amino functionality.
摘要翻译：在约120°F至约40°F的温度范围内提供钻井液基本上恒定的等效循环密度的方法包括向钻井液中添加钻井液添加剂，其中钻井液添加剂包括反应产物的具有单个羧基部分的羧酸; 和具有至少两个伯氨基官能团和任选至少一个仲氨基官能团的多胺。

2. 发明申请

US20100009873A1 Thermally Stable Compositions and Use Thereof in Drilling Fluids 有权
标题翻译：热稳定组合物及其在钻井液中的应用
公开(公告)号：US20100009873A1
公开(公告)日：2010-01-14
申请号：US12517410
申请日：2007-10-22
申请人： David Dino , Jeffrey Thompson , Richard Geurtsen
发明人： David Dino , Jeffrey Thompson , Richard Geurtsen
IPC分类号： C09K8/24 , C08G18/00
CPC分类号： C09K8/34 , C09K8/035 , C09K8/36
摘要： A composition is comprised of a mixture of the reaction product of an amine and a poly-functional isocyanate, and the reaction product of (i) a carboxylic acid with at least two carboxylic moieties; (ii) a polyamine having an amine functionality of two or more; and a chemical selected from the group consisting of (i) alkoxylated alkyl amines, (ii) fatty acid amides and (iii) mixtures thereof, and it is used as a drilling fluid additive.
摘要翻译：组合物由胺和多官能异氰酸酯的反应产物和（i）羧酸与至少两个羧基部分的反应产物的混合物组成; （ii）胺官能度为2以上的多胺; 和选自（i）烷氧基化烷基胺，（ii）脂肪酸酰胺和（iii）其混合物）的化学物质，并且其用作钻井液添加剂。

3. 发明授权

US07345010B2 Compositions for drilling fluids useful to provide flat temperature rheology to such fluids over a wide temperature range and drilling fluids containing such compositions 有权
标题翻译：用于在宽温度范围内为这种流体提供平坦温度流变性的钻井液的组合物和含有这种组合物的钻井液
公开(公告)号：US07345010B2
公开(公告)日：2008-03-18
申请号：US10304167
申请日：2002-11-27
申请人： Jeffrey Thompson , David Dino , Richard Jobbins , Mark Matyi, Jr.
发明人： Jeffrey Thompson , David Dino , Richard Jobbins , Mark Matyi, Jr.
IPC分类号： C09K8/22
CPC分类号： C08G69/34 , C09K8/32
摘要： The invention is of oil-based drilling fluids including invert emulsion fluids that are able to maintain a relatively consistent rheological profile over a wide temperature range. The invention also includes new additives that enable the preparation of drilling fluids with viscosities that are less affected by temperature over a temperature range from less than about 40° F. to more than about 250° F. compared to conventional fluids. These additives are based on reaction products of polyamines and carboxylic acids with two or more carboxylic moieties combined with alkoxylated amines and fatty acid amides. In addition, this invention permits the use of reduced amounts of organoclay rheological additives in drilling fluids.
摘要翻译：本发明是一种油基钻井液，包括能够在宽的温度范围内保持相对一致的流变特征的反相乳液。本发明还包括新的添加剂，其能够制备具有在常规流体下比在小于约40°F至大于约250°F的温度范围内受温度影响较小的粘度的钻井液。这些添加剂基于多胺和羧酸与两个或多个羧酸部分与烷氧基化胺和脂肪酸酰胺结合的反应产物。此外，本发明允许在钻井液中使用减少量的有机粘土流变添加剂。

4. 发明授权

US06462096B1 Organophilic clay additives and oil well drilling fluids with less temperature dependent rheological properties containing said additives 有权
标题翻译：亲油性粘土添加剂和油井钻井液，具有较低的温度依赖性流变性能，含有所述添加剂
公开(公告)号：US06462096B1
公开(公告)日：2002-10-08
申请号：US09535549
申请日：2000-03-27
申请人： David Dino , Jeffrey Thompson
发明人： David Dino , Jeffrey Thompson
IPC分类号： C09K700
CPC分类号： C01B33/44 , C09K8/32 , Y10S507/901
摘要： Conventional organophilic clays, when used as rheological additives in oil based invert muds, display marked viscosity loses in the mud when these muds are heated much above 350° F., whereas muds prepared according to the present invention are dramatically more viscosity stable at temperatures through 500° F. The present invention relates to the discovery of oil based invert emulsion drilling fluids that provides more stable drilling fluid viscosity and anti-settling performance over varying temperatures when compared to conventional fluids containing organoclays. As a result, the inventive fluids of this invention are ideal candidates for high temperature applications. This invention in another aspect of this invention is a process for improving the rheological properties of oil well drilling fluids particularly useful for oil-based invert emulsion types of drilling fluids. The new process uses as a rheological viscosifer for such fluids as a specific organoclay which when added to a drilling fluid at from about 0.5 and 5% by weight creates an inventive drilling fluid composition less sensitive to the very hot temperatures found in the drilling hole, and in the long stem of drilling pipe.
摘要翻译：常规的亲有机粘土当用作油基反向泥浆中的流变添加剂时，当这些泥浆被加热到高于350°F时，在泥浆中显示出显着的粘度损失，而根据本发明制备的泥浆在通过 500°F。本发明涉及油基反相乳液钻井液的发现，当与含有机粘土的常规流体相比时，其能够在变化的温度下提供更稳定的钻井液粘度和抗沉降性能。因此，本发明的发明流体是高温应用的理想候选物。本发明在本发明的另一方面是一种改进油井钻井液流变性能的方法，特别适用于油基反相乳液型钻井液。新方法用作这种流体的流变粘稠剂，例如特定的有机粘土，当以约0.5和5重量％的量加入到钻井液中时，会产生对钻孔中发现的非常高的温度敏感的本发明的钻井液组合物，并在钻杆的长杆上。

5. 发明授权

US08389447B2 Organophilic clay additives and oil well drilling fluids with less temperature dependent rheological properties 有权
标题翻译：亲油性粘土添加剂和具有较低温度依赖性流变性能的油井钻井液
公开(公告)号：US08389447B2
公开(公告)日：2013-03-05
申请号：US12793895
申请日：2010-06-04
申请人： David Dino , Jeffrey Thompson
发明人： David Dino , Jeffrey Thompson
IPC分类号： C09K8/60
CPC分类号： C01B33/44 , C09K8/32 , C09K8/36
摘要： An additive composition including a synergistic combination of a hectorite organoclay composition and an attapulgite organoclay composition. The hectorite organoclay composition includes (i) a first organic cation provided by an alkoxylated quaternary ammonium salt; and ii) a second organic cation wherein such second organic cation is not provided by an alkoxylated quaternary ammonium salt. The attapulgite organoclay composition includes (iii) a third organic cation provided by an alkoxylated quaternary ammonium salt; and (iv) a fourth organic cation wherein such third organic cation is not provided by an alkoxylated quaternary ammonium salt.
摘要翻译：包含锂蒙脱石有机粘土组合物和凹凸棒有机粘土组合物的协同组合的添加剂组合物。锂蒙脱石有机粘土组合物包括（i）由烷氧基化季铵盐提供的第一有机阳离子; 和ii）第二有机阳离子，其中所述第二有机阳离子不由烷氧基化季铵盐提供。凹凸棒有机粘土组合物包括（iii）由烷氧基化季铵盐提供的第三有机阳离子; 和（iv）第四有机阳离子，其中这种第三有机阳离子不由烷氧基化季铵盐提供。

6. 发明授权

US07906461B2 Thermally stable compositions and use thereof in drilling fluids 有权
标题翻译：热稳定组合物及其在钻井液中的应用
公开(公告)号：US07906461B2
公开(公告)日：2011-03-15
申请号：US12517410
申请日：2007-10-22
申请人： David Dino , Jeffrey Thompson , Richard Geurtsen
发明人： David Dino , Jeffrey Thompson , Richard Geurtsen
IPC分类号： C09K8/32 , C09K8/60 , E21B21/00 , E21B43/16
CPC分类号： C09K8/34 , C09K8/035 , C09K8/36
摘要： A composition is comprised of a mixture of the reaction product of an amine and a poly-functional isocyanate, and the reaction product of (i) a carboxylic acid with at least two carboxylic moieties; (ii) a polyamine having an amine functionality of two or more; and a chemical selected from the group consisting of (i) alkoxylated alkyl amines, (ii) fatty acid amides and (iii) mixtures thereof, and it is used as a drilling fluid additive.
摘要翻译：组合物由胺和多官能异氰酸酯的反应产物和（i）羧酸与至少两个羧基部分的反应产物的混合物组成; （ii）胺官能度为2以上的多胺; 和选自（i）烷氧基化烷基胺，（ii）脂肪酸酰胺和（iii）其混合物）的化学物质，并且其用作钻井液添加剂。

7. 发明申请

US20080188382A1 Compositions for Drilling Fluids Useful to Provide Flat Temperature Rheology to Such Fluids Over a Wide Temperature Range, and Drilling Fluids Containing Such Compositions 审中-公开
标题翻译：用于在宽温度范围内向这种流体提供平面温度流变性的钻井液组合物和含有这种组合物的钻井液
公开(公告)号：US20080188382A1
公开(公告)日：2008-08-07
申请号：US11963182
申请日：2007-12-21
申请人： Jeffrey Thompson , David Dino , Richard Jobbins , Mark Matyi
发明人： Jeffrey Thompson , David Dino , Richard Jobbins , Mark Matyi
IPC分类号： C09K8/68
CPC分类号： C08G69/34 , C09K8/32
摘要： The invention is of oil-based drilling fluids including invert emulsion fluids that are able to maintain a relatively consistent rheological profile over a wide temperature range. The invention also includes new additives that enable the preparation of drilling fluids with viscosities that are less affected by temperature over a temperature range from less than about 40° F. to more than about 250° F. compared to conventional fluids. These additives are based on reaction products of polyamines and carboxylic acids with two or more carboxylic moieties combined with alkoxylated amines and fatty acid amides. In addition, this invention permits the use of reduced amounts of organoclay rheological additives in drilling fluids.
摘要翻译：本发明是一种油基钻井液，包括能够在宽的温度范围内保持相对一致的流变特征的反相乳液。本发明还包括新的添加剂，其能够制备具有在常规流体下比在小于约40°F至大于约250°F的温度范围内受温度影响较小的粘度的钻井液。这些添加剂基于多胺和羧酸与两个或多个羧酸部分与烷氧基化胺和脂肪酸酰胺结合的反应产物。此外，本发明允许在钻井液中使用减少量的有机粘土流变添加剂。

8. 发明申请

US20070197403A1 Organophilic clay additives and oil well drilling fluids with less temperature dependent rheological properties 审中-公开
标题翻译：亲油性粘土添加剂和具有较低温度依赖性流变性能的油井钻井液
公开(公告)号：US20070197403A1
公开(公告)日：2007-08-23
申请号：US11359786
申请日：2006-02-22
申请人： David Dino , Jeffrey Thompson
发明人： David Dino , Jeffrey Thompson
IPC分类号： C09K8/64
CPC分类号： C09K8/32 , C01B33/44
摘要： Conventional organophilic clays, when used as rheological additives in oil and oil based invert muds, display marked viscosity loses in the mud when these muds are heated much above 350° F., whereas muds prepared according to the present invention are dramatically more viscosity-stable at temperatures through 400° F. The present invention relates to the discovery of oil and oil based invert emulsion drilling fluids that provides more stable drilling fluid viscosity and anti-settling performance over varying temperatures when compared to conventional fluids containing conventional organoclays. As a result, the inventive fluids of this invention are ideal candidates for high temperature applications. This invention in another aspect of this invention is a process for improving the rheological properties of oil well drilling fluids particularly useful for oil-based invert emulsion types of drilling fluids. The new process uses as a rheological viscosifer for such fluids a specific organoclay which when added to a drilling fluid at from about 0.5 and 5% by weight creates an inventive drilling fluid composition less sensitive to the very hot temperatures found in the drilling hole, and in the long stem of drilling pipe.
摘要翻译：常规的亲有机粘土当用作石油和油基反相泥浆中的流变添加剂时，当这些泥浆被加热到高于350°F时，在泥浆中显示出显着的粘度损失，而根据本发明制备的泥浆显着地更粘稠本发明涉及油相和油基反相乳液钻井液的发现，当与常规有机粘土的常规流体相比时，其提供了在变化的温度下更稳定的钻井液粘度和抗沉降性能。因此，本发明的发明流体是高温应用的理想候选物。本发明在本发明的另一方面是一种改进油井钻井液流变性能的方法，特别适用于油基反相乳液型钻井液。新方法用作这种流体的流变粘稠剂，特定的有机粘土当以约0.5和5重量％加入到钻井液中时产生对钻孔中发现的非常高的温度不太敏感的本发明的钻井液组合物，以及在钻杆的长杆上。

9. 发明授权

US08303958B2 Method of treating immunological disorders by administering truncated BAFF receptors 有权
标题翻译：通过施用截短的BAFF受体来治疗免疫疾病的方法
公开(公告)号：US08303958B2
公开(公告)日：2012-11-06
申请号：US13213826
申请日：2011-08-19
申请人： Christine Ambrose , Jeffrey Thompson , Yen-Ming Hsu , Dingyi Wen , Yaping Sun
发明人： Christine Ambrose , Jeffrey Thompson , Yen-Ming Hsu , Dingyi Wen , Yaping Sun
IPC分类号： A61K38/00 , A61K38/17 , A61K38/18 , C07K14/435 , C07K14/705 , C07K14/71 , C07K14/715
CPC分类号： C07K14/715 , A61K38/00 , A61K39/00 , A61K2039/505 , C07K14/70578 , C07K14/7151 , C07K16/18 , C07K16/2866 , C07K2317/52 , C07K2317/73 , C07K2319/30
摘要： The disclosure provides a non-naturally occurring BAFF-R glycoprotein having a deletion in the extracellular domain which results in an altered 0-linked glycosylation pattern. The disclosure also provides methods and pharmaceutical compositions for treating B-cell- and T-cell-mediated disorders.
摘要翻译：本公开提供在细胞外结构域中具有缺失的非天然存在的BAFF-R糖蛋白，其导致改变的O-连接的糖基化模式。本公开还提供了用于治疗B细胞和T细胞介导的病症的方法和药物组合物。

10. 发明申请

US20110311530A1 TRUNCATED BAFF RECEPTORS 有权
标题翻译：截断BAFF受体
公开(公告)号：US20110311530A1
公开(公告)日：2011-12-22
申请号：US13213826
申请日：2011-08-19
申请人： Christine Ambrose , Jeffrey Thompson , Yen-Ming Hsu , Dingyi Wen , Yaping Sun
发明人： Christine Ambrose , Jeffrey Thompson , Yen-Ming Hsu , Dingyi Wen , Yaping Sun
IPC分类号： A61K38/17 , C12N15/12 , C12N15/63 , C12N5/10 , C12P21/02 , C07K19/00 , A61K48/00 , A61K39/395 , A61P37/06 , A61P9/10 , A61P29/00 , A61P35/00 , A61P31/12 , A61P13/12 , C07K14/715
CPC分类号： C07K14/715 , A61K38/00 , A61K39/00 , A61K2039/505 , C07K14/70578 , C07K14/7151 , C07K16/18 , C07K16/2866 , C07K2317/52 , C07K2317/73 , C07K2319/30
摘要： The disclosure provides a non-naturally occurring BAFF-R glycoprotein having a deletion in the extracellular domain which results in an altered 0-linked glycosylation pattern. The disclosure also provides methods and pharmaceutical compositions for treating B-cell- and T-cell-mediated disorders.
摘要翻译：本公开提供在细胞外结构域中具有缺失的非天然存在的BAFF-R糖蛋白，其导致改变的O-连接的糖基化模式。本公开还提供了用于治疗B细胞和T细胞介导的病症的方法和药物组合物。

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