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1. 发明申请

US20070248643A1 Polymerizable emulsions for tissue engineering 失效
标题翻译：用于组织工程的可聚合乳液
公开(公告)号：US20070248643A1
公开(公告)日：2007-10-25
申请号：US11799145
申请日：2007-05-01
申请人： David Devore , Paul Ducheyne , Charles Cohen
发明人： David Devore , Paul Ducheyne , Charles Cohen
IPC分类号： A61K9/00
CPC分类号： A61L27/26 , A61K31/00 , A61K31/74 , A61L27/38 , A61L27/50 , A61L27/52 , A61L27/54 , A61L2300/256 , A61L2300/414 , A61L2300/43 , A61L2300/64 , C08F290/048
摘要： Provided are biocompatible viscoelastic solid materials derived from polymerization of fluid water-in-oil emulsions, along with methods of their preparation and methods for their use for tissue engineering applications, including for reforming diseased, damaged or degenerated intervertebral discs by acceptably non-invasive means.
摘要翻译：提供衍生自流体油包水乳液的聚合的生物相容性粘弹性固体材料及其制备方法及其用于组织工程应用的方法，包括通过可接受的非侵入性方式重建患病，受损或退化的椎间盘。

2. 发明申请

US20070218124A1 Polymerizable emulsions for tissue engineering 失效
公开(公告)号：US20070218124A1
公开(公告)日：2007-09-20
申请号：US11799347
申请日：2007-05-01
申请人： David Devore , Paul Ducheyne , Charles Cohen
发明人： David Devore , Paul Ducheyne , Charles Cohen
IPC分类号： A61K9/127 , A61K9/107 , A61K9/14
CPC分类号： A61L27/26 , A61K31/00 , A61K31/74 , A61L27/38 , A61L27/50 , A61L27/52 , A61L27/54 , A61L2300/256 , A61L2300/414 , A61L2300/43 , A61L2300/64 , C08F290/048
摘要： Provided are biocompatible viscoelastic solid materials derived from polymerization of fluid water-in-oil emulsions, along with methods of their preparation and methods for their use for tissue engineering applications, including for reforming diseased, damaged or degenerated intervertebral discs by acceptably non-invasive means.

3. 发明授权

US07651682B2 Polymerizable emulsions for tissue engineering 失效
标题翻译：用于组织工程的可聚合乳液
公开(公告)号：US07651682B2
公开(公告)日：2010-01-26
申请号：US10977521
申请日：2004-10-29
申请人： David Devore , Paul Ducheyne , Charles Cohen
发明人： David Devore , Paul Ducheyne , Charles Cohen
IPC分类号： A61K31/74 , A61K6/083 , A61F2/00
CPC分类号： A61L27/26 , A61K31/00 , A61K31/74 , A61L27/38 , A61L27/50 , A61L27/52 , A61L27/54 , A61L2300/256 , A61L2300/414 , A61L2300/43 , A61L2300/64 , C08F290/048
摘要： Provided are biocompatible viscoelastic solid materials derived from polymerization of fluid water-in-oil emulsions, along with methods of their preparation and methods for their use for tissue engineering applications, including for reforming diseased, damaged or degenerated intervertebral discs by acceptably non-invasive means.
摘要翻译：提供衍生自流体油包水乳液的聚合的生物相容性粘弹性固体材料及其制备方法及其用于组织工程应用的方法，包括通过可接受的非侵入性方式重建患病，受损或退化的椎间盘。

4. 发明授权

US07651683B2 Polymerizable emulsions for tissue engineering 失效
公开(公告)号：US07651683B2
公开(公告)日：2010-01-26
申请号：US11799347
申请日：2007-05-01
申请人： David Devore , Paul Ducheyne , Charles Cohen
发明人： David Devore , Paul Ducheyne , Charles Cohen
IPC分类号： A61K31/74 , A61K6/083 , A61F2/00
CPC分类号： A61L27/26 , A61K31/00 , A61K31/74 , A61L27/38 , A61L27/50 , A61L27/52 , A61L27/54 , A61L2300/256 , A61L2300/414 , A61L2300/43 , A61L2300/64 , C08F290/048
摘要： Provided are biocompatible viscoelastic solid materials derived from polymerization of fluid water-in-oil emulsions, along with methods of their preparation and methods for their use for tissue engineering applications, including for reforming diseased, damaged or degenerated intervertebral discs by acceptably non-invasive means.

5. 发明授权

US07537754B2 Polymerizable emulsions for tissue engineering 失效
标题翻译：用于组织工程的可聚合乳液
公开(公告)号：US07537754B2
公开(公告)日：2009-05-26
申请号：US11799145
申请日：2007-05-01
申请人： David Devore , Paul Ducheyne , Charles Cohen
发明人： David Devore , Paul Ducheyne , Charles Cohen
IPC分类号： A61K31/74 , A61K6/083 , A61F2/00
CPC分类号： A61L27/26 , A61K31/00 , A61K31/74 , A61L27/38 , A61L27/50 , A61L27/52 , A61L27/54 , A61L2300/256 , A61L2300/414 , A61L2300/43 , A61L2300/64 , C08F290/048
摘要： Provided are biocompatible viscoelastic solid materials derived from polymerization of fluid water-in-oil emulsions, along with methods of their preparation and methods for their use for tissue engineering applications, including for reforming diseased, damaged or degenerated intervertebral discs by acceptably non-invasive means.
摘要翻译：提供衍生自流体油包水乳液的聚合的生物相容性粘弹性固体材料及其制备方法及其用于组织工程应用的方法，包括通过可接受的非侵入性方式重建患病，受损或退化的椎间盘。

6. 发明申请

US20050112186A1 Polymerizable emulsions for tissue engineering 失效
标题翻译：用于组织工程的可聚合乳液
公开(公告)号：US20050112186A1
公开(公告)日：2005-05-26
申请号：US10977521
申请日：2004-10-29
申请人： David Devore , Paul Ducheyne , Charles Cohen
发明人： David Devore , Paul Ducheyne , Charles Cohen
IPC分类号： A61K9/127 , A61K9/14 , A61K31/00 , A61K31/74 , A61L27/50 , A61L27/52 , C08F290/04
CPC分类号： A61L27/26 , A61K31/00 , A61K31/74 , A61L27/38 , A61L27/50 , A61L27/52 , A61L27/54 , A61L2300/256 , A61L2300/414 , A61L2300/43 , A61L2300/64 , C08F290/048
摘要： Provided are biocompatible viscoelastic solid materials derived from polymerization of fluid water-in-oil emulsions, along with methods of their preparation and methods for their use for tissue engineering applications, including for reforming diseased, damaged or degenerated intervertebral discs by acceptably non-invasive means.
摘要翻译：提供衍生自流体油包水乳液的聚合的生物相容性粘弹性固体材料及其制备方法及其用于组织工程应用的方法，包括通过可接受的非侵入性方式重建患病，受损或退化的椎间盘。

7. 发明申请

US20050118236A1 Bioactive, resorbable scaffolds for tissue engineering 审中-公开
标题翻译：生物活性，可吸收的组织工程支架
公开(公告)号：US20050118236A1
公开(公告)日：2005-06-02
申请号：US10721028
申请日：2003-11-24
申请人： Qing-Qing Qiu , Charles Cohen , Paul Ducheyne
发明人： Qing-Qing Qiu , Charles Cohen , Paul Ducheyne
IPC分类号： A61B20060101 , A61K9/70 , A61K45/00 , A61L27/10 , A61L27/34 , A61L27/44 , A61L27/56
CPC分类号： A61L27/446 , A61L27/10 , A61L27/34 , A61L27/56 , Y10T442/2525 , C08L67/04
摘要： Flexible, bioactive glass meshes and scaffolds made therefrom are provided. The meshes comprise interwoven bioactive glass fibers that can be coated with resorbable polymers. Meshes can also be woven from glass fibers and resorbable polymers. Scaffolds can be constructed by a plurality of meshes, which can have varying porosities to create porosity gradients in the scaffold. Methods of making scaffolds are provided which can comprise pulling bioactive glass fibers, winding the fibers, forming the fibers into bundles, coating the fibers with a resorbable polymer, and creating a biaxial weave with the bundles. Soft tissue engineering methods are also provided for creating scaffolds for incubating cells such as fibroblasts and chondroblasts. Meshes and scaffolds are suitable for tissue engineering, such as bone tissue engineering and cartilage tissue engineering.
摘要翻译：提供由其制成的柔性，生物活性玻璃网和支架。网格包括交织的生物活性玻璃纤维，其可以涂覆有可再吸收的聚合物。网格也可以由玻璃纤维和可再吸收的聚合物编织。支架可以由多个网孔构成，其可以具有不同的孔隙度以在支架中产生孔隙度梯度。提供制备支架的方法，其可以包括拉动生物活性玻璃纤维，缠绕纤维，将纤维形成束，用可再吸收的聚合物涂覆纤维，以及用束形成双轴织造。还提供软组织工程方法用于产生用于孵育细胞如纤维母细胞和软骨细胞的支架。网格和支架适用于组织工程，如骨组织工程和软骨组织工程。

8. 发明授权

US11135174B2 Coated mesoporous nanoparticles 有权
公开(公告)号：US11135174B2
公开(公告)日：2021-10-05
申请号：US14110839
申请日：2012-04-12
申请人： Paul Ducheyne , Sanjib Bhattacharyya
发明人： Paul Ducheyne , Sanjib Bhattacharyya
IPC分类号： A61K9/51 , A61K47/60 , A61K9/50 , A61K47/69
摘要： Provided are methods for producing mesoporous nanoparticles that can, once loaded, retain small or large molecules (e.g., molecules having a molecular weight that is less or greater than about 900 Da) until release is desired, upon which time the mesoporous nanoparticles can release the loaded molecule in a controlled manner for a desired period of time, including an extended period of time. Also disclosed are methods for treating a subject comprising administering to the subject a mesoporous nanoparticle according to the present disclosure.

9. 发明申请

US20090324695A1 BIOCOMPATIBLE POLYMER CERAMIC COMPOSITE MATRICES 审中-公开
标题翻译：生物易燃聚合物陶瓷复合材料
公开(公告)号：US20090324695A1
公开(公告)日：2009-12-31
申请号：US12476009
申请日：2009-06-01
申请人： Paul Ducheyne , David I. Devore
发明人： Paul Ducheyne , David I. Devore
IPC分类号： A61K9/00 , A61P17/02
CPC分类号： A61K9/1641 , A61K9/0014
摘要： Biocompatible composites of flexible polymers/copolymers films and dispersed solid silica-based ceramic microparticles are provided. The composites uniquely combine material and drug delivery properties that are essential for wound dressings and drug delivery applications. The flexible copolymer films are preferably tyrosine-based polycarbonates, and the ceramic microparticles are biodegradable silica-based glass particles that are preferably processed by a sol-gel methodology. The copolymers and the ceramic microparticles independently can contain therapeutic agents, are independently capable of binding these agents, and can independently release such agents. It is sufficient that either the polymer or the ceramic contains therapeutic agents, although both may contain them.
摘要翻译：提供柔性聚合物/共聚物膜和分散的固体二氧化硅基陶瓷微粒的生物相容性复合材料。复合材料独特地结合材料和药物递送性质，这对于伤口敷料和药物递送应用至关重要。柔性共聚物膜优选为酪氨酸基聚碳酸酯，并且陶瓷微粒为可生物降解的二氧化硅基玻璃颗粒，其优选通过溶胶 - 凝胶法加工。共聚物和陶瓷微粒独立地可以含有治疗剂，独立地能够结合这些试剂，并且可以独立地释放这些试剂。聚合物或陶瓷都含有治疗剂就足够了，尽管两者都可能含有它们。

10. 发明授权

US06224913B1 Conditioning of bioactive glass surfaces in protein containing solutions 失效
标题翻译：调节含蛋白质溶液中的生物活性玻璃表面
公开(公告)号：US06224913B1
公开(公告)日：2001-05-01
申请号：US08977093
申请日：1997-11-24
申请人： Paul Ducheyne , Shulamith Radin
发明人： Paul Ducheyne , Shulamith Radin
IPC分类号： A61K3342
CPC分类号： A61L27/56 , A61F2310/00293 , A61F2310/00796 , A61K9/501 , A61L27/12 , A61L27/32 , A61L27/34 , A61L27/50 , A61L27/54 , A61L2300/252 , A61L2300/402 , A61L2300/406 , A61L2300/41 , A61L2300/414 , A61L2300/45 , Y10S623/908 , Y10S623/911 , Y10S623/919 , Y10S623/923 , Y10T428/2993 , C08L89/06
摘要： Conditioning of the surface of silica-based glass or ceramic by differential immersion in a serum protein-containing solution, and the resultant microporous Ca—P surface layer having serum-protein like organic molecules, as defined herein intermingled throughout, is described.
摘要翻译：描述了通过在含血清蛋白的溶液中差异浸渍来调节二氧化硅基玻璃或陶瓷的表面，并且所得的所有微结构的具有如蛋白质如有机分子的蛋白质如表面层混合在一起。

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